Protein Alignment Myo28B1 and MYO15B

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001381987.1
• Gene: MYO15B / 80022
• HGNCID: 14083
• Length: 3096
• Species: Homo sapiens
• Alignment Length: 2501
• Identity: 583/2501 - (23%)
• Similarity: 973/2501 - (38%)
• Gaps: 665/2501 - (26%)

  Fly    67 EDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAE 131
            ||:||:..|..:.:.::|..|:.|:....|||:.|.:|:.:||::.||:::......|..:....
Human   720 EDMEDLARLRLVCDSSVLLCLKKRFHLGRIYTFGGPVLLVLNPHRSLPLFSPEVQASYHPRKALS 784

  Fly   132 LPPHIFAISDNAFQRLQRLKENQCVVI-----SGESGAGKTESTKLILQYLAAI----SGKHSWI 187
            ..||||||..:|:...|...::.|:::     ||.||:||||:.|.|:|:|:::    :|..
Human   785 TTPHIFAIVASAYDLAQNTGQDPCILLCSSHCSGHSGSGKTEAAKKIMQFLSSLEQDQTGNR--- 846

  Fly   188 EQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDER 252
            |.|:.:..||:.:||:|||:.|.|:||||: :...:..||.|.||.:..||||.||:|||::.||
Human   847 ECQVEDMLPILSSFGHAKTILNANASRFGQ-VFCLYLQQGVIVGASVSHYLLETSRVVFQAQAER 910

  Fly   253 NYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPE 317
            ::|:||.:||||.:.|||||.|  |.|..|:||.||....|.|:.||:||..:..|::.|...||
Human   911 SFHVFYKLLAGLDSIERERLSL--QGPETYYYLNQGQACRLQGKEDAQDFEGLLKALQGLGLCPE 973

  Fly   318 EVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVH 382
            |:.::.::|||||.|||:.|:::|..:...|.:.....:...|:||.:|...|..|:|:|.....
Human   974 ELNAVWAVLAAILQLGNICFSSSERESQEVAAVSSWAEIHTAARLLRVPPECLEGAVTRRVTETP 1038

  Fly   383 GEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIG---VLDIFGFENF 444
            ...|:.||..|:|.:.|||..|:||..:|.|::||.|..:....:.  .|||   |:|.:|||..
Human  1039 YGQVSRSLPVESAFDARDALAKALYSRLFHRLLRRTNARLAPPGEG--GSIGTVTVVDAYGFEAL 1101

  Fly   445 DNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSL 509
            ..|..||||.|.|:|.||.|....:...|::|.:.|.::|..:.....:..|||:..:|.:|:|:
Human  1102 RVNGLEQLCNNLASERLQLFSSQMLLAQEEEECRRELLSWVPVPQPPRESCLDLLVDQPHSLLSI 1166

  Fly   510 IDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFS 574
            :|.::...:.||.|.|:|.|..||:...|.|.: ....:|.:|||||.|.|....||.:|||...
Human  1167 LDAQTWLSQATDHTFLQKSHYHHGDHPSYAKPR-LPLPVFTVRHYAGTVTYQVHKFLNRNRDQLD 1230

  Fly   575 GDLRTLVQRSTNKYLVDIFPHEMPMDT-AKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNE 638
            ..:..::.:|..:.:..:|....|... .:.:|||..:|:.:|:.|:..|.::|.|||:|:.||.
Human  1231 PAVVEMLGQSQLQLVGSLFQEAEPQSRGGRGRPTLASRFQQALEDLIARLGRSHVYFIQCLTPNP 1295

  Fly   639 YKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLAR 703
            .|.|..||......||..:.::|....|.|.:|:|..:.||:..::.| ...|..:..|..|...
Human  1296 GKLPGLFDVGHVTEQLHQAAILEAVGTRSANFPVRVPFEAFLASFQAL-GSEGQEDLSDREKCGA 1359

