Protein Alignment Myo28B1 and Myh10

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_017453033.1
• Gene: Myh10 / 79433
• RGDID: 71000
• Length: 2007
• Species: Rattus norvegicus
• Alignment Length: 2164
• Identity: 544/2164 - (25%)
• Similarity: 904/2164 - (41%)
• Gaps: 522/2164 - (24%)

  Fly     3 AGYSPRKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCD--DRNKQFWVPAGDVLKAMHITS 65
            |.::.:|  .||:..:..      .|.|..::.|:...::.:  :..|:..|...|:.| |:...
  Rat    28 ADWTAKK--LVWIPSERH------GFEAASIKEERGDEVMVELAENGKKAMVNKDDIQK-MNPPK 83

  Fly    66 QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLA 130
            ...||||..|..|.|.::|.||::||...|||||:|...|.||||:.||||:...|::||.|...
  Rat    84 FSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRH 148

  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSW--------- 186
            |:||||:|||::|::.:.:.:|:|.::.:|||||||||:||.::||||.::..|..
  Rat   149 EMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQE 213

  Fly   187 ----------IEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEK 241
                      :|:|:::||||:|:|||||||:|||||||||:|.|.|...|.|.||.|:.|||||
  Rat   214 SPKPVKPQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEK 278

  Fly   242 SRIVFQSRDERNYHIFYCMLAGLSTAERERLK--LQEQSPSQYHYLAQGGCFTLPGRGDAKDFAD 304
            ||.|.|::|||.:||||.:|:|..    |.||  |..:..:.|.:|: .|...:||:.|..:|.:
  Rat   279 SRAVRQAKDERTFHIFYQLLSGAG----EHLKSDLLLEGFNNYRFLS-NGYIPIPGQQDKDNFQE 338

  Fly   305 IRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISA 369
            ...||.::.|..||:.|:|.:::::|..||:.|  .:..|...|.:.:....|::..|||:.:..
  Rat   339 TMEAMHIMGFSHEEILSMLKVVSSVLQFGNISF--KKERNTDQASMPENTVAQKLCHLLGMNVME 401

  Fly   370 LNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIG 434
            ...|:....|.|..::|..:.:||.|....:|..|:.|:.:|..:|.|||:.:::...|..:.||
  Rat   402 FTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIG 466

  Fly   435 VLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDL 498
            :|||.|||.|:.||||||||||.||.|||.|...:|.:||:|||.|.|.|..|:| .|.|..:||
  Rat   467 ILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDL 531

  Fly   499 I--GMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSL-FGIRHYAGVVMY 560
            |  ...|..:::|:|||..|||.||:|.:|||..:.|:.|.:.|.:..:... |.|.||||.|.|
  Rat   532 IERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDY 596

  Fly   561 NPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFP------------------HEMPMD------- 600
            ....:|.||.|..:.::.||:.:|:::::.:::.                  ||.|:|
  Rat   597 KADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSVSGLHEPPVDRIVGLDQ 661

  Fly   601 ----------TAKKQP-----TLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELC 650
                      :|.|..     |:...::.||..||.||...:|.|:|||.||..|.....|..|.
  Rat   662 VTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLV 726

  Fly   651 VRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICE---VALPA 712
            :.|||.:|::|..||.|.|:|.|..::.|.:||.:|.|...|....|    .:|.||   .||..
  Rat   727 LDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMD----GKQACERMIRALEL 787

  Fly   713 DSD-RQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRR-YMKRYRE--AIITVQR 773
            |.: .:.|::|:|.|....|.||.:|...:...|:..|...|..|.|: :.|:.::  |:..:||
  Rat   788 DPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQR 852

  Fly   774 YWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTK---FTMVRCRTIKLQALSRGYLVRKDFQKKL- 834
            .....|:.|.:|..|              :.||   ...|..:..:|||.....|..|:.|.|:
  Rat   853 NCAAYLKLRHWQWWR--------------VFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVE 903

  Fly   835 -----LERRKQNQLKKEELLK--------------------LAKMKEAEELLR--LQQLKEQKER 872
                 :||:.|..|:::.:|.                    .||.:|.||:|.  ..:::|::||
  Rat   904 GELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEER 968

  Fly   873 EQREQQEKRLQE------EQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPP 931
            .|..|.||:..:      |::|..|..||..|.:..|..:.:.|.:::|   ...|:.:||....
  Rat   969 NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEE---VLLLEDQNSKFIK 1030

  Fly   932 PTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQ--MVDDVFRFLNDEP------DAALRK 988
            ...|     :..|.|...:::....|....:....:||  |:.|:...|..|.      :.|.||
  Rat  1031 EKKL-----MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1090

  Fly   989 LNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASK 1053
            |:    |:|..|...:                      |..|.:...||..|.|.|..:....::
  Rat  1091 LD----GETTDLQDQI----------------------AELQAQVDELKVQLTKKEEELQGALAR 1129

  Fly  1054 AIWLTILRFMGDLPDVVSSPTLHVFDN-----ENLMSDLASLLNTSDSYKPRLFVRQSQRR-IPK 1112
                      ||      ..|||. :|     ..|.:.:|.|....:|.|......:.|:| :.:
  Rat  1130 ----------GD------DETLHK-NNALKVARELQAQIAELQEDFESEKASRNKAEKQKRDLSE 1177

