Protein Alignment Myo28B1 and Myo1c

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001401097.1
• Gene: Myo1c / 65261
• RGDID: 620443
• Length: 1063
• Species: Rattus norvegicus
• Alignment Length: 1085
• Identity: 359/1085 - (33%)
• Similarity: 546/1085 - (50%)
• Gaps: 175/1085 - (16%)

  Fly    52 VPAGDVLKAMH---------------------ITSQE--DVEDMITLGDL-QEYTILRNLQNRYA 92
            :|.|::::.:|                     :|:::  .|:|.:.|.:. .|...:.||:.|:.
  Rat     8 IPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFR 72

  Fly    93 KQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVV 157
            :.|||||.|.:||::|||:.|.|||.:.::.||..|..|:|||:||::|..::.|:..:.:|.|:
  Rat    73 ENLIYTYIGPVLVSVNPYRDLQIYTRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVM 137

  Fly   158 ISGESGAGKTESTKLILQYLA---AISGKHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYI 219
            |||||||||||:||.:||:.|   ....:...:..:::::||::||||||||:|||||||||||:
  Rat   138 ISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYM 202

  Fly   220 EIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHY 284
            :::|..:||..|..|..|||||||:|.|:..|||:|:||.:|.|.......||.| |::|..|.|
  Rat   203 DVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHVFYQLLEGGEEEALRRLGL-ERNPQSYLY 266

  Fly   285 LAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAE 349
            |.:|.|..:....|..|:..:|.|:.|:.|..:||..:||::|::|||||:.|.|.|.:|   |:
  Rat   267 LVKGQCAKVSSINDKSDWKVVRKALSVIDFTEDEVEDLLSIVASVLHLGNIHFAADEDSN---AQ 328

  Fly   350 IDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRI 414
            :.....|:.:.:|||:..:.|..|||.|.|...||.:.:.|:.|.|...|||..|::|...|..:
  Rat   329 VTTENQLKYLTRLLGVEGTTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWL 393

  Fly   415 VRRINETI-NKQVDQP----MNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQ 474
            ||:||.:: :|..:.|    ...:|:|||:|||.|.:|||||.||||.||.|||.|:....|.||
  Rat   394 VRKINRSLASKDAESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQ 458

  Fly   475 DEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFP-KGTDQTLLEKLH--VQHGNRS 536
            :||:.|.|.|:.:::.:|:.|.||:..|...::|::|||...| :.||.|.||||.  ::|....
  Rat   459 EEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTIKHHPHF 523

  Fly   537 IYVK--GKTTQTSL----FGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPH 595
            :..|  .:.|:.||    |.:.||||.|.|:..|||:||.|....:|:..:..|||..:...|..
  Rat   524 LTHKLADQKTRKSLDRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSTNPIMAQCFDK 588

  Fly   596 EMPMDTAKKQP-TLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGM 659
            ....|  ||:| |:..:|:.||..|:..|....|.:|||||||:.|:|..||:.|...|::|.|:
  Rat   589 SELSD--KKRPETVATQFKMSLLQLVEILRSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGL 651

  Fly   660 METARIRRAGYPIRHAYRAFVERYRLLVPPVGPL----EQCDCRKLARQICEVALPADSDRQY-- 718
            ||..|:||||:..|..|.||::||:.|.|...|:    .|.....|.|.:      .....:|
  Rat   652 MENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPVWTGRPQDGVAVLVRHL------GYKPEEYKM 710

  Fly   719 GKTKLFLR-------DEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWR 776
            |:||:|:|       .||  |||::|..|..|    ||...|...:|:...|.:.:.|.:|.:||
  Rat   711 GRTKIFIRFPKTLFATED--SLEVRRQSLATK----IQAAWRGFHWRQKFLRVKRSAICIQSWWR 769

  Fly   777 GRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYL---------------- 825
            |.|.|||               ||::.....|:.|        |.||::
  Rat   770 GTLGRRK---------------AAKRKWAAQTIRR--------LIRGFILRHAPRCPENAFFLDH 811

  Fly   826 VRKDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLR-------------------LQQLKEQK- 870
            ||..|...|..:..:|.|..........::||.||||                   .|||:::.
  Rat   812 VRTSFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQLQQKAV 876

  Fly   871 -------EREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSL 928
                   :::...|...||....||..|..:...|.....:..:...||.:...|....::|..|
  Rat   877 ASEIFKGKKDNYPQSVPRLFISTRLGTEEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLL 941

  Fly   929 PPPPTTLIVAAPLPTRPASAVTRI----------NTIPESPGTIDV--ESSKQMVDDVFRFLNDE 981
            ..|...:||      ..|....||          :::.:|...:.|  |.|||..|.|.     :
  Rat   942 LTPSAVVIV------EDAKVKQRIDYANLTGISVSSLSDSLFVLHVQREDSKQKGDVVL-----Q 995

  Fly   982 PDAALRKLNNIS-SGDTIRLPKSVPNNIDTSDFSYLKYAATYFGG 1025
            .|..:..|...: |.|.:       |||:.:..|     .|:.||
  Rat   996 SDHVIETLTKTALSADRV-------NNININQGS-----ITFAGG 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	269/668 (40%)
		IQ	765..785	CDD:197470	9/19 (47%)
		Atrophin-1	<820..>946	CDD:460830	33/168 (20%)
		MyTH4	1031..1239	CDD:470587
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
Myo1c	NP_001401097.1	MYSc_Myo1	62..718	CDD:276829	269/667 (40%)
		IQCG	751..781	CDD:467744	13/44 (30%)
		Myosin_TH1	874..1055	CDD:461801	37/178 (21%)