  Fly   704 QICEVALPADSDRQY-GKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGI------RRVLFR--- 758
            .:.:| |.|:|...: |.||:.|:::....||..|.|...:::|.:.|..      :|||.|
Human  1360 VLSQV-LGAESPLYHLGATKVLLQEQGWQRLEELRDQQRSQALVDLHRSFHTCISRQRVLPRMQA 1423

  Fly   759 ---------RYMKRYREA---IITVQRYWRGRLQRR-KYQVMR-QGFH------------RLGAC 797
                     ||::| |.|   :.|:....:..|||| :.|:.| ||:|            .||..
Human  1424 RMRGFQARKRYLRR-RAALGQLNTILLVAQPLLQRRQRLQLGRWQGWHSSERALERVPSMELGRL 1487

  Fly   798 IAAQQLTTKF------------TMVRCRTIKLQA------------LSRGYLVRKDFQKKLLERR 838
            ....:|....            ::..|...::.|            ......|...||:..|.|.
Human  1488 EIPAELAVMLKTAESHRDALAGSITECLPPEVPARPSLTLPADIDLFPFSSFVAIGFQEPSLPRP 1552

  Fly   839 KQNQLK---------KEELLKLAKMKEAEELLRL------------------------------- 863
            .|...|         .:..|.:.|:     :|||
Human  1553 GQPLAKPLTQLDGDNPQRALDINKV-----MLRLLGDGSLESWQRQIMGAYLVRQGQCRPGLRNE 1612

  Fly   864 --QQLKEQKEREQREQQEKR-----------------LQE-------EQRLKAEAAARNALAMAA 902
              .||..|..:...|||.:|                 ||:       :|..:..||......:.|
Human  1613 LFSQLVAQLWQNPDEQQSQRGWALMAVLLSAFPPLPVLQKPLLKFVSDQAPRGMAALCQHKLLGA 1677

  Fly   903 VQQKR------RTKPVKQ----------------------------------------------- 914
            ::|.:      |..|..|
Human  1678 LEQSQLASGATRAHPPTQLEWLAGWRRGRMALDVFTFSEECYSAEVESWTTGEQLAGWILQSRGL 1742

  Fly   915 EAPK------------------------------------------------------APTLQAR 925
            |||.                                                      ||.:||
Human  1743 EAPPRGWSVSLHSRDAWQDLAGCDFVLDLISQTEDLGDPARPRSYPITPLGSAEAIPLAPGIQA- 1806

  Fly   926 NSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQM---VDDVFR-----FLND-E 981
            .||||.|         |..||.      |:|....|.:|:.|..:   :|.:|:     .|:| |
Human  1807 PSLPPGP---------PPGPAP------TLPSRDHTGEVQRSGSLDGFLDQIFQPVISSGLSDLE 1856

  Fly   982 PDAAL--RKLNNISSGDT-----------IRLPKSVPN--------------------------- 1006
            ...||  |.....:.|.|           |::|...|.
Human  1857 QSWALSSRMKGGGAIGPTQQGYPMVYPGMIQMPAYQPGMVPAPMPMMPAMGTVPAMPAMVVPPQP 1921

  Fly  1007 ---NIDTSDF-----SYLKYAATYFGGGATAQHERKPLKKSLLKHEHP--IDEMASKAIWLTILR 1061
               ::|....     ::::..|.......|||.....|::.:.:.:..  ..|.||:|
Human  1922 PLPSLDAGQLAVQQQNFIQQQALILAQQMTAQAMSLSLEQQMQQRQQQARASEAASQA------- 1979

  Fly  1062 FMGDLPDVVSS-----PTLHVFDNENLMSDLASLLNTSDS-----YKPRLFVRQS---QR----- 1108
                .|..|:|     ||.......:|.|:...|..||:.     |:|:.|.::.   ||
Human  1980 ----SPSAVTSKPRKPPTPPEKPQRDLGSEGGCLRETSEEAEDRPYQPKSFQQKRNYFQRMGQPQ 2040

