Protein Alignment Myo28B1 and myo6

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_031758531.1
• Gene: myo6 / 493193
• XenbaseID: XB-GENE-1012303
• Length: 1300
• Species: Xenopus tropicalis
• Alignment Length: 1180
• Identity: 353/1180 - (29%)
• Similarity: 543/1180 - (46%)
• Gaps: 243/1180 - (20%)

  Fly     1 MDAG---YSP------RKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGD 56
            ||.|   ::|      :.|:.|.:.|.:.|.|   |.               :.:.|.|..|...
 Frog     1 MDDGKPVWAPHPTDGFQLGKIVDIGPDSLTIE---PL---------------NQKGKTFLAPINQ 47

  Fly    57 VLKAMHITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILP-IYTNRE 120
            |..|...||:. |||..:|..|.|.|:|.|:|.||:|..||||..::|:|:|||..:| :||:.:
 Frog    48 VFPAEEDTSKH-VEDNCSLMYLNEATLLHNIQVRYSKDKIYTYVANILIAVNPYFDVPKLYTSEQ 111

  Fly   121 IQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHS 185
            |:.|..|||..||||::||:|.||:.::.||.:|.:::||||||||||:||.:|:||....|...
 Frog   112 IKQYHGKSLGTLPPHVYAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGSGQ 176

  Fly   186 WIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRD 250
            .|:::|:||||::|||||||||||:|||||||::||.|..:.::.|..:..||||||||..|.:|
 Frog   177 DIDERIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNSVVGGFVSHYLLEKSRICVQGQD 241

  Fly   251 ERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQG--------------------------- 288
            ||||||||.:.||.....|::|.|  .||..:.||.:|
 Frog   242 ERNYHIFYRLCAGAPEDIRQKLFL--CSPDTFRYLNRGCTRYFASKDTDKQILQNRKSPEEDEYL 304

  Fly   289 --GCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRF-TATEVANLATAEI 350
              |....|...|..||..:..|||.:.....|...:..::|.:|||||:.| .|...:...|...
 Frog   305 KHGALKDPLLDDHGDFNRMCIAMKKIGLDDTEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCTLRK 369

  Fly   351 DDTPNLQRVAQLLGIPISALNAALTQRTIF-----VHGEHVTTSLSKEAAIEGRDAFVKSLYDGI 410
            ..:.:||..|:|||:....|..:||.|.:.     ..|..:...|..:.|...|||..|::|..:
 Frog   370 KSSESLQCCAKLLGLDQDDLQVSLTSRVMLTTAGGTKGTVIKVPLKVQQAENARDALAKAIYSHL 434

  Fly   411 FVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQD 475
            |..:|.|:|:..  ..::....||||||.|||.|::|||||.||||.||.|||||...|.|.||:
 Frog   435 FDHVVNRVNQCF--PFERSSFFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQE 497

  Fly   476 EYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNR----- 535
            .||.|.:....:.:.|||..:|||..|.:.::.::|||::.|:.|||.....:|.:|.|.
 Frog   498 LYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPTDQHFTSAVHQKHKNHFRLTI 562

  Fly   536 ----SIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFP-- 594
                .:.|.........|.:||:||.|.|....|:|||.|:....|.:|:..|.:|::.::|.
 Frog   563 PRKSKLAVHRNIRDDEGFIVRHFAGAVCYETTQFVEKNNDALHMSLESLICESKDKFVRELFESA 627

  Fly   595 --HEMPMDTAKKQPTLCV-----KFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVR 652
              |:   |..:|...|..     ||:..|::|:..|......||||||||.......|:....:.
 Frog   628 NNHK---DLKQKTGKLSFISVGNKFKTQLNLLLEKLRSTGSSFIRCIKPNLKMTSHQFEGAQILS 689

  Fly   653 QLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICEVALPADSDRQ 717
            ||:.|||:....:.:.|:|.|.::......|:..:|  ..:.:.|.|...:.:.:.....::|.:
 Frog   690 QLQCSGMVSVLDLMQGGFPSRASFHELYNMYKKYMP--AKMSRLDPRLFCKALFKALGLNENDYK 752

  Fly   718 YGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRV----LFRRYMK---------------R 763
            :|.||:|.|....|..:    |:|......:...||||    :..|:.|               :
 Frog   753 FGLTKVFFRPGKFAEFD----QIMKSDPDHLAELIRRVNHWLICSRWKKVQWCALCVIKLKNKIQ 813

  Fly   764 YR-EAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIK---------LQ 818
            || .|.|.:|:..|..|.|:|::....|                  ||:.:|:|         :.
 Frog   814 YRASACIKMQKTIRMWLCRKKHKPRIDG------------------MVKVQTLKKRLDKFNEVVN 860

  Fly   819 ALSRG-------------------------YLVRKDFQKKL-------------LERRKQNQLKK 845
            ||..|                         .:.|:..:::.             |::||:.:.:.
 Frog   861 ALKEGKAEMSKQVKDLELSIDALLSKIKNTIMTREQIEREYDNLVKSSGQLLNSLQKRKKEEEEA 925

  Fly   846 EELLKL-------AKMKEAEELLRLQQ-----LK---------EQKEREQREQQEKRLQEEQRLK 889
            |.|.|:       .|.:||||.||.::     ||         |::||::||::|||:|.|..::
 Frog   926 ERLHKIQEEMERERKRREAEEELRRKEENERRLKAEIEAKRKQEEEERKKREEEEKRIQAEVEMQ 990

  Fly   890 -AEAAARNALAMAAVQQKRRTKPVKQEAPKA---------PTLQARNSLPPPPTTLIVAAPLPTR 944
             |......:...|.::|:||.:.:.....::         |....|:.      |:.|..|.|..
 Frog   991 LARDREEESQQQAILEQERRDRELAMRIAQSEAELINEDGPDSALRSD------TVGVLQPSPVN 1049

  Fly   945 PASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNID 1009
            ..:...|.....|       |.:|:|.|                  .:|.|..::..||.. ::.
 Frog  1050 YKAGEDRTKLTME-------EMAKEMTD------------------ILSRGGQVQATKSAA-SVK 1088

  Fly  1010 TSDFSYLKYA 1019
            ..|.|..|||
 Frog  1089 KHDLSKWKYA 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	251/698 (36%)
		IQ	765..785	CDD:197470	8/20 (40%)
		Atrophin-1	<820..>946	CDD:460830	39/194 (20%)
		MyTH4	1031..1239	CDD:470587
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
myo6	XP_031758531.1	Myosin_N	2..40	CDD:460670	9/55 (16%)
		MYSc_Myo6	71..761	CDD:276833	251/698 (36%)
		CBD_MYO6-like	772..916	CDD:409646	25/161 (16%)
		MYO6_MIU_linker	1001..1074	CDD:412090	16/103 (16%)
		MyUb_Myo6	1088..1128	CDD:439319	5/11 (45%)
		Myosin-VI_CBD	1183..1273	CDD:465157