DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo28B1 and MYO15A

DIOPT Version :9

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:XP_016880204.1 Gene:MYO15A / 51168 HGNCID:7594 Length:3531 Species:Homo sapiens


Alignment Length:2581 Identity:671/2581 - (25%)
Similarity:1021/2581 - (39%) Gaps:788/2581 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 LKAMHITSQ--ED-VEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNR 119
            |.:|....|  || ||||..|.||||.|:|.||:.|:.:.|||||.||:||::||||:..||...
Human  1210 LPSMRFREQHGEDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPYQMFGIYGPE 1274

  Fly   120 EIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKH 184
            ::|.|..::|.|.|||:||:::.||.::...|:|||::||||||:||||:|||||:||||::.|.
Human  1275 QVQQYNGRALGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAMNQKR 1339

  Fly   185 SWIEQ--QIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQ 247
            ..::|  ||:||.|::|:|||||||||||||||||::|| |...|.|.||...||||||||||||
Human  1340 EVMQQVIQILEATPLLESFGNAKTVRNDNSSRFGKFVEI-FLEGGVISGAITSQYLLEKSRIVFQ 1403

  Fly   248 SRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVL 312
            :::||||||||.:||||....|:...|||  ...|:||.|||...:.|:.||.||..:.|||:||
Human  1404 AKNERNYHIFYELLAGLPAQLRQAFSLQE--AETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVL 1466

  Fly   313 SFKPEEVWSILSLLAAILHLGNLRF-----TATEVANLATAEIDDTPNLQRVAQLLGIPISALNA 372
            .|..|:..||..:||:||||||:.|     .|.|||::.:|.     .:|.||:||.|....|..
Human  1467 GFSSEDQDSIFRILASILHLGNVYFEKYETDAQEVASVVSAR-----EIQAVAELLQISPEGLQK 1526

  Fly   373 ALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLD 437
            |:|.:......|.:.|.|:.|:|::.|||..|.||..:|..::.|:|..::.:  |...||.:||
Human  1527 AITFKVTETMREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVNALVSPR--QDTLSIAILD 1589

  Fly   438 IFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMK 502
            |:|||:...||||||||||||||||..|...:|:.||:||..|.|:||.|.|.|||..::||.:|
Human  1590 IYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFADNQPCINLISLK 1654

  Fly   503 PMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLE 567
            |..::.::|::..||:.||.|.|:|.|..||...:|.|.|..... |.|:||||.|.|....||:
Human  1655 PYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPLPE-FTIKHYAGKVTYQVHKFLD 1718

  Fly   568 KNRDSFSGDLRTLVQRSTNKYLVDIF----PHEMPMDTAK--------KQPTLCVKFRNSLDMLM 620
            ||.|....|:..|..||..:.:..:|    |...|....|        |..|:..||:.||..|:
Human  1719 KNHDQVRQDVLDLFVRSRTRVVAHLFSSHAPQAAPQRLGKSSSVTRLYKAHTVAAKFQQSLLDLV 1783

  Fly   621 RTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRL 685
            ..:.:.:|.|:||:|||..|||..|:.::.:.||||||::||.|||:.|:|:|..::.|::||..
Human  1784 EKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKEGFPVRLPFQGFIDRYCC 1848

  Fly   686 LV------PPVGPLEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKS 744
            ||      |..|.:    |..:..::|:| :|  :..:.|.:||||::.....||..|..::..:
Human  1849 LVALKHDLPANGDM----CVSVLSRLCKV-MP--NMYRVGVSKLFLKEHLYQLLESMREHVLNLA 1906

  Fly   745 IVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTM 809
            .:|:||.:|....:|..:..|..||.:|...||.|.|::||.||:..                  
Human  1907 ALTLQRCLRGFFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRSL------------------ 1953

  Fly   810 VRCRTIKLQALSRGYLVRKDFQKKLLERR---------KQNQLKKEELLKLAKMKEAEELLRLQQ 865
                 :|.::|...|:.|:.:.|...|.|         :|.:|.|.|::.:..::...||..|.|
Human  1954 -----VKFRSLVHAYVSRRRYLKLRAEWRCQVEGALLWEQEELSKREVVAVGHLEVPAELAGLLQ 2013

  Fly   866 LKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAP-KAPTLQARNSLP 929
                                      |.|...||.           |.|.|| :.|.|||     
Human  2014 --------------------------AVAGLGLAQ-----------VPQVAPVRTPRLQA----- 2036

  Fly   930 PPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISS 994
                                                               ||            
Human  2037 ---------------------------------------------------EP------------ 2038

  Fly   995 GDTIRLPKSVPNNIDTSDFSYLKYAATYF---GGGATAQHERKPLKKSLLKHEHPIDEMASKAIW 1056
              .:.||      :|.:::...|:...:|   ..|......|.||.:  |..||..:.:   :|:
Human  2039 --RVTLP------LDINNYPMAKFVQCHFKEPAFGMLTVPLRTPLTQ--LPAEHHAEAV---SIF 2090

