DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lectin-46Ca and CD209

DIOPT Version :9

Sequence 1:	NP_652633.1	Gene:	lectin-46Ca / 53523	FlyBaseID:	FBgn0040093	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_066978.1	Gene:	CD209 / 30835	HGNCID:	1641	Length:	404	Species:	Homo sapiens

Alignment Length:	133	Identity:	29/133 - (21%)
Similarity:	55/133 - (41%)	Gaps:	18/133 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GKCFYVGIKKINWFGAQNNCLRKGLNLADVSTMEDFKAVVHYVTSQVGFDDFWFGGNDLQSEGRF 106
            |.|:::...:.||..:...|...|..|..:.:.|:...:....:....|.  |.|.:||..||.:
Human   265 GNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFT--WMGLSDLNQEGTW 327

  Fly   107 KYISSGKLV----RY--MGDSNIVEPTQRSNLDDCLEIRIRPNVTVVLDVNCQEKKYFICEQNQM 165
            :::....|:    :|  .|:.|.|      ..:||.|.    :.....|..|...|::||:::..
Human   328 QWVDGSPLLPSFKQYWNRGEPNNV------GEEDCAEF----SGNGWNDDKCNLAKFWICKKSAA 382

  Fly   166 KCA 168
            .|:
Human   383 SCS 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-46Ca	NP_652633.1	CLECT	43..162	CDD:153057	27/124 (22%)
CD209	NP_066978.1	Endocytosis signal	14..15
		Endocytosis signal. /evidence=ECO:0000255	16..18
		Endocytosis signal. /evidence=ECO:0000255	31..34
		transmembrane domain	36..59
		PilO	38..>184	CDD:294757
		neck domain	60..249
		CLECT_DC-SIGN_like	256..379	CDD:153060	28/125 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150829
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940