DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo28B1 and MYA1

DIOPT Version :9

Sequence 1:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster
Sequence 2:	NP_173201.2	Gene:	MYA1 / 838333	AraportID:	AT1G17580	Length:	1520	Species:	Arabidopsis thaliana

Alignment Length:	1413	Identity:	441/1413 - (31%)
Similarity:	663/1413 - (46%)	Gaps:	295/1413 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GEYVWVKPQNTT---SEFAVPFGARI-VRTEKTQTLVCDDR-NKQFWVPAGDVLKAMHITSQEDV 69
            |.:|||:..:..   .|.....|..: |:|:|.:|:|.:.. .|....|:|            .|
plant     9 GSHVWVEDPHLAWIDGEVTRIDGINVHVKTKKGKTVVTNVYFPKDTEAPSG------------GV 61

  Fly    70 EDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILP-IYTNREIQLYRNKSLAELP 133
            :||..|..|.|..:||||:.||....||||||::|:|:||:|.|| ||....::.|:..:|.||.
plant    62 DDMTKLSYLHEPGVLRNLETRYELNEIYTYTGNILIAVNPFQRLPHIYETDMMEQYKGIALGELS 126

  Fly   134 PHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHS----WIEQQIIEA 194
            ||:|||.|.|::.:....:|..:::||||||||||:||::::|||.:.|:..    .:|||::|:
plant   127 PHVFAIGDAAYRAMINEGKNNSILVSGESGAGKTETTKMLMRYLAFLGGRSGVEGRTVEQQVLES 191

  Fly   195 NPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYC 259
            ||::||||||||:||:|||||||::||:|...|.|.||.|:.||||:||:...|..|||||.||.
plant   192 NPVLEAFGNAKTLRNNNSSRFGKFVEIQFDKNGRISGAAIRTYLLERSRVCQISDPERNYHCFYL 256

  Fly   260 MLAGLSTAERERLKLQE-QSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSIL 323
            :.|    |..|.:|..: ::|.::|||.|..|:.|.|..||.::.:.|.||.|:....||..:|.
plant   257 LCA----APPEDIKKYKLENPHKFHYLNQSSCYKLDGVDDASEYLETRRAMDVVGISNEEQEAIF 317

  Fly   324 SLLAAILHLGNLRF-TATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVT 387
            .::||||||||:.| ...|:.:....:.|...:|...|:||.....:|..||.:|.:....|.:|
plant   318 RVVAAILHLGNIDFGKGEEIDSSVIKDKDSRSHLNMAAELLMCNAQSLEDALIRRVMVTPEEIIT 382

  Fly   388 TSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQL 452
            .:|..:.||..||...|::|..:|..||.:||.:|. |..:..:.||||||:|||:|..|||||.
plant   383 RTLDPDNAIASRDTLAKTIYSHLFDWIVNKINTSIG-QDPRSKSIIGVLDIYGFESFKCNSFEQF 446

  Fly   453 CINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFP 517
            |||:.||.|||.|..|:|||||:||..|.|.|.:|||.|||.:|:||..||..::||:||...||
plant   447 CINFTNEKLQQHFNQHVFKMEQEEYTKEEIAWSYIEFIDNQDVLELIEKKPGGIISLLDEACMFP 511

  Fly   518 KGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQ 582
            |.|.:|..:||.........:.|.|.::|. |.|.||||.|.|....|::||:|....:.:.|..
plant   512 KSTHETFSQKLFQTFKEHERFAKPKLSRTD-FTISHYAGEVTYQSNHFIDKNKDYIVAEHQALFT 575

  Fly   583 RSTNKYLVDIFPHEMPMDTAK--KQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNF 645
            .|..|::..:| |.:..|:::  |..::..:|:..|..||.:|:...|::|||||||...:|..|
plant   576 ASNCKFVAGLF-HALHEDSSRSSKFSSIGSRFKQQLHSLMESLNGTEPHYIRCIKPNNVLKPGIF 639

  Fly   646 DKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICEVAL 710
            :....:.|||..|::|..||..||||.|.|:..|::|:.||.|.|  ||.....|:|   |::.|
plant   640 ENFNVIHQLRCGGVLEAIRISCAGYPTRLAFYDFLDRFGLLAPEV--LEGNYDDKVA---CQMIL 699

  Fly   711 PADS--DRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQR 773
            ...|  |.|.||||:|||....|.|:.:|::::..:...|||..|..:.|:..:..|.|.|.:|.
plant   700 DKKSLTDYQIGKTKIFLRAGQMAELDARRAEVLGNAARVIQRQFRTCMARKNYRSIRNAAIVLQS 764

