DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo28B1 and MYO10

DIOPT Version :9

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:NP_036466.2 Gene:MYO10 / 4651 HGNCID:7593 Length:2058 Species:Homo sapiens


Alignment Length:2316 Identity:611/2316 - (26%)
Similarity:991/2316 - (42%) Gaps:494/2316 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KGEYVWVKPQ--------NTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITS 65
            :|..||::..        |:.:|     |..:.||:..|...    .||..:....| .|||.|:
Human     7 EGTRVWLRENGQHFPSTVNSCAE-----GIVVFRTDYGQVFT----YKQSTITHQKV-TAMHPTN 61

  Fly    66 QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQ-ILPIYTNREIQLYRNKSL 129
            :|.|:||.:|.:|...:|:.||..||.:..||||.||:|.::|||| |..:|....::.|..:.|
Human    62 EEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAGLYEPATMEQYSRRHL 126

  Fly   130 AELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAIS---------GKHS 185
            .|||||||||::..::.|.:..:|||::|||||||||||||||||::|:.||         .|.|
Human   127 GELPPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLILKFLSVISQQSLELSLKEKTS 191

  Fly   186 WIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRD 250
            .:|:.|:|::||||||||||||.|:|||||||::::....:|.|||.||..|||||:|:|.|:..
Human   192 CVERAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPG 256

  Fly   251 ERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFK 315
            ||||||||.:||||...|||...|  .:|..||||.|.||.......|.:.|.::..||.|:.|.
Human   257 ERNYHIFYALLAGLEHEEREEFYL--STPENYHYLNQSGCVEDKTISDQESFREVITAMDVMQFS 319

  Fly   316 PEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIF 380
            .|||..:..|||.||||||:.|...     ..|::.....|.|.|:|||:..:.|..|||||::|
Human   320 KEEVREVSRLLAGILHLGNIEFITA-----GGAQVSFKTALGRSAELLGLDPTQLTDALTQRSMF 379

  Fly   381 VHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFD 445
            :.||.:.|.|:.:.|::.||:...:||...|..::::||..|....|  ..|||:|||||||||:
Human   380 LRGEEILTPLNVQQAVDSRDSLAMALYACCFEWVIKKINSRIKGNED--FKSIGILDIFGFENFE 442

  Fly   446 NNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLI 510
            .|.|||..||||||.||::|..|||.:||.||..|.:.|:.|::.||.:.|||| .|.:.|::||
Human   443 VNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLI-EKKLGLLALI 506

  Fly   511 DEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSG 575
            :|||.||:.||.|||||||.||.|...|||.:....: ||::||||.|.|:..|.||||||:|..
Human   507 NEESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNN-FGVKHYAGEVQYDVRGILEKNRDTFRD 570

  Fly   576 DLRTLVQRSTNKYLVDIFPH---EMPMDTAK-----KQPTLCVKFRNSLDMLMRTLSQAHPYFIR 632
            ||..|::.|...::.|:|.|   ....||.|     ::||:..:|::||..||.|||.::|:|:|
Human   571 DLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRRPTVSSQFKDSLHSLMATLSSSNPFFVR 635

  Fly   633 CIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCD 697
            |||||..|.|..||:.:.:.|||||||:||.|||:|||.:|..::.|.:||::|:..:...|  |
Human   636 CIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPE--D 698

  Fly   698 CRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMK 762
            .|.....:.::...::|:.|.||||:|||:..:..||.:|.:.:..:.:.|:..:...|.|:..:
Human   699 VRGKCTSLLQLYDASNSEWQLGKTKVFLRESLEQKLEKRREEEVSHAAMVIRAHVLGFLARKQYR 763

  Fly   763 RYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVR 827
            :....::.:|:.:|..|.||::..:::     .|.:..:||                  ||.:.|
Human   764 KVLYCVVIIQKNYRAFLLRRRFLHLKK-----AAIVFQKQL------------------RGQIAR 805

  Fly   828 KDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLKA-E 891
            :.:::.|.|:|:|.:.||:|..:..|.:|.|.    ::.:|::|.|.|.|||:..:::|.|:| :
Human   806 RVYRQLLAEKREQEEKKKQEEEEKKKREEEER----ERERERREAELRAQQEEETRKQQELEALQ 866

  Fly   892 AAARNALAMAAVQQKRRTKPVKQ------EAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVT 950
            .:.:.|.....:::::..|.|::      |......::.:..|.....:|   ..|..|....:.
Human   867 KSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASL---QKLQERRDQELR 928

  Fly   951 RINTIPESPGTIDVESSKQMVDDVFRFLN-DEPDAALRKLN---NISSGDTIRLPKSVPNNIDTS 1011
            |:.           |.:.:...:....|| ||.|..:|.:.   ::.|..:..|.:|........
Human   929 RLE-----------EEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEFSSELAESACEEKPNF 982

