Protein Alignment Myo28B1 and MYO5A

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001369277.1
• Gene: MYO5A / 4644
• HGNCID: 7602
• Length: 1904
• Species: Homo sapiens
• Alignment Length: 2135
• Identity: 540/2135 - (25%)
• Similarity: 834/2135 - (39%)
• Gaps: 671/2135 - (31%)

  Fly    41 LVCDDRN----KQFWVP----------------AGDVLKAMHITSQEDVE--------------- 70
            |.|.|..    .:.|:|                .||.:..:|:...:|:|
Human    24 LTCLDETALKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRN 88

  Fly    71 --------DMITLGDLQEYTILRNLQNRYA-KQLIYTYTGSMLVAINPYQILPIYTNREIQLYRN 126
                    |:..|..|.|..:|.||:.|:. .:|||||.|.:|||||||:.||||....|..|..
Human    89 PDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDIINAYSG 153

  Fly   127 KSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSW--IEQ 189
            :::.::.|||||:::.|::::.|.:.||.:::|||||||||.|.|..::|.|.:||..|.  :|:
Human   154 QNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGSASEANVEE 218

  Fly   190 QIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNY 254
            :::.:|||||:.|||||.||||||||||||||.|..:..|.||.::.|||||||:|||:.:||||
Human   219 KVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNY 283

  Fly   255 HIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEV 319
            ||||.:.|.....|.:.|:|  .:...::|..|||...:.|..|||:.|..|.|..:|.......
Human   284 HIFYQLCASAKLPEFKMLRL--GNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQ 346

  Fly   320 WSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGE 384
            ..|..:||.||||||:.||:.: |:..|......| |....:|:|:....:...|..|.:....|
Human   347 MGIFRILAGILHLGNVGFTSRD-ADSCTIPPKHEP-LCIFCELMGVDYEEMCHWLCHRKLATATE 409

  Fly   385 HVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSF 449
            .....:||..|...|||..|.:|..:|..||..:|:.::..|.| .:.||||||:|||.|:.|||
Human   410 TYIKPISKLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQ-HSFIGVLDIYGFETFEINSF 473

  Fly   450 EQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEES 514
            ||.|||||||.|||.|..|:||:||:||..|.|.|..|:|.|||..::||..| :.::.|:|||.
Human   474 EQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESK-LGILDLLDEEC 537

  Fly   515 KFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRT 579
            |.|||||.|..:||:..|.|:....:........|.|:|:|..|.|...||||||:|:...:...
Human   538 KMPKGTDDTWAQKLYNTHLNKCALFEKPRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIK 602

  Fly   580 LVQRSTNKYLVDIFPHE-------------------MPMDTAKKQP---------TLCVKFRNSL 616
            :::.|..|.|.::|..:                   .|....|.:|         |:..:|||||
Human   603 VLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRPGQMAKEHKKTVGHQFRNSL 667

  Fly   617 DMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVE 681
            .:||.||:...|:::||||||::|.|..||::..|:|||..|::||.||..||:|.|..|:.|..
Human   668 HLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFS 732

  Fly   682 RYRLLVPPVGPLEQCDCRKLARQICEVALP---ADSDR-QYGKTKLFLRDEDDASLELQRSQLML 742
            |||:|      ::|.|.....:|.|:..|.   .|.|: |:||||:|.|....|.||..|:..:.
Human   733 RYRVL------MKQKDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEKLRADKLR 791

  Fly   743 KSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGR--------LQRRKYQVMRQGFHRLGACIA 799
            .:.:.||:.||..|.|:...|.|:|.||:|||.||.        |:|.|...:.|.:.|:
Human   792 AACIRIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAKFLRRTKAATIIQKYWRM----- 851

  Fly   800 AQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQK-------------------------------- 832
             ..:..::.:.|..||.||:..||:|.|..::|
Human   852 -YVVRRRYKIRRAATIVLQSYLRGFLARNRYRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIY 915

  Fly   833 ------KLLERRKQNQLKKE--------------------------------------------- 846
                  :::.:|:..:||.|
Human   916 LQCCFRRMMAKRELKKLKIEARSVERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGI 980

  Fly   847 ------------ELLKLAKMKEA-----------EELLRLQQLKEQKEREQR------------- 875
                        |.|:|:: :||           ||:.:|::..||...|::
Human   981 YNSETEKLRSDLERLQLSE-EEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKCIEEHADRYKQET 1044

  Fly   876 EQQEKRLQEEQR-LKAEAAARN------ALAMAAVQQKRRTKPVKQ-----------------EA 916
            ||....|:||.. ||.|..|.|      |..|....:|:..:..||                 |.
Human  1045 EQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQNLLNEF 1109

  Fly   917 PKAPTLQARNSLPPPPTTLIVAAPLPTRP---------------ASAVTRINTIP---ESPG--- 960
            .:   |:.|........||:|..|.|...               :|.:..:..||   |.|.
Human  1110 SR---LEERYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFSSEIAEMEDIPSRTEEPSEKK 1171

  Fly   961 --------------TIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTS 1011
                          ..::|..||::.|.   |:.:.:..||..........||
Human  1172 VPLDMSLFLKLQKRVTELEQEKQVMQDE---LDRKEEQVLRSKAKEEERPQIR------------ 1221

