DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lectin-24A and CD209

DIOPT Version :9

Sequence 1:	NP_652637.1	Gene:	lectin-24A / 53543	FlyBaseID:	FBgn0040104	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_066978.1	Gene:	CD209 / 30835	HGNCID:	1641	Length:	404	Species:	Homo sapiens

Alignment Length:	229	Identity:	46/229 - (20%)
Similarity:	92/229 - (40%)	Gaps:	48/229 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QLDALKADVSNI--KASQLSKDEKLDRM---------EREQFAMHESLETINRYLTVKLDRTKLQ 130
            :|..|||.|..:  |:.|....::|.|:         :.:|..:::.|..:...:....:::|.|
Human   172 ELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQ 236

  Fly   131 LEAIKNTMDYMKAQMD----------GYFSAINGVQCLQPGFEKIGDRYFYIEEDVELNWLDAQA 185
              .|...:..:||.::          .:|.               |:.||.  .:.:.||.|:..
Human   237 --EIYQELTQLKAAVERLCHPCPWEWTFFQ---------------GNCYFM--SNSQRNWHDSIT 282

  Fly   186 KCRRMGGHLASIKTKQEFDAIVEKLDDSKS---YFLGVNENTKTG--DFVSAASGKSCLYHEWGP 245
            .|:.:|..|..||:.:|.:.:  :|..|:|   .::|:::..:.|  .:|..:.........|..
Human   283 ACKEVGAQLVVIKSAEEQNFL--QLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNR 345

  Fly   246 GEPHHNNDQERCVSILRKLMHVGNCTYEKRFICQ 279
            ||| :|..:|.|........:...|...|.:||:
Human   346 GEP-NNVGEEDCAEFSGNGWNDDKCNLAKFWICK 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-24A	NP_652637.1	CLECT	169..280	CDD:153057	28/116 (24%)
CD209	NP_066978.1	Endocytosis signal	14..15
		Endocytosis signal. /evidence=ECO:0000255	16..18
		Endocytosis signal. /evidence=ECO:0000255	31..34
		transmembrane domain	36..59
		PilO	38..>184	CDD:294757	5/11 (45%)
		neck domain	60..249		16/78 (21%)
		CLECT_DC-SIGN_like	256..379	CDD:153060	30/143 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010