Protein Alignment Myo28B1 and MYO15A

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_016880204.1
• Gene: MYO15A / 51168
• HGNCID: 7594
• Length: 3531
• Species: Homo sapiens
• Alignment Length: 2581
• Identity: 671/2581 - (25%)
• Similarity: 1021/2581 - (39%)
• Gaps: 788/2581 - (30%)

  Fly    58 LKAMHITSQ--ED-VEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNR 119
            |.:|....|  || ||||..|.||||.|:|.||:.|:.:.|||||.||:||::||||:..||...
Human  1210 LPSMRFREQHGEDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPYQMFGIYGPE 1274

  Fly   120 EIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKH 184
            ::|.|..::|.|.|||:||:::.||.::...|:|||::||||||:||||:|||||:||||::.|.
Human  1275 QVQQYNGRALGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAMNQKR 1339

  Fly   185 SWIEQ--QIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQ 247
            ..::|  ||:||.|::|:|||||||||||||||||::|| |...|.|.||...||||||||||||
Human  1340 EVMQQVIQILEATPLLESFGNAKTVRNDNSSRFGKFVEI-FLEGGVISGAITSQYLLEKSRIVFQ 1403

  Fly   248 SRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVL 312
            :::||||||||.:||||....|:...|||  ...|:||.|||...:.|:.||.||..:.|||:||
Human  1404 AKNERNYHIFYELLAGLPAQLRQAFSLQE--AETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVL 1466

  Fly   313 SFKPEEVWSILSLLAAILHLGNLRF-----TATEVANLATAEIDDTPNLQRVAQLLGIPISALNA 372
            .|..|:..||..:||:||||||:.|     .|.|||::.:|.     .:|.||:||.|....|..
Human  1467 GFSSEDQDSIFRILASILHLGNVYFEKYETDAQEVASVVSAR-----EIQAVAELLQISPEGLQK 1526

  Fly   373 ALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLD 437
            |:|.:......|.:.|.|:.|:|::.|||..|.||..:|..::.|:|..::.:  |...||.:||
Human  1527 AITFKVTETMREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVNALVSPR--QDTLSIAILD 1589

  Fly   438 IFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMK 502
            |:|||:...||||||||||||||||..|...:|:.||:||..|.|:||.|.|.|||..::||.:|
Human  1590 IYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFADNQPCINLISLK 1654

  Fly   503 PMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLE 567
            |..::.::|::..||:.||.|.|:|.|..||...:|.|.|..... |.|:||||.|.|....||:
Human  1655 PYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPLPE-FTIKHYAGKVTYQVHKFLD 1718

  Fly   568 KNRDSFSGDLRTLVQRSTNKYLVDIF----PHEMPMDTAK--------KQPTLCVKFRNSLDMLM 620
            ||.|....|:..|..||..:.:..:|    |...|....|        |..|:..||:.||..|:
Human  1719 KNHDQVRQDVLDLFVRSRTRVVAHLFSSHAPQAAPQRLGKSSSVTRLYKAHTVAAKFQQSLLDLV 1783

  Fly   621 RTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRL 685
            ..:.:.:|.|:||:|||..|||..|:.::.:.||||||::||.|||:.|:|:|..::.|::||..
Human  1784 EKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKEGFPVRLPFQGFIDRYCC 1848

  Fly   686 LV------PPVGPLEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKS 744
            ||      |..|.:    |..:..::|:| :|  :..:.|.:||||::.....||..|..::..:
Human  1849 LVALKHDLPANGDM----CVSVLSRLCKV-MP--NMYRVGVSKLFLKEHLYQLLESMREHVLNLA 1906

  Fly   745 IVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTM 809
            .:|:||.:|....:|..:..|..||.:|...||.|.|::||.||:..
Human  1907 ALTLQRCLRGFFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRSL------------------ 1953

  Fly   810 VRCRTIKLQALSRGYLVRKDFQKKLLERR---------KQNQLKKEELLKLAKMKEAEELLRLQQ 865
                 :|.::|...|:.|:.:.|...|.|         :|.:|.|.|::.:..::...||..|.|
Human  1954 -----VKFRSLVHAYVSRRRYLKLRAEWRCQVEGALLWEQEELSKREVVAVGHLEVPAELAGLLQ 2013

  Fly   866 LKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAP-KAPTLQARNSLP 929
                                      |.|...||.           |.|.|| :.|.|||
Human  2014 --------------------------AVAGLGLAQ-----------VPQVAPVRTPRLQA----- 2036

  Fly   930 PPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISS 994
                                                               ||
Human  2037 ---------------------------------------------------EP------------ 2038

  Fly   995 GDTIRLPKSVPNNIDTSDFSYLKYAATYF---GGGATAQHERKPLKKSLLKHEHPIDEMASKAIW 1056
              .:.||      :|.:::...|:...:|   ..|......|.||.:  |..||..:.:   :|:
Human  2039 --RVTLP------LDINNYPMAKFVQCHFKEPAFGMLTVPLRTPLTQ--LPAEHHAEAV---SIF 2090

