Protein Alignment Myo28B1 and myo7bb

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_021322881.3
• Gene: myo7bb / 566034
• ZFINID: ZDB-GENE-070912-482
• Length: 2160
• Species: Danio rerio
• Alignment Length: 2232
• Identity: 831/2232 - (37%)
• Similarity: 1252/2232 - (56%)
• Gaps: 223/2232 - (9%)

  Fly     8 RKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGD--VLKAMHITSQEDVE 70
            :||::||::     |...||.|..:..:...|..:.||..|:..:|.||  .||.||.||.|.|:
Zfish     5 KKGDHVWIE-----SSIGVPIGGYVKISGSGQYCLIDDEGKEHSIPEGDRAALKPMHPTSVEGVD 64

  Fly    71 DMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPH 135
            |||.||||.|..:||||..|:.:.:||||.||:|||:|||::|||||..::|.|..:.|.|||||
Zfish    65 DMICLGDLSEAGLLRNLFLRHKQGIIYTYIGSVLVAMNPYEMLPIYTADQVQQYHGRKLGELPPH 129

  Fly   136 IFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIMEA 200
            ||||:|:.:..::|.|.|||.:||||||||||||||||||:|||:||:|||||||||:||||:||
Zfish   130 IFAIADSCYFNMRRNKRNQCCIISGESGAGKTESTKLILQFLAAVSGQHSWIEQQIIQANPILEA 194

  Fly   201 FGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLS 265
            ||||||:|||||||||||:||.|...|.|:||.::||||||||:..|:..|||||||||||||:.
Zfish   195 FGNAKTIRNDNSSRFGKYVEIFFNKAGVIEGAHMEQYLLEKSRVCHQALQERNYHIFYCMLAGMQ 259

  Fly   266 TAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAIL 330
            :..::.|.|.:  .|:::||.:|.|.|..||.||.:||.||:|:|||:|...:.|.|..||||||
Zfish   260 SDHKKTLSLGD--ASEFNYLTEGDCLTCDGRDDADEFARIRSALKVLTFTDRDCWEIFKLLAAIL 322

  Fly   331 HLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAA 395
            |:||:.|.:|.:.|:.:.::..:.:...:|:||.:..:||:.:||.|:...:.|.||..||.|.|
Zfish   323 HMGNIDFQSTIMNNMDSCDVLSSSHFSVIAKLLEVDDAALDKSLTHRSFMTNREMVTKPLSSEQA 387

  Fly   396 IEGRDAFVKSLYDGIFVRIVRRINETINK-QVDQP---MNSIGVLDIFGFENFDNNSFEQLCINY 456
            .:.||||.|:||..:||.:..:||..|:| |.|:|   ..|||:|||||||||..|||||||||:
Zfish   388 TDIRDAFAKALYGRLFVWMFTKINSAIHKPQTDEPSYTRQSIGLLDIFGFENFPQNSFEQLCINF 452

  Fly   457 ANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTD 521
            |||:||||||.|:||:|||||..|.|:|:.|.|.|||:.|||:.:||:|:::||||||.||||||
Zfish   453 ANEHLQQFFVRHVFKLEQDEYTKEGISWKRIAFNDNQKTLDLLALKPLNILALIDEESHFPKGTD 517

  Fly   522 QTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTN 586
            .|:|.||..:|....:|:..:......||::|:||:|.|:..||||||||:.|.|:..|:::|:|
Zfish   518 ATMLNKLSQEHKGNKLYISSRGDHRIHFGVQHFAGLVYYDCEGFLEKNRDTVSMDILELIRKSSN 582

  Fly   587 KYLVDIFPHEMPMDTAKKQ------------------------PTLCVKFRNSLDMLMRTLSQAH 627
            |.|..||..|:.:::.|..                        .||..:||.|||.||:.||...
Zfish   583 KLLKQIFEKEINVNSVKNSNKMNKAVMTPKNSLRQVNESRRQISTLSGQFRQSLDSLMKALSLCQ 647

  Fly   628 PYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGP 692
            |:||||.|||:.|.|..|::|||::|||||||:||.|||:.||||||.::.|:.|||.|:..:
Zfish   648 PFFIRCFKPNDKKLPMVFNRELCMQQLRYSGMLETIRIRKLGYPIRHTFKDFLHRYRALLKSI-- 710

  Fly   693 LEQCD-----CRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGI 752
              .||     ..|....||...:..:.|.:.||||:|||...|..|||:|:|.:.:..:.|||.:
Zfish   711 --DCDPNTEPAAKCCAAICRTLIKDEEDWKIGKTKVFLRGHHDTYLELERAQELYRKALIIQRVM 773

