Protein Alignment Myo28B1 and myo15b

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_073774764.1
• Gene: myo15b / 795537
• ZFINID: ZDB-GENE-030131-4797
• Length: 3191
• Species: Danio rerio
• Alignment Length: 2745
• Identity: 617/2745 - (22%)
• Similarity: 985/2745 - (35%)
• Gaps: 937/2745 - (34%)

  Fly     1 MDAGYSPRKGEYVWVKPQN--------TTSEFAVPF----------------GARIVRT------ 35
            |..|..|...|..|.:.|.        ..||..:|.                .|.|:.|
Zfish   716 MGEGLLPSPMEMHWAQTQQMCGDPQDWLRSENLLPHQTVEKLTKWTVYQDDEHAHIIPTHNGRGP 780

  Fly    36 ----EKTQTLVCDDRNK-QFWVPAGDVLKAMHITSQEDVEDMITLGDLQEYTILRNLQNRYAKQL 95
                :.||.::.:..|. |..:|...  :|:.:   ::|||:..|.::.|.::|.||:.|:.:..
Zfish   781 WESEDPTQNMLEERLNSTQVMMPGSS--QAVEV---DEVEDLAQLEEVCESSVLLNLKKRFHRDS 840

  Fly    96 IYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISG 160
            ||||.|:||::|||::.:.|||....|.|:.|.....||||:||:|.||.:.|...:..|::|||
Zfish   841 IYTYIGNMLLSINPFKPINIYTEELRQQYQGKEKHNNPPHIYAIADAAFCQSQTTTQEHCIIISG 905

  Fly   161 ESGAGKTESTKLILQYLAAI-SGKHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFT 224
            :||:||||:||||:.||::: .|::..:.|. :|..||:|:||||||:.|:||||||||:.|...
Zfish   906 QSGSGKTEATKLIVHYLSSMYQGRNDKLRQP-MEVLPILESFGNAKTILNNNSSRFGKYLHIHIL 969

  Fly   225 PQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGG 289
             ||.:.|..:.:|||||||||||:::|||||:||.:|||::..:::.|.|  |....|.||.||.
Zfish   970 -QGVVVGTSLSKYLLEKSRIVFQAKEERNYHVFYELLAGMNEWDKQDLYL--QGAETYFYLNQGR 1031

  Fly   290 CFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTP 354
            ...|.|:.|.:||..:...::.:....:::.:|.::|::||.|||:.|::.|..:...|.|....
Zfish  1032 ACELLGKYDKQDFILLVHCLETIGLHADQLATIWAVLSSILQLGNICFSSYESESFEVARIFSEA 1096

  Fly   355 NLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRIN 419
            ..:||..||.:...||...:|.|......:.:...||.|:|||.|||..|:||..:|..::.|||
Zfish  1097 EARRVGNLLQVSAEALQTVITHRVTETTYDRIYCPLSVESAIESRDAIAKTLYSVLFDWLLERIN 1161

  Fly   420 E-TINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHIN 483
            | .|..::|   :::|::||:|||:...|||||||||:|||.||||....:...||:||..|||.
Zfish  1162 EWLIPTEMD---STVGIVDIYGFEDLCVNSFEQLCINFANEQLQQFVNRALVAQEQEEYSAEHIQ 1223

  Fly   484 WQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSL 548
            |..|..:|:...||||..:|..::.::|:::..|:.||.|.|:|.|..|||...|.|.| ....:
Zfish  1224 WYPIVLEDSNGCLDLISARPYGILRILDDQTSLPQATDHTFLQKCHYHHGNCPYYTKPK-IPLPV 1287

  Fly   549 FGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEMPMDTAKKQ-------- 605
            |.|.||||.|.|....||.||.|.|..::..|..||..:.:..:|.........:|:
Zfish  1288 FTIYHYAGAVTYQVHNFLNKNHDQFRPEVLELFARSRLQMVSGLFRKVQERYIQQKELGRARGHR 1352

