DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo28B1 and MYO9B

DIOPT Version :9

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:NP_004136.2 Gene:MYO9B / 4650 HGNCID:7609 Length:2157 Species:Homo sapiens


Alignment Length:2298 Identity:553/2298 - (24%)
Similarity:854/2298 - (37%) Gaps:816/2298 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 WVKPQNTTSEFAVPFGARIVRTEKTQT----LVCDDRNKQFWVPAGDVLKAMHI----------- 63
            ||...|.:....|....|..:.|..|.    .:..:||      |...:|.:|:           
Human    76 WVLDANDSPVHRVLLWPRRAQDEHPQEDGYYFLLQERN------ADGTIKYVHMQLVAQATATRR 134

  Fly    64 --------TSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNRE 120
                    ..|.|.:|:..|.:|.|..:|:||::|:.:|.||||.||:||||||::.||||..:.
Human   135 LVERGLLPRQQADFDDLCNLPELTEGNLLKNLKHRFLQQKIYTYAGSILVAINPFKFLPIYNPKY 199

  Fly   121 IQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAIS--GK 183
            :::|.|:.|.:|.||:||::|.|:..:.|.:.|||:|||||||:|||:||..::..|.|:|  |.
Human   200 VKMYENQQLGKLEPHVFALADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGY 264

  Fly   184 HSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQS 248
            .|.:|:.|:.|.|::||||||||..|:|||||||:|::.:...|.::||.:::|||||||:|.|.
Human   265 ASGVERTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVSYLESGIVRGAVVEKYLLEKSRLVSQE 329

  Fly   249 RDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLS 313
            :||||||:||.:|.|:|..||:..:|::  |..|.||.|.......|.....||..::.||:::.
Human   330 KDERNYHVFYYLLLGVSEEERQEFQLKQ--PEDYFYLNQHNLKIEDGEDLKHDFERLKQAMEMVG 392

  Fly   314 FKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRT 378
            |.|.....|.::|:|||:|||:.:...........|:.....|..::|||.:....|...||:|.
Human   393 FLPATKKQIFAVLSAILYLGNVTYKKRATGREEGLEVGPPEVLDTLSQLLKVKREILVEVLTKRK 457

  Fly   379 IFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETI--NKQVDQPMN--SIGVLDIF 439
            .....:.:....|...||..||:..||||..:|..||.|||..:  .|.|::.::  ||||||||
Human   458 TVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDVEEAVSCLSIGVLDIF 522

  Fly   440 GFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPM 504
            |||:|:.|||||.|||||||.||.:|..||||:||:|||.|.|.|.:|.:.||...:.||..||.
Human   523 GFEDFERNSFEQFCINYANEQLQYYFNQHIFKLEQEEYQGEGITWHNIGYTDNVGCIHLISKKPT 587

  Fly   505 NLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKN 569
            .|..|:||||.||..|.||||.|...||.:.. |..|.......|.|:|:||.|.|....|.|||
Human   588 GLFYLLDEESNFPHATSQTLLAKFKQQHEDNK-YFLGTPVMEPAFIIQHFAGKVKYQIKDFREKN 651

  Fly   570 RDSFSGDLRTLVQRSTNKYL--------VDIF--------------------------------- 593
            .|....|:..|::.|.:.|:        |.:|                                 
Human   652 MDYMRPDIVALLRGSDSSYVRELIGMDPVAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAAGMS 716

  Fly   594 -------PHEMP----------------------------------------------------- 598
                   |.|:|                                                     
Human   717 SPGAQSHPEELPRGASTPSEKLYRDLHNQMIKSIKGLPWQGEDPRSLLQSLSRLQKPRAFILKSK 781

  Fly   599 ------------------------------------MDTAKKQPTLCVKFRNSLDMLMRTLSQAH 627
                                                :...||.|::..:|:.||:.|:..|.:|.
Human   782 GIKQKQIIPKNLLDSKSLKLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAE 846

  Fly   628 PYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGP 692
            |:|||||:.|..|:...||.||.::||||:||:||.||||:||..::.::.|.|::::|:|.   
Human   847 PFFIRCIRSNAEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLPK--- 908

