Protein Alignment Myo28B1 and myo9ab

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001410713.1
• Gene: myo9ab / 562199
• ZFINID: ZDB-GENE-080424-6
• Length: 2304
• Species: Danio rerio
• Alignment Length: 1930
• Identity: 488/1930 - (25%)
• Similarity: 765/1930 - (39%)
• Gaps: 597/1930 - (30%)

  Fly    69 VEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELP 133
            |.|:.:|.||.|:|:|.||:.|:.::.||||.||:|:|:||::.||||..:.:::|....|.:|.
Zfish   150 VADLCSLPDLNEHTMLENLRGRFRQENIYTYVGSILIAVNPFKFLPIYNPKYVKMYDKHRLGQLE 214

  Fly   134 PHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQIIEANP 196
            |||||::|.|:..:.:...|||:|||||||:|||:||..::.:|.|:|  |..|.:||.|:.|.|
Zfish   215 PHIFAVADAAYHAMLQRHRNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGP 279

  Fly   197 IMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCML 261
            ::||||||||..|:|||||||:|::.:...|.::||.:::|||||||:|:|..:|||||:||.:|
Zfish   280 VLEAFGNAKTAHNNNSSRFGKFIQVNYQESGTVRGAYVEKYLLEKSRLVYQEHNERNYHVFYYLL 344

  Fly   262 AGLSTAERERLKLQEQSPSQYHYLAQ----------GG-------CFTLPGRGDAKDFADIRAAM 309
            ||.|..||....|..  |.:||||.|          |.       ||::.......||..::.||
Zfish   345 AGASEDERRSFHLLR--PEEYHYLNQITKSVHKQHWGNHCDTELDCFSVEAEDLKHDFERLQLAM 407

  Fly   310 KVLSFKPEEVWSILSLLAAILHLGNLRFT----ATEVANLATAEIDDTPNLQRVAQLLGIPISAL 370
            :::.|.|.....|.|||:|||||||:|:.    ..:..::...|:     |..|::||.:....|
Zfish   408 EMVGFLPTTRKQIFSLLSAILHLGNIRYKKKTFRDDSIDICNPEV-----LPIVSELLEVKEEML 467

  Fly   371 NAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGV 435
            ..|||.|.....||.:.                          :..::.|.:         ||||
Zfish   468 FEALTTRKTVTVGERLI--------------------------VPYKLAEIL---------SIGV 497

  Fly   436 LDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIG 500
            |||||||:::||||||.|||:|||.||.:|..|:||:||:||::|.|||..|::.||...::||.
Zfish   498 LDIFGFEDYENNSFEQFCINFANETLQHYFNQHVFKLEQEEYRSEGINWHMIDYIDNTACINLIS 562

  Fly   501 MKPMNLMSLIDEESKFPKGTDQTLLEKLHVQH-GNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLG 564
            .||..|:.|:|||..||:.::||||:|...|| ||  .|::........|.||||||.|.|:...
Zfish   563 KKPTALLHLLDEECNFPQASNQTLLDKFKRQHEGN--AYMEFPAVMEPAFIIRHYAGKVKYSVKD 625

  Fly   565 FLEKNRDSFSGDLRTLVQRSTNKYL---------------------------------------- 589
            |.|||.|....|:.:|::.|...::
Zfish   626 FREKNTDHLRPDIVSLLKSSRKAFICGLMGLDPVASFRWAVIRAFFRALVAFRHAGLQHRDNRSS 690

  Fly   590 ----------------------------------------------------------------- 589
                                                                             
Zfish   691 GSDVHLQPQKSVDSFSFLHHPVHQRSLEILQRCKDDRYNSCVSRRSPRTPLSDLQGANTFSSNGR 755

  Fly   590 ------VDIFPHE---------------------------------------------------- 596
                  |..|.||
Zfish   756 GWRSERVSSFAHEDEGIFVNSVNNRLLERAQGILMRNKNYKPKPSLPKHLLDVKSLKYLSSLTLH 820

