Protein Alignment Myo28B1 and Myo19

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_079690.2
• Gene: Myo19 / 66196
• MGIID: 1913446
• Length: 963
• Species: Mus musculus
• Alignment Length: 1014
• Identity: 308/1014 - (30%)
• Similarity: 477/1014 - (47%)
• Gaps: 199/1014 - (19%)

  Fly    68 DVEDMITL-GDLQEY----------------------TILRNLQNRYAKQLIYTYTGSMLVAINP 109
            |.|...:| |||:|:                      |:||.||.||.:.:.||..|..|||:||
Mouse    13 DAEGRASLKGDLREFLGGEIPLHQLDDLTKVNPVTLETVLRCLQARYTEDIFYTNAGCTLVALNP 77

  Fly   110 YQILPIYTNREIQLYRNKSLAE---------LPPHIFAISDNAFQRLQRLKE--NQCVVISGESG 163
            ::.:|       |||..:.:.|         |.||||.:.:..::.::.|.|  ||.:|:|||||
Mouse    78 FKHVP-------QLYAPELMQEYHAAPQPQKLKPHIFTVGEQTYRNVKSLIEPVNQSIVVSGESG 135

  Fly   164 AGKTESTKLILQYLAAISGKHS---------WIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYI 219
            ||||.:::.::::.|.::...:         .|||:|:.:||:|||||||.|:||.|||||||:|
Mouse   136 AGKTWTSRCLMKFYAVVAASPTSCENHKIAERIEQRILNSNPVMEAFGNACTLRNSNSSRFGKFI 200

  Fly   220 EIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHY 284
            :::......:.||.:|.|||||:|:..|:..|||:||||.:..|.:..||          .|:|
Mouse   201 QLQLNRAQQMTGAAVQTYLLEKTRVACQASSERNFHIFYQICKGATKDER----------LQWH- 254

  Fly   285 LAQGGCFT-LPGRGDAKD---FADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANL 345
            |.:|..|: ||....:.:   |...|.||..|........:|..:||.:|||||:.|..:|...|
Mouse   255 LPEGTAFSWLPNPESSLEEDCFEVTREAMLHLGIDTPTQNNIFKVLAGLLHLGNVHFVDSEDEAL 319

  Fly   346 ATAEIDDTP-NLQRVAQLLGIPISALNAALTQRTIFVHGEH--VTTSLSKEAAIEGRDAFVKSLY 407
            ....:|||. :::..|.||.:|...|..::..|||....:.  .....|:......||...|.:|
Mouse   320 PCQVMDDTKVSVRTSALLLQLPEKMLLESMQIRTIKAGKQQQVFQKPCSRAECDTRRDCLAKLIY 384

  Fly   408 DGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKM 472
            ..:|..:|..||.:|..........||:||::|||:|.|||.||||||||||.|||.||.|..:.
Mouse   385 ARLFDWLVSVINSSICADSKSWTAFIGLLDVYGFESFPNNSLEQLCINYANEKLQQHFVAHYLRA 449

  Fly   473 EQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLE-KLHVQHGNRS 536
            :|:||:.|.:.|..:.:||||..|||:...|:::.|||:||.:..:.:....|: ::......|.
Mouse   450 QQEEYEVEGLEWSFVNYQDNQTCLDLLEGSPISICSLINEECRLNRPSSAAQLQTRIESTLAGRP 514

  Fly   537 IYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEMPMDT 601
            .....|.::...|.:.|:||.|.|:..|.:|||:|....:|..|:|:|.:..|..:||......|
Mouse   515 CLGHNKLSREPSFVVVHFAGPVRYHTAGLVEKNKDPVPPELTELLQQSQDPLLTMLFPANPEEKT 579

  Fly   602 AK------KQPTLCV--KFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSG 658
            .:      :.|.|.|  ||:.||:.|::.|....|::|||||||...:|:.|.:|..:.||...|
Mouse   580 QEELSGQSRAPALTVVSKFKASLEQLLQVLHNTTPHYIRCIKPNSQSQPQTFLQEEVLNQLEACG 644

  Fly   659 MMETARIRRAGYPIRHAYRAFVERYRL--------------LVPPVGPLEQCDCRK--------- 700
            ::||..|..||:|||.:::.|:|||:|              |.|..|..||..|.|
Mouse   645 LVETIHISAAGFPIRVSHQNFIERYKLLRRLGPRMSSGLGGLEPAEGSSEQPLCAKEATLQPLLQ 709

  Fly   701 -----LARQICEVALPADSDRQ------YGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRR 754
                 |...|...|.|:|..:.      .|:||:|:.|.....||..|:|::.:....||.|.||
Mouse   710 DILHALPALIQTAATPSDPAKNTQIPLYCGRTKIFMTDSMLELLECGRAQMLEQCARCIQCGWRR 774

  Fly   755 VLFRRYMKRYREAIITVQRYWRGRLQRRKYQ-------VMRQGFHRLG---ACIAAQQL------ 803
            ...::..|:.|.|:: :|..:|..|.|:..:       |::..:|:..   ||:|:::|
Mouse   775 HRLQKQEKQRRAAVL-IQAAFRSWLTRKHIRRLHIAATVIKHAWHKWRIRMACLASKELDGMEEK 838

  Fly   804 -------TTKFTMVRCRTIKLQALSR----GYLVR------KDFQKKLLERRKQNQLKKEELLKL 851
                   |.:.:|....|..|.|:..    |.::.      :.||:||:
Mouse   839 PMPQAPGTLRSSMSPAHTRFLGAIIHLWPLGLVLANSADGVRGFQRKLV---------------- 887

  Fly   852 AKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEA 916
                 |...|||..          ::...::|..|:.:|...:..||...:::...|..|
Mouse   888 -----AHACLRLPS----------DRPSNKVQTPQQDQAGITSIRALPQGSIKFHCRKSP----- 932

  Fly   917 PKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINTI 955
                 ||..:..|.|             .||.||..|.|
Mouse   933 -----LQYADICPDP-------------SASCVTGFNQI 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	247/736 (34%)
		IQ	765..785	CDD:197470	6/19 (32%)
		Atrophin-1	<820..>946	CDD:460830	20/135 (15%)
		MyTH4	1031..1239	CDD:470587
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
Myo19	NP_079690.2	MYSc_Myo19	49..746	CDD:276846	247/714 (35%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	602..624		10/21 (48%)
		IQCD	776..>801	CDD:467745	6/25 (24%)
		MyMOMA region. /evidence=ECO:0000250|UniProtKB:Q96H55	829..963		32/179 (18%)