DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo28B1 and MYO9A

DIOPT Version :9

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:XP_011519915.1 Gene:MYO9A / 4649 HGNCID:7608 Length:2638 Species:Homo sapiens


Alignment Length:2570 Identity:598/2570 - (23%)
Similarity:957/2570 - (37%) Gaps:871/2570 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLA 130
            |:|.:|:.:|.||.|.|:|.||:||:..:.||||.||:|:.|||::.||||..:.:::|.|..|.
Human   145 QKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLG 209

  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAIS--GKHSWIEQQIIE 193
            :|.|||:|::|.|:..:.:.|:|||:|||||||:|||:||..::.:|.|:|  |..|.:||.|:.
Human   210 KLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILG 274

  Fly   194 ANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFY 258
            |.|::||||||||..|:|||||||:|::.:...|.:.||.:::|||||||:|:|..:|||||:||
Human   275 AGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFY 339

  Fly   259 CMLAGLSTAERERLKLQEQSPSQYHYL------------------AQGGCFTLPGRGDAKDFADI 305
            .:|||.|..||....|::  |.:||||                  ::..|||:.|.....||..:
Human   340 YLLAGASEDERSAFHLKQ--PEEYHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERL 402

  Fly   306 RAAMKVLSFKPEEVWSILSLLAAILHLGNL-------RFTATEVANLATAEIDDTPNLQRVAQLL 363
            :.||:::.|.|:....|.|||:|||||||:       |..:.::.|.....|        |::||
Human   403 QLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYRDDSIDICNPEVLPI--------VSELL 459

  Fly   364 GIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQ 428
            .:....|..||..|.....||.:........|:..|::..||||..:|..||.|||..:....|.
Human   460 EVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDL 524

  Fly   429 PMN----SIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF 489
            ..|    |||||||||||:::||||||.|||:|||.||.:|..||||:||:||:.|.|:|.:|::
Human   525 EHNTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDY 589

  Fly   490 QDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHY 554
            .||...::||..||..|:.|:||||.||:.|:||||:|...||.:.| |::........|.|:||
Human   590 IDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEDNS-YIEFPAVMEPAFIIKHY 653

  Fly   555 AGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKY---LVDIFP---------------------- 594
            ||.|.|....|.|||.|....|:..|::.|.|.:   ::.|.|                      
Human   654 AGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREA 718

  Fly   595 ----------HEMPMDTA----------------------------------------------- 602
                      |:   |||                                               
Human   719 GKRNIHRKTGHD---DTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSD 780

  Fly   603 ----------------------------------------------------------------- 602
                                                                             
Human   781 LQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNKN 845

  Fly   603 ---------------------------------------KKQPTLCVKFRNSLDMLMRTLSQAHP 628
                                                   ||.|::..:|:.||..||.||.||.|
Human   846 FKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEP 910

  Fly   629 YFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPL 693
            ||::||:.|..|.|..|...|.:|||||:||:||.|||::||..:::::.||..:.:|:|.....
Human   911 YFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPRNIIP 975

  Fly   694 EQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFR 758
            .:.:.:...|:|   .|..| :.|.|||.:||::::...|:....|.:|:.|:.:||..|.:|.|
Human   976 SKFNIQDFFRKI---NLNPD-NYQVGKTMVFLKEQERQHLQDLLHQEVLRRIILLQRWFRVLLCR 1036

  Fly   759 RYMKRYREAIITVQRY--------------------------------WRGRLQRRKYQVMRQGF 791
            ::....|:|.:.:||:                                ||..|:|::|..:|...
Human  1037 QHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAALLQASWRAHLERQRYLELRAAA 1101

  Fly   792 --------------HRLGACIAAQ----QLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKLLERR 838
                          |....||.|:    :.:.::...|.:.|.||:..||:..|:.|  |.|:.:
Human  1102 IVIQQKWRDYYRRRHMAAICIQARWKAYRESKRYQEQRKKIILLQSTCRGFRARQRF--KALKEQ 1164

  Fly   839 KQNQLKKE-----------------------------ELLKLAKMKEAEELLRLQQ------LKE 868
            :..:.|.|                             .:..:.:.|...|..|:.:      |||
Human  1165 RLRETKPEVGLVNIKGYGSLEIQGSDPSGWEDCSFDNRIKAIEECKSVIESNRISRESSVDCLKE 1229