  Fly   753 RRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKL 817
            .....|:.....|:|.:.:|:.|||..::|.:..::|||.||.|.:.:::|..::...|...|.|
Zfish   774 LAHKDRKNFINKRKAALVLQKNWRGYKEKRDFCTVKQGFARLQAKVRSRKLHEEYMRRRAAAIVL 838

  Fly   818 QALSRGYLVRKDFQKK-------------LLERRKQNQLKKEELLKLAKMKEAEEL--LRLQQLK 867
            |..:||.|.||:.:.|             ||.|:...::|.||.| .|:.|:|:||  |.|||..
Zfish   839 QTQTRGLLARKELKSKKEAVILLQAQTRGLLARKSLKRMKSEEFL-TAQEKQAQELAALELQQRL 902

  Fly   868 EQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPP 932
            |:..|:..|..:.:..|::.:              |:......|......:.|..:........|
Zfish   903 EELLRKNEETAKSQNNEDEEM--------------VENIFNFLPTAIAGQEGPAPEGFEEFEAEP 953

  Fly   933 TTL----IVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNIS 993
            ..|    ::.:|:      ..|::.:||||.....|:..::..:|
Zfish   954 AKLEEVELIESPV------VETKVMSIPESSEDHQVKEEEEEEED-------------------- 992

  Fly   994 SGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLT 1058
                             .:||:.|:|:.:|.|.:|..:.::.|::.||.||...|.:|...:|..
Zfish   993 -----------------DEFSFSKFASLHFQGASTHSYIQQRLRQPLLYHEDEGDTLACLTVWWI 1040

  Fly  1059 ILRFMGDLPDVVSSPTLHVFD--NENL-------MSDLASLLNTSDSYKPRLFVRQSQRR----- 1109
            |||||||||:........:.|  ..||       :|:|..|        .:.|:|:..::
Zfish  1041 ILRFMGDLPEPKQERVSAMADPIQRNLGQRQARRLSNLVGL--------DQKFLRKKMKQQKGGG 1097

  Fly  1110 ------IPKPLASGEKEAQ-EFYQH----------WLNVPTSHLEKIHFIIGHGIIKNSLRDEIL 1157
                  ||:.....|.::| |..|.          ..:.|.:.|||:|.|:|:.|::..:||||.
Zfish  1098 KRKHSAIPEEEPEEEPKSQMEAVQEEQVVLFGEGPTFDRPMTPLEKLHIIVGYAIVRPDIRDEIY 1162

  Fly  1158 AQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLV 1222
            .||||||..|.:|.|.:|||:|||:||..|.|::....:|:||::.|.::..|. ..:||.|||.
Zfish  1163 CQICKQLTGNKNRKSVNRGWILLSICLGIFSPTERLTKYLQSFIRCGPSEYSAY-CAERLRRTLA 1226

  Fly  1223 NGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGL 1287
            ||.|.:||...||.::..::|:.:.:.||||:...|.||:|||:.|....:.|...|.|:|||.|
Zfish  1227 NGERNEPPCWVELQSVENKNPIGVAVGLMDGRNISLTVDSASTSAEVCTAISQNTNLQDSFGFSL 1291

  Fly  1288 VMSLNGKLMPLGAGQEHVLDAISECEQ-------RQLDAPWKLYIRKEMFATWYDPSMDPKATQL 1345
            ..::..|:..||:|.:|:|||:|.|||       .:..|||:||.|||:|..|:|.|.|..:|:|
Zfish  1292 YAAMYEKMWSLGSGSQHILDAVSMCEQEEKRQGREEQHAPWRLYFRKEIFTPWHDCSSDQISTEL 1356

  Fly  1346 IYKQILNGLKCGEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIEN 1410
            ||:||::|||.|||....|.|...:.|...:|::|....|     ||...:..|.:  ....|||
Zfish  1357 IYRQIIHGLKNGEYLSDKEDDYVQLAAKHYYVQHGSESSL-----EIAQKIVRDCM--NMTIIEN 1414

  Fly  1411 WS-----RLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKL 1470
            .|     :|:.:.:.:..|:...      ....:.|.:...:|...||:..|:|:|.....||.:
Zfish  1415 KSLVKLVQLVNSAHTQGPYINTN------TPVYKVKSETVEYAQQKWPIHFSKLYEAQVISGPSV 1473

  Fly  1471 QSDELMLGINSAGLFLIDETEQVLASCCFSEVLKVHVESDDK---LHVMTFQHVNFVLQCSSAQD 1532
            ..|:.::.:|..|:|..||||.......:.||.::.:.|:|:   |..:|.....:.|:....::
Zfish  1474 PQDQFVVVVNWKGVFFQDETEGEFLQLSYPEVSRIEIVSEDRSGGLVCLTTPKGMYELKIVKGKE 1538

