Protein Alignment Myo28B1 and Myo15a

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001414755.1
• Gene: Myo15a / 501699
• RGDID: 1561873
• Length: 3512
• Species: Rattus norvegicus
• Alignment Length: 2549
• Identity: 668/2549 - (26%)
• Similarity: 1028/2549 - (40%)
• Gaps: 764/2549 - (29%)

  Fly    66 QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLA 130
            ::.||||..|.||||.|:|.||:.|:.:.|||||.||:||::|||::..||...::|.|..::|.
  Rat  1210 EDGVEDMTQLEDLQETTVLTNLKTRFERNLIYTYIGSILVSVNPYRMFAIYGPEQVQQYSGRALG 1274

  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQ-QIIEA 194
            |.|||:|||::.||.::...|:||||:||||||:||||:|||:|:.|||::.:...::| :|:||
  Rat  1275 ENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLLLRCLAAMNQRRDVMQQIKILEA 1339

  Fly   195 NPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYC 259
            .|::|||||||||||||||||||::|| |...|.|.||...||||||||||||:::||||||||.
  Rat  1340 TPLLEAFGNAKTVRNDNSSRFGKFVEI-FLEGGVICGAITSQYLLEKSRIVFQAKNERNYHIFYE 1403

  Fly   260 MLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILS 324
            :||||....|:...|||  ...|:||.|||...:.|:.||.||..:.|||:||.|..|:..||..
  Rat  1404 LLAGLPAQLRQAFSLQE--AETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFTSEDQDSIFR 1466

  Fly   325 LLAAILHLGNLRF-----TATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGE 384
            :||:||||||:.|     .|.|||::.:|.     .:|.||:||.:....|..|:|.:......|
  Rat  1467 ILASILHLGNVYFEKHETDAQEVASVVSAR-----EIQAVAELLQVSPEGLQKAITFKVTETIRE 1526

  Fly   385 HVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSF 449
            .:.|.|:.|:|::.|||..|.||..:|..::.|:|..::.:  |...||.:|||:|||:...|||
  Rat  1527 KIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSPK--QDTLSIAILDIYGFEDLSFNSF 1589

  Fly   450 EQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEES 514
            |||||||||||||..|...:|:.||:||..|.::|:.|.|.|||..::||.:||..::.::|::.
  Rat  1590 EQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADNQPCINLISLKPYGILRILDDQC 1654

  Fly   515 KFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRT 579
            .||:.||.|.|:|.|..||...:|.|.|..... |.|:||||.|.|....||:||.|....|:..
  Rat  1655 CFPQATDHTFLQKCHYHHGANPLYCKPKMPLPE-FTIKHYAGKVTYQVHKFLDKNHDQVRQDVLD 1718

  Fly   580 LVQRSTNKYLVDIF--------PHEMPMDTA----KKQPTLCVKFRNSLDMLMRTLSQAHPYFIR 632
            |...|..:.:..:|        |..:...::    .|..|:..||:.||..|:..:.:.:|.|:|
  Rat  1719 LFVHSRTRVVAHLFSSHAAQTAPPRLGKSSSITRLYKAHTVAAKFQQSLLDLVEKMERCNPLFVR 1783

  Fly   633 CIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLL------VPPVG 691
            |:|||..|||..|:.::.:.||||||::||.|||:.|:|:|..::.|::|||.|      ||..|
  Rat  1784 CLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVRLPFQVFIDRYRCLVALKLNVPADG 1848

  Fly   692 PLEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVL 756
            .:    |..|..::|.|.  .|..| .|.:||||::.....||..|.:::.::.:|:||.:|...
  Rat  1849 DM----CVSLLSRLCTVT--PDMYR-VGVSKLFLKEHLHQLLESMRERVLNRAALTLQRYLRGFF 1906

  Fly   757 FRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALS 821
            .:|..:..|:.||.:|...||.|.|::||.|||..                       :|.::|.
  Rat  1907 TQRRFRSLRQKIILLQSRARGFLARQRYQQMRQSL-----------------------LKFRSLV 1948

  Fly   822 RGYLVRKDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQ 886
            ..|:.|:.:.|...|||                                    |..||..|:|::
  Rat  1949 HTYVNRRRYLKLRAERR------------------------------------RRAQEAWLREQE 1977

  Fly   887 RLKAEAAARNALAMAAVQQKRRTKPVKQ-EAPK--APTLQARNSLPPP--PTTLIVAAPLPTRPA 946
            .|                .||...||:. |.|.  |..|||...|.|.  |...||.||.
  Rat  1978 EL----------------SKREVVPVRHLEVPAEVAGLLQAAAGLKPSSVPQVAIVRAPR----- 2021

  Fly   947 SAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTS 1011
                                           |..||              .:.||      :|.:
  Rat  2022 -------------------------------LQAEP--------------CVTLP------LDIN 2035

