Protein Alignment Myo28B1 and myo16

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_001920958.3
• Gene: myo16 / 563752
• ZFINID: ZDB-GENE-070912-470
• Length: 1910
• Species: Danio rerio
• Alignment Length: 1182
• Identity: 303/1182 - (25%)
• Similarity: 489/1182 - (41%)
• Gaps: 273/1182 - (23%)

  Fly    17 PQNTTSEFAVPFGARIVRTEK-----------TQTLVCDDRNKQFWVPAGDVLKAMHITSQEDVE 70
            |....:..|:|...|....||           ||....|:.....:..|...|:.:.:......:
Zfish   360 PVKKLATMALPISRRDSLLEKEAMFRDSGGALTQQASLDNGLDGSYPSAAGKLEQVKLMPPAPND 424

  Fly    71 DMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKS---LAEL 132
            |:.:|.:|.:.::|..:|.|:|...||||.|.:|:.||||:.||||:|...|||.:.|   .:.|
Zfish   425 DLASLSELTDSSLLYEMQKRFANDQIYTYIGHILLLINPYKDLPIYSNLVSQLYLSSSGRLCSSL 489

  Fly   133 PPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSW-IEQQIIEANP 196
            |||||:.::.||..:.:.:..||.:||||||:||:.:.|.||::|||.|....: :|.::...|.
Zfish   490 PPHIFSSAERAFHMMFQERRPQCFIISGESGSGKSVACKHILKHLAARSSPKGFALEPRMKHVNV 554

  Fly   197 IMEAFGNAKTVRNDNSSRFGKYIEIRF-TPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCM 260
            |:||||:|||..|.:.|||.|.|.::: ..:..:...|:..|:|||||::.....::|::|||.|
Zfish   555 ILEAFGHAKTQMNTSGSRFIKLISLQYCDKRKTLLRGRLYTYMLEKSRVICMPPHQQNFNIFYLM 619

  Fly   261 LAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFAD-----------IRAAMKVLSF 314
            ..|||..|:.:|.|.       :.||. .|......|::...|.           ::.|::.|.|
Zfish   620 AEGLSAEEKSQLYLN-------NVLAH-RCLNTAAPGESPAVASACPQSREKLLALKQALRALGF 676

  Fly   315 KPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTI 379
            ...||.::..|::|:||||:|||||...|:  ||.:.|...|.|||.:|.:....|::|||....
Zfish   677 NKLEVENVFVLISALLHLGDLRFTALTDAD--TAFVSDLQLLDRVAGMLQVSSEDLSSALTSDVQ 739

  Fly   380 FVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRIN---ETINKQVDQPMNSIGVLDIFGF 441
            ...|:.:|...:.|.:...||...|:||..:|..:|..||   :...:....|...|.:||||||
Zfish   740 CFKGDVITRRHTVEMSNHHRDLLTKALYGRLFSLLVNNINFYLQGHEETTGDPALEISILDIFGF 804

  Fly   442 ENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQ-QILDLIGMKPMN 505
            |.|..|::||||||..||.:.||....:|:.||.|...|.:..:.:....:| .:||....||..
Zfish   805 EEFQRNAYEQLCINMVNERIHQFTAEVLFQQEQHECLQEGVAMETLRSLGSQTAVLDFFFQKPQG 869

  Fly   506 LMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTT-----------QTSLFGIRHYAGVVM 559
            ::.:|||||:..:..:..|.::|.:|..:.:......||           |...|.:.|:||.:.
Zfish   870 VLCIIDEESQSLRPCEVNLYKRLQIQLDSSATDAVSLTTKDGNGNPPPKDQGPSFTVTHFAGKMT 934

  Fly   560 YNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEM--------------------------- 597
            |:..|.|::|:|....::..:::.|.|..:..:|..::
Zfish   935 YDLTGSLDRNKDVLPQNILFVMKTSENVLIHQMFQCKLTQTGSLVPQHQRMKLRGPKGTLINKST 999

  Fly   598 ---PMDTAKKQP------------------------TLCVKFRNSLDMLMRTLSQAHPYFIRCIK 635
               |...|||..                        |:.|:.:|||..:...|....|:||:|::
Zfish  1000 TLNPARDAKKYVELNKLLKKKGASSFLQRLERCGPITVAVQLKNSLCEITSKLQSCTPHFIQCVR 1064

  Fly   636 PNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPV------GPLE 694
            ||...:|..||......||:|.|::|..|:.|.|||:|.::.:|:.|||.||..:      ...|
Zfish  1065 PNNASKPDVFDSFHVSSQLQYVGVLEMVRMIRYGYPVRLSFSSFLSRYRELVDTIITDRKKATTE 1129

  Fly   695 QCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRR 759
            : .||.:... |::     ...|.|.:|:||
Zfish  1130 E-KCRHILLH-CKL-----QGWQMGNSKVFL---------------------------------- 1153

  Fly   760 YMKRYREAIITVQRYWRG-RLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRG 823
                         |||:. .|..|.:|:     ||                   :.|..|.:.||
Zfish  1154 -------------RYWQADHLNDRCHQL-----HR-------------------KIIICQKVMRG 1181

  Fly   824 YLVRKDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLRLQ------------------------ 864
            :|.|:..:::|..|       |:||..:.:..:..|.|.|:
Zfish  1182 WLARQQVRRRLTSR-------KQELCNVQRFLQGAEDLGLRTYDNLVIQNAADIARENDRLRGHI 1239

  Fly   865 ---QLKEQKEREQREQQE-KRLQEEQRLKAEAAARNA---------------LAM---------A 901
               .|.|:.|...:|:.. ||:.|:.....:.|.|..               |.|         |
Zfish  1240 SAPPLGERPEPVGKEEDSPKRVVEKSGRGNDVANRGGNRPIRHFRSSSVPLPLVMDSLVHSSIGA 1304

  Fly   902 AVQQKRRTKPVKQEAPKAPTLQARNSLPPP-----PTTLI------VAAPLPTRPASAVTRINTI 955
            :::...:..|...:.....:|.:....|||     |.|.:      |:|.|...|..:.......
Zfish  1305 SIKAALQPTPHSTDEGNGGSLSSPRKQPPPKPKRDPNTRLSASYEAVSAGLSIAPKDSPAEGQAS 1369

  Fly   956 PE-SPGTIDVESSKQMV------DDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSDF 1013
            |. ||....:..|..:.      ||........|....|..|...:|....:  |||:....:|
Zfish  1370 PSGSPPNTQLSPSDSLAKPRPHSDDYSTMKKIPPPKPKRSPNTKLTGSYEEI--SVPSPARPTD- 1431

  Fly  1014 SYLKYAATYFGG 1025
              :|..:...||
Zfish  1432 --MKLVSLVRGG 1441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	226/735 (31%)
		IQ	765..785	CDD:197470	5/20 (25%)
		Atrophin-1	<820..>946	CDD:460830	34/188 (18%)
		MyTH4	1031..1239	CDD:470587
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
myo16	XP_001920958.3	ANKYR	83..330	CDD:440430
		ANK repeat	113..144	CDD:293786
		ANK repeat	146..207	CDD:293786
		ANK repeat	242..273	CDD:293786
		ANK repeat	275..306	CDD:293786
		Motor_domain	435..1154	CDD:473979	227/782 (29%)
		NYAP_N	1242..1672	CDD:464717	40/205 (20%)
		NYAP_C	1726..>1772	CDD:464724