DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-21Ca and ASGR1

DIOPT Version :9

Sequence 1:	NP_652642.2	Gene:	lectin-21Ca / 53552	FlyBaseID:	FBgn0040107	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_001662.1	Gene:	ASGR1 / 432	HGNCID:	742	Length:	291	Species:	Homo sapiens

Alignment Length:	238	Identity:	45/238 - (18%)
Similarity:	88/238 - (36%)	Gaps:	63/238 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 IEGQEKETNDKIKVIHDNVDNEFNALSAKIKNVK----NIQRHLASLELQLQETKKAL-----NL 128
            |..|..:..::::.:.:...|...:..|::|.:.    |:.|.:.|||.||::.:|.|     :|
Human    59 IGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSL 123

  Fly   129 SVEAKKVM------------------PKTEIPSQFQKIGWRHFFIEKKHKVDWFK--------AT 167
            .:..|:.:                  .:|..|     :.|    :|.:....||.        |.
Human   124 LLHVKQFVSDLRSLSCQMAALQGNGSERTCCP-----VNW----VEHERSCYWFSRSGKAWADAD 179

  Fly   168 SMCHKMGAHLLTIQSEDELDAIRTELKDINDGSHDFWLDINDIA---KWGEFISLATGMNPPFLK 229
            :.|....|||:.:.|.:|...::..:..:|.     |:.::|..   ||.:.....||    |..
Human   180 NYCRLEDAHLVVVTSWEEQKFVQHHIGPVNT-----WMGLHDQNGPWKWVDGTDYETG----FKN 235

  Fly   230 WHKHRPQ------VQIHQRCVHLR-GGEMMDGKCSEQFLFICQ 265
            |...:|.      :...:.|.|.. .|...|..|...:.::|:
Human   236 WRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCE 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-21Ca	NP_652642.2	CLECT	158..265	CDD:153057	24/124 (19%)
ASGR1	NP_001662.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Endocytosis signal. /evidence=ECO:0000255	5..8
		Lectin_N	17..144	CDD:309178	16/84 (19%)
		CLECT_DC-SIGN_like	154..279	CDD:153060	28/143 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910