Protein Alignment Myo28B1 and MYO1

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 2160
• Identity: 550/2160 - (25%)
• Similarity: 892/2160 - (41%)
• Gaps: 534/2160 - (24%)

  Fly     1 MDAGYSPRKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMH-IT 64
            |..|.|......||:..:...          .|:.|    |:..|.||..:....:.:..:| :.
Yeast     1 MTGGQSCSSNMIVWIPDEKEV----------FVKGE----LMSTDINKNKFTGQEEQIGIVHPLD 51

  Fly    65 SQE---------------------DVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAIN 108
            |.|                     .||:|..|..|.|.::|.||:.||...|||||:|..|||||
Yeast    52 STEVSNLVQVRISDVFPVNPSTFDKVENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAIN 116

  Fly   109 PYQILPIYTNREIQLYRNK------------SLAELPPHIFAISDNAFQRLQRLKENQCVVISGE 161
            ||..|.:|:...|.||.||            |..:||||||||::.|::.|....::|.::::||
Yeast   117 PYHNLNLYSEDHINLYHNKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGE 181

  Fly   162 SGAGKTESTKLILQYLAAI-SGKHSWI------------EQQIIEANPIMEAFGNAKTVRNDNSS 213
            |||||||:||.||||||:| ||..|.|            |.:|:::|||:|:||||:||||:|||
Yeast   182 SGAGKTENTKKILQYLASITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSS 246

  Fly   214 RFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQS 278
            ||||:|:|.|...|.|.||.|:.|||||||||.|:..||||||||.:|:||..:|.:.|:|:.::
Yeast   247 RFGKFIKIEFNEHGMINGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRN 311

  Fly   279 PSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVA 343
            ...|..|:......:||..|.::|.::.:|:.::.|..:::..|..::|.||.:||:.| .::.|
Yeast   312 VKDYKILSNSNQDIIPGINDVENFKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEF-VSDRA 375

  Fly   344 NLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYD 408
            ..|:.:.|    :..:...||:.......|:.:.......|.|:.|.:.:.|....:|..::||:
Yeast   376 EQASFKND----VSAICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYE 436

  Fly   409 GIFVRIVRRINETINKQVDQ---PMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIF 470
            .:|..||    :.|||.:|.   .:|.||:|||.|||.|:|||||||||||.||.|||||..|:|
Yeast   437 RLFGYIV----DMINKNLDHGSATLNYIGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMF 497

  Fly   471 KMEQDEYQNEHINWQHIEF-QDNQQILDLIGMK--PMNLMSLIDEESKFPKGTDQTLLEKLHVQH 532
            .:||.||..|:|.|.:|:: :|.|..:|||..|  |..::.|:|||:..||.||::...||....
Yeast   498 VLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPTGVLPLLDEEAVLPKSTDESFYSKLISTW 562

  Fly   533 GNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHE- 596
            ...|...|....:.. |.::||||.|.|...|:|.||:|..:.:|.:|:..|.|..:..:|..|
Yeast   563 DQNSSKFKRSRLKNG-FILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEG 626

  Fly   597 -----------MPMDTAKKQ------PTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKN 644
                       :.....||.      .|...:.|.....|:..|:..||:|:|||.||..|:.|.
Yeast   627 EKSSSAGVEANISNQEVKKSARTSTFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKT 691

  Fly   645 FDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLA--RQICE 707
            |::.|.:.|||.:|::|..|:.|.|||.|.|::.|.:|||:|.|..........:..|  :|.||
Yeast   692 FNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCE 756

  Fly   708 ---VALPADSD-RQYGKTKLFLRDEDDASLELQR----SQLMLKSIVTIQRG--IRRVLFRRYMK 762
               .:|..|:. .:.|.||||.:....|.||.|:    :.:|:|...|| ||  :|:.:.....|
Yeast   757 FLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNNIMIKLTATI-RGYTVRKEITYHLQK 820