  Fly   597 -------MPMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQL 654
                   :.:...||.|::..:|..||:.||.||.|:.|||::||:.|..|.|..|:..|.:|||
Zfish   821 DRITKSLLHLHKKKKPPSISAQFNVSLNKLMETLGQSEPYFVKCIRSNAEKLPLRFNDALVLRQL 885

  Fly   655 RYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICEVALPAD---SDR 716
            ||:||:||.|||::||.::::::.|...:.:|:|......|...|:..|.       ||   |..
Zfish   886 RYTGMLETVRIRQSGYSVKYSFKDFAHHFHVLLPAGFSASQMGIREFLRS-------ADLEPSGY 943

  Fly   717 QYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRG---- 777
            |.|::.:||.:.....|:.:..|.:|:.||.:||..|....|::..|.|.|...:||:||.
Zfish   944 QVGRSMVFLHERLRQRLQDELHQEVLRRIVCLQRSFRTQRDRKHFCRQRRAARLIQRWWRSCISQ 1008

  Fly   778 ----------------RLQ--------RRKYQVMRQGFHRLGACIAAQQLTTKFTMV-------R 811
                            |||        ||.|...|:....:..| ..:.|.|:.|..       |
Zfish  1009 ADGSVCALELQQGAALRLQAVWRGFRARRLYLQQRRAVLIIQRC-WRRVLNTRNTAATLIQAVWR 1072

  Fly   812 CRT------------IKLQALSRGYLVRKDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLRLQ 864
            .||            :.|||..||...|:.. :.|.|::.:.|.|....:..:..:..||..:|:
Zfish  1073 TRTHRRSFLQQRRAAVTLQAACRGQQSRQRC-RILREQQCREQSKHPSTVTKSLHQNTEEAEKLE 1136

  Fly   865 QLKEQ---------------KEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTK---- 910
            ::.|:               |.|.:||.:.:|..|:        |..:|.:..|:....|:
Zfish  1137 EVWEKQTTDPPPKAVDDSTLKSRNKRESRRQRELEQ--------ATFSLELLKVRSGSNTEDAQI 1193

  Fly   911 -PVKQEAPKAPTLQARNSL--------PPPPTTLIVAAPL---PTRPASAV-----------TRI 952
             |.|...|...:..::.|.        ......|..:.|:   .|.||::.           :.|
Zfish  1194 PPSKHHPPHQASTDSQESFELLENEDSASAKLELSKSEPMEVNQTSPAASFKPHFYIPDEDGSPI 1258

  Fly   953 NTIPESPGTI-DVESSKQMVDDVFRFLNDEP--DAALRKL--------NNISSGDTIRLPKSVPN 1006
            |:.|::|... .:...|:.|..:.....:.|  .::|:.|        |..|:.|...:|:...|
Zfish  1259 NSAPQTPNRAKQIREKKESVVVIISMQKENPVDRSSLQTLEAQDVPLSNGESASDCSIIPEPRTN 1323

  Fly  1007 N-IDT-SDFSY--------LKYAAT--------------------YFGGGATAQHERKPLKKSLL 1041
            : :|| |.||.        |:.||:                    ......||.:...|.|:|.|
Zfish  1324 HELDTGSSFSVSSKPLQLDLRSAASNEEPSEPKADVQKKFVSQSISISMKETAANVAFPPKRSRL 1388

  Fly  1042 KHEHPIDEMASKAIWLTILRFMG-------DL--------------------------------- 1066
            .......::.::...|.|.|..|       |:
Zfish  1389 TFSKSDKDLVNQERSLAIQREAGFRSLKNRDVTRAGCKKKARMARTRSDFLSRACSTEADCEEDE 1453

  Fly  1067 ---------------PDVVSSPTLH-VFDNENLMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLA 1115
                           |...|||.:. ||.:::.||.                 ::.|:||.|.::
Zfish  1454 DDEYEDTPVLSCTRPPHSPSSPDIDCVFHSDSEMSS-----------------QKEQKRIQKTMS 1501

