DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo28B1 and XIH

DIOPT Version :9

Sequence 1:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster
Sequence 2:	NP_194600.2	Gene:	XIH / 828991	AraportID:	AT4G28710	Length:	1516	Species:	Arabidopsis thaliana

Alignment Length:	1264	Identity:	411/1264 - (32%)
Similarity:	624/1264 - (49%)	Gaps:	202/1264 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILP-IYTNREIQLYRNKSLAEL 132
            |:||..|..|.|..:|:|:::|:....||||||::|:|:||::.|| :|.|..:|.|:.....||
plant    63 VDDMTRLAYLHEPGVLQNMKSRFDINEIYTYTGNILIAVNPFRRLPHLYNNHMMQQYKGAGFGEL 127

  Fly   133 PPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGK----HSWIEQQIIE 193
            .||.||::|.|:::::....:|.:::||||||||||:|||::||||.:.|:    ...:|::::|
plant   128 SPHPFAVADAAYRQMKNQGISQSILVSGESGAGKTETTKLLMQYLADMGGRAVSEGRTVEKKVLE 192

  Fly   194 ANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFY 258
            :||::|||||||||||:|||||||::||:|..:|.|.||.|:.||||:||:...|..|||||.||
plant   193 SNPVLEAFGNAKTVRNNNSSRFGKFVEIQFDQRGRISGAAIRTYLLERSRVCQVSDPERNYHCFY 257

  Fly   259 CMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSIL 323
             ||......:.::.||.:  |.::|||.|..|..|....|||::.:.|.||.|:....||..:|.
plant   258 -MLCAAPPEDIKKWKLAD--PRKFHYLNQSQCIELERMDDAKEYRETRKAMDVVGINSEEQEAIF 319

  Fly   324 SLLAAILHLGNLRFTATEVANLATAEIDDTPN--LQRVAQLLGIPISALNAALTQRTIFVHGEHV 386
            .::||||||||:.|...:.|: ::|..|||.|  |:..|:|......||..:|.:|.|...||.:
plant   320 QVVAAILHLGNVEFGKGKEAD-SSAPKDDTSNYHLKTAAELFMCDEQALEDSLCKRVIVTRGETI 383

  Fly   387 TTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQ 451
            |..|.:|:|...|||..|::|..:|..||.:||::|.:..|... .||||||:|||:|..|||||
plant   384 TKCLDQESAALSRDALAKTVYSRLFDWIVNKINDSIGQDPDSEY-LIGVLDIYGFESFKTNSFEQ 447

  Fly   452 LCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKF 516
            .|||..||.|||.|..|:||||||||..|.|:|.:|||.|||:|||||..|...::||::|...|
plant   448 FCINLTNEKLQQHFNQHVFKMEQDEYNKEEIDWSYIEFVDNQEILDLIEKKAGGIISLLNEACMF 512

  Fly   517 PKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLV 581
            |:.|.:|..||::....:...:.|.|.::|. |.|.||||.|.|....|||||:|....:.:||:
plant   513 PRATHETFAEKMYQTFKDHKHFSKPKLSRTD-FTICHYAGDVTYQTEQFLEKNKDYVVAEHQTLL 576

  Fly   582 QRSTNKYLVDIFPHEMPMDTAKKQ--PTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKN 644
            ..|...::..:|| .:..|..||.  .::..:|:..|..|:.|||...|::|||:|||...:|..
plant   577 NASRCAFVASLFP-LLAEDANKKSKFSSISSRFKQQLVTLLETLSTTEPHYIRCVKPNNLLKPLI 640

  Fly   645 FDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPV-------GPLEQCD---CR 699
            |:.:..::|||..|:||..||..||:|.|..:..|:||:.:|.|.|       .||...|   |:
plant   641 FENQNVLQQLRCGGVMEAIRISCAGFPTRKKFEEFLERFSVLAPEVLDKSTDGWPLSSTDDVACK 705

  Fly   700 KLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRY 764
            ||..::      |....|.||||:|||....|.|:.:|::::.::...|||..|..|.|:.....
plant   706 KLLEKV------ALQGYQIGKTKVFLRAGQMADLDARRNEVLGRAASRIQRKFRSYLSRKTFLML 764