  Fly   763 RYREAIITVQRYWRGRLQRRKYQVMRQG-----FHRLGACIAAQQLTTKFTMVRCRTIKLQALS- 821
            ..:..:|       |...|...:::::.     |.|:     ...||:...|.|.:....|...
Yeast   821 LKKTRVI-------GNTFRLYNRLVKEDPWFNLFIRI-----KPLLTSSNDMTRTKKFNEQINKL 873

  Fly   822 RGYLVRKDFQKKLLERRKQ---NQL---------KKEELLK----LAKMKEAEELLRLQ--QLKE 868
            :..|...:.:||.||.:.|   |:|         :||.|.|    |.::|.:.|.|:.|  .|..
Yeast   874 KNDLQEMESKKKFLEEKNQKTVNELENTQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDDLVS 938

  Fly   869 QKEREQREQQE-KRLQEEQRLKAEAAARNALAMAAVQQKRRTKP---VKQEAPKAPTLQARNSLP 929
            :|:...||:.| .:..||...|.:..........|..:|..:|.   :||    ...|....|..
Yeast   939 EKDEISREKLEVAQNLEEAHQKIQGLQETIREREATLEKLHSKNNELIKQ----ISDLNCDISKE 999

  Fly   930 PPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLND-----EPD-----A 984
            ....:||..:.|  :..:.:.|:.         ||.:||   ::..:..||     |.|     .
Yeast  1000 QSSQSLIKESKL--KLENEIKRLK---------DVINSK---EEEIKSFNDKLSSSEEDLDIKLV 1050

  Fly   985 ALRKLNNISSGDTIRLPKSVPNNID----TSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEH 1045
            .|.|..||:..   ||...|..|.|    ..:|...|         |...::.|..:..|||.:.
Yeast  1051 TLEKNCNIAMS---RLQSLVTENSDLRSKNENFKKEK---------AALNNQLKNKESELLKMKE 1103

  Fly  1046 PID----EMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVRQS 1106
            .||    |:|:         |.....|.||       ::..:.::|.........||      .:
Yeast  1104 KIDNHKKELAT---------FSKQRDDAVS-------EHGKITAELKETRIQLTEYK------SN 1146

  Fly  1107 QRRIPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLN---- 1167
            .::|.:..::.::|.:|..|...|   |.:|.::         :|...|:.|::.:::.||
Yeast  1147 YQKIKEEYSNFQRETKEQEQKKRN---SLVESLN---------DSKIKELEARLSQEISLNQYLN 1199

  Fly  1168 ---------PSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLE----- 1218
                     .:.||..|     |...|..|..||     ....|....||..|...:.||
Yeast  1200 KRISGNSVETNISSTRR-----STSYSDDPLDKE-----DIIKKYYDLQLAFTEITRNLENEIEE 1254

  Fly  1219 -RTLVNGPRCQPPSL----FELHAIRGR----------------------HPL------RLDIHL 1250
             :.|::..|.....|    ||...|:.:                      .||      ..||:.
Yeast  1255 KKNLISRLRFTETRLASSSFEDQKIKAQMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKESDINK 1319

  Fly  1251 M----DGQQRRLQVD--AASTAREAVNQL------CQG---MGLTDTFGFGL------VMSLNGK 1294
            :    |..:|:|.::  |...|..|::.|      .||   :..:|.:....      |.||..|
Yeast  1320 LMLEVDYLKRQLDIETRAHYDAENAISALHSKFRKIQGESSLSSSDIYKLKFEASEERVKSLEDK 1384

  Fly  1295 L----------MPLGAGQEHVL---DAISECEQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLI 1346
            |          :|:|    .::   |:||:.|:.         ||                   .
Yeast  1385 LKTMPLRDRTNLPVG----DIIKNRDSISKYEEE---------IR-------------------Y 1417

  Fly  1347 YKQILNGLKCGEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENW 1411
            ||  |...|..|....|...::.:             .|.|:.|:....:.|:.|...::.:|:.
Yeast  1418 YK--LENYKLQEILNESNGKLSQL-------------TLDLRQSKSKEALLSEQLDRLQKDLEST 1467