  Fly  1116 SGEKEAQEFYQHWLNVPTSHLE-KIHF--IIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGW 1177
            ||:....:..:..::...|.:. |:.|  ...||..|.|.|               .||:.|.
Zfish  1502 SGDLGKMDSLRKSMSQTDSRVRGKMRFWSKSKHGDKKISSR---------------GRSADSE-- 1549

  Fly  1178 LLLSLCLSCFPP--------------SKE-FEPHL-------RSFMKQGTAQLQATPSLQRLERT 1220
              |:...:..||              ||| .||.|       |..:|..:..|::|.........
Zfish  1550 --LTDRRNDSPPGSPEHAGVSERRRDSKENREPMLGMMSMKRRRSLKISSVSLESTAWQNDALHI 1612

  Fly  1221 LVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGF 1285
            |.:....:..:.|.:..|.       |:...|| |:...||.  ..::|:.:.  .:.:.:::..
Zfish  1613 LTSTADYRSMNDFLMKKIS-------DLDAEDG-QKDTAVDV--VFKKALKEF--RLNIFNSYST 1665

  Fly  1286 GLVMSLNGKLM---PLGAGQEHVLDAISECEQRQ-LDAPWKLYIRK-----EMFATWYDPSMD-- 1339
            .|.|. :|:.:   .|.|..||:|:.....|||. .::|.|:::..     :.|.|.|.| ||
Zfish  1666 ALAMD-DGRSIRYKDLYALFEHILEKSMRLEQRDWSESPVKVWVNTFKVFLDEFMTEYKP-MDGT 1728

  Fly  1340 -------------PKATQLIYKQILNGLKCGEYR-------CRS---EKDIAMVCAL---ACFVE 1378
                         .|.:..:.:.:.:..|..:|.       |.|   ..|.|.||.|   ||..:
Zfish  1729 ISKAPKPERKKRRKKESDTVEEHMGHIFKSTQYSIPTYCEFCSSLIWMMDKACVCKLCRYACHKK 1793

  Fly  1379 YGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAKED 1443
            .    .||:.......|.|.  |:..:..:| .|||.:           ::..:.|..:|.
Zfish  1794 C----CLRMTTKCSKKFDPE--LSSRQFGVE-LSRLTS-----------DERSVPLVVEKL---- 1836

  Fly  1444 ICLFAHLSWPMRHSRLFE-VVRKEGPKLQSDELMLGI----NSAGLFLIDETEQVLASCCFSEVL 1503
                  :::...|....| :.||.|...:..||..|:    ||..  |.|....|:||     ||
Zfish  1837 ------INYIEMHGLYTEGIYRKSGSTNKIKELKQGLDTDANSVN--LDDYNIHVIAS-----VL 1888

  Fly  1504 KVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRS 1548
            |..:. |....:|||:.....|:....||..||:..:...:.|.|
Zfish  1889 KQWLR-DLPNPLMTFELYEEFLRAMGLQDKREVVQGVYSIIDQLS 1932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	266/841 (32%)
		IQ	765..785	CDD:197470	11/47 (23%)
		Atrophin-1	<820..>946	CDD:460830	28/156 (18%)
		MyTH4	1031..1239	CDD:470587	49/288 (17%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	22/99 (22%)
		B41	1248..1429	CDD:214604	46/217 (21%)
		PH-like	1454..1547	CDD:473070	27/97 (28%)
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
myo9ab	NP_001410713.1	Ubl1_cv_Nsp3_N-like	16..111	CDD:475130
		MYSc_Myo9	163..952	CDD:276836	265/839 (32%)
		MSCRAMM_ClfA	<1471..1581	CDD:468110	31/145 (21%)
		C1_Myosin-IXa	1749..1806	CDD:410433	13/60 (22%)
		RhoGAP_myosin_IXA	1815..2000	CDD:239871	35/148 (24%)