DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-21Ca and CD209

DIOPT Version :9

Sequence 1:	NP_652642.2	Gene:	lectin-21Ca / 53552	FlyBaseID:	FBgn0040107	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_066978.1	Gene:	CD209 / 30835	HGNCID:	1641	Length:	404	Species:	Homo sapiens

Alignment Length:	222	Identity:	42/222 - (18%)
Similarity:	96/222 - (43%)	Gaps:	26/222 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 QVNETRKQLAKIEGQEKETNDKIKVIHDNVDNEFNALSAKIKNV------KNIQRHLASLEL--- 117
            ::.|..::|.:::....|..:|.|  ...:..|...|.|.:..:      :.|.:.|..|:.
Human   165 KMQEIYQELTRLKAAVGELPEKSK--QQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVG 227

  Fly   118 QLQETKKALNLSVEAKKVMPKTE-----IPSQFQKIGWRHFFIEKKHKVDWFKATSMCHKMGAHL 177
            :|.|..|...:..|..::....|     .|.::.......:|:....: :|..:.:.|.::||.|
Human   228 ELPEKSKQQEIYQELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQR-NWHDSITACKEVGAQL 291

  Fly   178 LTIQSEDELDAIRTELKDINDGSHDF-WLDINDIAKWG--EFISLATGMNPPFLK-WHKHRPQVQ 238
            :.|:|.:|.:.::.:    :..|:.| |:.::|:.:.|  :::. .:.:.|.|.: |::..|...
Human   292 VVIKSAEEQNFLQLQ----SSRSNRFTWMGLSDLNQEGTWQWVD-GSPLLPSFKQYWNRGEPNNV 351

  Fly   239 IHQRCVHLRGGEMMDGKCSEQFLFICQ 265
            ..:.|....|....|.||:....:||:
Human   352 GEEDCAEFSGNGWNDDKCNLAKFWICK 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-21Ca	NP_652642.2	CLECT	158..265	CDD:153057	23/110 (21%)
CD209	NP_066978.1	Endocytosis signal	14..15
		Endocytosis signal. /evidence=ECO:0000255	16..18
		Endocytosis signal. /evidence=ECO:0000255	31..34
		transmembrane domain	36..59
		PilO	38..>184	CDD:294757	3/18 (17%)
		neck domain	60..249		15/85 (18%)
		CLECT_DC-SIGN_like	256..379	CDD:153060	26/129 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010