DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-24Db and CLEC4A

DIOPT Version :9

Sequence 1:	NP_652641.1	Gene:	lectin-24Db / 53550	FlyBaseID:	FBgn0040102	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_057268.1	Gene:	CLEC4A / 50856	HGNCID:	13257	Length:	237	Species:	Homo sapiens

Alignment Length:	186	Identity:	44/186 - (23%)
Similarity:	73/186 - (39%)	Gaps:	45/186 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 FERKLQKLEQNQKDELTKLGAQQSANQVTLKEIYTKVFW---PK-FERIGSRLFYINHKDAYDWQ 257
            |::..|.||:....||.....:.....:.::|    ..|   || ::...|..::|:.:.| .||
Human    69 FQKYSQLLEKKTTKELVHTTLECVKKNMPVEE----TAWSCCPKNWKSFSSNCYFISTESA-SWQ 128

  Fly   258 SAVDFCRDMGGYIAAIKDQEELDAISARLDDKS-YWLGIND--------------LQSSNTYVSV 307
            .:...|..|..::..|..|||.|.|...|.::| |::|::|              ...|:|:
Human   129 DSEKDCARMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTF--- 190

  Fly   308 ASGREVEFLNWNAGEPNHGNEDENCVELIRSK------MNDDPCHRKKHVICQTDK 357
                      |:..||:..|  |.||.|...|      .||..|...:..:|:..|
Human   191 ----------WHPREPSDPN--ERCVVLNFRKSPKRWGWNDVNCLGPQRSVCEMMK 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-24Db	NP_652641.1	ExsD	<44..>156	CDD:293411
		NAT_SF	<170..>229	CDD:302625	6/31 (19%)
		CLECT	247..354	CDD:153057	31/127 (24%)
CLEC4A	NP_057268.1	ITIM motif. /evidence=ECO:0000269\|PubMed:20530286	5..10
		CLECT_DC-SIGN_like	106..232	CDD:153060	35/141 (25%)
		Mannose binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	195..197		1/1 (100%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	207..209		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010