DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo28B1 and MYO7A

DIOPT Version :9

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:XP_011543348.2 Gene:MYO7A / 4647 HGNCID:7606 Length:2258 Species:Homo sapiens


Alignment Length:2243 Identity:904/2243 - (40%)
Similarity:1275/2243 - (56%) Gaps:269/2243 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 YSPRKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCDDRNKQFWVPAGDV--LKAMHITSQE 67
            |:...|::||: ......||.||.||.:...:..|..|.||.:.:.|:...:.  :|.||.||..
Human    32 YAVLPGDHVWM-DLRLGQEFDVPIGAVVKLCDSGQVQVVDDEDNEHWISPQNATHIKPMHPTSVH 95

  Fly    68 DVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAEL 132
            .|||||.||||.|..|||||..||...||||||||:|||:||||:|.||:...|:.|.||.:.|:
Human    96 GVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEM 160

  Fly   133 PPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSWIEQQIIEANPI 197
            |||||||:||.:..::|...:||.:||||||||||||||||||:||||||:|||||||::||.||
Human   161 PPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATPI 225

  Fly   198 MEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLA 262
            :||||||||:||||||||||||:|.|..:|||:||:|:||||||||:..|:.||||||:|||||.
Human   226 LEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVFYCMLE 290

  Fly   263 GLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLA 327
            |:|..::::|.|.:  .|.|:|||.|.|.|..||.|::::|:||:|||||.|...|.|.|..|||
Human   291 GMSEDQKKKLGLGQ--ASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISKLLA 353

  Fly   328 AILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSK 392
            ||||||||::.|....||...|:..:|:|...|.||.:....|.:.||.||:...||.|:|.||:
Human   354 AILHLGNLQYEARTFENLDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLITRGETVSTPLSR 418

  Fly   393 EAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPM----NSIGVLDIFGFENFDNNSFEQLC 453
            |.|::.||||||.:|..:||.||.:||..|.|...|.:    .|||:|||||||||..|||||||
Human   419 EQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLC 483

  Fly   454 INYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPK 518
            ||:|||:||||||.|:||:||:||..|.|:|.||||.|||..||:|..||||::|||||||||||
Human   484 INFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPK 548

  Fly   519 GTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQR 583
            |||.|:|.||:.||...:.|:..|....:.|||.|:||:|.|...||||||||:..||:..||..
Human   549 GTDTTMLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQLVHS 613

  Fly   584 STNKYLVDIFPHEMPM--DTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFD 646
            |.||::..||..::.|  :|.|:.|||..:|:.||::|||||....|:|:|||||||:|:|..||
Human   614 SRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFD 678

  Fly   647 KELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGP-LEQCDCRKLARQICEVAL 710
            :.||||||||||||||.||||||||||:::..||||||:|:|.|.| .:|.|.|...:::.|..|
Human   679 RHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRGTCQRMAEAVL 743

  Fly   711 PADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYW 775
            ....|.|.||||:||:|..|..||::|.:.:...::.:|:.||....|....:.:.|...:||:|
Human   744 GTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLKLKNAATLIQRHW 808

  Fly   776 RGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQKKL------ 834
            ||...|:.|.:||.||.||.|...:::|..::.:.|.|.|:.||..|.|||||.|:.:|      
Human   809 RGHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQFQARCRAYLVRKAFRHRLWAVLTV 873

  Fly   835 -------LERRKQNQLKKEEL--LKLAKMKEAEE--LLRLQQLKEQKEREQREQQEK-----RLQ 883
                   :.||...:|:.|.|  |:..||:.|||  |.:....|:.||..:|:.||:     |..
Human   874 QAYARGMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLRKEMSAKKAKEEAERKHQERLAQLARED 938

  Fly   884 EEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASA 948
            .|:.||.:.|||....:....::.|.:||...          :.:......|..:..||.:...|
Human   939 AERELKEKEAARRKKELLEQMERARHEPVNHS----------DMVDKMFGFLGTSGGLPGQEGQA 993

  Fly   949 VTRINTIPESPGTIDVE-SSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSD 1012
            .:         |..|:| ..::||:       ::.|||              ||....:..|.|:
Human   994 PS---------GFEDLERGRREMVE-------EDLDAA--------------LPLPDEDEEDLSE 1028

  Fly  1013 FSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPTLH- 1076
            :.:.|:|||||.|..|..:.|:|||:.||.|:...|::|:.|:|:||||||||||:    |..| 
Human  1029 YKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPE----PKYHT 1089

  Fly  1077 -VFDNENLMSDLASLLNT--SDSYKPRLFVRQSQ------------------------------R 1108
             :.|....:..:..:..|  ..:||..|...|.:                              .
Human  1090 AMSDGSEKIPVMTKIYETLGKKTYKRELQALQGEGEAQLPEGQKKSSVRHKLVHLTLKKKSKLTE 1154

  Fly  1109 RIPKPLASGEKEAQ-----EFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNP 1168
            .:.|.|..||...|     |      :.|||:|||:|||||:||::.:|||||..||.|||..||
Human  1155 EVTKRLHDGESTVQGNSMLE------DRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTHNP 1213

  Fly  1169 SRSSYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLF 1233
            |:|||:|||:|:|||:.||.||::|..:||:|:..|... .|....:||.||.|||.|.||||..
Human  1214 SKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHGGPPG-YAPYCEERLRRTFVNGTRTQPPSWL 1277

  Fly  1234 ELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPL 1298
            ||.|.:.:.|:.|.:..|||..:.|..|:|:||:|..|.|...:.|.|.|||.|.::|..|:..|
Human  1278 ELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSL 1342