  Fly  1057 LTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLASGEKEA 1121
            ..|||||||       |.|| ...||:..
Human  2091 KLILRFMGD-------PHLH-GARENIFG------------------------------------ 2111

  Fly  1122 QEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSC 1186
                              ::|:..|:....||||||||:..|::.|.:..:..||||||:.|||.
Human  2112 ------------------NYIVQKGLAVPELRDEILAQLANQVWHNHNAHNAERGWLLLAACLSG 2158

  Fly  1187 FPPSKEFEPHLRSFMK-------QGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPL 1244
            |.||..|..:|..|:.       |...|.:...::.|.::......|..||:..|..|...:..:
Human  2159 FAPSPCFNKYLLKFVSDYGRNGFQAVCQHRLMQAMGRAQQQGSGAARTLPPTQLEWTATYEKASM 2223

  Fly  1245 RLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAI 1309
            .||:...:|.|....|.:.||..|....:.:..||.|.:....|...||......||.::|||.:
Human  2224 ALDVGCFNGDQFSCPVHSWSTGEEVAGDILRHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLV 2288

  Fly  1310 SECEQRQLDAP-WKLYI-------------RKEMFA-TW-------------------------- 1333
            |:.|..: |.| .|.|.             .|.:|. :|
Human  2289 SDLELLR-DFPRQKSYFIVGTEGPAASRGGPKVVFGNSWDSDEDMSTRPQPQEHMPKVLDSDGYS 2352

  Fly  1334 -------------------------------------------YDPSMD------PKATQLIYKQ 1349
                                                       :||.:.      .|.|.:.|:.
Human  2353 SHNQDGTNGETEAQRGTATHQESDSLGEPAVPHKGLDCYLDSLFDPVLSYGDADLEKPTAIAYRM 2417

  Fly  1350 ILNGLKCGEYRCRSEK--------------DIAMVCALACFV----------------------- 1377
            ...|...|.....:|.              |.:.:.....|:
Human  2418 KGGGQPGGGSSSGTEDTPRRPPEPKPIPGLDASTLALQQAFIHKQAVLLAREMTLQATALQQQPL 2482

  Fly  1378 --------------------EYGPGE-----ILRLKPSEI------------------------- 1392
                                ..|.|.     :||..|..:
Human  2483 SAALRSLPAEKPPAPEAQPTSVGTGPPAKPVLLRATPKPLAPAPLAKAPRLPIKPVAAPVLAQDQ 2547

  Fly  1393 ----------------------------------------------------------------- 1392
                                                                             
Human  2548 ASPETTSPSPELVRYSTLNSEHFPQPTQQIKNIVRQYQQPFRGGRPEALRKDGGKVFMKRPDPHE 2612

  Fly  1393 ------------------------------------------TAFVPSDLLAPGERAIEN----- 1410
                                                      |:.:||..|.|.|...:.
Human  2613 EALMILKGQMTHLAAAPGTQVSREAVALVKPVTSAPRPSMAPTSALPSRSLEPPEELTQTRLHRL 2677

  Fly  1411 ------------WSRLI--AATYEKSSYVKEEQNDLLL---------EAQKRAKED-----ICLF 1447
                        |...:  ...|.|.||....|.|||.         ||..|..||     ..||
Human  2678 INPNFYGYQDAPWKIFLRKEVFYPKDSYSHPVQLDLLFRQILHDTLSEACLRISEDERLRMKALF 2742

  Fly  1448 AHL-----------------------SWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDE 1489
            |..                       :|.:..||:|......|..:|    :|.::..|:.|:..
Human  2743 AQNQLDTQKPLVTESVKRAVVSTARDTWEVYFSRIFPATGSVGTGVQ----LLAVSHVGIKLLRM 2803

  Fly  1490 TE---------QVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLR 1545
            .:         :||.:..|:::|.|.:.|.:.|. ........:|..:.|.....:::..:..|:
Human  2804 VKGGQEAGGQLRVLRAYSFADILFVTMPSQNMLE-FNLASEKVILFSARAHQVKTLVDDFILELK 2867

  Fly  1546 QRSSYGVAL------DPVVEGDLEDCLVLNPGDLIE----------FEAG-------VTGAQLMA 1587
            :.|.|.||:      ||.:       |..:.||:|.          :.||       |...:|..
Human  2868 KDSDYVVAVRNFLPEDPAL-------LAFHKGDIIHLQPLEPPRVGYSAGCVVRRKVVYLEELRR 2925

  Fly  1588 GNAQDCYR-GCVNGQWGQFLAGNVRVLATLTKPSEKLQDILREGRFQEPPKP------------- 1638
            ......:| |.::|:.|:|             |||.:|........|.|.:|
Human  2926 RGPDFGWRFGTIHGRVGRF-------------PSELVQPAAAPDFLQLPTEPGRGRAAAVAAAVA 2977