  Fly  1012 DFSYLKYAATYF---GGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSP 1073
            ::...|:...:|   ..|......:.||.:.|::|     ...:.:::..|||||||       |
  Rat  2036 NYPMAKFIRCHFKEPSFGMLTVPLKMPLTQMLVEH-----HAEAISVFKLILRFMGD-------P 2088

  Fly  1074 TLHVFDNENLMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLASGEKEAQEFYQHWLNVPTSHLEK 1138
            .||                                                       .|..:..
  Rat  2089 HLH-------------------------------------------------------GTQEMIL 2098

  Fly  1139 IHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQ 1203
            .::|:..|:::.:||||||||:..|::.||:..:..||||||:.|||.|.||...:..|..|:..
  Rat  2099 GNYIVHQGLVEPALRDEILAQLANQVWRNPNAYNAKRGWLLLAACLSGFAPSSHLDKFLLKFVSD 2163

  Fly  1204 -GTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAR 1267
             |....||....:.|:.......|..||:..|..||:.:..:.||:...:|.|....|...||..
  Rat  2164 YGQNGFQAVCQHRLLQAMGSGAARTFPPTQLEWTAIQEKASMALDVSCFNGDQFSCPVHPWSTGE 2228

  Fly  1268 EAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISECEQRQLDAP-WKLYI------ 1325
            .....:.:..||.|.:....|...||......||.::|||.:|:.|..: |.| .|.|.
  Rat  2229 AVAGDILKHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLR-DFPRQKSYFIVGAEG 2292

  Fly  1326 -------RKEMFATWYDPSMD----PKATQLIYK------------------------------- 1348
                   .:.:|...:|...|    |:....:.|
  Rat  2293 PLAGRGDTRGVFGNCWDSDEDTPTRPQPQDHVAKMPDFDGYCSHKEDGTNGETAAQRWASNRQAV 2357

  Fly  1349 ----------QILNG---------LKCGE----------YRCR---------SEK---------- 1365
                      :.|:|         |.||:          ||.:         ||.
  Rat  2358 DNTGEPAVPPRELDGYLDSLFDPVLACGDVDLEKPTAIAYRMKGGGQPGSSASEDTPRRLPEPKL 2422

  Fly  1366 ------DIAMVCALACFV----------------------------------------------- 1377
                  |.:.:.....|:
  Rat  2423 KPIPGLDASTLALQQAFIHRQAVLLAREMTLQALALQQQPLSATSRPQLPERPLPPEARPKTVGT 2487

  Fly  1378 -------------------------------------------------------------EYGP 1381
                                                                         |:.|
  Rat  2488 GPPAKPVLVRPTPQSLAPGSVAKSPKIPSKPVAAPILARDWTAPESISSSPELVRYSTLNSEHFP 2552

  Fly  1382 -----------------------------GEILRLKPS--------------------------E 1391
                                         |::.|..|.                          |
  Rat  2553 QPTQQIKSIIKQYKQPPWAGHPEARRTDGGKVFRRPPDPHEEALMILKGQKTQLAVVPGTQVSRE 2617

  Fly  1392 ITAFV-----------------PSDLLAPGERAIEN-----------------WSRLI--AATYE 1420
            ..|.|                 ||..|.|.|..::.                 |...:  ...|.
  Rat  2618 AVALVKPVTSAPRPCMGAAPVQPSRSLEPPEDPVQTQLHRLVNPNFYGYQDAPWRIFLRKEVFYP 2682

  Fly  1421 KSSYVKEEQNDLLL---------EAQKRAKED-----ICLFAHL--------------------- 1450
            |.:|....|.|||.         ||..|..||     ..|||..
  Rat  2683 KDNYSHPVQLDLLFRQILHDTLSEACLRISEDERLQMKALFAQNQLDTQRPLVTESVKRAAINMA 2747

  Fly  1451 --SWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETE---------QVLASCCFSEVLK 1504
              ||.:..||||..:...|..:|    :|.::..|:.|:...:         :||.:..|:::|.
  Rat  2748 RDSWEIYFSRLFPAMGSVGTGVQ----ILAVSHTGVKLLRMAKGNREASRRLRVLCAYSFADILF 2808

  Fly  1505 VHVESDDKLHV-MTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVALDPVVEGDLEDCLVL 1568
            |.:.|.:.|.. :|.:.|  :|..:.|:....:::..:..|::.|.|.||:...:..|.| .|..
  Rat  2809 VTMPSQNMLEFNLTNEKV--ILFSARARQVKTLVDTFILELKKDSDYVVAVRNFLSEDPE-LLSF 2870

  Fly  1569 NPGDLIE----------FEAG-------VTGAQLMAGNAQDCYR-GCVNGQWGQFLAGNVRVLAT 1615
            :.||:|.          :.||       |...:|........:| |.|:|:.|:|
  Rat  2871 HKGDIIHLQSLEPPRIGYSAGCVVRKKLVYLEELRRRGPDFGWRFGAVHGRVGRF---------- 2925