  Fly  1057 LTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLASGEKEA 1121
            ..|||||||       |.|| ...||:..                                    
Human  2091 KLILRFMGD-------PHLH-GARENIFG------------------------------------ 2111

  Fly  1122 QEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSC 1186
                              ::|:..|:....||||||||:..|::.|.:..:..||||||:.|||.
Human  2112 ------------------NYIVQKGLAVPELRDEILAQLANQVWHNHNAHNAERGWLLLAACLSG 2158

  Fly  1187 FPPSKEFEPHLRSFMK-------QGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPL 1244
            |.||..|..:|..|:.       |...|.:...::.|.::......|..||:..|..|...:..:
Human  2159 FAPSPCFNKYLLKFVSDYGRNGFQAVCQHRLMQAMGRAQQQGSGAARTLPPTQLEWTATYEKASM 2223

  Fly  1245 RLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAI 1309
            .||:...:|.|....|.:.||..|....:.:..||.|.:....|...||......||.::|||.:
Human  2224 ALDVGCFNGDQFSCPVHSWSTGEEVAGDILRHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLV 2288

  Fly  1310 SECEQRQLDAP-WKLYI-------------RKEMFA-TW-------------------------- 1333
            |:.|..: |.| .|.|.             .|.:|. :|                          
Human  2289 SDLELLR-DFPRQKSYFIVGTEGPAASRGGPKVVFGNSWDSDEDMSTRPQPQEHMPKVLDSDGYS 2352

  Fly  1334 -------------------------------------------YDPSMD------PKATQLIYKQ 1349
                                                       :||.:.      .|.|.:.|:.
Human  2353 SHNQDGTNGETEAQRGTATHQESDSLGEPAVPHKGLDCYLDSLFDPVLSYGDADLEKPTAIAYRM 2417

  Fly  1350 ILNGLKCGEYRCRSEK--------------DIAMVCALACFV----------------------- 1377
            ...|...|.....:|.              |.:.:.....|:                       
Human  2418 KGGGQPGGGSSSGTEDTPRRPPEPKPIPGLDASTLALQQAFIHKQAVLLAREMTLQATALQQQPL 2482

  Fly  1378 --------------------EYGPGE-----ILRLKPSEI------------------------- 1392
                                ..|.|.     :||..|..:                         
Human  2483 SAALRSLPAEKPPAPEAQPTSVGTGPPAKPVLLRATPKPLAPAPLAKAPRLPIKPVAAPVLAQDQ 2547

  Fly  1393 ----------------------------------------------------------------- 1392
                                                                             
Human  2548 ASPETTSPSPELVRYSTLNSEHFPQPTQQIKNIVRQYQQPFRGGRPEALRKDGGKVFMKRPDPHE 2612

  Fly  1393 ------------------------------------------TAFVPSDLLAPGERAIEN----- 1410
                                                      |:.:||..|.|.|...:.     
Human  2613 EALMILKGQMTHLAAAPGTQVSREAVALVKPVTSAPRPSMAPTSALPSRSLEPPEELTQTRLHRL 2677

  Fly  1411 ------------WSRLI--AATYEKSSYVKEEQNDLLL---------EAQKRAKED-----ICLF 1447
                        |...:  ...|.|.||....|.|||.         ||..|..||     ..||
Human  2678 INPNFYGYQDAPWKIFLRKEVFYPKDSYSHPVQLDLLFRQILHDTLSEACLRISEDERLRMKALF 2742

  Fly  1448 AHL-----------------------SWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDE 1489
            |..                       :|.:..||:|......|..:|    :|.::..|:.|:..
Human  2743 AQNQLDTQKPLVTESVKRAVVSTARDTWEVYFSRIFPATGSVGTGVQ----LLAVSHVGIKLLRM 2803

  Fly  1490 TE---------QVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLR 1545
            .:         :||.:..|:::|.|.:.|.:.|. ........:|..:.|.....:::..:..|:
Human  2804 VKGGQEAGGQLRVLRAYSFADILFVTMPSQNMLE-FNLASEKVILFSARAHQVKTLVDDFILELK 2867

  Fly  1546 QRSSYGVAL------DPVVEGDLEDCLVLNPGDLIE----------FEAG-------VTGAQLMA 1587
            :.|.|.||:      ||.:       |..:.||:|.          :.||       |...:|..
Human  2868 KDSDYVVAVRNFLPEDPAL-------LAFHKGDIIHLQPLEPPRVGYSAGCVVRRKVVYLEELRR 2925

  Fly  1588 GNAQDCYR-GCVNGQWGQFLAGNVRVLATLTKPSEKLQDILREGRFQEPPKP------------- 1638
            ......:| |.::|:.|:|             |||.:|........|.|.:|             
Human  2926 RGPDFGWRFGTIHGRVGRF-------------PSELVQPAAAPDFLQLPTEPGRGRAAAVAAAVA 2977