  Fly   693 LEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLF 757
             :...||::...:.|.......:.|.||||:||::.:..:|:....:.:::.|:.:|...|.||.
Human   909 -DAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLE 972

  Fly   758 RRY---MKR-----------YR--------EAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAA 800
            ||:   |||           ||        :|.:.:|..|||..||:.|:..:|..         
Human   973 RRHFLQMKRAAVTIQACWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSI--------- 1028

  Fly   801 QQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQNQLKKEELLKLAKM----------- 854
                          |:||:|.||:|.||.|.:.:.|::|..: |:.|.|:.|:.           
Human  1029 --------------IRLQSLCRGHLQRKSFSQMISEKQKAEE-KEREALEAARAGAEEGGQGQAA 1078

  Fly   855 ---------------------------------------KEA---EELLRLQQL-------KEQK 870
                                                   |||   |:.|..|:.       |...
Human  1079 GGQQVAEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPS 1143

  Fly   871 EREQREQQEKRLQEE--------QRLKAEAAAR-------NALAMAAVQQKRRTKP------VKQ 914
            .||:||.:.:|..|.        |..|.|:|.|       ....::.::.|:.::.      |:.
Human  1144 SREKRESRRQRGLEHVKFQNKHIQSCKEESALREPSRRVTQEQGVSLLEDKKESREDETLLVVET 1208

  Fly   915 EA----PKAPTLQAR----------------NSLPPP-----PTTLI----VAAPLP-------- 942
            ||    .|.||.|.:                :..|.|     ||:|.    |:.|.|        
Human  1209 EAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDSRVSPPAPGSAPETPE 1273

  Fly   943 --TRPASAVTRINTIPESPG----------------TIDVESSKQMV------------------ 971
              ::|..: .|:...|:|||                .:::...|::|                  
Human  1274 DKSKPCGS-PRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVAAASPSAMLSQSLDLSDR 1337

  Fly   972 --------------------DDVFRFL--------------------------------NDEPDA 984
                                .||.:.|                                :..|||
Human  1338 HRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETTDGERSAKKPAVQKKKPGDASSLPDA 1402

  Fly   985 AL------------------------------RKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYA 1019
            .|                              .:|.|..||..:....::...::.......::|
Human  1403 GLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEELENAVSGHVVLEATTMKKGLEAPSGQQHRHA 1467

  Fly  1020 A----TYFGGG--------------------------ATAQHERKPLKKSLL-------KHEHPI 1047
            |    |...||                          .|..:|.|.|.:.||       ..:.||
Human  1468 AGEKRTKEPGGKGKKNRNVKIGKITVSEKWRESVFRQITNANELKYLDEFLLNKINDLRSQKTPI 1532

  Fly  1048 DEMASKAIWLTILRFMGDLPDVVSSPT--LHV-----FDN-ENLMSDLA---------------- 1088
            :.:..:|    ..:|..::..:.|.|.  :||     .:| :.::|:||                
Human  1533 ESLFIEA----TEKFRSNIKTMYSVPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQ 1593

  Fly  1089 SLLN------TSDSYKPRLFVRQSQRRIPKPLASGEKEAQE-----FYQHWLNVPTSHLEKIHFI 1142
            |||:      |.:.::|   |:||:.:  |.....|:..||     |..:.:::|.|..:.:.:|
Human  1594 SLLDEFTRGYTKNDFEP---VKQSKAQ--KKKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYI 1653

  Fly  1143 IGHGIIKNSLRDE-ILAQICKQ------LYLNPSRSSYSRGWL--------LLSLCLSCFPPSKE 1192
                    .|.|: :|..:||.      ::...|..||:.|..        ...:|:......|.
Human  1654 --------WLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSDKA 1710

  Fly  1193 FEP--------HLRS--------FMKQGTAQ--------LQATPSLQRLERTLVNGPRCQPPSLF 1233
            ..|        |:..        :.|.|.|.        ||..|:..:||.             |
Human  1711 SVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLEN-------------F 1762

  Fly  1234 ELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFG-FGLVMSLNGKLMP 1297
            .:|||.|                        ..::.:.:|.:.:.....:| |...:.|..|...
Human  1763 PIHAITG------------------------VLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQ 1803