  Fly  1299 GAGQEHVLDAISECEQ-------RQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKC 1356
            |:|.:||:||||:|||       ::.:|||:|:.|||:|..|:.||.|..||.|||:|::.|:|.
Human  1343 GSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHSPSEDNVATNLIYQQVVRGVKF 1407

  Fly  1357 GEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEK 1421
            |||||..|.|:|.:.:...||:||...||....:.:..::|...:.| .:.:|.|::|..|.::|
Human  1408 GEYRCEKEDDLAELASQQYFVDYGSEMILERLLNLVPTYIPDREITP-LKTLEKWAQLAIAAHKK 1471

  Fly  1422 SSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFL 1486
            ..|.:..     .:||| .|||:..:|...||:..||.:|..:..||.|..:::::.:|..|::.
Human  1472 GIYAQRR-----TDAQK-VKEDVVSYARFKWPLLFSRFYEAYKFSGPSLPKNDVIVAVNWTGVYF 1530

  Fly  1487 IDETEQVLASCCFSEVLKVHVESDDKL--------------H----------------------- 1514
            :||.||||....|.|::.|....:.::              |                       
Human  1531 VDEQEQVLLELSFPEIMAVSSSRECRVWLSLGCSDLGCAAPHSGWAGLTPAGPCSPCWSCRGAKT 1595

  Fly  1515 ------VMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVAL--DPVVEGDLEDCLVLNPG 1571
                  :.|.:...:....|:|:|..:::...|:.||:||.|.|||  :|...|:....|....|
Human  1596 TAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPAGEESGFLSFAKG 1660

  Fly  1572 DLIEFEAGVTGAQLMAGNAQDCYRGCVNG------QWGQFLAGNVRVLATLTKPSEKL------- 1623
            |||..:.. ||.|:|..       |..||      |.|.|...:|.|:.|:|.|..::       
Human  1661 DLIILDHD-TGEQVMNS-------GWANGINERTKQRGDFPTDSVYVMPTVTMPPREIVALVTMT 1717

  Fly  1624 ----QDILR--EGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKAPLSK--------- 1673
                ||::|  :.|..||.        .|.:.:.:.:.:..:||.|   .|..||:         
Human  1718 PDQRQDVVRLLQLRTAEPE--------VRAKPYTLEEFSYDYFRPP---PKHTLSRVMVSKARGK 1771

  Fly  1674 -----FSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDI-ARSNLPVN--TDLIFQPALQH 1730
                 .:.||||..|||.::....|.|:|.:....:||||||. ::....||  ||.||:..|:.
Human  1772 DRLWSHTREPLKQALLKKLLGSEELSQEACLAFIAVLKYMGDYPSKRTRSVNELTDQIFEGPLKA 1836

  Fly  1731 PLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADA-LADACL 1794
            ..|.||.|.|::|||:||....||:|||:||:|.|||..||.:::..:...|:.|... ||..||
Human  1837 EPLKDEAYVQILKQLTDNHIRYSEERGWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCL 1901

  Fly  1795 KRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLE 1859
            :||:::|..|.||..|||:|||.||.:...|:||:||||||.||||:||.|:..:...:||.||.
Human  1902 QRLQKALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQNIATRLL 1966

  Fly  1860 LKSPVGYSIFLKTGDRVYAMPEEEFVFDFITQLIYWLRQQRTIRSISDG-----QYQLHFMRKLW 1919
            |||..|:|:|:|..|:|.::||.:|.|||:..|..|:::.|.|:   ||     .||:.||:|||
Human  1967 LKSSEGFSLFVKIADKVLSVPENDFFFDFVRHLTDWIKKARPIK---DGIVPSLTYQVFFMKKLW 2028

  Fly  1920 LNNHPGEDLNGDMIFSYPQELHKYLKGYYPIDCEQASRLAILVYSA--DHDVS-LQRLPEVLTRL 1981
            ....||:|...|.||.|.|||.|||:||:....|:..:|..|:|..  :.|.| ...:|::|..|
Human  2029 TTTVPGKDPMADSIFHYYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPSIPKLLREL 2093

  Fly  1982 IPEDLIPLQTVAEWRQQILPKVHRDHL--TEDHAKILFLQELSHFACFGSTFFVVKQQNDDALPE 2044
            :|:|||...:..:|::.|:...:: |.  :::.||:.||:.:..:..|||.||.||..:      
Human  2094 VPQDLIRQVSPDDWKRSIVAYFNK-HAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKVHH------ 2151

  Fly  2045 TLLIAINSTGFHMLDPTTKEILRSYEYSQLGIW 2077
                     |....:......|..:..|.||:|
Human  2152 ---------GLLRAEEEGNRALIKHRDSSLGLW 2175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 393/681 (58%)
MYSc_Myo7 81..726 CDD:276832 375/651 (58%)
IQ 765..785 CDD:197470 7/19 (37%)
DUF4355 827..>887 CDD:290964 24/81 (30%)
MyTH4 1031..1239 CDD:295320 96/246 (39%)
B41 1248..1429 CDD:214604 73/187 (39%)
FERM_N 1248..>1288 CDD:286467 16/39 (41%)
FERM_B-lobe 1342..1429 CDD:271216 30/86 (35%)
PH-like 1454..1547 CDD:302622 25/135 (19%)
MyTH4 1674..1819 CDD:214535 64/148 (43%)
B41 1827..2032 CDD:214604 85/214 (40%)
FERM_N 1829..>1877 CDD:286467 25/47 (53%)
FERM_M 1936..2032 CDD:278785 32/100 (32%)
FERM_C2_MyoVII 2028..2121 CDD:270020 12/50 (24%)
MYO7AXP_011543348.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1958
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D21221at33208
OrthoFinder 1 1.000 - - FOG0001409
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - O PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.730

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