Protein Alignment Myo28B1 and MYO1C

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001074248.1
• Gene: MYO1C / 4641
• HGNCID: 7597
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 984
• Identity: 335/984 - (34%)
• Similarity: 509/984 - (51%)
• Gaps: 139/984 - (14%)

  Fly    52 VPAGDVLKAMH---------------------ITSQE--DVEDMITLGDL-QEYTILRNLQNRYA 92
            ||.|::::.:|                     :|:::  .|:|.:.|.:. .|...:.||:.|:.
Human     8 VPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFR 72

  Fly    93 KQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVV 157
            :.|||||.|.:||::|||:.|.||:.:.::.||..|..|:|||:||::|..::.|:..:.:|.|:
Human    73 ENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVM 137

  Fly   158 ISGESGAGKTESTKLILQYLA---AISGKHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYI 219
            |||||||||||:||.:||:.|   ....:...:..:::::||::||||||||:|||||||||||:
Human   138 ISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYM 202

  Fly   220 EIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHY 284
            :::|..:||..|..|..|||||||:|.|:..|||:||||.:|.|.......||.| |::|..|.|
Human   203 DVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGL-ERNPQSYLY 266

  Fly   285 LAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAE 349
            |.:|.|..:....|..|:..:|.|:.|:.|..:||..:||::|::|||||:.|.|.|.:|   |:
Human   267 LVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESN---AQ 328

  Fly   350 IDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRI 414
            :.....|:.:.:||.:..|.|..|||.|.|...||.:.:.|:.|.|...|||..|::|...|..:
Human   329 VTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWL 393

  Fly   415 VRRINETI-NKQVDQP----MNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQ 474
            |.:||.:: :|.|:.|    ...:|:|||:|||.|.:|||||.||||.||.|||.|:....|.||
Human   394 VGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQ 458

  Fly   475 DEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFP-KGTDQTLLEKLH--VQHGNRS 536
            :||:.|.|.|:.:::.:|:.|.||:..|...::|::|||...| :.||.|.||||.  |:|....
Human   459 EEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHF 523

  Fly   537 IYVK--GKTTQTSL----FGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPH 595
            :..|  .:.|:.||    |.:.||||.|.|:..|||:||.|....:|:..:..|.|..:...|..
Human   524 LTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDR 588

  Fly   596 EMPMDTAKKQP-TLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGM 659
            ....|  ||:| |:..:|:.||..|:..|....|.::||||||:.|:|..||:.|...|::|.|:
Human   589 SELSD--KKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGL 651

  Fly   660 METARIRRAGYPIRHAYRAFVERYRLLVPPVGPL----EQCDCRKLARQICEVALPADSDRQY-- 718
            :|..|:||||:..|..|.||::||:.|.|...|.    .|.....|.|.:      .....:|
Human   652 LENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHL------GYKPEEYKM 710

  Fly   719 GKTKLFLR-------DEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWR 776
            |:||:|:|       .||  :||::|..|..|    ||...|...:|:...|.:.:.|.:|.:||
Human   711 GRTKIFIRFPKTLFATED--ALEVRRQSLATK----IQAAWRGFHWRQKFLRVKRSAICIQSWWR 769

  Fly   777 GRLQRRKYQVMRQGFHRLGACIAAQQLTTKFTMVRCRTIKLQALSRGYL---------------- 825
            |.|.|||               ||::.....|:.|        |.||::
Human   770 GTLGRRK---------------AAKRKWAAQTIRR--------LIRGFVLRHAPRCPENAFFLDH 811

  Fly   826 VRKDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLR-------------------LQQLKEQK- 870
            ||..|...|..:..||.|..........::||.||||                   .|||:::.
Human   812 VRTSFLLNLRRQLPQNVLDTSWPTPPPALREASELLRELCIKNMVWKYCRSISPEWKQQLQQKAV 876

  Fly   871 -------EREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSL 928
                   :::...|...||....||..:..:...|.....:..:...||.:...|....::|..|
Human   877 ASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLL 941

  Fly   929 PPPPTTLIV 937
            ..|...:||
Human   942 LTPNAVVIV 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	267/668 (40%)
		IQ	765..785	CDD:197470	9/19 (47%)
		Atrophin-1	<820..>946	CDD:460830	33/161 (20%)
		MyTH4	1031..1239	CDD:470587
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
MYO1C	NP_001074248.1	MYSc_Myo1	62..718	CDD:276829	267/667 (40%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	608..630		9/21 (43%)
		IQCG	751..781	CDD:467744	13/44 (30%)
		Myosin_TH1	874..1055	CDD:461801	14/77 (18%)