Protein Alignment Myo28B1 and myo5c

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_691143.2
• Gene: myo5c / 562676
• ZFINID: ZDB-GENE-131127-196
• Length: 1746
• Species: Danio rerio
• Alignment Length: 1963
• Identity: 526/1963 - (26%)
• Similarity: 810/1963 - (41%)
• Gaps: 467/1963 - (23%)

  Fly    11 EYVW--------VKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITSQE 67
            |:||        .||.::..|..:..|..:                .:.:..|:.|..:.   ..
Zfish    19 EHVWKSAEILTDFKPGDSELELQLEDGTEL----------------HYPLEGGEKLPPLR---NP 64

  Fly    68 DV----EDMITLGDLQEYTILRNLQNRYAK-QLIYTYTGSMLVAINPYQILPIYTNREIQLYRNK 127
            |:    .|:..|..|.|..:|.||:.|:.: ::||||.|.:|||:|||:.||||.:..|..|..:
Zfish    65 DILVGENDLTALSYLHEPAVLHNLKVRFVESKIIYTYCGIILVAVNPYKQLPIYGDAVIHAYSGQ 129

  Fly   128 SLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAI--SGKHSWIEQQ 190
            ::.:|.|||||:::.|::::.|..:||.:::|||||||||.|.:..::|.|.:  ||..:.:|.:
Zfish   130 NMGDLDPHIFAVAEEAYKQMARNNKNQSIIVSGESGAGKTVSARYAMRYFAMVSKSGSKTRVEDK 194

  Fly   191 IIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYH 255
            ::.:|||.||.|||||.|||||||||||.||.|..:..|.||.::.|||||||:||||.:|||||
Zfish   195 VLASNPITEAIGNAKTTRNDNSSRFGKYTEISFDKRYQIIGANMRTYLLEKSRVVFQSENERNYH 259

  Fly   256 IFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVW 320
            |||.|.|..:..|.:.|:|  ....:::|...||...:.|..|..|.|:.|....:|..|.....
Zfish   260 IFYQMCACANQPEFKGLRL--LGAEKFNYTRLGGEIEIEGVDDRADMAETRRTFNLLGLKENFQT 322

  Fly   321 SILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEH 385
            .:..:|||||||||:...|.:.........|  |:|.....|:|:....::..|..|.|.:..|.
Zfish   323 DVFKVLAAILHLGNVIIKAKDPEKSFIGSRD--PHLAIFCDLMGVSTENMSRWLCHRRIVLSTET 385

  Fly   386 VTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETI---NKQVDQPMNSIGVLDIFGFENFDNN 447
            |.....:|.|:..|||..|.:|..:|..::.:||..:   .||    .:.||||||:|||.|:.|
Zfish   386 VVKPQPRERAVNARDALAKHIYAHLFNWVIHKINHALMVPGKQ----HSFIGVLDIYGFETFEIN 446

  Fly   448 SFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDE 512
            ||||.|||||||.|||.|..|:||:||:||..|.|.|..|:|.|||.::|||..| |.::.|:||
Zfish   447 SFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILDLLDE 510

  Fly   513 ESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDL 577
            |..||:|||:..|:||:...|::.::.|.:.:..| |.|:|:|..|.|...||||||||:...:|
Zfish   511 ECLFPQGTDKNWLQKLYNFLGSKPLFEKPRLSNDS-FMIQHFADKVEYQCKGFLEKNRDTLYEEL 574

  Fly   578 RTLVQRSTNKYLVDIFPHEMPMDTAKK-------QP-----------TLCVKFRNSLDMLMRTLS 624
            ..:::.|....|...|..| ..|:..|       ||           |:..|||:||.:||.||:
Zfish   575 VDIMRASQFALLAGFFKEE-EADSGHKIIKVTPAQPRVKASNKQLRSTVGDKFRSSLYLLMETLN 638