  Fly   774 YWRGRLQRRKYQVMR---------QGFHR--------------------LGACIA---------- 799
            :.||.:.|..::.:|         :.|.|                    |.|.||
plant   765 FLRGEIARAVHKKLRIEAAALRVQKNFRRYVDRKSFVTTRSSTIVLQTGLRAMIARSEFRLRRQR 829

  Fly   800 -----------AQQLTTKFTMV-----------RC-------RTIKLQALSRGYLVRKDFQKKL- 834
                       .:|..:.:|.:           ||       |.:|:.|...|.|  ||.:.||
plant   830 KAAIVLQAHWRGRQAFSYYTRLQKAAIVTQCAWRCRLARRELRMLKMAARDTGAL--KDAKNKLE 892

  Fly   835 -----------LERRKQNQLKKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQ-- 886
                       ||:|.:..|::.::.::||::||...:|| ||||......:||:..|:..|:
plant   893 QRVEELSLRLHLEKRLRTDLEEAKVQEVAKLQEALHTMRL-QLKETTAMVVKEQEAARVAIEEAS 956

  Fly   887 -----------------------RLKAEAA--------ARNALAMAAVQQKRRTKPVKQEAPKAP 920
                                   |||...:        |::|...|.||.:...|.:::...|..
plant   957 SVNKEPVVVEDTEKIDSLSNEIDRLKGLLSSETHKADEAQHAYQSALVQNEELCKKLEEAGRKID 1021

  Fly   921 TLQ--------------------ARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVE 965
            .||                    .:.:|...|||..:|    .||.:.:  |...||.....:.|
plant  1022 QLQDSVQRFQEKVFSLESENKVLRQQTLTISPTTRALA----LRPKTTI--IQRTPEKDTFSNGE 1080

  Fly   966 SSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQ 1030
            :::....:.    .|.|.   :.||.....:...|.||:..:|..|
plant  1081 TTQLQEPET----EDRPQ---KSLNQKQQENQELLLKSISEDIGFS------------------- 1119

  Fly  1031 HERKPLKKSL----LKHEHPIDEMASKAIWLTILRF------MGDLPDVV-----SSPTLHVFDN 1080
             |.||:...|    |.|.... |:...:|:..|:..      |.:..||:     :|.||.:|..
plant  1120 -EGKPVAACLIYKCLIHWRSF-EVERTSIFNRIIETIASAIEMQENSDVLCYWLSNSATLLMFLQ 1182

  Fly  1081 ENLMSDLASLLNTSDSYKPR-------LF--VRQSQRRIPK----PLASGE---------KEAQE 1123
            ..|.:.....:.|     ||       ||  |.||.|..|:    |..:|.         ::.:.
plant  1183 RTLKAGATGSITT-----PRRRGMPSSLFGRVSQSFRGSPQSAGFPFMTGRAIGGGLDELRQVEA 1242

  Fly  1124 FYQHWL--NVPTSHLEKIHFIIGHGIIKNSLRDEI--LAQICKQLYLNPSRSSYSRG-------- 1176
            .|...|  ...|:.||||     :|:|::.::.||  |...|.|:...| ||...:|
plant  1243 KYPALLFKQQLTAFLEKI-----YGMIRDKMKKEISPLLASCIQVPRTP-RSGLVKGRSQNTQNN 1301

  Fly  1177 ----------WLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSL 1214
                      |..:..||:         .|||      |.:....|||
plant  1302 VVAPKPMIAHWQNIVTCLN---------GHLR------TMRANYVPSL 1334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	287/685 (42%)
		MYSc_Myo7	81..726	CDD:276832	277/655 (42%)
		IQ	765..785	CDD:197470	7/19 (37%)
		DUF4355	827..>887	CDD:290964	22/96 (23%)
		MyTH4	1031..1239	CDD:295320	57/243 (23%)
		B41	1248..1429	CDD:214604
		FERM_N	1248..>1288	CDD:286467
		FERM_B-lobe	1342..1429	CDD:271216
		PH-like	1454..1547	CDD:302622
		MyTH4	1674..1819	CDD:214535
		B41	1827..2032	CDD:214604
		FERM_N	1829..>1877	CDD:286467
		FERM_M	1936..2032	CDD:278785
		FERM_C2_MyoVII	2028..2121	CDD:270020
MYA1	NP_173201.2	Myosin_N	9..47	CDD:397036	11/37 (30%)
		MYSc_Myo11	73..717	CDD:276835	277/655 (42%)
		IQ	850..872	CDD:197470	2/21 (10%)
		Smc	<867..>1114	CDD:224117	57/262 (22%)
		MyosinXI_CBD	1099..1486	CDD:271259	62/283 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	530	1.000	Domainoid score	I63
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810