  Fly  1616 LTKPSEKLQDILREGRFQEPPKP---------------TPRANYSRRRQ---------------- 1649
               |||.:|........|.|.:|               .......|||:
  Rat  2926 ---PSELVQPAAAPDFLQLPAEPGRGRAAAVAAAVASAAAAREVGRRREGPPVRARSADSGEDSV 2987

  Fly  1650 ----HNISQLAESHFREP---------LDSDKAPLSKFSPEPL---KAPLLKAVVKVPP--LFQQ 1696
                ..:.:.|:.:||:|         |.|.:...||...:.|   |.|:.::::::..  |.:.
  Rat  2988 ALPPSTMLEFAQKYFRDPRRRPRDGLKLKSKEDRESKTLEDMLCFTKVPIQESLIELSDSNLNKM 3052

  Fly  1697 ALVMHHHILKYMGDI---ARSNLPVNTDLIFQPALQHPLLCDELYCQLMKQLSDNPSSESE--KR 1756
            |:.|...::::|||.   .::.|.|...|: :....|.::.||.|||::||::||.||:.:  :|
  Rat  3053 AVDMFVAVMRFMGDAPLKGQNELDVLCTLL-KFCGDHEVMRDECYCQIVKQITDNTSSKQDSCQR 3116

  Fly  1757 GWDLLYLATGLVAPSVLVMRELIILLR-------MRADALADACLKRLKRSLAQGQRKKAPHLIE 1814
            ||.|||:.....:.|.:....||..|:       :....:|.||.:.|:::|..|.|.:.|..:|
  Rat  3117 GWRLLYILAAYYSCSEVFYPYLIRFLQHVSWTPGLPFQGIAKACEQNLQKTLRFGGRLEFPSSME 3181

  Fly  1815 VEGI-----QQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSPVG---YSIFLK 1871
            :..:     .:|.|.:     .|.......:|::.|...::|..:...:.|..|..   |.||:.
  Rat  3182 LRAMLAGRSSKRQLFL-----LPGGLERHLKIKTCTVALDVIEGLCSEMALTRPEAFDEYVIFVV 3241

  Fly  1872 T--GDRVYAMPEEEFVFDFITQLIYWLRQQRTIRSISDGQYQLHFMRKLWLNNHPGEDLNGDMI- 1933
            |  |..|..:..:.::.|..:.:     :|      .||.|.|.|.|.||  :.|.:..|...:
  Rat  3242 TNRGQHVCPLSCQAYILDVASGM-----EQ------VDGGYTLWFRRVLW--DQPLKFENELYVT 3293

  Fly  1934 FSYPQELHKYLKGYY-------PID--CEQASRLAILVYSA-DHDVSLQRLPEV--LTRLIPEDL 1986
            ..|.|.|..||||.:       |.:  .:|.|:||.|.:.| ||..    ||.|  :...||..|
  Rat  3294 MHYNQVLPDYLKGLFSSVPASQPTEQQLQQVSKLASLQHRAKDHFY----LPSVREVQEYIPAQL 3354

  Fly  1987 IP-------LQTVAEWRQQILPKVHRDHLTEDHAKILFLQELSHFACFGSTFFVVKQQNDDALPE 2044
            ..       |..|::.|||      ...|:...|:..||..||.|..|||:||.::..::..:|.
  Rat  3355 YHTTAGDTWLNLVSQHRQQ------TQALSPHQARAQFLGLLSAFPLFGSSFFFIQSCSNVLVPA 3413

  Fly  2045 TLLIAINSTGFHMLDPTTKEILRSYEYSQL-GIW------SSGKNHFHIRFGNMIGASKLLCSTT 2102
            ..::|:|..|.:.|...|.|::......:: ..|      :|...:..|..|::.....:.....
  Rat  3414 PCILAVNHNGLNFLSTKTHELIVKIPLKEIQSTWTQQPTANSSYPYVEISLGDVAAQRTMQLQLE 3478

  Fly  2103 QGYKMDDLLASYVK 2116
            ||.::..::|.:|:
  Rat  3479 QGLELCRVVAVHVE 3492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	292/668 (44%)
		IQ	765..785	CDD:197470	8/19 (42%)
		Atrophin-1	<820..>946	CDD:460830	30/130 (23%)
		MyTH4	1031..1239	CDD:470587	51/208 (25%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	25/104 (24%)
		B41	1248..1429	CDD:214604	55/482 (11%)
		PH-like	1454..1547	CDD:473070	21/102 (21%)
		MyTH4	1674..1819	CDD:214535	43/166 (26%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	20/98 (20%)
		B41	1827..2032	CDD:214604	61/229 (27%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	19/96 (20%)
Myo15a	NP_001414755.1	None