  Fly  1109 ---RIPKPLA-----------SGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQ 1159
               |..||.|           ..|:|.:|..|....|.|   ..:.......|:|..|: :..|:
Human  2041 ITVRTMKPPAKVHIPQGEAQEEEEEEEEEEEQEEQEVET---RAVPSPPPPPIVKKPLK-QGGAK 2101

  Fly  1160 ICKQLYLNPSRS----------SYSRGWLLLSLCLSCFP----PSKEFEPHLRSFM-KQGTAQLQ 1209
            ..|:....|::.          :..||.::.|  ....|    ||:|....:|.:. :.|...:.
Human  2102 APKEAEAEPAKETAAKGHGQGPAQGRGTVVRS--SDSKPKRPQPSREIGNIIRMYQSRPGPVPVP 2164

  Fly  1210 ATPSL-------------QRLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQVD 1261
            ..||.             :.|.:..:||....||.|..... :|..|.     :....:..||:.
Human  2165 VQPSRPPKAFLRKIDPKDEALAKLGINGAHSSPPMLSPSPG-KGPPPA-----VAPRPKAPLQLG 2223

  Fly  1262 AASTAREAVNQLCQGMGLTDTFGFGLVMSLN-----GKLMPLGAGQEHVLDAISECEQRQLD--- 1318
            .:|:.:|.     || .|.|.||..|.::..     ...:|| ......|.|...|..:.::
Human  2224 PSSSIKEK-----QG-PLLDLFGQKLPIAHTPPPPPAPPLPL-PEDPGTLSAERRCLTQPVEDQG 2281

  Fly  1319 ------------------APWKLYIRKEMFATWYDPSMDPKATQLIYKQILNG------LKCGEY 1359
                              .||||::|||:|....:.| .|...:|:.:|||..      ::..:.
Human  2282 VSTQLLAPSGSVCFSYTGTPWKLFLRKEVFYPRENFS-HPYYLRLLCEQILRDTFSESCIRISQN 2345

  Fly  1360 RCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSY 1424
            ..|..||:           .|..|:              ||
Human  2346 ERRKMKDL-----------LGGLEV--------------DL------------------------ 2361

  Fly  1425 VKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDE 1489
                  |.|...:...|:.|.:.|..:|....||.|.|..:.|    ||..:|.::..||.|:..
Human  2362 ------DSLTTTEDSVKKRIVVAARDNWANYFSRFFPVSGESG----SDVQLLAVSHRGLRLLKV 2416

  Fly  1490 TE---------QVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLR 1545
            |:         ::|.|..|:|||.|.......|. ::.:....||..:.|:....::...|:.|:
Human  2417 TQGPGLRPDQLKILCSYSFAEVLGVECRGGSTLE-LSLKSEQLVLHTARARAIEALVELFLNELK 2480

  Fly  1546 QRSSYGVALDPVVEGDLEDCLVL--NPGDLIEFEAGVT---GAQLMAGNAQDCYRGCVNGQWGQF 1605
            :.|.|.:||...:   .::|.:|  :.||||:.....|   |.|.          |...|:.|.|
Human  2481 KDSGYVIALRSYI---TDNCSLLSFHRGDLIKLLPVATLEPGWQF----------GSAGGRSGLF 2532

  Fly  1606 LAGNVRVLATLTKPSEKLQ--------------DILREGRFQE-PPKPTPRANYSRRRQHNISQL 1655
            .|..|:..|.......|.|              .:.|..|..| |..|..:|:.......::|.:
Human  2533 PADIVQPAAAPDFSFSKEQRSGWHKGQLSNGEPGLARWDRASERPAHPWSQAHSDDSEATSLSSV 2597

  Fly  1656 A-----ESH-----------FRE-----------PLDSDKAPLSKFSPEPLKAPLLKAVVKVPPL 1693
            |     :||           ||.           ....|...|.:::..|::..||.....|..|
Human  2598 AYAFLPDSHSYTMQEFARRYFRRSQALLGQTDGGAAGKDTDSLVQYTKAPIQESLLSLSDDVSKL 2662

