DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-24A and CLEC12B

DIOPT Version :9

Sequence 1:	NP_652637.1	Gene:	lectin-24A / 53543	FlyBaseID:	FBgn0040104	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_001123470.1	Gene:	CLEC12B / 387837	HGNCID:	31966	Length:	276	Species:	Homo sapiens

Alignment Length:	241	Identity:	46/241 - (19%)
Similarity:	90/241 - (37%)	Gaps:	68/241 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EILANEARKDQIQLNI--QLDALKADVSNIKASQLSKDEKLDRME-------REQFAMHESLETI 116
            :|.::..:..|:|..|  |.|.|...:.|  ::.||.:|:..:.:       :||.|:
Human    70 DINSDSEKLSQLQKTIQQQQDNLSQQLGN--SNNLSMEEEFLKSQISSVLKRQEQMAI------- 125

  Fly   117 NRYLTVKLDRTKLQLEAIKNTMDYMKAQMDGYFSAINGVQCLQPGFEKIGDRY----FYIEEDVE 177
                       ||..|.|.:|.|:               :| .| ..|:...|    :|...:.|
Human   126 -----------KLCQELIIHTSDH---------------RC-NP-CPKMWQWYQNSCYYFTTNEE 162

  Fly   178 LNWLDAQAKCRRMGGHLASIKTKQEFDAIVEKLDDSKSYF-LGVNENTKTGDFVSAASGKSCLYH 241
            ..|.:::..|......|..|.:.:|.|.::.:.....|:| ||::.:         :||:|..:.
Human   163 KTWANSRKDCIDKNSTLVKIDSLEEKDFLMSQPLLMFSFFWLGLSWD---------SSGRSWFWE 218

  Fly   242 EWGPGEP--------HHNNDQERCVSILRKLMHVGNCTYEKRFICQ 279
            :.....|        ...|..:.|....:..:::..|:.|..:||:
Human   219 DGSVPSPSLFSTKELDQINGSKGCAYFQKGNIYISRCSAEIFWICE 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-24A	NP_652637.1	CLECT	169..280	CDD:153057	23/124 (19%)
CLEC12B	NP_001123470.1	ITIM motif	5..10
CLEC12B	NP_001123470.1	CLECT_NK_receptors_like	143..265	CDD:153063	24/131 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000