  Fly   625 QAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPP 689
            ...|:::|||||||.|.|..:|....|:|||..|::||.||....||.|..|..|..||.:|:..
Zfish   639 ATTPHYVRCIKPNEEKLPFEYDSRRVVQQLRACGVLETIRISAQSYPSRWTYVEFYSRYSILMSQ 703

  Fly   690 VGPLEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRR 754
             ..|:..:.::..|.:.:..:|..:..::|:||:|.|....|.||..|...:..:.||||:.:|.
Zfish   704 -SELKLGEKKQTCRTVLQRLIPDSNQYKFGRTKIFFRAGQVAYLEKLRLDHLRAACVTIQKHVRG 767

  Fly   755 VLFRRYMKRYREAIITVQRYWRGRLQRR---KYQVMRQGFHRLGACIAAQQLTTKFTMVRC---- 812
            ...||.....|:|.:.:|.|.||:.|.|   ..|.::||:    |.|..|:....|.:.|.
Zfish   768 WRQRRSFLNIRQAALIIQLYVRGKKQIRCTVTAQALKQGW----AAIVIQRHCRGFLVRRIYQLV 828

  Fly   813 --RTIKLQALSRGYLVRKDFQKKLLERRKQNQLKKEELLKLAKMK---------EAEELLRLQQL 866
              ..:.:||.:||::.||.: ||::...|...|:|.....|.:.:         ..:...|:|||
Zfish   829 LRAAVTIQAFTRGWMARKRY-KKMVAEHKALVLQKYARAWLVRRRFQTMRRLVINVQLSYRVQQL 892

  Fly   867 KEQKEREQREQ---QEK-------RLQEEQRLKAEAAARNALA--MAAVQQKRRTKPVKQEAPKA 919
            :::.|.:.:|.   .||       |.|..::::|..|....|.  |:|:.|:.:|.  .:||.:|
Zfish   893 RKKVEEQNKENCGLMEKLTSLSNARAQGLEKIQALEAELGKLTNEMSALVQRAKTN--SEEANQA 955

  Fly   920 ------------------------PTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPG 960
                                    .|:|.::........|:       .......|:..:.|...
Zfish   956 IDVLQNDKEKLVEENKALERKLKDTTVQMQDQFEDVKRKLM-------EDLEREERLRKVAEHNS 1013

  Fly   961 TIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGG 1025
            .:..|.|            |:...|:::.|.....:.|||...|..::.|:.
Zfish  1014 ELQKEDS------------DKEIVAIKEENRRLREERIRLQTQVEEDVKTNT------------- 1053

  Fly  1026 GATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILR------------------------FMGDL 1066
                  |.:.....|.||...|.::..:...|.|.|                        .:||.
Zfish  1054 ------ELQEQMLQLTKHVKVIPDLRKEINNLQIQRAEAEKTLRAQNLQARAKMNLITRQLLGDA 1112

  Fly  1067 --PDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLASGEKEAQEFYQHWL 1129
              .|::........||.:   |.|.|:...|..:....|.::|.|..|.....:.||..|....|
Zfish  1113 TEQDLIQRLNEEASDNND---DGADLITAFDGMERAAKVMETQLREQKDAHESQLEALIFKNEHL 1174

  Fly  1130 NVPTSHLE-------KIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSCF 1187
            :.....|:       .|:..||..:.:.:..:.::.::.:|:
Zfish  1175 SKENEQLQALFQEKSDINQSIGQEVTRLTAENMVIPELKQQV----------------------- 1216

  Fly  1188 PPSKEFEPH---LRSFMKQGTAQLQATPSLQRLERTL---VNGPRCQPPSLFELHAIRGRHPLRL 1246
               .|...|   |.|.::..||::.|  .|:.|...|   |...:.|              ..||
Zfish  1217 ---SELNRHKHELESQLQDQTAEMSA--KLKELSSALHLAVEEEQSQ--------------RRRL 1262