  Fly  1012 DFSYLKYAATYFGGGATAQHE---RKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVS-- 1071
                          ||..::|   |:.|:....|.::.::|: .||:      .....|:|.:
Human  1222 --------------GAELEYESLKRQELESENKKLKNELNEL-RKAL------SEKSAPEVTAPG 1265

  Fly  1072 SPTLHVFDNENLMSDLASLLNTSDSYKPRLFVRQSQRRIPKPLASGEKEAQEFYQHWLNVPTSHL 1136
            :|...|     ||..|.|:....|..|..:.:.:||      |.| :|||.:        |...
Human  1266 APAYRV-----LMEQLTSVSEELDVRKEEVLILRSQ------LVS-QKEAIQ--------PKDD- 1309

  Fly  1137 EKIHFIIGHGIIKNSLRDE--ILAQICK--------QLYLNPSRSSYSRG------------WLL 1179
                        ||::.|.  :|..:.|        |.|:....::.|..            ||:
Human  1310 ------------KNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNRSSALDYHELNEDGELWLV 1362

  Fly  1180 LSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPL 1244
                         :|.     :||....|::  .||..:|:..|          |..|:||
Human  1363 -------------YEG-----LKQANRLLES--QLQSQKRSHEN----------EAEALRG---- 1393

  Fly  1245 RLDIHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMP---LGAGQEHVL 1306
              :|..:..:..|.|            ||               ::.|.:|.|   :.|..:|.:
Human  1394 --EIQSLKEENNRQQ------------QL---------------LAQNLQLPPEARIEASLQHEI 1429

  Fly  1307 DAISE----CEQRQLDAP-----WKLYIRKEMFATWYDPSMDPKATQLIYKQI-LNGLKCGEYRC 1361
            ..::.    .|:...|.|     :::.:.|.|...........|..:.:.||: :...|.||...
Human  1430 TRLTNENLYFEELYADDPKKYQSYRISLYKRMIDLMEQLEKQDKTVRKLKKQLKVFAKKIGELEV 1494

  Fly  1362 RSEKDIAMVCALACFVEYGPGEIL--RLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSY 1424
            ...::|:            ||:|:  .::|..|            .|..:::..::       .|
Human  1495 GQMENIS------------PGQIIDEPIRPVNI------------PRKEKDFQGML-------EY 1528

  Fly  1425 VKEEQ----NDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLF 1485
            .||::    .:|:||.:.|.                     |.....|.|.:..|.:.:..|...
Human  1529 KKEDEQKLVKNLILELKPRG---------------------VAVNLIPGLPAYILFMCVRHADYL 1572

  Fly  1486 LIDETEQVLASCCFSEVLKVHVESDDKLHVMTFQHVNF--VLQCSSAQDANEVINYMLDNLRQRS 1548
            ..|:..:.|.:...:.:.||..:..|....::|...|.  .|.|.......|  .:|..|..:::
Human  1573 NDDQKVRSLLTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEE--GFMKHNTSRQN 1635

  Fly  1549 SYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVL 1613
                          |.|  |...||.|:.      |:::..|...|:..            ||||
Human  1636 --------------EHC--LTNFDLAEYR------QVLSDLAIQIYQQL------------VRVL 1666

  Fly  1614 ATLTKP--------SEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSDKAP 1670
            ..:.:|        .|.:|.:       ...|||.    .|:|..:|:.  |..:  .|||....
Human  1667 ENILQPMIVSGMLEHETIQGV-------SGVKPTG----LRKRTSSIAD--EGTY--TLDSILRQ 1716

  Fly  1671 LSKF---------SPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLPVNTDL---- 1722
            |:.|         .||     |:|.|||             .:...:|.|..:||.:..|:
Human  1717 LNSFHSVMCQHGMDPE-----LIKQVVK-------------QMFYIIGAITLNNLLLRKDMCSWS 1763

  Fly  1723 ----------------------------IFQPALQHPLLCD---------ELYCQLMKQLSD--- 1747
                                        ..:|.:|...|..         |..|.:...|:.
Human  1764 KGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKKTDDDAEAICSMCNALTTAQI 1828

  Fly  1748 -------NPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADA---LADA 1792
                   .|.:|.|:|             .||..:|.:.:.||.|.|:   |.||
Human  1829 VKVLNLYTPVNEFEER-------------VSVSFIRTIQMRLRDRKDSPQLLMDA 1870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	277/679 (41%)
		IQ	765..785	CDD:197470	12/27 (44%)
		Atrophin-1	<820..>946	CDD:460830	43/283 (15%)
		MyTH4	1031..1239	CDD:470587	45/234 (19%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	15/102 (15%)
		B41	1248..1429	CDD:214604	31/195 (16%)
		PH-like	1454..1547	CDD:473070	17/94 (18%)
		MyTH4	1674..1819	CDD:214535	33/182 (18%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
MYO5A	NP_001369277.1	COG5022	35..1472	CDD:227355	440/1590 (28%)
		MYSc_Myo5	107..775	CDD:276831	277/679 (41%)
		Myo5a_CBD	1530..1904	CDD:271262	83/444 (19%)