  Fly  1639 --TPRANYSRRRQ--------------------HNISQLAESHFREPLDSDKAPLSKFSPEP--- 1678
              .......|||:                    :.:.:.|:.:||:|....:..|...|.||
Human  2978 SAAAAQEVGRRREGPPVRARSADHGEDALALPPYTMLEFAQKYFRDPQRRPQDGLRLKSKEPRES 3042

  Fly  1679 ---------LKAPLLKAVVKV--PPLFQQALVMHHHILKYMGDI---ARSNLPVNTDLIFQPALQ 1729
                     .|.||.::::::  ..|.:.|..|...::::|||.   .:|:|.|..:|: :....
Human  3043 RTLEDMLCFTKTPLQESLIELSDSSLSKMATDMFLAVMRFMGDAPLKGQSDLDVLCNLL-KLCGD 3106

  Fly  1730 HPLLCDELYCQLMKQLSDNPSSESE--KRGWDLLYLATGLVAPSVLVMRELIILLR-------MR 1785
            |.::.||.|||::||::||.||:.:  :|||.|||:.|...:.|.::...|...|:       :.
Human  3107 HEVMRDECYCQVVKQITDNTSSKQDSCQRGWRLLYIVTAYHSCSEVLHPHLTRFLQDVSRTPGLP 3171

  Fly  1786 ADALADACLKRLKRSLAQGQRKKAPHLIEVEGI-----QQRCLHIYHKIYFPDDTVEAFEIESHT 1845
            ...:|.||.:.|:::|..|.|.:.|..||:..:     .:|.|.:     .|.......:|::.|
Human  3172 FQGIAKACEQNLQKTLRFGGRLELPSSIELRAMLAGRSSKRQLFL-----LPGGLERHLKIKTCT 3231

  Fly  1846 RGAELIADIAQRLELKSPVG---YSIFLKT--GDRVYAMPEEEFVFDFITQLIYWLRQQRTIRSI 1905
            ...:::.:|...:.|..|..   |.||:.|  |..|..:....::.|..:::     :|
Human  3232 VALDVVEEICAEMALTRPEAFNEYVIFVVTNRGQHVCPLSRRAYILDVASEM-----EQ------ 3285

  Fly  1906 SDGQYQLHFMRKLWLNNHPGEDLNGDMI-FSYPQELHKYLKGYY-------PID--CEQASRLAI 1960
            .||.|.|.|.|.||  :.|.:..|...: ..|.|.|..||||.:       |.:  .:|.|:||.
Human  3286 VDGGYMLWFRRVLW--DQPLKFENELYVTMHYNQVLPDYLKGLFSSVPASRPSEQLLQQVSKLAS 3348

  Fly  1961 LVYSA-DHDVSLQRLPEV--LTRLIPEDLIPLQTVAEWRQQILPKVHRDH---LTEDHAKILFLQ 2019
            |.:.| ||..    ||.|  :...||..|......:.|..  |...||..   |:...|:..||.
Human  3349 LQHRAKDHFY----LPSVREVQEYIPAQLYRTTAGSTWLN--LVSQHRQQTQALSPHQARAQFLG 3407

  Fly  2020 ELSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEY-------SQLGIW 2077
            .||....|||:||.::..::.|:|...::|||..|.:.|...|.|::..:..       :|....
Human  3408 LLSALPMFGSSFFFIQSCSNIAVPAPCILAINHNGLNFLSTETHELMVKFPLKEIQSTRTQRPTA 3472

  Fly  2078 SSGKNHFHIRFGNMIGASKLLCSTTQGYKMDDLLASYVK-YFNEHE 2122
            :|...:..|..|::.....|.....||.::..::|.:|: ..:.||
Human  3473 NSSYPYVEIALGDVAAQRTLQLQLEQGLELCRVVAVHVENLLSAHE 3518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	297/669 (44%)
		IQ	765..785	CDD:197470	8/19 (42%)
		Atrophin-1	<820..>946	CDD:460830	26/135 (19%)
		MyTH4	1031..1239	CDD:470587	54/214 (25%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	28/174 (16%)
		B41	1248..1429	CDD:214604	52/483 (11%)
		PH-like	1454..1547	CDD:473070	18/101 (18%)
		MyTH4	1674..1819	CDD:214535	48/175 (27%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	20/98 (20%)
		B41	1827..2032	CDD:214604	59/225 (26%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	22/100 (22%)
MYO15A	XP_016880204.1	SGP	<320..364	CDD:435798
		PHA03247	<723..1144	CDD:223021
		MYSc_Myo15	1236..1888	CDD:276838	297/669 (44%)
		IQ	1926..1947	CDD:197470	8/20 (40%)
		MyTH4	2066..2218	CDD:214535	54/218 (25%)
		PHA03247	<2433..2673	CDD:223021	13/239 (5%)
		SH3_MYO15A	2872..2951	CDD:213000	21/98 (21%)
		MyTH4	3051..3205	CDD:214535	45/154 (29%)
		FERM_M	3300..3420	CDD:459788	37/125 (30%)
		FERM_C_MyoXV	3416..3517	CDD:270022	22/100 (22%)