  Fly  1533 ANEVINYMLDNLRQRSSYGVALDPVVEGDLEDCLVLNPGDLI----EFEAGVTGAQLMAGNAQDC 1593
            ..|::|..:..|::||.|.||:..:...:....|....||::    :.|..:....:.|.|.:..
Zfish  1539 LVELVNMFISGLKERSMYAVAIQDLSRQEDPTLLSYRRGDVLYIIKDGEYSLEEGWIKARNERTS 1603

  Fly  1594 YRGCVNGQWGQFLAGNVRVLATLTKPSEKLQDILR----EGRFQEPPKPTPRANYSRRRQH-NIS 1653
            ..|.|:       ...:::|..||:|:|:..::|.    ..:...|..|......:.|..| .:.
Zfish  1604 QTGAVS-------LDAIQILPMLTRPTEETLNLLNLSPARRKSVMPVLPQKEELSTERVAHMTLK 1661

  Fly  1654 QLAESHFREPLD------SDKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGD-- 1710
            :.:..:||:|::      ..|..|...|.||||.||::.:.....|...|......|||||||
Zfish  1662 EFSFDYFRDPVNEGRRGKGGKEKLWANSKEPLKQPLIRNLQGNSELCHLASDSFTAILKYMGDYP 1726

  Fly  1711 IARSNLPVN-TDLIFQPALQHPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLV 1774
            :.....|:: |:.||.||..|..|.||:|||:|||:::|.:..|.:|||.||:|..||..||.|:
Zfish  1727 VKHVRTPIDLTNQIFGPATAHVELRDEIYCQIMKQMTNNRNGLSMERGWQLLWLCCGLFPPSQLL 1791

  Fly  1775 MRELIILLRMR-ADALADACLKRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVEA 1838
            :|.....|..| .:.||.|||:|::..|:...||..||.:||:.||.....|:||::||:||.|.
Zfish  1792 LRHAQRFLESRPREPLASACLQRMQAMLSIEGRKLPPHQVEVDAIQNNSTQIFHKVHFPNDTSEI 1856

  Fly  1839 FEIESHTRGAELIADIAQRLELKSPVGYSIFLKTGDRVYAMPEEEFVFDFITQLIYWLRQQRTIR 1903
            ||:.:.||..:|..:||:.|.|.||.|||:|:||..:|.:|..||:.||.:.||....::.:.:|
Zfish  1857 FEVTTTTRIKDLCRNIAKDLRLSSPEGYSLFVKTSTKVESMNSEEYFFDNLRQLTDVTKKGKKVR 1921

  Fly  1904 SISDG--QYQLHFMRKLWLNNHPGEDLNGDMIFSYPQELHKYLKGYYPIDCEQASRLAILVYSAD 1966
            ..:..  .|.:.||||||.|..||:|:..|::|.:||||.|||:||:.:..|....|..|::...
Zfish  1922 EATPTIVPYLVLFMRKLWFNVIPGKDITADLMFHFPQELPKYLRGYHSVSKEDMIALGGLLFRTR 1986

  Fly  1967 HDVSLQR---LPEVLTRLIPEDLIPLQTVAEWRQQILPKVHRD-HLTEDHAKILFLQELSHFACF 2027
            .|....:   :|.:|..|:|.|...:.|..:|::.|:...::. .::.|.||:.||:.:|.:..|
Zfish  1987 VDADKSQFVMIPRMLKELVPADQQKIMTAEDWKKHIINSYNKQAGMSVDEAKLQFLKTVSPWPTF 2051

  Fly  2028 GSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQLGIWSSGKNHFHIRFGNMI 2092
            |..||.|||.::...|..::|:|:..|..:::..|||:|.::.:|::..||||..:||:..||::
Zfish  2052 GCAFFEVKQTSEKNYPSVIMISISKQGISLINSKTKEVLAAHLFSKITSWSSGSTYFHMTIGNLV 2116

  Fly  2093 GASKLLCSTTQGYKMDDLLASY 2114
            ..:.|||.|:||||:.|||:||
Zfish  2117 QGNTLLCETSQGYKISDLLSSY 2138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	345/677 (51%)
		IQ	765..785	CDD:197470	7/19 (37%)
		Atrophin-1	<820..>946	CDD:460830	32/144 (22%)
		MyTH4	1031..1239	CDD:470587	79/238 (33%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	40/97 (41%)
		B41	1248..1429	CDD:214604	70/192 (36%)
		PH-like	1454..1547	CDD:473070	23/95 (24%)
		MyTH4	1674..1819	CDD:214535	61/148 (41%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	39/95 (41%)
		B41	1827..2032	CDD:214604	75/210 (36%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	36/87 (41%)
myo7bb	XP_021322881.3	None