DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo28B1 and myo7bb

DIOPT Version :9

Sequence 1:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster
Sequence 2:	XP_021322875.1	Gene:	myo7bb / 566034	ZFINID:	ZDB-GENE-070912-482	Length:	2189	Species:	Danio rerio

Alignment Length:	2261	Identity:	831/2261 - (36%)
Similarity:	1253/2261 - (55%)	Gaps:	252/2261 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGD--VLKAMHITSQEDVE 70
            :||::||::     |...||.|..:..:...|..:.||..|:..:|.||  .||.||.||.|.|:
Zfish     5 KKGDHVWIE-----SSIGVPIGGYVKISGSGQYCLIDDEGKEHSIPEGDRAALKPMHPTSVEGVD 64

  Fly    71 DMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPH 135
            |||.||||.|..:||||..|:.:.:||||.||:|||:|||::|||||..::|.|..:.|.|||||
Zfish    65 DMICLGDLSEAGLLRNLFLRHKQGIIYTYIGSVLVAMNPYEMLPIYTADQVQQYHGRKLGELPPH 129

  Fly   136 IFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIMEA 200
            ||||:|:.:..::|.|.|||.:||||||||||||||||||:|||:||:|||||||||:||||:||
Zfish   130 IFAIADSCYFNMRRNKRNQCCIISGESGAGKTESTKLILQFLAAVSGQHSWIEQQIIQANPILEA 194

  Fly   201 FGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLS 265
            ||||||:|||||||||||:||.|...|.|:||.::||||||||:..|:..|||||||||||||:.
Zfish   195 FGNAKTIRNDNSSRFGKYVEIFFNKAGVIEGAHMEQYLLEKSRVCHQALQERNYHIFYCMLAGMQ 259

  Fly   266 TAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAIL 330
            :..::.|.|.:  .|:::||.:|.|.|..||.||.:||.||:|:|||:|...:.|.|..||||||
Zfish   260 SDHKKTLSLGD--ASEFNYLTEGDCLTCDGRDDADEFARIRSALKVLTFTDRDCWEIFKLLAAIL 322

  Fly   331 HLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAA 395
            |:||:.|.:|.:.|:.:.::..:.:...:|:||.:..:||:.:||.|:...:.|.||..||.|.|
Zfish   323 HMGNIDFQSTIMNNMDSCDVLSSSHFSVIAKLLEVDDAALDKSLTHRSFMTNREMVTKPLSSEQA 387

  Fly   396 IEGRDAFVKSLYDGIFVRIVRRINETINK-QVDQP---MNSIGVLDIFGFENFDNNSFEQLCINY 456
            .:.||||.|:||..:||.:..:||..|:| |.|:|   ..|||:|||||||||..|||||||||:
Zfish   388 TDIRDAFAKALYGRLFVWMFTKINSAIHKPQTDEPSYTRQSIGLLDIFGFENFPQNSFEQLCINF 452

  Fly   457 ANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTD 521
            |||:||||||.|:||:|||||..|.|:|:.|.|.|||:.|||:.:||:|:::||||||.||||||
Zfish   453 ANEHLQQFFVRHVFKLEQDEYTKEGISWKRIAFNDNQKTLDLLALKPLNILALIDEESHFPKGTD 517

  Fly   522 QTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTN 586
            .|:|.||..:|....:|:..:......||::|:||:|.|:..||||||||:.|.|:..|:::|:|
Zfish   518 ATMLNKLSQEHKGNKLYISSRGDHRIHFGVQHFAGLVYYDCEGFLEKNRDTVSMDILELIRKSSN 582

  Fly   587 KYLVDIFPHEMPMDTAKKQ------------------------PTLCVKFRNSLDMLMRTLSQAH 627
            |.|..||..|:.:::.|..                        .||..:||.|||.||:.||...
Zfish   583 KLLKQIFEKEINVNSVKNSNKMNKAVMTPKNSLRQVNESRRQISTLSGQFRQSLDSLMKALSLCQ 647

  Fly   628 PYFIRCIKPNEYKEP-----------------------------KNFDKELCVRQLRYSGMMETA 663
            |:||||.|||:.|.|                             :.|::|||::|||||||:||.
Zfish   648 PFFIRCFKPNDKKLPMVSIHFNITYILSSCEDAFKMTFSLYFPHQVFNRELCMQQLRYSGMLETI 712

  Fly   664 RIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCD-----CRKLARQICEVALPADSDRQYGKTKL 723
            |||:.||||||.::.|:.|||.|:..:    .||     ..|....||...:..:.|.:.||||:
Zfish   713 RIRKLGYPIRHTFKDFLHRYRALLKSI----DCDPNTEPAAKCCAAICRTLIKDEEDWKIGKTKV 773

  Fly   724 FLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMR 788
            |||...|..|||:|:|.:.:..:.|||.:.....|:.....|:|.:.:|:.|||..::|.:..::
Zfish   774 FLRGHHDTYLELERAQELYRKALIIQRVMLAHKDRKNFINKRKAALVLQKNWRGYKEKRDFCTVK 838

