Protein Alignment Myo28B1 and myh7bb

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_009295034.2
• Gene: myh7bb / 560945
• ZFINID: ZDB-GENE-090311-5
• Length: 1935
• Species: Danio rerio
• Alignment Length: 2001
• Identity: 499/2001 - (24%)
• Similarity: 845/2001 - (42%)
• Gaps: 446/2001 - (22%)

  Fly    28 FG--ARIVRTEKTQTLVCD----DRNKQFWVP--------------AGDVLKA------MHITSQ 66
            ||  |..:|....:.|...    |..|:.|:|              .||.:..      |....:
Zfish    10 FGEAATFLRKTNLEQLAAQSHAFDGKKRVWIPDEKEAYIEVEIKDTDGDKVMVETKDGRMLTVKE 74

  Fly    67 EDV-----------EDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNRE 120
            ||:           |||..|..|.|.::|.||..||:..:||||:|...|.:|||:.||:|::..
Zfish    75 EDIQQMNPPKFDLMEDMAMLTHLNEASVLFNLSRRYSFWMIYTYSGLFCVTVNPYKWLPVYSSEV 139

  Fly   121 IQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISG--- 182
            :..|:.|..:::||||::|:|||:..:.:.:|||.::|:||||||||.:||.::||.|.|:.
Zfish   140 VAAYKGKRRSDVPPHIYSIADNAYNDMLKNRENQSMLITGESGAGKTVNTKRVIQYFAIIAALGE 204

  Fly   183 ----KHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSR 243
                |...:|.|||||||.|||||||||:||||||||||:|.|.|.|.|.:..|.|..|||||||
Zfish   205 AGGKKGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDIYLLEKSR 269

  Fly   244 IVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAA 308
            ::||...||:|||:|.:|:. ...|.:.:.|...:|..||:.:| |..|:....|..:......|
Zfish   270 VIFQQTGERSYHIYYQILSH-RKPELQDMLLVSSNPFDYHFCSQ-GVITVDNMDDGDELLATDHA 332

  Fly   309 MKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAA 373
            |..|.|.|||.:....::..|:|.||::|...:  ....||.|.|.:..:.:.|:||..:.|...
Zfish   333 MDTLGFTPEEKYGCYKIVGGIMHFGNMKFKVKQ--REEQAEADGTESADKASYLMGISSADLIKG 395

  Fly   374 LTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDI 438
            |....:.|..|::....:.|.......|..|:.||.:|..:|.|||:|:...:.:.. .||||||
Zfish   396 LLHPRVKVGNEYIVRGQTVEQVTYAVGALAKATYDRMFKWLVGRINKTLYTAIPRQF-FIGVLDI 459

  Fly   439 FGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDLIGMK 502
            .|||.|:.|:|||:|||:.||.|||||..|:|.:||:||:.|.|.|..|:| .|.|..:||| .|
Zfish   460 AGFEIFEFNNFEQMCINFTNEKLQQFFNHHMFILEQEEYKTEGIEWTFIDFGLDLQACIDLI-EK 523

  Fly   503 PMNLMSLIDEESKFPKGTDQTLLEKLHVQ-HGNRSIYVK----GKTTQTSLFGIRHYAGVVMYNP 562
            |:.::|:::||..|||.|:.:...||:.. .|....::|    .|....:.|.:.||||||.||.
Zfish   524 PLGILSILEEECMFPKATESSFKAKLYDNLLGKSPNFLKPRPDKKRKYDTHFELVHYAGVVPYNI 588

  Fly   563 LGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEMPMDT-AKKQP-------------TLCVKFR 613
            .|:|:||||..:..:..:.|||:||.:..:|.:.:.:|: ::.:|             |:....:
Zfish   589 NGWLDKNRDPLNETVVGIFQRSSNKLMSSLFENFISLDSGSEAKPGSKEKRKKGASFQTVSQLHK 653

  Fly   614 NSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRA 678
            .:|:.||..|....|:|:|||.|||.|.|...:..|.:.|||.:|::|..||.|.|:|.|..|..
Zfish   654 ENLNKLMTNLRSTQPHFVRCIIPNEAKNPGMMEPFLVLHQLRCNGVLEGIRICRKGFPNRILYAE 718