  Fly  1694 FQQALVMHHHILKYMGDIARSNLPVNTDLIFQ--PALQHPLLCDELYCQLMKQLSDNPSSESEKR 1756
               |:.....::::|||.::.......||:::  ...|...|.||:|||::||::.:|..|...|
Human  2663 ---AVASFLALMRFMGDQSKPRGKDEMDLLYELLKLCQQEKLRDEIYCQVIKQVTGHPRPEHCTR 2724

  Fly  1757 GWDLLYLATGLVAPSVLVMRELIILLRMR--ADALADACLKRLKRSLAQGQRKKAPHLIEVEG-I 1818
            ||..|.|.||...||..:|..|...|:..  :..||.:..:.|:|::..|.|::.|...|::. :
Human  2725 GWSFLSLLTGFFPPSTRLMPYLTKFLQDSGPSQELARSSQEHLQRTVKYGGRRRMPPPGEMKAFL 2789

  Fly  1819 QQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSP---VGYSIFL--KTGDRVYA 1878
            :.:.:.:. .|:.|........|::.|..||:..::.:::.:..|   ..:::||  :....|..
Human  2790 KGQAIRLL-LIHLPGGVDYRTNIQTFTVAAEVQEELCRQMGITEPQEVQEFALFLIKEKSQLVRP 2853

  Fly  1879 MPEEEFVFDFI--------TQLIYWLRQQRTIRSISDGQYQLHFMRKLWLNNHPGEDLNGDMIFS 1935
            :...|::...:        ::.::|             :..|||....:::.|
Human  2854 LQPAEYLNSVVVDQDVSLHSRRLHW-------------ETPLHFDNSTYISTH------------ 2893

  Fly  1936 YPQELHKYLKGYYPIDCEQASRLAILVYSADHDVSLQRLPEV---------LTRLIPEDLIPLQT 1991
            |.|.|..||:|..|:..:..::||.|       .:||.|.:.         |...:|:.|.....
Human  2894 YSQVLWDYLQGKLPVSAKADAQLARL-------AALQHLSKANRNTPSGQDLLAYVPKQLQRQVN 2951

  Fly  1992 VAEWRQQILPKVHRDHLTEDH----AKILFLQELSHFACFGSTFFVVKQQNDDALPETLLIAINS 2052
            .|..:..:..::.|   .|.|    |:|.|::.:|....||.|.:.|.:.:..||....|:.:|.
Human  2952 TASIKNLMGQELRR---LEGHSPQEAQISFIEAMSQLPLFGYTVYGVLRVSMQALSGPTLLGLNR 3013

  Fly  2053 TGFHMLDPTTKEILRSYEYSQLGIWSSGKNH 2083
            ....::||:::.:     |.::.:.|..:.|
Human  3014 QHLILMDPSSQSL-----YCRIALKSLQRLH 3039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	226/658 (34%)
		IQ	765..785	CDD:197470	7/23 (30%)
		Atrophin-1	<820..>946	CDD:460830	42/298 (14%)
		MyTH4	1031..1239	CDD:470587	53/269 (20%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	25/116 (22%)
		B41	1248..1429	CDD:214604	37/212 (17%)
		PH-like	1454..1547	CDD:473070	25/101 (25%)
		MyTH4	1674..1819	CDD:214535	42/149 (28%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	15/106 (14%)
		B41	1827..2032	CDD:214604	43/230 (19%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	12/56 (21%)
MYO15B	NP_001381987.1	PHA03307	9..>358	CDD:223039
		PRK12678	272..>494	CDD:237171
		MYSc_Myo35	734..1382	CDD:276861	226/658 (34%)
		MyTH4	1598..1700	CDD:459939	17/101 (17%)
		PH-like	2387..2481	CDD:473070	25/98 (26%)
		SH3_MYO15B	2485..2539	CDD:213001	18/66 (27%)
		MyTH4	2643..2781	CDD:214535	40/140 (29%)
		FERM_M	2879..2993	CDD:459788	31/135 (23%)
		FERM_C_MyoXV	2989..3090	CDD:270022	12/56 (21%)