  Fly   789 QGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKK-------------LLERRKQ 840
            |||.||.|.:.:::|..::...|...|.||..:||.|.||:.:.|             ||.|:..
Zfish   839 QGFARLQAKVRSRKLHEEYMRRRAAAIVLQTQTRGLLARKELKSKKEAVILLQAQTRGLLARKSL 903

  Fly   841 NQLKKEELLKLAKMKEAEEL--LRLQQLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAV 903
            .::|.||.| .|:.|:|:||  |.|||..|:..|:..|..:.:..|::.:              |
Zfish   904 KRMKSEEFL-TAQEKQAQELAALELQQRLEELLRKNEETAKSQNNEDEEM--------------V 953

  Fly   904 QQKRRTKPVKQEAPKAPTLQARNSLPPPPTTL----IVAAPLPTRPASAVTRINTIPESPGTIDV 964
            :......|......:.|..:........|..|    ::.:|:      ..|::.:||||.....|
Zfish   954 ENIFNFLPTAIAGQEGPAPEGFEEFEAEPAKLEEVELIESPV------VETKVMSIPESSEDHQV 1012

  Fly   965 ESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATA 1029
            :..::..:|                                     .:||:.|:|:.:|.|.:|.
Zfish  1013 KEEEEEEED-------------------------------------DEFSFSKFASLHFQGASTH 1040

  Fly  1030 QHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPTLHVFD--NENL-------MS 1085
            .:.::.|::.||.||...|.:|...:|..|||||||||:........:.|  ..||       :|
Zfish  1041 SYIQQRLRQPLLYHEDEGDTLACLTVWWIILRFMGDLPEPKQERVSAMADPIQRNLGQRQARRLS 1105

  Fly  1086 DLASLLNTSDSYKPRLFVRQSQRR-----------IPKPLASGEKEAQ-EFYQH----------W 1128
            :|..|        .:.|:|:..::           ||:.....|.::| |..|.          .
Zfish  1106 NLVGL--------DQKFLRKKMKQQKGGGKRKHSAIPEEEPEEEPKSQMEAVQEEQVVLFGEGPT 1162

  Fly  1129 LNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPSKEF 1193
            .:.|.:.|||:|.|:|:.|::..:||||..||||||..|.:|.|.:|||:|||:||..|.|::..
Zfish  1163 FDRPMTPLEKLHIIVGYAIVRPDIRDEIYCQICKQLTGNKNRKSVNRGWILLSICLGIFSPTERL 1227

  Fly  1194 EPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRL 1258
            ..:|:||::.|.::..|. ..:||.|||.||.|.:||...||.::..::|:.:.:.||||:...|
Zfish  1228 TKYLQSFIRCGPSEYSAY-CAERLRRTLANGERNEPPCWVELQSVENKNPIGVAVGLMDGRNISL 1291

  Fly  1259 QVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISECEQ-------RQ 1316
            .||:|||:.|....:.|...|.|:|||.|..::..|:..||:|.:|:|||:|.|||       .:
Zfish  1292 TVDSASTSAEVCTAISQNTNLQDSFGFSLYAAMYEKMWSLGSGSQHILDAVSMCEQEEKRQGREE 1356

  Fly  1317 LDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACFVEYGP 1381
            ..|||:||.|||:|..|:|.|.|..:|:|||:||::|||.|||....|.|...:.|...:|::|.
Zfish  1357 QHAPWRLYFRKEIFTPWHDCSSDQISTELIYRQIIHGLKNGEYLSDKEDDYVQLAAKHYYVQHGS 1421

  Fly  1382 GEILRLKPSEITAFVPSDLLAPGERAIENWS-----RLIAATYEKSSYVKEEQNDLLLEAQKRAK 1441
            ...|     ||...:..|.:  ....|||.|     :|:.:.:.:..|:...      ....:.|
Zfish  1422 ESSL-----EIAQKIVRDCM--NMTIIENKSLVKLVQLVNSAHTQGPYINTN------TPVYKVK 1473

  Fly  1442 EDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLASCCFSEVLKVH 1506
            .:...:|...||:..|:|:|.....||.:..|:.::.:|..|:|..||||.......:.||.::.
Zfish  1474 SETVEYAQQKWPIHFSKLYEAQVISGPSVPQDQFVVVVNWKGVFFQDETEGEFLQLSYPEVSRIE 1538

  Fly  1507 VESDDK---LHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVALDPVVEGDLEDCLVL 1568
            :.|:|:   |..:|.....:.|:....::..|::|..:..|::||.|.||:..:...:....|..
Zfish  1539 IVSEDRSGGLVCLTTPKGMYELKIVKGKELVELVNMFISGLKERSMYAVAIQDLSRQEDPTLLSY 1603

  Fly  1569 NPGDLI----EFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLATLTKPSEKLQDILR- 1628
            ..||::    :.|..:....:.|.|.:....|.|:       ...:::|..||:|:|:..::|.
Zfish  1604 RRGDVLYIIKDGEYSLEEGWIKARNERTSQTGAVS-------LDAIQILPMLTRPTEETLNLLNL 1661