  Fly  1012 DFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGD-------LPDV 1069
            :||. .|.......|..|..:  ..|.|....||...:..:..|     |...|       :.|.
Human   983 NFSQ-PYPEEEVDEGFEADDD--AFKDSPNPSEHGHSDQRTSGI-----RTSDDSSEEDPYMNDT 1039

  Fly  1070 VSSPTLHVFDNENLMS----DLASLLNTSDSYKPRLFVRQSQRRIPKP---------------LA 1115
            | .||....|:..|::    |..||.|:| |.:....:.|:...:|.|               :.
Human  1040 V-VPTSPSADSTVLLAPSVQDSGSLHNSS-SGESTYCMPQNAGDLPSPDGDYDYDQDDYEDGAIT 1102

  Fly  1116 SGEKE--AQEFYQHW-----LNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSY 1173
            ||...  :..:...|     .:|.|.:....:.....| .::|..|.  .:.....:......||
Human  1103 SGSSVTFSNSYGSQWSPDYRCSVGTYNSSGAYRFSSEG-AQSSFEDS--EEDFDSRFDTDDELSY 1164

  Fly  1174 SRGWLLLSLCLSCFPPSKEFEPHLRSF--MKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELH 1236
            .|..:...:.|          |:..||  ||.|                                
Human  1165 RRDSVYSCVTL----------PYFHSFLYMKGG-------------------------------- 1187

  Fly  1237 AIRGRHPLRLDIHLMDGQQRRLQVDAAST------AREAVNQLCQGMGLTDTFGFGLVMSLNGKL 1295
                         ||:..:||..|....|      .:||:.|                    |.|
Human  1188 -------------LMNSWKRRWCVLKDETFLWFRSKQEALKQ--------------------GWL 1219

  Fly  1296 MPLGAGQEHVLDAISECEQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYR 1360
            ...|.|.       |...:|.....|  ::.::....:::...:.|            || |...
Human  1220 HKKGGGS-------STLSRRNWKKRW--FVLRQSKLMYFENDSEEK------------LK-GTVE 1262

  Fly  1361 CRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYV 1425
            .|:.|:|.....    .|.|...|:..:...:.|..|.|        ...|..:::..:..:...
Human  1263 VRTAKEIIDNTT----KENGIDIIMADRTFHLIAESPED--------ASQWFSVLSQVHASTDQE 1315

  Fly  1426 KEEQNDLLLEAQKRAK-------EDICLFAHLSWPMRHSRLFEVV--------RKEGPKLQSDEL 1475
            .:|.:|.....|....       :.:|.......|    ..|.::        ..:.|:.....:
Human  1316 IQEMHDEQANPQNAVGTLDVGLIDSVCASDSPDRP----NSFVIITANRVLHCNADTPEEMHHWI 1376

  Fly  1476 MLGINSAGLFLIDETEQVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYM 1540
            .|...|.|...::..|.::......|     |::..|:..:..:...|||..:|           
Human  1377 TLLQRSKGDTRVEGQEFIVRGWLHKE-----VKNSPKMSSLKLKKRWFVLTHNS----------- 1425

  Fly  1541 LDNLRQRSSYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQF 1605
            ||..:......:.|..:|...|  |.|:.|.:.|..|.|.....:.  ..:.|||          
Human  1426 LDYYKSSEKNALKLGTLVLNSL--CSVVPPDEKIFKETGYWNVTVY--GRKHCYR---------- 1476

  Fly  1606 LAGNVRVLATLTKPSEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSD--- 1667
              ...::|...|:.|..:|::..    .:.|..||           ..||.:......|:||   
Human  1477 --LYTKLLNEATRWSSAIQNVTD----TKAPIDTP-----------TQQLIQDIKENCLNSDVVE 1524

  Fly  1668 ----KAPLSKFSPEPLKAPLL---------------------KAVVKVPPLFQQALVMHHHILKY 1707
                :.|:.:::..||.:|||                     ...:|:....||        |:.
Human  1525 QIYKRNPILRYTHHPLHSPLLPLPYGDINLNLLKDKGYTTLQDEAIKIFNSLQQ--------LES 1581

  Fly  1708 MGDIARSNLPVNTDLIFQPALQ--HPL--LCDELYCQLMKQLS--DNPSSESEKRGWDLLYLATG 1766
            |.|      |:.   |.|..||  |.|  |.|||||||:||.:  .:|.|......|.:|...:.
Human  1582 MSD------PIP---IIQGILQTGHDLRPLRDELYCQLIKQTNKVPHPGSVGNLYSWQILTCLSC 1637