  Fly  1639 --TPRANYSRRRQ--------------------HNISQLAESHFREPLDSDKAPLSKFSPEP--- 1678
              .......|||:                    :.:.:.|:.:||:|....:..|...|.||   
Human  2978 SAAAAQEVGRRREGPPVRARSADHGEDALALPPYTMLEFAQKYFRDPQRRPQDGLRLKSKEPRES 3042

  Fly  1679 ---------LKAPLLKAVVKV--PPLFQQALVMHHHILKYMGDI---ARSNLPVNTDLIFQPALQ 1729
                     .|.||.::::::  ..|.:.|..|...::::|||.   .:|:|.|..:|: :....
Human  3043 RTLEDMLCFTKTPLQESLIELSDSSLSKMATDMFLAVMRFMGDAPLKGQSDLDVLCNLL-KLCGD 3106

  Fly  1730 HPLLCDELYCQLMKQLSDNPSSESE--KRGWDLLYLATGLVAPSVLVMRELIILLR-------MR 1785
            |.::.||.|||::||::||.||:.:  :|||.|||:.|...:.|.::...|...|:       :.
Human  3107 HEVMRDECYCQVVKQITDNTSSKQDSCQRGWRLLYIVTAYHSCSEVLHPHLTRFLQDVSRTPGLP 3171

  Fly  1786 ADALADACLKRLKRSLAQGQRKKAPHLIEVEGI-----QQRCLHIYHKIYFPDDTVEAFEIESHT 1845
            ...:|.||.:.|:::|..|.|.:.|..||:..:     .:|.|.:     .|.......:|::.|
Human  3172 FQGIAKACEQNLQKTLRFGGRLELPSSIELRAMLAGRSSKRQLFL-----LPGGLERHLKIKTCT 3231

  Fly  1846 RGAELIADIAQRLELKSPVG---YSIFLKT--GDRVYAMPEEEFVFDFITQLIYWLRQQRTIRSI 1905
            ...:::.:|...:.|..|..   |.||:.|  |..|..:....::.|..:::     :|      
Human  3232 VALDVVEEICAEMALTRPEAFNEYVIFVVTNRGQHVCPLSRRAYILDVASEM-----EQ------ 3285

  Fly  1906 SDGQYQLHFMRKLWLNNHPGEDLNGDMI-FSYPQELHKYLKGYY-------PID--CEQASRLAI 1960
            .||.|.|.|.|.||  :.|.:..|...: ..|.|.|..||||.:       |.:  .:|.|:||.
Human  3286 VDGGYMLWFRRVLW--DQPLKFENELYVTMHYNQVLPDYLKGLFSSVPASRPSEQLLQQVSKLAS 3348

  Fly  1961 LVYSA-DHDVSLQRLPEV--LTRLIPEDLIPLQTVAEWRQQILPKVHRDH---LTEDHAKILFLQ 2019
            |.:.| ||..    ||.|  :...||..|......:.|..  |...||..   |:...|:..||.
Human  3349 LQHRAKDHFY----LPSVREVQEYIPAQLYRTTAGSTWLN--LVSQHRQQTQALSPHQARAQFLG 3407

  Fly  2020 ELSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEY-------SQLGIW 2077
            .||....|||:||.::..::.|:|...::|||..|.:.|...|.|::..:..       :|....
Human  3408 LLSALPMFGSSFFFIQSCSNIAVPAPCILAINHNGLNFLSTETHELMVKFPLKEIQSTRTQRPTA 3472

  Fly  2078 SSGKNHFHIRFGNMIGASKLLCSTTQGYKMDDLLASYVK-YFNEHE 2122
            :|...:..|..|::.....|.....||.::..::|.:|: ..:.||
Human  3473 NSSYPYVEIALGDVAAQRTLQLQLEQGLELCRVVAVHVENLLSAHE 3518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 312/702 (44%)
MYSc_Myo7 81..726 CDD:276832 297/669 (44%)
IQ 765..785 CDD:197470 8/19 (42%)
DUF4355 827..>887 CDD:290964 12/68 (18%)
MyTH4 1031..1239 CDD:295320 54/214 (25%)
B41 1248..1429 CDD:214604 52/483 (11%)
FERM_N 1248..>1288 CDD:286467 9/39 (23%)
FERM_B-lobe 1342..1429 CDD:271216 23/299 (8%)
PH-like 1454..1547 CDD:302622 18/101 (18%)
MyTH4 1674..1819 CDD:214535 48/175 (27%)
B41 1827..2032 CDD:214604 59/225 (26%)
FERM_N 1829..>1877 CDD:286467 11/52 (21%)
FERM_M 1936..2032 CDD:278785 35/110 (32%)
FERM_C2_MyoVII 2028..2121 CDD:270020 22/100 (22%)
MYO15AXP_016880204.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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