  Fly   765 REAIITVQRYWRGRLQRRKYQ------------------VMRQGFHRLGACIAAQQLTTKFTMVR 811
            |:....:|...||:|.|..::                  :.|:.:..|.....:.||..:....|
plant   765 RKVATNMQAVCRGQLSRLIFEGLRRDAAVLEIQRDIRMHLARKSYKELYFAAVSIQLGIRGMASR 829

  Fly   812 CRTIKLQALSRGYLVRKDFQKKLLERRKQNQLKK---------------EELLKLAKMKEAEELL 861
            .| ::.|...:..::.:...:|.|.:....:|||               :||.|| || .|:|..
plant   830 GR-LRFQRQDKAAIMIQSHCRKFLAQLHYQRLKKAAITTQSAWRARLARKELRKL-KM-AAKETG 891

  Fly   862 RLQQLKEQKEREQRE-----QQEKRLQ---EEQRLKAEAAARNALAMAAVQQK-------RRTKP 911
            .|:..|.:.|::..|     |.|||::   ||.:.:..|..|:||....:|.|       :..:.
plant   892 VLEAAKSKLEKQVEELTWKLQLEKRMRTDMEESKTQENAKLRSALEEMQLQFKETKALHLQEVEA 956

  Fly   912 VKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFR 976
            .|:.|...|.||   .:|...|.|:...                     |.:.|..|.:|..
plant   957 AKKMAETVPVLQ---EVPVVDTELVEKL---------------------TSENEKLKSLVSS--- 994

  Fly   977 FLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKSLL 1041
             |:.:.|...:|....|..:..||.:::.             |.|......||.||   |::.:|
plant   995 -LDQKIDETEKKFEERSKINEERLKQAIE-------------AETTIVNLKTAVHE---LQEKIL 1042

  Fly  1042 KHEHPIDEMASKAIWLTILRFMGDLP--DVVSSPTLHVFDNENLM--SDLASLLNT----SDSYK 1098
            ..|.....:..|    ::::..|.||  .|..|...|....|:..  |::.:|..|    ||:..
plant  1043 DVESENKILRQK----SLIQASGHLPPTPVKGSQNGHFSSKESPFNGSEIETLARTQEQESDAKT 1103

  Fly  1099 PRLFVRQSQRRI---------------PKPLASGEKEAQEFYQ---HWLNVP---TSHLEKIHFI 1142
            .|..:.:.:..|               .||:|     |...|:   ||.:..   ||..:::..:
plant  1104 RRYHLDRQRENIGALINCVVNNIGFNQGKPVA-----AFTIYKCLLHWKSFEAERTSVFDRLVQM 1163

  Fly  1143 IGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWL-----LLSLCLSCFPPSKEFEPHLRSFMK 1202
            || ..||:...:|.||.                 ||     ||.:              ::..:|
plant  1164 IG-SAIKDEGDNEHLAY-----------------WLSNTSTLLFM--------------IQQSLK 1196

  Fly  1203 QGTAQLQATPSLQRLERTLVNGPRCQPPS 1231
            .|....|.||....|...:..|.|..|.|
plant  1197 PGATPQQKTPVSTSLFGRMAMGFRSAPSS 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	290/686 (42%)
		MYSc_Myo7	81..726	CDD:276832	280/663 (42%)
		IQ	765..785	CDD:197470	6/19 (32%)
		DUF4355	827..>887	CDD:290964	23/82 (28%)
		MyTH4	1031..1239	CDD:295320	50/235 (21%)
		B41	1248..1429	CDD:214604
		FERM_N	1248..>1288	CDD:286467
		FERM_B-lobe	1342..1429	CDD:271216
		PH-like	1454..1547	CDD:302622
		MyTH4	1674..1819	CDD:214535
		B41	1827..2032	CDD:214604
		FERM_N	1829..>1877	CDD:286467
		FERM_M	1936..2032	CDD:278785
		FERM_C2_MyoVII	2028..2121	CDD:270020
XIH	NP_194600.2	Myosin_N	12..47	CDD:280832
		MYSc	56..738	CDD:214580	290/687 (42%)
		MYSc_Myo11	75..726	CDD:276835	280/663 (42%)
		Apolipoprotein	893..1041	CDD:279749	41/191 (21%)
		DUF4355	893..1011	CDD:290964	31/145 (21%)
		Ax_dynein_light	<978..1023	CDD:287215	10/82 (12%)
		MyosinXI_CBD	1109..1486	CDD:271259	31/154 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	530	1.000	Domainoid score	I63
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810