DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-24Db and CLEC4M

DIOPT Version :9

Sequence 1:	NP_652641.1	Gene:	lectin-24Db / 53550	FlyBaseID:	FBgn0040102	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	NP_055072.3	Gene:	CLEC4M / 10332	HGNCID:	13523	Length:	399	Species:	Homo sapiens

Alignment Length:	353	Identity:	91/353 - (25%)
Similarity:	157/353 - (44%)	Gaps:	72/353 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VLQPLLDHIVK-----HQEQWNTSEALWLNETQ-----------GKLDRIQ---TQLAAQALSLE 93
            ||..:|..:.|     .||| :..:|::.|.||           .||..|.   |||.|....|.
Human    64 VLVAILVQVSKVPSSLSQEQ-SEQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELP 127

  Fly    94 ESAQKVPGDIKDRLDRMEHLQTTLQESLKKMP--AELDARLMKMENQQKTLGDQLENQINLTKES 156
            |         |.:|..:....|.|:.::.::|  ::|.....::...:..:|:..|      |..
Human   128 E---------KSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTRLKAAVGELPE------KSK 177

  Fly   157 QQD---QLEALKNAM-PINFEMRLAQIEEQQKLLQETLKKIPEDFERKLQKLEQNQKDELTKLGA 217
            .|:   :|..||.|: .:..:.:|.:|.::...|:..:.::||  :.|||::.|    |||:|.|
Human   178 LQEIYQELTRLKAAVGELPEKSKLQEIYQELTELKAAVGELPE--KSKLQEIYQ----ELTQLKA 236

  Fly   218 Q--QSANQVTLKEIYTKVFWPK--FERI------------GSRLFYINHKDAYDWQSAVDFCRDM 266
            .  :..:|...::||.::...|  |||:            |:..|..|.:  .:|..:|..|:::
Human   237 AVGELPDQSKQQQIYQELTDLKTAFERLCRHCPKDWTFFQGNCYFMSNSQ--RNWHDSVTACQEV 299

  Fly   267 GGYIAAIKDQEELDAISARL--DDKSYWLGINDLQSSNTYVSV-ASGREVEFLN-WNAGEPNH-G 326
            ...:..||..||.:.:..:.  .::..|:|::||....|:..| .|.....|.. ||:||||: |
Human   300 RAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEGTWQWVDGSPLSPSFQRYWNSGEPNNSG 364

  Fly   327 NEDENCVELIRSKMNDDPCHRKKHVICQ 354
            |||  |.|...|..||:.|....:.||:
Human   365 NED--CAEFSGSGWNDNRCDVDNYWICK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-24Db	NP_652641.1	ExsD	<44..>156	CDD:293411	29/128 (23%)
		NAT_SF	<170..>229	CDD:302625	15/60 (25%)
		CLECT	247..354	CDD:153057	33/111 (30%)
CLEC4M	NP_055072.3	Endocytosis signal. /evidence=ECO:0000250	14..15
		transmembrane domain	44..71		3/6 (50%)
		7 X approximate tandem repeats	108..269		44/181 (24%)
		DUF342	<140..251	CDD:302792	27/122 (22%)
		CLECT_DC-SIGN_like	268..391	CDD:153060	36/127 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I5380
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.060