DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-24Db and Clec4a

DIOPT Version :9

Sequence 1:	NP_652641.1	Gene:	lectin-24Db / 53550	FlyBaseID:	FBgn0040102	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_001005899.2	Gene:	Clec4a / 474143	RGDID:	1359662	Length:	240	Species:	Rattus norvegicus

Alignment Length:	193	Identity:	47/193 - (24%)
Similarity:	83/193 - (43%)	Gaps:	56/193 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 FERKLQKLEQNQKDELTKLGAQQSANQVTLKE--------IYTKVFW---PK-FERIGSRLFYI- 248
            |::..|.||:           :::...:|.||        :..:..|   || ::..||..:::
  Rat    69 FQKYSQFLEE-----------KKAIKGITHKELNCIKNVLLMEEKSWSCCPKNWKPFGSHCYWVT 122

  Fly   249 NHKDAY---DWQSAVDFCRDMGGYIAAIKDQEELDAISARLD-DKSYWLGINDLQSSNTYVSVAS 309
            .|...|   .|..:...|..||.::..|..:||.|.|:..|: |.:|::|:.|           |
  Rat   123 KHTSTYSKASWNESEKNCFSMGAHLLVIHSKEEQDFITGILNRDAAYFIGLWD-----------S 176

  Fly   310 G-REVEFLN----------WNAGEPNHGNEDENCVELIRSK----MNDDPCHRKKHVICQTDK 357
            | |:.::::          |:.|||:  ::||.||.:....    .||.||..|:..:||..|
  Rat   177 GHRQWQWVSQTPYNASATFWHKGEPS--SDDEKCVIINHLNSGWGWNDIPCSGKQQSVCQMKK 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-24Db	NP_652641.1	ExsD	<44..>156	CDD:293411
		NAT_SF	<170..>229	CDD:302625	7/39 (18%)
		CLECT	247..354	CDD:153057	32/126 (25%)
Clec4a	NP_001005899.2	ITIM motif	5..10
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..38
		CLECT_DC-SIGN_like	107..235	CDD:153060	37/140 (26%)
		Mannose binding. /evidence=ECO:0000250\|UniProtKB:Q9UMR7	200..202		1/1 (100%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000250\|UniProtKB:Q9UMR7	211..213		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010