DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lectin-33A and CLEC4A

DIOPT Version :9

Sequence 1:	NP_001097145.1	Gene:	lectin-33A / 53516	FlyBaseID:	FBgn0040096	Length:	177	Species:	Drosophila melanogaster
Sequence 2:	NP_057268.1	Gene:	CLEC4A / 50856	HGNCID:	13257	Length:	237	Species:	Homo sapiens

Alignment Length:	163	Identity:	39/163 - (23%)
Similarity:	65/163 - (39%)	Gaps:	31/163 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LIALILECANA---------QTCPLPFSRVGNKCYHVSLQEANWHVADRSCRKLGAELMVLDNQE 66
            |:...|||...         ..||..:....:.||.:|.:.|:|..:::.|.::.|.|:|::.||
Human    84 LVHTTLECVKKNMPVEETAWSCCPKNWKSFSSNCYFISTESASWQDSEKDCARMEAHLLVINTQE 148

  Fly    67 DKLLTTTFLKS-----MGLSFTQSWHHSVWAGINCLGNRRTFLLARNGETVPYLNWVPLEPNNAS 126
            ::......|:.     :|||..:...|..|..........||             |.|.||::
Human   149 EQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTF-------------WHPREPSD-- 198

  Fly   127 PEEDCV--GFANYNGAFGYHDIECKVQFPYVCQ 157
            |.|.||  .|......:|::|:.|......||:
Human   199 PNERCVVLNFRKSPKRWGWNDVNCLGPQRSVCE 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lectin-33A	NP_001097145.1	CLECT	24..157	CDD:214480	34/139 (24%)
CLEC4A	NP_057268.1	ITIM motif. /evidence=ECO:0000269\|PubMed:20530286	5..10
		CLECT_DC-SIGN_like	106..232	CDD:153060	35/141 (25%)
		Mannose binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	195..197		1/1 (100%)
		N-acetyl-D-glucosamine binding. /evidence=ECO:0000269\|PubMed:27015765, ECO:0007744\|PDB:5B1X	207..209		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	53	1.000	Inparanoid score	I5451
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000024
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.990