Protein Alignment Myo28B1 and MYO1E

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_004989.2
• Gene: MYO1E / 4643
• HGNCID: 7599
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 1213
• Identity: 348/1213 - (28%)
• Similarity: 546/1213 - (45%)
• Gaps: 253/1213 - (20%)

  Fly    62 HITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRN 126
            |......|:||:.|..:.|.:|:.||:.||....|:||.||:|:::||::.:|.:..:||::|:.
Human    14 HNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQG 78

  Fly   127 KSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISG---KHSWIE 188
            .:..|.||||:|::||.::.:...:|||||:||||||||||.:.|.|:.|::.:||   |...::
Human    79 AAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVK 143

  Fly   189 QQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERN 253
            ..|:::||::|||||||||||:||||||||.||:|:|.|...|.:|..:||||||:|.::..||:
Human   144 DIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERS 208

  Fly   254 YHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEE 318
            :||||.::.|.|..::..|.:  .|...|:||:..|.:.:....|.::|.:...||.|:....||
Human   209 FHIFYQLIEGASAEQKHSLGI--TSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEE 271

  Fly   319 VWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFV-- 381
            ...:|.::|.||||||:.|  .||.|.|..|.::.  |...|.||||....|...||.|.:..
Human   272 QTLVLQIVAGILHLGNISF--KEVGNYAAVESEEF--LAFPAYLLGINQDRLKEKLTSRQMDSKW 332

  Fly   382 --HGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENF 444
              ..|.:..:|:.|.|...|||..|:|:..:|..:|..||:.:.|  |....:||||||:|||.|
Human   333 GGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEK--DHEEYNIGVLDIYGFEIF 395

  Fly   445 DNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMK--PMNLM 507
            ..|.|||.|||:.||.|||.|:....|.||:||..|.|.|..||:.:|:.:.|||..|  |..:|
Human   396 QKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIM 460

  Fly   508 SLIDE----ESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEK 568
            |::|:    .....:|.|||||:||.:|.|:...:    .:....|.|.||||.|.|:..||.|:
Human   461 SILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHF----NSWNQGFIIHHYAGKVSYDMDGFCER 521

  Fly   569 NRDSFSGDLRTLVQRSTNKYLVDIFPHEMPMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRC 633
            |||....||..|:|.|...::..:||..:..|...:..|...|.:...:.|:.||.:..|::|||
Human   522 NRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRC 586

  Fly   634 IKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDC 698
            |||||.|:|:::::.....|:.|.|:.|..|:|||||..|..::.|::||.:|.....|..|.:.
Human   587 IKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEE 651

  Fly   699 RKLARQICEVALPADSDR-QYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMK 762
            ::....:.: ::..|||: |.|::|:|::..:...|                  :..:..|:|..
Human   652 KQGVLHLLQ-SVNMDSDQFQLGRSKVFIKAPESLFL------------------LEEMRERKYDG 697

  Fly   763 RYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYLVR 827
            ..|    .:|:.||..:.|:||..||:.        |:..|..|
Human   698 YAR----VIQKSWRKFVARKKYVQMREE--------ASDLLLNK--------------------- 729

  Fly   828 KDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLKAEA 892
                    :.|::|.:.:..:.....|:|..|   |||...::|:..
Human   730 --------KERRRNSINRNFIGDYIGMEEHPE---LQQFVGKREKID------------------ 765

  Fly   893 AARNALAMAAVQQKRRTKPVKQE---APKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINT 954
                 .|....:..||.|.||::   .||...|..|..:...|...:|...|..:  ..:.||.:
Human   766 -----FADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRK--IEIERILS 823

  Fly   955 IPESPGTIDVESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYA 1019
            :          |...|.||:|.....|.|:.|..:                  ..|...|.|
Human   824 V----------SLSTMQDDIFILHEQEYDSLLESV------------------FKTEFLSLL--- 857

  Fly  1020 ATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLM 1084
                    ..::|.|..|:..||..:.::....|..|
Human   858 --------AKRYEEKTQKQLPLKFSNTLELKLKKENW---------------------------- 886

  Fly  1085 SDLASLLNTSDSYKPRLFVRQSQRRIPKPLASGEKEAQEFYQHWLNV----PTSHLEKIHFIIGH 1145
                                       .|.::|.....:|:|.:.::    |::.:.::.  ||.
Human   887 ---------------------------GPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVS--IGP 922

  Fly  1146 GIIKNSLRDEILAQICKQLYLNPSR------SSYSRGWLLLSLCLSCFPPSKEFE---------- 1194
            |:.|||               .|:|      :.||.|....:..:...||...:.
Human   923 GLPKNS---------------RPTRRNTTQNTGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYV 972

  Fly  1195 --PHLRSFMKQGTAQL---QATPSLQRLERTLVNGPRCQPPSL 1232
              ||.....:.....|   .|.|.|.|.:.|..:.....|.||
Human   973 PYPHAPGSQRSNQKSLYTSMARPPLPRQQSTSSDRVSQTPESL 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	256/658 (39%)
		IQ	765..785	CDD:197470	6/19 (32%)
		Atrophin-1	<820..>946	CDD:460830	22/128 (17%)
		MyTH4	1031..1239	CDD:470587	36/227 (16%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
MYO1E	NP_004989.2	MYSc_Myo1	33..679	CDD:276829	256/658 (39%)
		Actin-binding. /evidence=ECO:0000255	581..591		7/9 (78%)
		Myosin_TH1	719..920	CDD:461801	51/361 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	919..966		13/63 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	993..1053		8/23 (35%)
		SH3_MyoIe_If_like	1056..1107	CDD:212761