  Fly   679 FVERYRLLVPPVGPLE-QCDCRKLARQICEVALPAD-SDRQYGKTKLFLRDEDDASLELQRSQLM 741
            |.:|||:|.|...|.: ..|.||...::.. :|..| :..::|.:|:|.:......||..|.:.:
Zfish   719 FKQRYRILNPLAIPEDTYVDSRKAVEKLLG-SLDIDHTQYKFGHSKVFFKAGLLGQLEDMRDERL 782

  Fly   742 LKSIVTIQ---RGIRRVLFRRYMKRYREAIITVQ---------RYW-------------RGRLQR 781
            .|.:..:|   ||....:.|:.|.:.:||::.:|         :.|             |.....
Zfish   783 SKVLTLLQAFCRGKLMRMERKRMMKEKEALMVIQWNIRAFYAVKNWPWMCLFFKIKPLLRSAATE 847

  Fly   782 RKYQVMRQGFHRLGACIAAQQLTTK------FTMVRCR---TIKLQALSRGYLVRKDFQKKLLER 837
            ::...:::.|.:|...:...::..|      .::|:.:   :::|||........:|....|::.
Zfish   848 KELATLKEEFQKLKEALERSEVKRKELEEKQVSLVQEKNDLSLQLQAEQDNLADAEDRCNLLIKA 912

  Fly   838 RKQNQLKKEELLK------------LAKMKEAE----EL------LRLQQLKEQKEREQREQQEK 880
            :.|.:.|.:||::            |||.::.|    ||      |.:...|.:||:...|.:.|
Zfish   913 KIQMEGKIKELMERLEDEEEMNATILAKKRKLEDECIELKKDLDDLEITLAKVEKEKHATENKVK 977

  Fly   881 RLQEEQRLKAEAAARNALAMAAVQ--QKRRTKPVKQEAPKAPTL-QARNSLPPPPTTLIVAAPLP 942
            .|.||.....|..:|.:....|:|  .::..:.::.|..|...| :|:..|......|..:....
Zfish   978 NLVEEMAALDETISRLSKEKKALQDAHQQALEDLQSEENKVNMLSKAKIKLEQQVDDLEGSLEQE 1042

  Fly   943 TRPASAVTRINTIPES------PGTIDVESSKQMVDDVFRFLND---------EPDAAL-----R 987
            .:....:.|:....|.      ..::|:::|||.:::..:..:.         |.:.||     :
Zfish  1043 KKVRMDLERVKRKLEGDLKLSVESSMDLDNSKQQLEERLKKKDHEMVQIGAKIEEEQALVIQLHK 1107

  Fly   988 KLNNISS----------GDTIRLPKSVPNNIDTS-DFSYLKYAATYFGGGATAQHE--------- 1032
            |:..:.:          .:.....||.....|.| :...|.......||..|||.|
Zfish  1108 KIKELQTRIEELEEELEAERAARSKSEKQRSDVSRELEELSERLEEAGGATTAQIEMNKKREADF 1172

  Fly  1033 ---RKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTS 1094
               |:.|:::.|.||..|..:..|                          :.:.::::...|:..
Zfish  1173 IKLRRDLEEASLHHETTIAMLRRK--------------------------HADTVAEMGEQLDNL 1211

  Fly  1095 DSYKPRLFVRQSQRRIP-KPLASG-----------EKEAQEFYQHWLNVPTSHLEKIHFIIGHGI 1147
            ...|.:|...:::.|:. :.|||.           ||..: .|:..||...:.:|:
Zfish  1212 QRVKQKLEKEKAETRMECEDLASNVEHLSRAKTTTEKMCR-MYEDQLNESKTKIEE--------- 1266

  Fly  1148 IKNSLRD----------------------EILA---------------QICKQLYLNPSRSSYSR 1175
            ::..|.|                      |:|.               ::.|||. ..|::..|.
Zfish  1267 LQRQLMDVTSQKARAQTESAEVSRRLEEKEVLVMQLQRTKIAFSQTVEELKKQLE-EESKAKNSL 1330

  Fly  1176 GWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRG 1240
            ...:.|....|....::||..     ::..::||...|...:|       ..|..:.:|..||:
Zfish  1331 AHAVQSSRHDCDLLREQFEEE-----QEAKSELQRALSKANIE-------IAQWRTKYETDAIQ- 1382