  Fly  1629 ---EGRFQEPPKPTPRANYSRRRQH-NISQLAESHFREPLD------SDKAPLSKFSPEPLKAPL 1683
               ..:...|..|......:.|..| .:.:.:..:||:|::      ..|..|...|.||||.||
Zfish  1662 SPARRKSVMPVLPQKEELSTERVAHMTLKEFSFDYFRDPVNEGRRGKGGKEKLWANSKEPLKQPL 1726

  Fly  1684 LKAVVKVPPLFQQALVMHHHILKYMGD--IARSNLPVN-TDLIFQPALQHPLLCDELYCQLMKQL 1745
            ::.:.....|...|......|||||||  :.....|:: |:.||.||..|..|.||:|||:|||:
Zfish  1727 IRNLQGNSELCHLASDSFTAILKYMGDYPVKHVRTPIDLTNQIFGPATAHVELRDEIYCQIMKQM 1791

  Fly  1746 SDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMR-ADALADACLKRLKRSLAQGQRKKA 1809
            ::|.:..|.:|||.||:|..||..||.|::|.....|..| .:.||.|||:|::..|:...||..
Zfish  1792 TNNRNGLSMERGWQLLWLCCGLFPPSQLLLRHAQRFLESRPREPLASACLQRMQAMLSIEGRKLP 1856

  Fly  1810 PHLIEVEGIQQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSPVGYSIFLKTGD 1874
            ||.:||:.||.....|:||::||:||.|.||:.:.||..:|..:||:.|.|.||.|||:|:||..
Zfish  1857 PHQVEVDAIQNNSTQIFHKVHFPNDTSEIFEVTTTTRIKDLCRNIAKDLRLSSPEGYSLFVKTST 1921

  Fly  1875 RVYAMPEEEFVFDFITQLIYWLRQQRTIRSISDG--QYQLHFMRKLWLNNHPGEDLNGDMIFSYP 1937
            :|.:|..||:.||.:.||....::.:.:|..:..  .|.:.||||||.|..||:|:..|::|.:|
Zfish  1922 KVESMNSEEYFFDNLRQLTDVTKKGKKVREATPTIVPYLVLFMRKLWFNVIPGKDITADLMFHFP 1986

  Fly  1938 QELHKYLKGYYPIDCEQASRLAILVYSADHDVSLQR---LPEVLTRLIPEDLIPLQTVAEWRQQI 1999
            |||.|||:||:.:..|....|..|::....|....:   :|.:|..|:|.|...:.|..:|::.|
Zfish  1987 QELPKYLRGYHSVSKEDMIALGGLLFRTRVDADKSQFVMIPRMLKELVPADQQKIMTAEDWKKHI 2051

  Fly  2000 LPKVHRD-HLTEDHAKILFLQELSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTTK 2063
            :...::. .::.|.||:.||:.:|.:..||..||.|||.::...|..::|:|:..|..:::..||
Zfish  2052 INSYNKQAGMSVDEAKLQFLKTVSPWPTFGCAFFEVKQTSEKNYPSVIMISISKQGISLINSKTK 2116

  Fly  2064 EILRSYEYSQLGIWSSGKNHFHIRFGNMIGASKLLCSTTQGYKMDDLLASY 2114
            |:|.::.:|::..||||..:||:..||::..:.|||.|:||||:.|||:||
Zfish  2117 EVLAAHLFSKITSWSSGSTYFHMTIGNLVQGNTLLCETSQGYKISDLLSSY 2167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	364/736 (49%)
		MYSc_Myo7	81..726	CDD:276832	345/706 (49%)
		IQ	765..785	CDD:197470	7/19 (37%)
		DUF4355	827..>887	CDD:290964	23/74 (31%)
		MyTH4	1031..1239	CDD:295320	79/238 (33%)
		B41	1248..1429	CDD:214604	70/192 (36%)
		FERM_N	1248..>1288	CDD:286467	17/39 (44%)
		FERM_B-lobe	1342..1429	CDD:271216	27/91 (30%)
		PH-like	1454..1547	CDD:302622	23/95 (24%)
		MyTH4	1674..1819	CDD:214535	61/148 (41%)
		B41	1827..2032	CDD:214604	75/210 (36%)
		FERM_N	1829..>1877	CDD:286467	22/47 (47%)
		FERM_M	1936..2032	CDD:278785	29/99 (29%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	36/87 (41%)
myo7bb	XP_021322875.1	MYSc_Myo7	75..776	CDD:276832	345/706 (49%)
		ERM	855..>997	CDD:330563	36/162 (22%)
		MyTH4	1176..1270	CDD:307090	43/94 (46%)
		B41	1279..1492	CDD:214604	75/225 (33%)
		PH-like	1486..1582	CDD:327399	23/95 (24%)
		SH3	1583..1635	CDD:327375	10/51 (20%)
		MyTH4	1718..1866	CDD:214535	61/147 (41%)
		B41	1873..2085	CDD:214604	75/211 (36%)
		FERM_C2_MyoVII	2081..2176	CDD:270020	36/87 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593573
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D21221at33208
OrthoFinder	1	1.000	-	-		FOG0001409
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650