DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-24A and CLEC4A

DIOPT Version :9

Sequence 1:	NP_652637.1	Gene:	lectin-24A / 53543	FlyBaseID:	FBgn0040104	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_057268.1	Gene:	CLEC4A / 50856	HGNCID:	13257	Length:	237	Species:	Homo sapiens

Alignment Length:	164	Identity:	43/164 - (26%)
Similarity:	73/164 - (44%)	Gaps:	23/164 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 KLQLEAIKNTMDYMKAQMDGYFSAINGVQCLQPGFEKIGDRYFYIEEDVELNWLDAQAKCRRMGG 192
            |...|.:..|::.:|..|....:|.:   |....::......::|..: ..:|.|::..|.||..
Human    79 KTTKELVHTTLECVKKNMPVEETAWS---CCPKNWKSFSSNCYFISTE-SASWQDSEKDCARMEA 139

  Fly   193 HLASIKTKQEFDAIVEKLDDSKSYFLGVN--ENTKTGDFVSAASGKSCLYHE----WGPGEPHHN 251
            ||..|.|::|.|.|.:.|.:..:||:|::  |..:...:|....     |:|    |.|.||...
Human   140 HLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTP-----YNESSTFWHPREPSDP 199

  Fly   252 NDQERCVSI-LRKL-----MHVGNCTYEKRFICQ 279
            |  ||||.: .||.     .:..||...:|.:|:
Human   200 N--ERCVVLNFRKSPKRWGWNDVNCLGPQRSVCE 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-24A	NP_652637.1	CLECT	169..280	CDD:153057	36/123 (29%)
CLEC4A	NP_057268.1	ITIM motif. /evidence=ECO:0000269\|PubMed:20530286	5..10
		CLECT_DC-SIGN_like	106..232	CDD:153060	36/134 (27%)
		Mannose binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	195..197		1/1 (100%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	207..209		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11773
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010