Protein Alignment Myo28B1 and MYO7B

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_047300391.1
• Gene: MYO7B / 4648
• HGNCID: 7607
• Length: 2298
• Species: Homo sapiens
• Alignment Length: 2250
• Identity: 867/2250 - (38%)
• Similarity: 1269/2250 - (56%)
• Gaps: 279/2250 - (12%)

  Fly     8 RKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGD--VLKAMHITSQEDVE 70
            |.|::||::|. :|.:..|..|..|...:..:.||.||..|:.|:.|.|  ||..||..|.:.|:
Human     5 RLGDHVWLEPP-STHKTGVAIGGIIKEAKPGKVLVEDDEGKEHWIRAEDFGVLSPMHPNSVQGVD 68

  Fly    71 DMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPH 135
            |||.||||.|..::.||..||.:..|||||||:|||:||:|:||:||..::|||.::.:.|||||
Human    69 DMIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPH 133

  Fly   136 IFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPIMEA 200
            :|||::|.:..::|.|.:||.:|||||||||||:||||||:||.|||:|||||||::|||||:||
Human   134 VFAIANNCYFSMKRNKRDQCCIISGESGAGKTETTKLILQFLATISGQHSWIEQQVLEANPILEA 198

  Fly   201 FGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLS 265
            ||||||:||||||||||||:|.|.|.|.|:||||:|:||||||:..|:.:|||||||||||.|:|
Human   199 FGNAKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVS 263

  Fly   266 TAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAIL 330
            ..:::.|.|  .:||:||||..|.|.:..|..||||:|.||:|||:|.|...|.|.::.||||||
Human   264 AEDKQLLSL--GTPSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLAAIL 326

  Fly   331 HLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAA 395
            ||||:.|.|:...||..:::.:||....|.:||.:....|...|.:.||.:.||.||.||:...|
Human   327 HLGNVGFMASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRSLNIAQA 391

  Fly   396 IEGRDAFVKSLYDGIFVRIVRRINETI-NKQVDQPMN---SIGVLDIFGFENFDNNSFEQLCINY 456
            .:.||||||.:|..:|:.||::||..| ......|.|   :||:|||||||||:||||||||||:
Human   392 ADRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCINF 456

  Fly   457 ANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTD 521
            |||:||||||.|:|.|||:||::|:|:|.:|.:.||:..|||:.:|||:::||:||||:||:|||
Human   457 ANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEESRFPQGTD 521

  Fly   522 QTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTN 586
            .|:|:||:..|.|...:::.|....:.|||.|:||.|.|...||||||||..|.|:.|||..|.|
Human   522 LTMLQKLNSVHANNKAFLQPKNIHDARFGIAHFAGEVYYQAEGFLEKNRDVLSTDILTLVYSSKN 586

  Fly   587 KYLVDIFPHEM---------------------PMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYF 630
            |:|.:||..|:                     ..|:.|:..||..:|:.|||.||:.|:...|||
Human   587 KFLREIFNLELAETKLGHGTIRQAKAGNHLFKSADSNKRPSTLGSQFKQSLDQLMKILTNCQPYF 651

  Fly   631 IRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLE- 694
            ||||||||||:|..||:|||:|||||||||||..||::|:|||:.:..|.:|:.:|:|....::
Human   652 IRCIKPNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRMQL 716

  Fly   695 QCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRR 759
            |...|::...|.:|.|..|.|.:.||||:||||..|..||:||||::.::.::||:.:|...:|:
Human   717 QGKLRQMTLGITDVWLRTDKDWKAGKTKIFLRDHQDTLLEVQRSQVLDRAALSIQKVLRGYRYRK 781

  Fly   760 YMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGY 824
            ...|.|.|.:|:|.:|||...||.::::..||.||.|...:|.|..::..:|.||::||||.|||
Human   782 EFLRQRRAAVTLQAWWRGYCNRRNFKLILVGFERLQAIARSQPLARQYQAMRQRTVQLQALCRGY 846

  Fly   825 LVRKDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLK 889
            ||           |:|.|.|:..::.:
Human   847 LV-----------RQQVQAKRRAVVVI-------------------------------------- 862

  Fly   890 AEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTLIVAA-------PLPTRPAS 947
             :|.||...|....||:           ||..:||         .|::.|       .||.:...
Human   863 -QAHARGMAARRNFQQR-----------KANGMQA---------PLVIPAEGQKSQGALPAKKRR 906