  Fly  1113 PLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGW 1177
            .|.:.:.|.::    .|:...:..|           ..:.|::.:|::.|.|.
  Rat  1178 ELEALKTELED----TLDTTAAQQE-----------LRTKREQEVAELKKALE------------ 1215

  Fly  1178 LLLSLCLSCFPPSKEFEPHLRSF-MKQGTAQLQATPSLQRLERTLVNGPR-------------CQ 1228
                      ..:|..|..::.. .:..||..:.:..|::.:|...|..:             |:
  Rat  1216 ----------DETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1270

  Fly  1229 PPSLFELHAIRGRHPLRLD-----IHLMDGQQRRLQVDAASTAREAVNQL---------CQGMGL 1279
            ...|.::.|.......:||     :|....:..||:|:.|..|.:..|:|         .:..|:
  Rat  1271 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGM 1335

  Fly  1280 TDTFGFGLVMSLNGKLMPLGAGQEHVLDAISECEQRQLDAPWKL-----YIRKEMFATWYDPSMD 1339
                          |.....||.|..|....|..|.:......|     .:.:|..:.......:
  Rat  1336 --------------KFAKDAAGLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1386

  Fly  1340 PKATQLIYKQIL--------------------NGLKCGEYRCRSEKDIAMVCALACFVE-----Y 1379
            .:|.:.:.||:|                    .||:  |.:.:..||:.   ||:..:|     |
  Rat  1387 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIEGLE--EAKKKLLKDVE---ALSQRLEEKVLAY 1446

  Fly  1380 GPGE----ILRLKPSEITAFV--PSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQK 1438
            ...|    .|:.:..::|..:  ...:::..|:..:.:.:|:|.....|:...||::....||::
  Rat  1447 DKLEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEARE 1511

  Fly  1439 RAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSD--ELMLGINSAG--LFLIDETEQVLASCCF 1499
            :..:.:.|...|...:.....||   ::..:|::|  :||...:..|  :..::::::.|....
  Rat  1512 KETKALSLARALEEALEAKEEFE---RQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV- 1572

  Fly  1500 SEVLKVHVE---------SDDKLHV---MTFQHVNFVLQCSSAQDANE-----------VINYML 1541
             |.::..:|         .|.||.:   |......|.....:..:.||           .:...|
  Rat  1573 -EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAEL 1636

  Fly  1542 DNLRQRSSYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGN-AQDCYRGCVNGQWGQF 1605
            ::.|::.:..||....:|.||:|         :|       ||:.|.| |:|
  Rat  1637 EDERKQRALAVASKKKMEIDLKD---------LE-------AQIEAANKARD------------- 1672

  Fly  1606 LAGNVRVLATLTKPSEKLQDILRE------------GRFQEPPKPTPR------------ANYSR 1646
                 .|:..|.|...:::|..||            .:.:|..|....            |:..|
  Rat  1673 -----EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1732

  Fly  1647 RRQHNISQLAESHFREPLDSDKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDI 1711
            .|:|     ||.. |:.| :|:...|......|.....:...::..|.::.            :.
  Rat  1733 ARRH-----AEQE-RDEL-ADEIANSASGKSALLDEKRRLEARIAQLEEEL------------EE 1778

  Fly  1712 ARSNLPVNTDLIFQPALQHPLLCDELYCQ-LMKQLSDNPSSESEKRGWDL---LYLATGLV---- 1768
            .:||:.:..|...:..||...|..||..: ...|.|||...:.|::..:|   |....|.|
  Rat  1779 EQSNMELLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF 1843

  Fly  1769 --------------------------APSVLV------MRELIILL---RMRADAL------ADA 1792
                                      |.:.||      ::|:.:.:   |..||..      |:|
  Rat  1844 KATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANA 1908

  Fly  1793 CLKRLKRSL---------AQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVEAFEIESHTRGA 1848
            .:|:|||.|         |...|:|.          ||.|         ||..||.|..|..
  Rat  1909 RMKQLKRQLEEAEEEATRANASRRKL----------QREL---------DDATEANEGLSRE--- 1951

  Fly  1849 ELIADIAQRLELKSPVGYS 1867
              ::.:..||....|:.:|
  Rat  1952 --VSTLKNRLRRGGPISFS 1968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	267/713 (37%)
		IQ	765..785	CDD:197470	5/21 (24%)
		Atrophin-1	<820..>946	CDD:460830	36/159 (23%)
		MyTH4	1031..1239	CDD:470587	36/227 (16%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	20/109 (18%)
		B41	1248..1429	CDD:214604	39/225 (17%)
		PH-like	1454..1547	CDD:473070	19/119 (16%)
		MyTH4	1674..1819	CDD:214535	36/202 (18%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	10/43 (23%)
		B41	1827..2032	CDD:214604	10/41 (24%)
		FERM_C2_MyoVII	2028..2121	CDD:270020
Myh10	XP_017453033.1	Myosin_N	31..76	CDD:460670	8/52 (15%)
		MYSc_Myh10	99..802	CDD:276952	267/713 (37%)
		Myosin_tail_1	879..1959	CDD:460256	233/1268 (18%)