DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo28B1 and VIIIA

DIOPT Version :9

Sequence 1:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster
Sequence 2:	NP_175453.2	Gene:	VIIIA / 841458	AraportID:	AT1G50360	Length:	1153	Species:	Arabidopsis thaliana

Alignment Length:	990	Identity:	359/990 - (36%)
Similarity:	526/990 - (53%)	Gaps:	162/990 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YSPRKGEYVWV----------KPQNTTSEFAVPFGARIVRTE------KTQTLVCDDRNKQFWVP 53
            |:.:|....||          |..:|:.|.:|     ||.||      |::||          ||
plant   101 YARKKVLQFWVQLPNGNWELGKIMSTSGEESV-----IVVTEGKVLKVKSETL----------VP 150

  Fly    54 AG-DVLKAMHITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYT 117
            |. |:|        :.|:|::.|..|.|..:|.||:.||.:.:|||..|.:|||:||::.:|:|.
plant   151 ANPDIL--------DGVDDLMQLSYLNEPAVLYNLEYRYNQDMIYTKAGPVLVAVNPFKEVPLYG 207

  Fly   118 NREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISG 182
            ||.|:.||.:|  ...||::||:|.|.:.:.|.:.||.::|||||||||||:.|:.:|||||:.|
plant   208 NRNIEAYRKRS--NESPHVYAIADTAIREMIRDEVNQSIIISGESGAGKTETAKIAMQYLAALGG 270

  Fly   183 KHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQ 247
             .|.||.:|::.|||:||||||||:||||||||||.|||.|:..|.|.||:||.:||||||:|..
plant   271 -GSGIEYEILKTNPILEAFGNAKTLRNDNSSRFGKLIEIHFSETGKISGAQIQTFLLEKSRVVQC 334

  Fly   248 SRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVL 312
            :..||:|||||.:.||.|...||:|.|  .|..||:||.|..|:::.|..||:.|..::.|:.::
plant   335 TEGERSYHIFYQLCAGASPTLREKLNL--TSAKQYNYLKQSNCYSINGVDDAERFHAVKEALDIV 397

  Fly   313 SFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQR 377
            ....|:..::.::|||:|.|||:.||..:..|....|.|:  :|..||:|:|..|:.|..||::|
plant   398 HVSKEDQENVFAMLAAVLWLGNVSFTIIDNENHVEPEPDE--SLSTVAKLIGCNINELKLALSKR 460

  Fly   378 TIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFE 442
            .:.|:.:.:...|:...||:.|||..||:|..:|..:|.:||:::.....:...||.:|||:|||
plant   461 NMRVNNDTIVQKLTLSQAIDARDALAKSIYACLFDWLVEQINKSLAVGKRRTGRSISILDIYGFE 525

  Fly   443 NFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLM 507
            :|:.|||||.|||||||.|||.|..|:||:||:||..:.|:|..::|:|||:.|.|...||:.|:
plant   526 SFNKNSFEQFCINYANERLQQHFNRHLFKLEQEEYIQDGIDWTRVDFEDNQECLSLFEKKPLGLL 590

  Fly   508 SLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDS 572
            ||:||||.||.|||.||..||. ||.|.:...:|  .:...|.:.||||.|.|...||||||||.
plant   591 SLLDEESTFPNGTDLTLANKLK-QHLNDNSCFRG--DRGKAFTVAHYAGEVTYETTGFLEKNRDL 652

  Fly   573 FSGDLRTLVQRSTNKYLVDIFPHEM----------PMDTA----KKQPTLCVKFRNSLDMLMRTL 623
            ...|...|:. |.:.:|...|...|          |:..|    .::.::..||:..|..||:.|
plant   653 LHSDSIQLLS-SCSCHLPQAFASSMLIYSEKPLVGPLHKAGGADSQRLSVATKFKGQLFQLMQRL 716

  Fly   624 SQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVP 688
            ....|:||||||||..:....:::.|.::|||..|::|..||.|:|:|.|..:..|..||..|:
plant   717 GNTTPHFIRCIKPNNVQSAGLYEQGLVLQQLRCCGVLEVVRISRSGFPTRMFHHKFARRYGFLL- 780

  Fly   689 PVGPLEQCDCRKLARQICEVA---------LPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKS 744
                ||..    .|:....|:         ||  ...|.|.||||.|......||..|:: .|..
plant   781 ----LENI----AAKDPLSVSVAILHQFNILP--EMYQVGYTKLFFRTGQIGVLEDTRNR-TLHG 834

  Fly   745 IVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGAC--------IAAQ 801
            |:.:|...|....|..:|..:..|..:|.:.||...|::|..:.|. ||..|.        ||:|
plant   835 ILRLQSYFRGHQARCRLKELKTGITILQSFVRGEKMRKEYTELLQR-HRASAAIQSHVKRRIASQ 898

  Fly   802 QLTTKFTMVRCRTIKLQALSRGYLVRK-----------------------------DFQKKLL-- 835
            |.  |.|:.....|  |:..||.|||:                             |.|:::|
plant   899 QY--KATVDASAVI--QSAIRGELVRRCAGDIGWLSSGGTKRNESDEVLVKASYLSDLQRRVLRT 959

  Fly   836 -----ERRKQNQLKKEELLKL--------AKMKEAEELLRLQQLKEQKEREQREQQEKRLQE--- 884
                 |:.::|.:.::.:.:.        .|||..||:.              ::|.|.||.
plant   960 EAALREKEEENDILRQRVQQYDNRWSEYETKMKSMEEIW--------------QKQMKSLQSSLS 1010

  Fly   885 --EQRLKAEAAARNA 897
              ::.|:.|.:|||:
plant  1011 IAKKSLEVEDSARNS 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	290/697 (42%)
		MYSc_Myo7	81..726	CDD:276832	282/667 (42%)
		IQ	765..785	CDD:197470	5/19 (26%)
		DUF4355	827..>887	CDD:290964	15/108 (14%)
		MyTH4	1031..1239	CDD:295320
		B41	1248..1429	CDD:214604
		FERM_N	1248..>1288	CDD:286467
		FERM_B-lobe	1342..1429	CDD:271216
		PH-like	1454..1547	CDD:302622
		MyTH4	1674..1819	CDD:214535
		B41	1827..2032	CDD:214604
		FERM_N	1829..>1877	CDD:286467
		FERM_M	1936..2032	CDD:278785
		FERM_C2_MyoVII	2028..2121	CDD:270020
VIIIA	NP_175453.2	MYSc_Myo8	171..817	CDD:276834	282/667 (42%)
VIIIA	NP_175453.2	MAD	848..>1029	CDD:368498	44/197 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810