Protein Alignment lectin-46Ca and NCAN

DIOPT Version :10

• Sequence 1: NP_652633.1
• Gene: lectin-46Ca / 53523
• FlyBaseID: FBgn0040093
• Length: 328
• Species: Drosophila melanogaster
• Sequence 2: NP_004377.2
• Gene: NCAN / 1463
• HGNCID: 2465
• Length: 1321
• Species: Homo sapiens
• Alignment Length: 420
• Identity: 91/420 - (21%)
• Similarity: 125/420 - (29%)
• Gaps: 184/420 - (43%)

  Fly    36 YLRELNGKCFYVG-IKKINWFGAQNNCLRKGLNLADVSTMEDFKAVVHYVTSQVGFDDFWFGGND 99
            :.|||.|:.|||| .:::...||:..|.|:|..||.|..:       |..         |..|.|
Human   254 FARELGGEVFYVGPARRLTLAGARAQCRRQGAALASVGQL-------HLA---------WHEGLD 302

  Fly   100 LQSEGRFKYISSGKLVRYMGDSNIVEPTQRSNLDDCLEIRIRPNVTVV---------------LD 149
            ....|   :::.|. |||    .|..|.:|..       ...|.|..|               .|
Human   303 QCDPG---WLADGS-VRY----PIQTPRRRCG-------GPAPGVRTVYRFANRTGFPSPAERFD 352

  Fly   150 VNCQEKKYFICEQNQMKCAVPAEDSGDGQKHSHEHLHHFHHDAGQ---------KDKQETGIKEQ 205
            ..|            .:...|....||.:..|       ..|.|:         ::.:.|..:|:
Human   353 AYC------------FRAHHPTSQHGDLETPS-------SGDEGEILSAEGPPVRELEPTLEEEE 398

  Fly   206 SVESD-SRPADNSNSTEIGVSKEKEAEG---APTPGD-----------------------GGGTT 243
            .|..| ..|..:|...|..:.:||:...   :|||||                       |.||.
Human   399 VVTPDFQEPLVSSGEEETLILEEKQESQQTLSPTPGDPMLASWPTGEVWLSTVAPSPSDMGAGTA 463

  Fly   244 ---------------------------------EPVFENGMENAAEPIAEQ---EQTVPP----- 267
                                             ||..:.|||.:|:|...:   .|..||
Human   464 ASSHTEVAPTDPMPRRRGRFKGLNGRYFQQQEPEPGLQGGMEASAQPPTSEAAVNQMEPPLAMAV 528

  Fly   268 ---GGTGP--------------PAAADATGAATPAPDAAAAEGATPAAAPP-------------- 301
               .|:|.              |.|..|.|.::|.|..     ..|...||
Human   529 TEMLGSGQSRSPWADLTNEVDMPGAGSAGGKSSPEPWL-----WPPTMVPPSISGHSRAPVLELE 588

  Fly   302 -AEGAPAAEAATPAPAAPEGEAT---PAPA 327
             ||| |:|..|||.......|||   |:||
Human   589 KAEG-PSARPATPDLFWSPLEATVSAPSPA 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lectin-46Ca	NP_652633.1	CLECT	43..162	CDD:153057	29/134 (22%)
NCAN	NP_004377.2	Ig_Neurocan	41..162	CDD:409483
		Ig strand A	41..44	CDD:409483
		Ig strand A'	47..49	CDD:409483
		Ig strand B	53..61	CDD:409483
		Ig strand C	75..81	CDD:409483
		Ig strand C'	90..93	CDD:409483
		Ig strand D	111..116	CDD:409483
		Ig strand E	122..128	CDD:409483
		Ig strand F	136..143	CDD:409483
		Ig strand G	153..162	CDD:409483
		Link_domain_CSPGs_modules_1_3	160..254	CDD:239594	91/420 (22%)
		Link_domain_CSPGs_modules_2_4	261..356	CDD:239597	29/137 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..414		11/58 (19%)
		PHA03247	<421..964	CDD:223021	45/203 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	456..479		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	494..513		7/18 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..579		11/51 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..731
		O-glycosylated at one site	708..712
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	820..844
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	876..955
		EGF	1012..1042	CDD:394967
		EGF_CA	1046..1082	CDD:238011
		CLECT	1088..1211	CDD:470576
		CCP	1215..1271	CDD:153056
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1275..1321