  Fly  1767 LVAPSVLVMRELIILLRMRADALADACLKRLKRSLAQGQRKKAPHLIEVEGIQQ-RCLHIYHKIY 1830
            ...||    |.::..|:..        |||::......:.:|.. |...|.::: :|     :.:
Human  1638 TFLPS----RGILKYLKFH--------LKRIREQFPGSEMEKYA-LFTYESLKKTKC-----REF 1684

  Fly  1831 FPD-DTVEA--------------------FEIESHTRGAELIADIAQRLELK-SPVGYSIFLKTG 1873
            .|. |.:||                    ..|.|||...|::..:.:.|.:: |...:::|...|
Human  1685 VPSRDEIEALIHRQEMTSTVYCHGGGSCKITINSHTTAGEVVEKLIRGLAMEDSRNMFALFEYNG 1749

  Fly  1874 DRVYAMPEEEFVFDFITQLIYWLRQQRTIRSISDGQYQLHFMRKLWL--NNHPGEDLNGDMIFSY 1936
            ....|:.....|.|.:.:    ..:......:.|..::.:|....:|  :|.|.:.:  :..|.:
Human  1750 HVDKAIESRTVVADVLAK----FEKLAATSEVGDLPWKFYFKLYCFLDTDNVPKDSV--EFAFMF 1808

  Fly  1937 PQELHKYLKGYYPIDCEQASRLAIL----------VYSA----DHDVSLQRLP------------ 1975
            .|.....:.|::|...|....||.|          :::|    :...|||||.            
Human  1809 EQAHEAVIHGHHPAPEENLQVLAALRLQYLQGDYTLHAAIPPLEEVYSLQRLKARISQSTKTFTP 1873

  Fly  1976 -----------------------EVLTRLIPE----DLIPLQTVAEWRQQILPKVHR-DHLTEDH 2012
                                   .|:.:.:.|    |:...:.|:..|..|:.|..: ..:.::.
Human  1874 CERLEKRRTSFLEGTLRRSFRTGSVVRQKVEEEQMLDMWIKEEVSSARASIIDKWRKFQGMNQEQ 1938

  Fly  2013 AKILFLQELSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQLGIW 2077
            |...::..:..:..:|||.|.| :..:...|:.|.:.:::....:........|..::|..  |.
Human  1939 AMAKYMALIKEWPGYGSTLFDV-ECKEGGFPQELWLGVSADAVSVYKRGEGRPLEVFQYEH--IL 2000

  Fly  2078 SSG---KNHFHIRFGNMIGASKLLCSTTQGYKMDDLLASYV 2115
            |.|   .|.:.|    ::...:||..|::...:..|:.:|:
Human  2001 SFGAPLANTYKI----VVDERELLFETSEVVDVAKLMKAYI 2037

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 318/692 (46%)
MYSc_Myo7 81..726 CDD:276832 306/662 (46%)
IQ 765..785 CDD:197470 5/19 (26%)
DUF4355 827..>887 CDD:290964 18/59 (31%)
MyTH4 1031..1239 CDD:295320 40/242 (17%)
B41 1248..1429 CDD:214604 30/186 (16%)
FERM_N 1248..>1288 CDD:286467 9/45 (20%)
FERM_B-lobe 1342..1429 CDD:271216 13/86 (15%)
PH-like 1454..1547 CDD:302622 15/100 (15%)
MyTH4 1674..1819 CDD:214535 42/171 (25%)
B41 1827..2032 CDD:214604 46/282 (16%)
FERM_N 1829..>1877 CDD:286467 13/69 (19%)
FERM_M 1936..2032 CDD:278785 24/149 (16%)
FERM_C2_MyoVII 2028..2121 CDD:270020 19/91 (21%)
MYO10NP_036466.2 MYSc 58..739 CDD:214580 318/693 (46%)
MYSc_Myo10 77..727 CDD:276840 306/662 (46%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 619..641 13/21 (62%)
SAH. /evidence=ECO:0000250|UniProtKB:F8VQB6, ECO:0000250|UniProtKB:P79114 815..908 22/96 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..840 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..866 8/18 (44%)
Mediates antiparallel dimerization. /evidence=ECO:0000269|PubMed:23012428 883..933 8/63 (13%)
MYO10_CC 883..933 CDD:293340 8/63 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1090 30/135 (22%)
PH-like 1181..>1223 CDD:302622 15/106 (14%)
PH2_MyoX 1215..1316 CDD:270108 22/154 (14%)
PH 1215..1308 CDD:278594 22/146 (15%)
PH3_MyoX-like 1381..1506 CDD:270109 31/171 (18%)
PH 1396..1495 CDD:278594 25/130 (19%)
MyTH4 1549..1695 CDD:214535 42/180 (23%)
B41 1704..1958 CDD:214604 42/259 (16%)
UBQ 1705..>1753 CDD:294102 9/47 (19%)
FERM_M 1796..1958 CDD:278785 27/163 (17%)
FERM_C_MyoX 1954..2042 CDD:270023 19/91 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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