  Fly  1241 RHPLRLDIHLMDGQQR---RLQVDAASTAREAVNQLCQGMGLT----DTFGFGLVMSL---NGKL 1295
                |.| .|.|.:::   |||  .:..|.||.|..|..:..|    .|....|::.|   |...
Zfish  1383 ----RTD-ELEDAKKKLVARLQ--GSEEAVEASNAKCASLEKTKHRLQTEIEDLMVDLERSNAVA 1440

  Fly  1296 MPLGAGQEHVLDAISECEQR------QLDAPWK--LYIRKEMF--ATWYDPSMDPKAT------- 1343
            :.|...|.:....:||..|:      :|:...|  ..:..|:|  ...|:.::|...|
Zfish  1441 IALDKKQRNFDKVLSEWRQKFEETQSELEGSQKESRSLSTELFKLKNSYEEALDQLETIKRENKN 1505

  Fly  1344 ----------------QLIY-----KQILNGLKCGEYRCRSEKDIAMVCALACFVEYGPGEILR- 1386
                            :.|:     |::|:..||.......|.:..:        |:...:.||
Zfish  1506 LQEEITDLTDQISQGNKTIHELEQMKKVLDHEKCDIQAALEEAEGTL--------EHEESKTLRV 1562

  Fly  1387 -LKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHL 1450
             |:.|:....|... ||..:..|:|..|....|.|..        ...|:|:.||:.
Zfish  1563 QLELSQTKTEVEKK-LAERDEEIDNLRRNHQRTLEGM--------QTTLDAETRARN-------- 1610

  Fly  1451 SWPMRHSRLFEVVRKEGPKLQSD--ELMLGINSAGLFLIDETEQVLASCCFSEVLKVHVESDDKL 1513
                      |.:|.: .|:::|  |:.:.:|.|....: |:::::.:... ::..:.||.|:.:
Zfish  1611 ----------EAIRVK-KKMENDMNEMEIHLNHANRQAV-ESQKMVRNLQL-QIKDLQVELDESM 1662

  Fly  1514 HVMTFQHVNFVL-QCSSAQDANEVINYMLDNLRQRSSYGVA-----LDPVVEGDL---------- 1562
            |     |...:. |.:..:..|.:::..|:.||     |||     :..|.|.:|
Zfish  1663 H-----HCEELKEQVAVTERRNTLLSAELEELR-----GVAEQTDRMRKVAEHELLESSERVNLL 1717

  Fly  1563 --EDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLATLTKPSEKLQD 1625
              ::.::||....:|     :...:::|...|..:.|.|.:                   ||.:.
Zfish  1718 HAQNTVMLNQKKKLE-----SDLSMLSGEVDDAQQECRNAE-------------------EKAKK 1758

  Fly  1626 ILREGRF--QEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKAPLSKFSPEPLKAPLLKAVV 1688
            .:.:...  :|..|....:::..|.:.|:.|..:. .:..||..:....|..    |..:.|..:
Zfish  1759 AITDAAMMAEELKKEQDTSSHLERMKRNMEQTIKD-LQNRLDEAEQIALKGG----KKQIQKMEI 1818

  Fly  1689 KVPPL-------------FQQALVMHHHILK---YMGDIARSNLPVNTDLI 1723
            :|..|             ||:.:..:...:|   |..:..|..|....|||
Zfish  1819 RVRELETELDCEQKKSAEFQKGIRKYERRIKELTYQTEEDRKTLLRMQDLI 1869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	259/673 (38%)
		IQ	765..785	CDD:197470	5/41 (12%)
		Atrophin-1	<820..>946	CDD:460830	31/150 (21%)
		MyTH4	1031..1239	CDD:470587	41/268 (15%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	26/110 (24%)
		B41	1248..1429	CDD:214604	46/230 (20%)
		PH-like	1454..1547	CDD:473070	18/95 (19%)
		MyTH4	1674..1819	CDD:214535	13/66 (20%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
myh7bb	XP_009295034.2	Myosin_N	33..77	CDD:460670	8/43 (19%)
		Motor_domain	100..767	CDD:473979	259/673 (38%)
		Myosin_tail_1	847..1924	CDD:460256	206/1157 (18%)