DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo28B1 and VIIIB

DIOPT Version :9

Sequence 1:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster
Sequence 2:	NP_001328307.1	Gene:	VIIIB / 828845	AraportID:	AT4G27370	Length:	1136	Species:	Arabidopsis thaliana

Alignment Length:	1056	Identity:	344/1056 - (32%)
Similarity:	519/1056 - (49%)	Gaps:	139/1056 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 WVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDV-------------------LK 59
            |...|.|.|......|..:|:....|.....:.:...|:.:.:.                   |.
plant    64 WSTEQITQSAEKEKTGNEVVKISTAQMSRAKNSHDPEWINSAEYFVREKLCVWCRVAANGQWHLG 128

  Fly    60 AMHITSQED------------------------------VEDMITLGDLQEYTILRNLQNRYAKQ 94
            .:|.||..|                              |||:..|..|.|.::|.||:.||::.
plant   129 KIHSTSSSDDVCVMLSANDDVVKVAMEEIFPANPEILEGVEDLTQLSYLNEPSLLYNLRVRYSQD 193

  Fly    95 LIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVIS 159
            |||:..|.:|:|:||::.:.||....:..|:..:|.  .||::|::|.|:..:.|.::||.::||
plant   194 LIYSKAGPVLIAVNPFKNVQIYGEEFLSAYQKNALD--APHVYAVADAAYDDMMREEKNQSIIIS 256

  Fly   160 GESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFT 224
            |||||||||:.|..:|||.|:.|....:|.:|::.|.|:||||||||.||||||||||.:||.|:
plant   257 GESGAGKTETAKYAMQYLEALGGGSFGVENEILKTNCILEAFGNAKTSRNDNSSRFGKLMEIHFS 321

  Fly   225 PQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGG 289
            .:|.|.||:::.:.|::||:......||.|||||.:.||.|...:||||:  ::.|:|:||.|..
plant   322 AKGKICGAKLETFSLDQSRVAQLCNGERCYHIFYQLCAGASPILKERLKI--KAASEYNYLNQSN 384

  Fly   290 CFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTP 354
            |.|:....||:.|..:..|..::....|......:||||:|.|||:.|...:..|......|:.
plant   385 CLTIDRTDDAQKFHKLMEAFNIVQIPQEYQERTFALLAAVLWLGNVSFEVIDNENHVEVVADEA- 448

  Fly   355 NLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRIN 419
             :..||.|:|.....|...|:...:....:.:...|:...|.:.||:..|.:|..:|..:|.:||
plant   449 -VTNVAMLMGCNSKKLMVVLSTCKLQAGRDCIAKRLTLRQATDMRDSLAKIIYASLFNWLVEQIN 512

  Fly   420 ETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINW 484
            .::.....:...||.:|||:|||:|.:|||||.|||||||.|||.|..|:||:||:||:.:.|:|
plant   513 ISLEVGNSRTGRSISILDIYGFESFKDNSFEQFCINYANERLQQHFNRHLFKLEQEEYEGDGIDW 577

  Fly   485 QHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLF 549
            ..:||.|||:.|:||..||:.|:||::|||.|||.||.|...||. ||.|.:...||:..:.  |
plant   578 TKVEFIDNQECLNLIEKKPIGLVSLLNEESNFPKATDTTFANKLK-QHLNANSCFKGERGRG--F 639

  Fly   550 GIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEMPMDTAK-------KQPT 607
            .|:||||.|:||..||||||||....||..|:.....: |:::|..:|..|..|       ...:
plant   640 RIKHYAGEVLYNTNGFLEKNRDPLHVDLIQLLSLCKCQ-LLNLFSTKMHHDFLKPATFSDSMNQS 703

  Fly   608 LCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPI 672
            :..||:..|..||..|....|:||||||||..:.|..:::...::|||..|::|..||.|:|||.
plant   704 VIAKFKGQLFKLMNKLEDTTPHFIRCIKPNSNQLPGLYEENHVLQQLRCCGVLEIVRISRSGYPT 768

  Fly   673 RHAYRAFVERY-------RLLVPPVGP----LEQCDCRKLARQICEVALPADSDRQYGKTKLFLR 726
            |..::....||       |:...|:..    |:||:            ||.:. .|.|.||::||
plant   769 RLTHQELAVRYGCLLLDTRISQDPLSTSKAILKQCN------------LPPEM-YQVGYTKIYLR 820

  Fly   727 DEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGF 791
            ....:.|| :|.:.:|:.|:.:|:..|....|.|....|.|.:.:|.|.||...||.|.|:.:
plant   821 TGVISVLE-ERKKYVLRGILGLQKQFRGYQTREYFHNMRNAAVILQSYIRGENARRNYIVVGE-- 882

  Fly   792 HRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQ-----NQLKKEELLKL 851
                :.|.:..:|.:..    ..|.||     |:|||...:|||...:|     |:.||......
plant   883 ----SAIVSTAITKELD----AAIHLQ-----YMVRKWLARKLLNSTQQKNKPRNEKKKTRRKST 934

  Fly   852 AKMKEAEELLRLQ--------------QLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAA 902
            .::.|.:|||..|              .||.:....|:|.:...||||.:...|....|...|.:
plant   935 KRVSEDKELLSEQFEVQPCVLADLQSRVLKVEAAIMQKEDENTALQEELQRFEERWLENETRMKS 999

  Fly   903 VQ---QKRRTKPVKQEAPK----APTLQARNSLPPPPTTLIVAAPLPTR----PASAVTRINTIP 956
            ::   ||..:......|..    ||...|.:......|   ::...||:    ..|.|..::|..
plant  1000 MEDTWQKHMSSMQMSLAAACKVLAPDKTASHGTDSEDT---MSFGTPTKELKGSLSDVNNLSTEF 1061

  Fly   957 ESPGTIDVESSKQMVD 972
            :....|..|..|.:|:
plant  1062 DQRSVIIHEDPKSLVE 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	270/722 (37%)
		MYSc_Myo7	81..726	CDD:276832	256/662 (39%)
		IQ	765..785	CDD:197470	8/19 (42%)
		DUF4355	827..>887	CDD:290964	22/78 (28%)
		MyTH4	1031..1239	CDD:295320
		B41	1248..1429	CDD:214604
		FERM_N	1248..>1288	CDD:286467
		FERM_B-lobe	1342..1429	CDD:271216
		PH-like	1454..1547	CDD:302622
		MyTH4	1674..1819	CDD:214535
		B41	1827..2032	CDD:214604
		FERM_N	1829..>1877	CDD:286467
		FERM_M	1936..2032	CDD:278785
		FERM_C2_MyoVII	2028..2121	CDD:270020
VIIIB	NP_001328307.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810