DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo28B1 and XIJ

DIOPT Version :9

Sequence 1:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster
Sequence 2:	NP_001319790.1	Gene:	XIJ / 824985	AraportID:	AT3G58160	Length:	1242	Species:	Arabidopsis thaliana

Alignment Length:	1029	Identity:	344/1029 - (33%)
Similarity:	530/1029 - (51%)	Gaps:	133/1029 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILP-IYTNREIQLYRNKSLA 130
            |.||||..|..|.|..:|.||..||....||||||::|:|:||:|.|| :|....::.|:.....
plant    60 EGVEDMTRLSYLHEPAVLDNLATRYELNEIYTYTGNILIAVNPFQGLPHLYDAEVMEKYKEAYFK 124

  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLA------AISGKHSWIEQ 189
            ||.||:|||...|::.:.....|:|:::|||||:||||:||::::|||      |:.|:  .:|.
plant   125 ELNPHVFAIGGIAYREMINEGRNKCILVSGESGSGKTETTKMLMRYLAYFGGHTAVEGR--TVEN 187

  Fly   190 QIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNY 254
            |::|:||::|||||||||:|:|||||||::||:|...|.|.||.|:.||||:||:...|..||||
plant   188 QVLESNPVLEAFGNAKTVKNNNSSRFGKFVEIQFDDVGRISGAAIRTYLLERSRVCQVSDPERNY 252

  Fly   255 HIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEV 319
            |.|| :|......:.||.||.:  |..:.||.|..|:.|.|..||:::...|.||.|:....:|.
plant   253 HCFY-LLCAAPPEDVERFKLGD--PKSFRYLNQSSCYKLDGVNDAEEYLATRRAMDVVGISEKEQ 314

  Fly   320 WSILSLLAAILHLGNLRFTATEVANLATAEIDDTP-NLQRVAQLLGIPISALNAALTQRTIFVHG 383
            .:|..::|:||||||:.|:..|.|:.::.:.:.:. :||..::||.....:|..||.:|.:....
plant   315 DAIFRVVASILHLGNIEFSKGEDADSSSVKDEQSMFHLQMTSELLMCDPHSLEDALCKRMMVTPE 379

  Fly   384 EHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNS 448
            |.:..||....|...||...|::|..:|..:|.:||.:|. |.......||||||:|||:|..||
plant   380 EVIKRSLDPLGAAVSRDGLAKTIYSRLFDWLVNKINISIG-QDSHSRRLIGVLDIYGFESFKTNS 443

  Fly   449 FEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEE 513
            |||.||||.||.|||.|..|:|||||.|||.|.|:|.::||.||:.::|||..||..:::|:||.
plant   444 FEQFCINYTNEKLQQHFNQHVFKMEQGEYQKEEIDWSYVEFVDNKDVVDLIEKKPGGIIALLDEA 508

  Fly   514 SKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLR 578
            ...||.|.:|..|||:....:...::|.|.|::. |.:.||||.|.|....||:||:|....:.:
plant   509 CMLPKSTPETFSEKLYHTFKDHKRFMKPKLTRSD-FTLVHYAGDVQYQSDQFLDKNKDYVVAEHQ 572

  Fly   579 TLVQRSTNKYLVDIFPHEMPMDTAK-KQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEP 642
            .|:..|...::..:|| .:|.:::| |..::..:|:..|..||.||:...|::|||:|||...:|
plant   573 DLLNASKCSFVSGLFP-PLPKESSKSKFSSIGARFKLQLQQLMETLNSTEPHYIRCVKPNNLLQP 636

  Fly   643 KNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPV--GPLEQCDCRKLARQI 705
            ..||....:.|||..|::|..|::.||||....:..|:.|:.:|.|.:  |..|       |...
plant   637 TVFDNANVLHQLRSGGVLEAIRVKCAGYPTNRTFIEFLNRFLILAPEILKGEYE-------AEVA 694

  Fly   706 CEVALPAD--SDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAI 768
            |:..|...  :..|.||:|:|||....|.|:..|::::.:|...||..:|..|.|......|.|.
plant   695 CKWILEKKGLTGYQIGKSKVFLRAGQMAELDAHRTRVLGESARMIQGQVRTRLTRERFVLMRRAS 759

  Fly   769 ITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQ-----QLTTK-FTMVRCRTIKLQALSRGYLVR 827
            :.:|..|||.:.|:..:.||    |..|.|..|     |:..| :...:...:.||:..|....|
plant   760 VNIQANWRGNIARKISKEMR----REEAAIKIQKNLRRQIAKKDYGKTKSSALTLQSGVRTMAAR 820

  Fly   828 KDFQKKLLER---------------RKQNQLKKEELLKLAKMKEAEELLRLQQLKEQKEREQREQ 877
            .:|:.||..|               ....:||:..||..:.::..   :..:||.:.|:.:::|:
plant   821 HEFRYKLTTRAATVIQAYWRGYSAISDYKKLKRVSLLCKSNLRGR---IARKQLGQSKQADRKEE 882

  Fly   878 QEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTLIVAAPLP 942
            .||    |::::....|..|:.|:.|....::    .:|......:|:.|:
plant   883 TEK----ERKVELSNRAEEAVDMSFVLHSEQS----DDAESGHGRKAKLSI-------------- 925

  Fly   943 TRPASAVTRINTIPESPGTIDVES---SKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSV 1004
                          ||...:|..|   |:|..|:.   |..|....|    :|.|.|
plant   926 --------------ESEDGLDKSSVLHSEQSDDEE---LGHERKTKL----SIESED-------- 961

  Fly  1005 PNNIDTSDFSYLKYAATYFGGGATAQHERKP---------LKKSLLKHEHPIDE 1049
             .:.|.||...:             :||||.         ::||.:.|....|:
plant   962 -GHSDQSDDEEI-------------EHERKTKHCIQAEDGIEKSYVMHSDQSDD 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	272/682 (40%)
		MYSc_Myo7	81..726	CDD:276832	260/657 (40%)
		IQ	765..785	CDD:197470	7/19 (37%)
		DUF4355	827..>887	CDD:290964	16/74 (22%)
		MyTH4	1031..1239	CDD:295320	8/28 (29%)
		B41	1248..1429	CDD:214604
		FERM_N	1248..>1288	CDD:286467
		FERM_B-lobe	1342..1429	CDD:271216
		PH-like	1454..1547	CDD:302622
		MyTH4	1674..1819	CDD:214535
		B41	1827..2032	CDD:214604
		FERM_N	1829..>1877	CDD:286467
		FERM_M	1936..2032	CDD:278785
		FERM_C2_MyoVII	2028..2121	CDD:270020
XIJ	NP_001319790.1	Myosin_N	9..46	CDD:397036
		MYSc_Myo11	74..717	CDD:276835	260/657 (40%)
		IQ	829..849	CDD:197470	1/19 (5%)
		DUF460	<1081..>1142	CDD:421465
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	530	1.000	Domainoid score	I63
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8405
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810