  Fly   869 QKEREQREQQEKR---LQEEQRLKAEAAARNALAMAAV----QQKRRTKPVKQEAPKAPTLQARN 926
            ...::|...|.:.   |||:..::....:...|....|    ::.||.:.::|.......|:.| 
Human  1230 SPNKQQERAQSQSGVDLQEDVLVRERPRSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVR- 1293

  Fly   927 SLPPPPTTLIVAAPLPTRPASAVTRINTIPE---SP-GTIDVESS-------------KQMVDDV 974
                   :|...:|...|..|.    ..:||   || ||.|.|||             |..::.|
Human  1294 -------SLGGISPSEDRRWST----ELVPEGLQSPRGTPDSESSQGSLELLSYEESQKSKLESV 1347

  Fly   975 F-----------------RFLNDEPDAALRKLNNISSGDTIR--------------------LPK 1002
            .                 :|  |..|.||...|..||.:.::                    |..
Human  1348 ISDEGDLQFPSPKISSSPKF--DSRDNALSASNETSSAEHLKDGTMKEMVVCSSESITCKPQLKD 1410

  Fly  1003 S-VPNNIDTSDFSYLKYAATYFGGGATAQHERKPLK-----------KSLLKHEHPIDEMASKAI 1055
            | :.|::.|  |.|:.              ::.|||           ..||::|    :.|.:|:
Human  1411 SFISNSLPT--FFYIP--------------QQDPLKTNSQLDTSIQRNKLLENE----DTAGEAL 1455

  Fly  1056 WLTILR-----FMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLA 1115
            .|.|.|     .......:|  |:|:...:..::..|.. |||....:.:...:|:::.:.:.:.
Human  1456 TLDINRETRRYHCSGKDQIV--PSLNTESSNPVLKKLEK-LNTEKEERQKQLQQQNEKEMMEQIR 1517

  Fly  1116 SG----EKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRG 1176
            ..    |||.:.|         ..:||..  ||..::..|      :...||....||.      
Human  1518 QQTDILEKERKAF---------KTIEKPR--IGECLVAPS------SYQSKQRVERPSS------ 1559

  Fly  1177 WLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGR 1241
              ||||..|    :|.....|.|...:..|..|...|...|.      |:.:|.::|        
Human  1560 --LLSLNTS----NKGELNVLGSLSLKDAALAQKDSSSAHLP------PKDRPVTVF-------- 1604

  Fly  1242 HPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVL 1306
                        .:|:.....:||.:|          |:.|...|..:::..||           
Human  1605 ------------FERKGSPCQSSTVKE----------LSKTDRMGTQLNVACKL----------- 1636

  Fly  1307 DAISECEQRQLDAPWKLY------IRKEMFA--TWYDPSMDPKATQLIYKQILNGLKCGEYRCRS 1363
             :.:...:|:...|.:.|      :.:|..|  .::.|. |..:..|:.|:.||           
Human  1637 -SNNRISKREHFRPTQSYSHNSDDLSREGNARPIFFTPK-DNMSIPLVSKEALN----------- 1688

  Fly  1364 EKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEE 1428
                          ...|    :|...:..|:.|..|..||:|     .::....::|.:.:...
Human  1689 --------------SKNP----QLHKEDEPAWKPVKLAGPGQR-----EQVARPAHKKKARMART 1730

  Fly  1429 QNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSD-----ELMLGINSA------ 1482
            ::|.|...         .||.               .||...:.|     |.:|.::.|      
Human  1731 RSDFLTRG---------TFAD---------------GEGDTEEDDYDDIIEPLLSLDQASHCELG 1771

  Fly  1483 ---GLFLIDETEQVLASCCFSEVLKVHVESDDKLH-VMTFQHVNFVLQCSSAQDANEVINYMLDN 1543
               .|.....::..:.|..||.     |:...||| .|:...:..:.....|.|::  |......
Human  1772 PAPSLGQASHSDSEMTSQRFSS-----VDEQAKLHKTMSQGEITKLAVRQKASDSD--IRPQRAK 1829

  Fly  1544 LR------QRSSYGVALDPVVEGDLE------DCLVLN--PGDLIEFEAGVTGAQLMAGNAQDCY 1594
            :|      |.......:.|..:.::.      |.:..:  |.:|..:..                
Human  1830 MRFWAKGKQGEKKTTRVKPTTQSEVSPLFAGTDVIPAHQFPDELAAYHP---------------- 1878

  Fly  1595 RGCVNGQWGQFLAGNVRVLATLTKP-SEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAES 1658
                                  |.| |.:|....|: .|:|..:|:|:|  .|:|...||.:|..
Human  1879 ----------------------TPPLSPELPGSCRK-EFKENKEPSPKA--KRKRSVKISNVALD 1918