  Fly   606 ---PTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRR 667
               .|:...|:.||..|...|.:....|:||.|||..|.|..||.:....|||:.|::||..||:
Zfish  1353 NQMSTVAANFQQSLTELTTRLERCKTTFVRCFKPNYVKLPGIFDVDYITTQLRHGGILETIHIRK 1417

  Fly   668 AGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQI---CEVALPADSDRQYGKTKLFLRDED 729
            .|:|||..:..|:|||.:|:.. .|:.|    .|..|:   .|.....|...|.|.||:||::..
Zfish  1418 EGFPIRIPFAQFMERYGVLLSQ-RPINQ----SLEEQVVTLIETIGAEDGQYQLGLTKVFLKETL 1477

  Fly   730 DASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRL 794
            ...:|.:.|.....:.|||||.||..:.||..:.:::..|.:|.:.||. |.|||      |.:|
Zfish  1478 YQQVEEKWSSTQTWAAVTIQRNIRGFICRRNFQFFKKKAIVIQSHIRGH-QARKY------FKQL 1535

  Fly   795 GACIAAQQLTTKF--TMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQNQLKKEELLKLAKMKEA 857
            ..|.      |:|  ||:..|                           |.:|:..      .||.
Zfish  1536 KQCF------TQFWATMMITR---------------------------NTIKRRH------WKEH 1561

  Fly   858 EELLRLQQLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTL 922
            .:..|::::  .|......:.:..:.|   :.||.:||    :.:...:.:...|.:.||  |.:
Zfish  1562 TDRSRVKEV--AKPTSSSSEMDVGILE---IPAELSAR----LRSSSGRSQGSGVSEVAP--PQV 1615

  Fly   923 QARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALR 987
            :|.:.|
Zfish  1616 KADHKL----------------------------------------------------------- 1621

  Fly   988 KLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMAS 1052
                           |:|.:||...||  :||.|....| ..|.:..||::.|...:|. |...:
Zfish  1622 ---------------SLPLDIDRHPFS--QYANTVLKDG-WCQAQGYPLQRPLTSLDHE-DARTA 1667

  Fly  1053 KAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLASG 1117
            ..|:..||||.||                   |||                            :|
Zfish  1668 LEIYKLILRFTGD-------------------SDL----------------------------NG 1685

  Fly  1118 EKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNS-----LRDEILAQICKQLYLNPSRSSYSRGW 1177
            .:|.                    ::|:.|::.|     :|||||||:....:....:.:..|||
Zfish  1686 WQEQ--------------------MLGNYIVEKSQIRPGIRDEILAQLVYLTWDGDRQETNLRGW 1730

  Fly  1178 LLLSLCLSCFPPSKEFE-PHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQ--PPSLFELHAIR 1239
            |||:.|||.|.||.:.| |.|:....:|..:.::....:.|....:..|.|:  ||:..|..|.:
Zfish  1731 LLLACCLSAFTPSPDLEKPLLKYVSDRGPGEYRSLCQHKLLTSLPLPSPACRRHPPTQLEWTANQ 1795

  Fly  1240 GRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGL-----------------TDTFGFGL 1287
            .:..:.|:::..:.::..::|::.:|..|..:.:....||                 ||..|...
Zfish  1796 RKGKMVLEVNTFNEEKLAVEVESWTTGEELASWILSYRGLTNATQGWSVSLLADEGWTDLTGCDF 1860

  Fly  1288 VMSL------------------------------------------------------------- 1291
            ||.|
Zfish  1861 VMDLLAGVESDVPMGHPPTENDYLFSDTSDRMETTDIDAFIPPAPSMQAPGLPSFEASHWNTYEP 1925

  Fly  1292 -------------------------------------------NGKLMP---LGAG--------- 1301
                                                       .|.:||   .|||
Zfish  1926 LSTYQGSQGRQMDSYVDDIFDPVFDHGPPDFDRMAMLNRRMRGGGGMMPSMYTGAGMPMNPAMAG 1990

