DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-24Db and CD209

DIOPT Version :9

Sequence 1:	NP_652641.1	Gene:	lectin-24Db / 53550	FlyBaseID:	FBgn0040102	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_066978.1	Gene:	CD209 / 30835	HGNCID:	1641	Length:	404	Species:	Homo sapiens

Alignment Length:	367	Identity:	92/367 - (25%)
Similarity:	156/367 - (42%)	Gaps:	98/367 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SVLQPLLDHIVK-----HQEQWNTSEALWLNETQ-----------GKLDRIQ---TQLAAQALSL 92
            ::|..||..:.|     .||| :..:|::.|.||           .||..|.   |||.|....|
Human    51 TLLAGLLVQVSKVPSSISQEQ-SRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGEL 114

  Fly    93 EESAQKVPGDIKDRLDRMEHLQTTLQESLKKMPAELDARLMKMENQ----QKTLGDQLENQINLT 153
            .|         |.:|..:....|.|:.::.::|.:  ::|.::..:    :..:|:..|
Human   115 PE---------KSKLQEIYQELTRLKAAVGELPEK--SKLQEIYQELTWLKAAVGELPE------ 162

  Fly   154 KESQQD---QLEALKNAMPINFEMRLAQIEEQQKLLQETLK------KIPEDFERKLQKLEQNQK 209
            |...|:   :|..||.|:.     .|.:..:||::.||..:      ::||  :.|.|::.|
Human   163 KSKMQEIYQELTRLKAAVG-----ELPEKSKQQEIYQELTRLKAAVGELPE--KSKQQEIYQ--- 217

  Fly   210 DELTKLGA------QQSANQVTLKEIYTKVF----------------WPKFERIGSRLFYINHKD 252
             |||:|.|      ::|..|    |||.::.                |..|:  |:..|..|.:
Human   218 -ELTRLKAAVGELPEKSKQQ----EIYQELTQLKAAVERLCHPCPWEWTFFQ--GNCYFMSNSQ- 274

  Fly   253 AYDWQSAVDFCRDMGGYIAAIKDQEE---LDAISARLDDKSYWLGINDLQSSNTYVSVASGREVE 314
             .:|..::..|:::|..:..||..||   |...|:| .::..|:|::||....|:..|.....:.
Human   275 -RNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSR-SNRFTWMGLSDLNQEGTWQWVDGSPLLP 337

  Fly   315 FLN--WNAGEPNHGNEDENCVELIRSKMNDDPCHRKKHVICQ 354
            ...  ||.||||:..| |:|.|...:..|||.|:..|..||:
Human   338 SFKQYWNRGEPNNVGE-EDCAEFSGNGWNDDKCNLAKFWICK 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-24Db	NP_652641.1	ExsD	<44..>156	CDD:293411	29/131 (22%)
		NAT_SF	<170..>229	CDD:302625	17/70 (24%)
		CLECT	247..354	CDD:153057	33/111 (30%)
CD209	NP_066978.1	Endocytosis signal	14..15
		Endocytosis signal. /evidence=ECO:0000255	16..18
		Endocytosis signal. /evidence=ECO:0000255	31..34
		transmembrane domain	36..59		3/7 (43%)
		PilO	38..>184	CDD:294757	34/155 (22%)
		neck domain	60..249		51/221 (23%)
		CLECT_DC-SIGN_like	256..379	CDD:153060	38/129 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010