  Fly  1659 HFREPLDSDKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLPVNT--D 1721
            ......||                 ::.:..|..|..    |...:||.:.|:...:...:|  |
Human  1919 SMHWQNDS-----------------VQIIASVSDLKS----MDEFLLKKVNDLDNEDSKKDTLVD 1962

  Fly  1722 LIFQPALQH-----------PLLCDE-----------LYCQLMK---QLSDNPS-SESEKRGWDL 1760
            ::|:.||:.           .|..|:           |:.|:::   :|....| .||..|.|  
Human  1963 VVFKKALKEFRQNIFSFYSSALAMDDGKSIRYKDLYALFEQILEKTMRLEQRDSLGESPVRVW-- 2025

  Fly  1761 LYLATGLVAPSVLVMRELIILLRMRADALADACLKRLKRSLAQGQRKKAPHLIEVEG-------- 1817
                   |....:.:.|.     |.....:|....::.::..:.:|||...|:|...        
Human  2026 -------VNTFKVFLDEY-----MNEFKTSDCTATKVPKTERKKRRKKETDLVEEHNGHIFKATQ 2078

  Fly  1818 ---------------IQQR------CLHIYH------------KIYFPDDTVEAFEIE-----SH 1844
                           |..|      |.:..|            |.|.|:.:...|.:|     |.
Human  2079 YSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSE 2143

  Fly  1845 TRGAELIAD-IAQRLELKSPVGYSIFLKTGDRVYAMPEEEFVFDFITQLIYWLRQ--QRTIRSIS 1906
            .|...|:.: :...:|:.......|:.|:|.               |..|..|||  .....|::
Human  2144 DRTVPLVVEKLINYIEMHGLYTEGIYRKSGS---------------TNKIKELRQGLDTDAESVN 2193

  Fly  1907 DGQYQLHFMR---KLWLNNHPGEDLNGDMIFSY-----PQELHKYLKGYYPIDCEQASRLAILVY 1963
            ...|.:|.:.   |.||.:.|...:..::...:     .||..:.::|.|.: .:|.||      
Human  2194 LDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSV-IDQLSR------ 2251

  Fly  1964 SADHDVSLQRLPEVLTRL------------------------IPEDLIPLQTVAEWRQQILPKVH 2004
              .|..:|:||...|.|:                        .|:...|||:|            
Human  2252 --THLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSV------------ 2302

  Fly  2005 RDHLTEDHAKILFLQELSHFACFGSTFFVVKQQN------DDALPETLLIAIN--STGFHMLDPT 2061
                 :|.:|.....||          .||:|.|      .|.  .:|..|.|  .|...::..:
Human  2303 -----QDISKTTTCVEL----------IVVEQMNKYKARLKDI--SSLEFAENKAKTRLSLIRRS 2350

  Fly  2062 TKEILRSYEYSQLGIWS-SGKNHFHIRFGNMIGAS 2095
            .|.:|.:..:..:...| |||.  .||.||..|.|
Human  2351 MKPVLIAVRFMNITRNSVSGKG--RIRRGNYPGPS 2383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 294/887 (33%)
MYSc_Myo7 81..726 CDD:276832 285/861 (33%)
IQ 765..785 CDD:197470 8/51 (16%)
DUF4355 827..>887 CDD:290964 17/97 (18%)
MyTH4 1031..1239 CDD:295320 47/227 (21%)
B41 1248..1429 CDD:214604 29/188 (15%)
FERM_N 1248..>1288 CDD:286467 7/39 (18%)
FERM_B-lobe 1342..1429 CDD:271216 13/86 (15%)
PH-like 1454..1547 CDD:302622 19/113 (17%)
MyTH4 1674..1819 CDD:214535 30/195 (15%)
B41 1827..2032 CDD:214604 47/256 (18%)
FERM_N 1829..>1877 CDD:286467 11/53 (21%)
FERM_M 1936..2032 CDD:278785 22/124 (18%)
FERM_C2_MyoVII 2028..2121 CDD:270020 21/77 (27%)
MYO9AXP_011519915.1 UBQ 6..110 CDD:294102
MYSc 143..1014 CDD:214580 294/886 (33%)
MYSc_Myo9 160..1004 CDD:276836 285/861 (33%)
C1 2072..2120 CDD:237996 4/47 (9%)
RhoGAP_myosin_IX 2133..2318 CDD:239842 44/235 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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