  Fly  1247 DIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISE 1311
            ...|.:.|:||.:.|...:..:..||..:...:|::.....:.....:|.......|..||....
Zfish  1263 QEELTESQRRREETDRQISELQEENQQLKKAQITESQAKNTLRLETSRLTAENMDFEEQLDMKDR 1327

  Fly  1312 CEQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACF 1376
            ..:|         ::.::.|.....:.:.||...:.|:.|..|   ||:...|..:..:.
Zfish  1328 LIKR---------LQDQIKALQTHAAANQKAAPAVPKEYLGML---EYKKEDEGRLIRIL----- 1375

  Fly  1377 VEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAK 1441
                   ||.|||..:..     .:.||
Zfish  1376 -------ILELKPRGVGV-----NMIPG------------------------------------- 1391

  Fly  1442 EDICLFAHLSWPMRHSRLFEVVR-----KEGPKLQSDELMLGINSAGLFLIDETEQVLASCCFSE 1501
                |.|||        ||..||     .:|.||:.  ||..|.:|                ..|
Zfish  1392 ----LAAHL--------LFMCVRHADYLNDGNKLKC--LMNNIITA----------------VKE 1426

  Fly  1502 VLKVHVESDDKLHVM---TFQHVNFVLQCSS----------AQDANEVINYMLDNLRQ-RSSYGV 1552
            |:..|.|:.:.|...   |:..:|.:.|.|.          .|:.|.:.|:.|...|| .|...:
Zfish  1427 VITEHQENFELLSFWLSNTYHFLNCLKQYSGEEEFMKHNTPRQNKNCLKNFDLSEHRQILSDLAI 1491

  Fly  1553 ALDPVVEGDLEDCL--VLNPGDLIEFEA--GV-----TG-------------------------- 1582
            .:.......:||.|  ::.|| ::|.|:  |:     ||
Zfish  1492 NIYHQFISVMEDALFPMIIPG-MLEHESLQGISSMKPTGLRKRSSSVFEDGGDSSTSEAFSVSSI 1555

  Fly  1583 -AQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLATLTKPSEKLQDILREGRFQEPPKPTPRANYSR 1646
             .:|...|:..|.:|......||.    ||.|..|...|.....:||        |.........
Zfish  1556 LQKLSTFNSSMCQQGMEPQLQGQI----VRQLFYLIGSSSVNCILLR--------KDLCSCRKGM 1608

  Fly  1647 RRQHNISQLAESHFREPLDSDKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDI 1711
            :.:.|||.| |...||     |..||..:.|.|           .||.|.|.:
Zfish  1609 QIRCNISYL-EEWLRE-----KDLLSSNAMETL-----------GPLSQIAWL------------ 1644

  Fly  1712 ARSNLPVN--TDLIFQPALQHPLLCDELYC-QLMKQL-SDNPSSESEKRGWDLLYLATGLVAPSV 1772
                |.||  ||   :.|.:....|.||.. |::|.| |..|..:.|||           ||||
Zfish  1645 ----LQVNKTTD---EDAAEIKQRCSELSAVQIVKILNSYTPIDDFEKR-----------VAPS- 1690

  Fly  1773 LVMRELIILLRMR 1785
             .:|::..||:.|
Zfish  1691 -FVRKVQALLQER 1702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	268/668 (40%)
		IQ	765..785	CDD:197470	8/22 (36%)
		Atrophin-1	<820..>946	CDD:460830	33/170 (19%)
		MyTH4	1031..1239	CDD:470587	42/246 (17%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	16/90 (18%)
		B41	1248..1429	CDD:214604	29/180 (16%)
		PH-like	1454..1547	CDD:473070	26/111 (23%)
		MyTH4	1674..1819	CDD:214535	31/116 (27%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
myo5c	XP_691143.2	COG5022	12..1333	CDD:227355	414/1443 (29%)
		MYSc_Myo5	82..739	CDD:276831	268/668 (40%)
		Myo5c_CBD	1366..1740	CDD:271260	104/483 (22%)