  Fly  1412 SR---LIAATYEKSSYVKE------EQNDLLL----EAQKRAKEDICLFA--------------H 1449
            .|   |:::|.::.....|      :.|:|.|    .|.|:|:||:...|              .
Yeast  1468 ERQKELLSSTIKQQKQQFENCMDDLQGNELRLREHIHALKQAEEDVKNMASIIEKLKTQNKQKEK 1532

  Fly  1450 LSWPMRHSR----------LFEVVR-KEGPKLQSDEL------MLGINSAGLFLIDETEQVLASC 1497
            |.|.....|          |.|:.| ::..|:.||:|      :..:.....: .||..::
Yeast  1533 LIWEREMERNDSDMQLQETLLELKRVQDVKKILSDDLAHLKERLSAVEDRSQY-TDEINRL---- 1592

  Fly  1498 CFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVALDPVVE--G 1560
              .|.|...::::..|. ..|..:.:.|: :|..|:...|:   |.|:|...|    ..|||  .
Yeast  1593 --KEELNCSLKAETNLK-KEFATLKYKLE-TSTNDSEAKIS---DLLKQLDHY----TKVVEMLN 1646

  Fly  1561 DLEDCLVLNPGDLIE-FEAGVTGAQLMAGNAQDCYR------GCVNGQWGQFLAGNVRVLATLTK 1618
            :.:|.:.|...:|.: :||..|..:.:.|......:      ..:|.:.......|    |.|:.
Yeast  1647 NEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLNQKTDALQISN----AALSS 1707

  Fly  1619 PSEKLQDILREGRFQEPPKPTPRANYSRRRQ-HNISQLAESHFREPLDSDKAPLSKFSPEPLKAP 1682
            .::|.::|..:.::.|..........||..: ....|.:.:.:::..|.:|.
Yeast  1708 STQKNKEITEKIKYLEETLQLQMEQNSRNGELVKTLQASCNGYKDKFDDEKQ------------- 1759

  Fly  1683 LLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLPVNTDLIFQPALQHPLLCDELYCQLMKQLSD 1747
                  |...|:::...:.               .:||||..|                :|.|.:
Yeast  1760 ------KNIDLYEENQTLQ---------------KLNTDLQLQ----------------LKNLHE 1787

  Fly  1748 NPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADALADACLKR--LKRSLAQGQRKKAP 1810
            ..|..:||..|             :..:.||..::.:..|...:...|.  |:|::.:.|.|.:.
Yeast  1788 RLSDTTEKNAW-------------LSKIHELENMVSLETDLKYEEMKKNKSLERAVEELQTKNSQ 1839

  Fly  1811 HLIEVEGIQQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADI-----AQRLELKSPVGYSIFL 1870
            ....:|      |...::..|.:.|:: :|.:        |:|:     .|.||:|..:..:...
Yeast  1840 QTDVIE------LANKNRSEFEEATLK-YEAQ--------ISDLEKYISQQELEMKKSIRDNSSY 1889

  Fly  1871 KTGDRVYAMPEE-EF 1884
            :  |:|..|.:| ||
Yeast  1890 R--DKVQEMAQEIEF 1902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	269/699 (38%)
		IQ	765..785	CDD:197470	3/19 (16%)
		Atrophin-1	<820..>946	CDD:460830	35/148 (24%)
		MyTH4	1031..1239	CDD:470587	46/234 (20%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	27/130 (21%)
		B41	1248..1429	CDD:214604	40/223 (18%)
		PH-like	1454..1547	CDD:473070	20/109 (18%)
		MyTH4	1674..1819	CDD:214535	22/146 (15%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	15/66 (23%)
		B41	1827..2032	CDD:214604	15/64 (23%)
		FERM_C2_MyoVII	2028..2121	CDD:270020
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	499/1862 (27%)
		Smc	1607..>1901	CDD:440809	67/386 (17%)