  Fly  1302 ---------------------------------------------------------QEHVLDAI 1309
                                                                     |:..:.|:
Zfish  1991 YGATPMMPNMMPATMPMMQPMPPMMMPTAMPQAMPAVNPQQMDQQQAFINQQALLLAQQMTMQAM 2055

  Fly  1310 SECEQRQLD-------------------------------------------------------- 1318
            |..:::|.|
Zfish  2056 SLSQKQQQDEMRRRESQRQSPRQRRRSPPRARSPSRSPSPKPRSRPQSQRTNHQTPKQAPEPLPK 2120

  Fly  1319 -------------------------------------------------------------APWK 1322
                                                                         .|.|
Zfish  2121 PRSPEPVTERDVRAPEDHGSFKEKRDFFQKIGTSDTRPKPAPKVAKPLIYANPPVSQPKSPPPVK 2185

  Fly  1323 LYIR-----------------------------KEMFATWYD-PSMDPKATQLI---YKQILNGL 1354
            ..::                             :|:...:.: |:.:|||.:.:   .||.|
Zfish  2186 TQVKPLPEPPQIQKSGRESPEPTSPKPEPTSNIREIIKQYQNRPNPEPKAYEPVRVPAKQFL--- 2247

  Fly  1355 KCGEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIEN--------- 1410
                 :....||.    |||.....||....:.:..|.....|..|.:.|.|:|.|
Zfish  2248 -----KKNDPKDE----ALAILKSQGPVSHQKKQWVEKPPSPPQQLESRGPRSISNSMKQKQLSL 2303

  Fly  1411 -------------------------------------------------------WSRLIAATY- 1419
                                                                   :|..:..:|
Zfish  2304 ADLFGSQRSQPLPRARESIPSPPPPIPDPPRQPAPALNQLNMMAEEESVRSQLHKFSASVYFSYP 2368

  Fly  1420 ---------EKSSYVKEEQN-----DLLLE----------------AQKRAKEDICLFAHL---- 1450
                     ::..|.:|:.|     :||.|                .::|..:|:....|:
Zfish  2369 IMPGKLFLRKELFYPREKFNHPYTLNLLCEQIMRDTYSDSCLRISREERRKMKDLLASFHIGTNI 2433

  Fly  1451 -----------------SWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETE------- 1491
                             :|....:|||.|....|    .|..|||::..|:.|:....
Zfish  2434 RSLDDAMKKRIVMAARDNWSNYFARLFNVKVGNG----GDAQMLGVSHRGIRLLKVARASGINPK 2494

  Fly  1492 --QVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVAL 1554
              :||.:..:|:||.|..:...|: |:|..:....|....|.....||...|..|.:.|.|.:|:
Zfish  2495 HLKVLHTFSYSQVLSVQQKGTGKV-VITLSNEELELHSQQAPQIAAVIRLFLMELIKNSEYVIAV 2558

  Fly  1555 DPVVEGDLEDCLVLNPGDLIE----------------------FEAGVT---------------- 1581
            ...|..| :..|..:.||.|:                      |...||
Zfish  2559 KSYVTDD-KSLLSFHRGDAIKLLNMDGLKDGWMFGSSGGRSGLFPVDVTQPCAPPDYHSSNMDRQ 2622

  Fly  1582 -----------GAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLATLTKPSEKLQDILRE---GRF 1632
                       .::::..|      |.:|.     :..||..:.|.|..|.....:.|.   |..
Zfish  2623 LERKKSMRVTSSSRIVPSN------GSINN-----MPANVAEINTSTNGSIYNMSVARSVAGGSE 2676

  Fly  1633 QEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKA----PLSKFSPEPLKAPL-LKAVVKVPP 1692
            ......:.:.:...|.|..:::.|...|.|.::....    .:.:::|.|::..| |.:..::..
Zfish  2677 YSVEVASIQRSEPEREQFIMTEFASKFFTEAINRGNMRSLNEMVEYTPNPIQESLILFSDSELTR 2741