  Fly   948 AVTRINTIPESPGTIDVESSKQMVDDVFRFLN--------------DEPDAALRKLNNISSGDTI 998
            ::            .|..:..:||:.||.||.              ::.::..:||..:.. ||:
Human   907 SI------------YDTVTDTEMVEKVFGFLPAMIGGQEGQASPHFEDLESKTQKLLEVDL-DTV 958

  Fly   999 RLPKSVPNNID-TSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRF 1062
            .:.:....::| .:::::.|:|.|||...|:..|.|:||:..||.||...|.:|:..||..||||
Human   959 PMAEEPEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNVILRF 1023

  Fly  1063 MGDLPDVVSSPTLHVFDNE---NLMSDLASLLNTSDSYKPRLFVRQSQR---------------- 1108
            |||||:    |.|:...::   ::|..:...|......:.....|.:||
Human  1024 MGDLPE----PVLYARSSQQGSSVMRQIHDTLGREHGAQVPQHSRSAQRSGCKDKGTKDISSMKL 1084

  Fly  1109 ----RIPKPLAS----GEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLY 1165
                ||...:||    || ||.|......:.|.|:|||:|||:|:.|::.||||||..||||||.
Human  1085 KRSSRITGQVASQLNIGE-EALEPDGLGADRPMSNLEKVHFIVGYAILRPSLRDEIYCQICKQLS 1148

  Fly  1166 LNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPP 1230
            .|...||.:|||:||||||.|||||:.|..:|.:|:.||.| .......:||.||..||.|.:||
Human  1149 ENFKTSSLARGWILLSLCLGCFPPSERFMKYLLNFIGQGPA-TYGPFCAERLRRTYANGVRAEPP 1212

  Fly  1231 SLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKL 1295
            :..||.|::.:..:.:.:.|..|:...:.||:|||:||....:....||:|..||.|.:::..|.
Human  1213 TWLELQAVKSKKHIPIQVILATGESLTVPVDSASTSREMCMHIAHKQGLSDHLGFSLQVAVYDKF 1277

  Fly  1296 MPLGAGQEHVLDAISECEQ-------RQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNG 1353
            ..||:|::|::|||:.|||       .|..:||::|.|||.|..|:|...||.:|:|||:|:|.|
Human  1278 WSLGSGRDHMMDAIARCEQMAQERGESQRQSPWRIYFRKEFFTPWHDSREDPVSTELIYRQVLRG 1342

  Fly  1354 LKCGEYRCRSEKDIAMVCALACFVEYG----------------PGEILRLKPSEITAFVPSDLLA 1402
            :..|||....|:::..:.|..|:|:.|                |.::.|.||.:    .|..|.:
Human  1343 VWSGEYSFEKEEELVELLARHCYVQLGASAESKAVQELLPSCIPHKLYRTKPPD----RPHTLRS 1403

  Fly  1403 -----PGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSW----PMR--H 1456
                 |.|   ..|....|.:...||....:.:...:.|..|.:.     |.:.|    ||:  |
Human  1404 KSHHWPCE---SRWWTPPACSGRCSSPGSSKSSHSQVMASDRGQG-----AGMGWAPRGPMQPSH 1460

  Fly  1457 SRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLASCCFSEVLKV----HVESDDKLHVMT 1517
            .||    ...||:|...:|:|.:|..||..:|:.|::|....|.||:.:    ..:...:| :::
Human  1461 CRL----SWPGPRLPKTQLILAVNWKGLCFLDQQEKMLLELSFPEVMGLATNREAQGGQRL-LLS 1520

  Fly  1518 FQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTG 1582
            ..|..:.....|:....|::...|:.|::||.:.:||......|....|....|||:.    :|.
Human  1521 TMHEEYEFVSPSSVAIAELVALFLEGLKERSIFAMALQDRKATDDTTLLAFKKGDLLV----LTK 1581

  Fly  1583 AQ-LMAGNAQDCYRGCVNGQWGQFLAGNVRVLATLTKPSEKLQDIL-----------REGRFQEP 1635
            .| |:|.......:....|:.|......:..:.|:||||.:|..:|           :||:|.||
Human  1582 KQGLLASENWTLGQNDRTGKTGLVPMACLYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQFTEP 1646

  Fly  1636 -PKPTPRANYSRRRQHNISQLAESHFREPLDSDKA-----PLSK-------FSPEPLKAPLLKAV 1687
             |:..|     :.:.|.:.:.:...||.| :.|..     ||::       :|.|||:.||||.|
Human  1647 RPEEPP-----KEKLHTLEEFSYEFFRAP-EKDMVSMAVLPLARARGHLWAYSCEPLRQPLLKRV 1705

