DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-24A and Clec4a

DIOPT Version :9

Sequence 1:	NP_652637.1	Gene:	lectin-24A / 53543	FlyBaseID:	FBgn0040104	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_001005899.2	Gene:	Clec4a / 474143	RGDID:	1359662	Length:	240	Species:	Rattus norvegicus

Alignment Length:	167	Identity:	39/167 - (23%)
Similarity:	74/167 - (44%)	Gaps:	32/167 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 TKLQLEAIKNTMDYMKAQMDGYFSAINGVQCLQPGFEKIGDRYFYIEEDV----ELNWLDAQAKC 187
            |..:|..|||.: .|:.:         ...|....::..|...:::.:..    :.:|.:::..|
  Rat    86 THKELNCIKNVL-LMEEK---------SWSCCPKNWKPFGSHCYWVTKHTSTYSKASWNESEKNC 140

  Fly   188 RRMGGHLASIKTKQEFDAIVEKLDDSKSYFLGV-NENTKTGDFVSAAS-GKSCLYHEWGPGEPHH 250
            ..||.||..|.:|:|.|.|...|:...:||:|: :...:...:||... ..|..:  |..|||
  Rat   141 FSMGAHLLVIHSKEEQDFITGILNRDAAYFIGLWDSGHRQWQWVSQTPYNASATF--WHKGEP-- 201

  Fly   251 NNDQERCVSILRKLMHVGN--------CTYEKRFICQ 279
            ::|.|:||.|    .|:.:        |:.:::.:||
  Rat   202 SSDDEKCVII----NHLNSGWGWNDIPCSGKQQSVCQ 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-24A	NP_652637.1	CLECT	169..280	CDD:153057	31/125 (25%)
Clec4a	NP_001005899.2	ITIM motif	5..10
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..38
		CLECT_DC-SIGN_like	107..235	CDD:153060	32/136 (24%)
		Mannose binding. /evidence=ECO:0000250\|UniProtKB:Q9UMR7	200..202		2/3 (67%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000250\|UniProtKB:Q9UMR7	211..213		1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010