  Fly  1298 LGAGQEHVLDAISECEQRQLDAPWKLYIRKEMFATWYDPS-MDPKATQLIYKQILNGLKCGEYR- 1360
            |.|... ||:.:.|.....|:   :|.......|...|.: |.|.|..:|:...|  |:|.:.. 
Human  1804 LAAIYA-VLEHLPEANHNSLE---RLIFHLVKVALLEDVNRMSPGALAIIFAPCL--LRCPDNSD 1862

  Fly  1361 -CRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSY 1424
             ..|.||:.                      :||..|        |..|:...|......|:.| 
Human  1863 PLTSMKDVL----------------------KITTCV--------EMLIKEQMRKYKVKMEEIS- 1896

  Fly  1425 VKEEQNDLLLEAQKRAKEDICLFAHLS-------WPMR--HSRLFEVVRKEGPK---LQSDEL-- 1475
                        |..|.|.|. |..||       ||::  .|..:|.|..:.||   :|.:||  
Human  1897 ------------QLEAAESIA-FRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEV 1948

  Fly  1476 MLGINSAGLFLIDETEQVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYM 1540
            :|...:||   .||..:       .|:|                    :.:..|.::..|.|.|.
Human  1949 LLEEEAAG---GDEDRE-------KEIL--------------------IERIQSIKEEKEDITYR 1983

  Fly  1541 LDNLRQRSSYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQF 1605
            |..|..|.|....||.......|        .|:|..||               ||...|     
Human  1984 LPELDPRGSDEENLDSETSASTE--------SLLEERAG---------------RGASEG----- 2020

  Fly  1606 LAGNVRVLATLTKPSEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKAP 1670
                        .|:..|..         |..|||                     .||.:..||
Human  2021 ------------PPAPALPC---------PGAPTP---------------------SPLPTVAAP 2043

  Fly  1671 ----LSKFSPEPLKAP-----LLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLPVNTDLIFQP 1726
                .|.|....:|.|     :..|.:|:||      .:..|:.::......:..||...   :|
Human  2044 PRRRPSSFVTVRVKTPRRTPIMPTANIKLPP------GLPSHLPRWAPGAREAAAPVRRR---EP 2099

  Fly  1727 ALQHPLLCDELYCQLMKQLSDNP 1749
            ..:.|   |:::...:...:|.|
Human  2100 PARRP---DQIHSVYITPGADLP 2119

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 287/836 (34%)
MYSc_Myo7 81..726 CDD:276832 278/787 (35%)
IQ 765..785 CDD:197470 8/27 (30%)
DUF4355 827..>887 CDD:290964 22/127 (17%)
MyTH4 1031..1239 CDD:295320 57/288 (20%)
B41 1248..1429 CDD:214604 32/184 (17%)
FERM_N 1248..>1288 CDD:286467 3/40 (8%)
FERM_B-lobe 1342..1429 CDD:271216 16/88 (18%)
PH-like 1454..1547 CDD:302622 21/99 (21%)
MyTH4 1674..1819 CDD:214535 15/81 (19%)
B41 1827..2032 CDD:214604
FERM_N 1829..>1877 CDD:286467
FERM_M 1936..2032 CDD:278785
FERM_C2_MyoVII 2028..2121 CDD:270020
MYO9BNP_004136.2 Myosin_IXb_RA 7..112 CDD:176374 7/35 (20%)
MYSc 141..950 CDD:214580 286/815 (35%)
MYSc_Myo9 160..941 CDD:276836 278/787 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..734 3/24 (13%)
Actin-binding. /evidence=ECO:0000305 844..855 7/10 (70%)
Neck or regulatory domain. /evidence=ECO:0000305 940..1044 32/126 (25%)
IQ 978..999 CDD:197470 5/20 (25%)
IQ 1000..1022 CDD:197470 7/21 (33%)
Tail. /evidence=ECO:0000305 1045..2157 224/1293 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1298 46/253 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1320..1410 7/89 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1455..1484 5/28 (18%)
C1 1633..1681 CDD:237996 10/55 (18%)
RhoGAP_myosin_IXB 1698..1883 CDD:239872 46/257 (18%)
Interaction with RHOA. /evidence=ECO:0000269|PubMed:26529257 1739..1744 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1980..2157 42/222 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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