  Fly  1688 VKVPPLFQQALVMHHHILKYMGDI-ARSNLPV--NTDLIFQPALQHPLLCDELYCQLMKQLSDNP 1749
            .....|:..|..:...||:||||. :|...|.  .||.||..|||||.|.||:|||::|||:.|.
Human  1706 HANVDLWDIACQIFVAILRYMGDYPSRQAWPTLELTDQIFTLALQHPALQDEVYCQILKQLTHNS 1770

  Fly  1750 SSESEKRGWDLLYLATGLVAPS--VLVMRELIILLRMRADALADACLKRLKRSLAQGQRKKAPHL 1812
            :..||:|||.||:|.|||..||  :|...:..|..| |...||..|.:|:::.|..|.||:.||.
Human  1771 NRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTR-RGKLLAPDCSRRIQKVLRTGPRKQPPHQ 1834

  Fly  1813 IEVEGIQQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSPVGYSIFLKTGDRVY 1877
            :|||..:|....|.||||||:||.|..|:.::||..::...||.||:|.|..|.|:|:|..|:|.
Human  1835 VEVEAAEQNVSRICHKIYFPNDTSEMLEVVANTRVRDVCDSIATRLQLASWEGCSLFIKISDKVI 1899

  Fly  1878 AMPEEEFVFDFITQLIYWLRQQRTIRSISDG-----QYQLHFMRKLWLNNHPGEDLNGDMIFSYP 1937
            :..|.:|.||.:.::..|:::.:..:   :|     .||::||||||||..||:|:|.|.|..|.
Human  1900 SQKEGDFFFDSLREVSDWVKKNKPQK---EGAPVTLPYQVYFMRKLWLNISPGKDVNADTILHYH 1961

  Fly  1938 QELHKYLKGYYPIDCEQASRLAILVYSA--DHDVS-LQRLPEVLTRLIPEDLIPLQTVAEWRQQI 1999
            |||.|||:|::....|.|..||.|:|.|  ::|.| |..:|::|..|:||:|..|.:..||::.|
Human  1962 QELPKYLRGFHKCSREDAIHLAGLIYKAQFNNDRSQLASVPKILRELVPENLTRLMSSEEWKKSI 2026

  Fly  2000 LPKV--HRDHLTEDHAKILFLQELSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTT 2062
            |...  |:|...|: ||:.||:.:..:..|||.||.|||.::.:.|:.:|||||..|..::.|.|
Human  2027 LLAYDKHKDKTVEE-AKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDVILIAINRHGVLLIHPKT 2090

  Fly  2063 KEILRSYEYSQLGIWSSGKNHFHIRFGNMIGASKLLCSTT 2102
            |::|.:|.::::..||||..:||:..|::...|:|||.|:
Human  2091 KDLLTTYPFTKISSWSSGSTYFHMALGSLGRGSRLLCETS 2130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	349/670 (52%)
		IQ	765..785	CDD:197470	9/19 (47%)
		Atrophin-1	<820..>946	CDD:460830	24/132 (18%)
		MyTH4	1031..1239	CDD:470587	94/234 (40%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	34/97 (35%)
		B41	1248..1429	CDD:214604	65/208 (31%)
		PH-like	1454..1547	CDD:473070	24/98 (24%)
		MyTH4	1674..1819	CDD:214535	68/149 (46%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	37/98 (38%)
		B41	1827..2032	CDD:214604	85/214 (40%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	31/74 (42%)
MYO7B	XP_047300391.1	MYSc_Myo7	79..748	CDD:276832	349/670 (52%)
		IQ	785..807	CDD:197470	10/21 (48%)
		MyTH4	992..1221	CDD:214535	94/234 (40%)
		FERM1_F1_Myosin-VII	1225..1323	CDD:340612	34/97 (35%)
		FERM_C1_MyoVII	1467..1550	CDD:270019	20/83 (24%)
		SH3	1551..1611	CDD:473055	14/63 (22%)
		MyTH4	1692..1839	CDD:214535	67/147 (46%)
		FERM2_F1_Myosin-VII	1846..1943	CDD:340613	37/99 (37%)
		B41	1848..2060	CDD:214604	85/215 (40%)
		FERM_C2_MyoVII	2056..>2131	CDD:270020	31/74 (42%)