  Fly  1693 LFQQALVMHHHILKYMGDIARSNLPVNTD---LIFQPALQHPLLCDELYCQLMKQLSDNPSSESE 1754
            |..|:.::   ::::|.|..........|   .|.|...:...|.||||||::||.:.:...|:.
Zfish  2742 LGAQSFMV---VMQFMLDQPMKKNQTEGDCVNFILQLGKEKEFLRDELYCQVIKQTTKHRIKENC 2803

  Fly  1755 KRGWDLLYLATGLVAPSVLVM----RELIILLRMRADA------LADACLKRLKRSLAQGQRKKA 1809
            .|||.|..|.||....|..::    |.|..:::   ||      ||:.|.|.|:|||..|.|:..
Zfish  2804 TRGWRLFNLVTGFFPCSNTLLPYCTRHLDTIIQ---DANHPYQELANICAKNLQRSLIFGGRRHI 2865

  Fly  1810 PHLIEVEGI----QQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSPVGYSIF- 1869
            |...|:|.|    ..|.|    .|..|..|..|.:|.|.:...|::.|....:.:.:|.....|
Zfish  2866 PSHSEMEAILAGRNSRRL----PIMLPGGTEFACKIRSFSVAFEVVQDFCTEMGIMNPAEMKEFS 2926

  Fly  1870 ----LKTGDRVYAMPEEEFVFDFITQLIYWLRQQRTIRSISDGQYQLHFMRKLWLNNHP---GED 1927
                .|.||....:..:|::|||:               :.||...|.|.|.:|  ..|   ..|
Zfish  2927 IHAAKKGGDVTRPIHSDEYLFDFL---------------LDDGSIALSFKRLIW--KQPLQFSND 2974

  Fly  1928 LNGDMIFSYPQELHKYLKGYYPIDC------EQASRLAILVYSADHDVSLQRLP---EV------ 1977
            |.  :.|.|...:..||:|...:..      :|.:.|..|.:.|   :.|..||   |:
Zfish  2975 LY--LEFHYQLLVASYLEGKMFLSMNSSTVYQQVAELTALQHLA---LGLNNLPSNAEIKQYHPR 3034

  Fly  1978 LTRLIPEDLIPLQTVAEWRQQILPKVHRDHLTEDHAKILFLQELSHFACFGSTFFVVKQQNDDAL 2042
            :..|...|...|.|:......:.|      ::...||..|::.:|....||...|..::.:..:.
Zfish  3035 MDGLNSTDERLLATIRAQFSTLGP------ISPLDAKARFIKSISSLPLFGFDIFTAQKVSHRSC 3093

  Fly  2043 PETLLIAINSTGFHMLDPTT---------------------KEILRSYEYSQLGIWSSGKNHFHI 2086
            |...|:|:|.....:|||.|                     |:.|.|.|.|    :.....|..:
Zfish  3094 PSPSLVAVNHEVITVLDPKTLNACLTMSMEDVLSLRSIRPKKDKLPSVEIS----FGGQTQHKTL 3154

  Fly  2087 RFGNMIGASKLLCST 2101
            .|.  :..:|.||.|
Zfish  3155 SFN--LKQAKELCHT 3167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	257/660 (39%)
		IQ	765..785	CDD:197470	7/19 (37%)
		Atrophin-1	<820..>946	CDD:460830	17/125 (14%)
		MyTH4	1031..1239	CDD:470587	50/215 (23%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	26/426 (6%)
		B41	1248..1429	CDD:214604	50/594 (8%)
		PH-like	1454..1547	CDD:473070	26/101 (26%)
		MyTH4	1674..1819	CDD:214535	47/162 (29%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	22/98 (22%)
		B41	1827..2032	CDD:214604	50/227 (22%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	21/95 (22%)
myo15b	XP_073774764.1	None