Protein Alignment Myo28B1 and MYH10

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001242941.1
• Gene: MYH10 / 4628
• HGNCID: 7568
• Length: 2007
• Species: Homo sapiens
• Alignment Length: 2171
• Identity: 540/2171 - (24%)
• Similarity: 899/2171 - (41%)
• Gaps: 536/2171 - (24%)

  Fly     3 AGYSPRKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCD--DRNKQFWVPAGDVLKAMHITS 65
            |.::.:|  .||:..:..      .|.|..::.|:...::.:  :..|:..|...|:.| |:...
Human    28 ADWTAKK--LVWIPSERH------GFEAASIKEERGDEVMVELAENGKKAMVNKDDIQK-MNPPK 83

  Fly    66 QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLA 130
            ...||||..|..|.|.::|.||::||...|||||:|...|.||||:.||||:...|::||.|...
Human    84 FSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRH 148

  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSW--------- 186
            |:||||:|||::|::.:.:.:|:|.::.:|||||||||:||.::||||.::..|..
Human   149 EMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQE 213

  Fly   187 ----------IEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEK 241
                      :|:|:::||||:|:|||||||:|||||||||:|.|.|...|.|.||.|:.|||||
Human   214 SPKPVKHQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEK 278

  Fly   242 SRIVFQSRDERNYHIFYCMLAGLSTAERERLK--LQEQSPSQYHYLAQGGCFTLPGRGDAKDFAD 304
            ||.|.|::|||.:||||.:|:|..    |.||  |..:..:.|.:|: .|...:||:.|..:|.:
Human   279 SRAVRQAKDERTFHIFYQLLSGAG----EHLKSDLLLEGFNNYRFLS-NGYIPIPGQQDKDNFQE 338

  Fly   305 IRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISA 369
            ...||.::.|..||:.|:|.:::::|..||:.|  .:..|...|.:.:....|::..|||:.:..
Human   339 TMEAMHIMGFSHEEILSMLKVVSSVLQFGNISF--KKERNTDQASMPENTVAQKLCHLLGMNVME 401

  Fly   370 LNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIG 434
            ...|:....|.|..::|..:.:||.|....:|..|:.|:.:|..:|.|||:.:::...|..:.||
Human   402 FTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIG 466

  Fly   435 VLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDL 498
            :|||.|||.|:.||||||||||.||.|||.|...:|.:||:|||.|.|.|..|:| .|.|..:||
Human   467 ILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDL 531

  Fly   499 I--GMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSL-FGIRHYAGVVMY 560
            |  ...|..:::|:|||..|||.||:|.:|||..:.|:.|.:.|.:..:... |.|.||||.|.|
Human   532 IERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDY 596

  Fly   561 NPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFP------------------HEMPMD------- 600
            ....:|.||.|..:.::.||:.:|:::::.:::.                  ||.|:|
Human   597 KADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSVSGLHEPPVDRIVGLDQ 661

  Fly   601 ----------TAKKQP-----TLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELC 650
                      :|.|..     |:...::.||..||.||...:|.|:|||.||..|.....|..|.
Human   662 VTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLV 726

  Fly   651 VRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICE---VALPA 712
            :.|||.:|::|..||.|.|:|.|..::.|.:||.:|.|...|....|    .:|.||   .||..
Human   727 LDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMD----GKQACERMIRALEL 787

  Fly   713 DSD-RQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRR-YMKRYRE--AIITVQR 773
            |.: .:.|::|:|.|....|.||.:|...:...|:..|...|..|.|: :.|:.::  |:..:||
Human   788 DPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQR 852

  Fly   774 YWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTK---FTMVRCRTIKLQALSRGYLVRKDFQKKL- 834
            .....|:.|.:|..|              :.||   ...|..:..:|||.....|..|:.|.|:
Human   853 NCAAYLKLRHWQWWR--------------VFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVE 903

  Fly   835 -----LERRKQNQLKKEELLK--------------------LAKMKEAEELLR--LQQLKEQKER 872
                 :||:.|..|:::.:|.                    .||.:|.||:|.  ..:::|::||
Human   904 GELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEER 968

  Fly   873 EQREQQEKRLQE------EQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPP 931
            .|..|.||:..:      |::|..|..||..|.:..|..:.:.|.:::|   ...|:.:||....
Human   969 NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEE---ILLLEDQNSKFIK 1030

  Fly   932 PTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQ--MVDDVFRFLNDEP------DAALRK 988
            ...|     :..|.|...:::....|....:....:||  |:.|:...|..|.      :.|.||
Human  1031 EKKL-----MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1090

  Fly   989 LNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPI------ 1047
            |:    |:|..|...:                      |..|.:...||..|.|.|..:
Human  1091 LD----GETTDLQDQI----------------------AELQAQIDELKLQLAKKEEELQGALAR 1129

  Fly  1048 --DEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLASLLNTSDSYKPRLFVRQSQRR- 1109
              ||...|...|.::|                    .|.:.:|.|....:|.|......:.|:|
Human  1130 GDDETLHKNNALKVVR--------------------ELQAQIAELQEDFESEKASRNKAEKQKRD 1174

  Fly  1110 IPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYS 1174
            :.:.|.:.:.|.::    .|:...:..|           ..:.|::.:|::.|.|.
Human  1175 LSEELEALKTELED----TLDTTAAQQE-----------LRTKREQEVAELKKALE--------- 1215

  Fly  1175 RGWLLLSLCLSCFPPSKEFEPHLRSF-MKQGTAQLQATPSLQRLERTLVNGPR------------ 1226
                         ..:|..|..::.. .:..||..:.:..|::.:|...|..:
Human  1216 -------------EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1267

  Fly  1227 -CQPPSLFELHAIRGRHPLRLD-----IHLMDGQQRRLQVDAASTAREAVNQL---------CQG 1276
             |:...|.::.|.......:||     :|....:..||:|:.|..|.:..|:|         .:.
Human  1268 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK 1332

  Fly  1277 MGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISECEQRQLDAPWKL-----YIRKEMFATWYDP 1336
            .|:              |.....|..|..|....|..|.:......|     .:.:|..:.....
Human  1333 KGI--------------KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1383

  Fly  1337 SMDPKATQLIYKQILN-GLKCGEYRCRSEKDIAMVCALACFVEYGPGEIL--------RLKPSEI 1392
            ..:.:|.:.:.||:|. ..:..:.:.:.:.|:..:.:|    |....::|        ||:...:
Human  1384 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESL----EEAKKKLLKDAEALSQRLEEKAL 1444

  Fly  1393 TAF--------------------------VPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQND 1431
             |:                          |.|:|    |:..:.:.:|:|.....|:...||::.
Human  1445 -AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNL----EKKQKKFDQLLAEEKSISARYAEERDR 1504

  Fly  1432 LLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSD--ELMLGINSAG--LFLIDETEQ 1492
            ...||:::..:.:.|...|...:.....||   ::..:|::|  :||...:..|  :..::::::
Human  1505 AEAEAREKETKALSLARALEEALEAKEEFE---RQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1566

  Fly  1493 VLASCCFSEVLKVHVE---------SDDKLHV---MTFQHVNFVLQCSSAQDANE---------- 1535
            .|....  |.::..:|         .|.||.:   |......|.....:..:.||
Human  1567 ALEQQV--EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1629

  Fly  1536 -VINYMLDNLRQRSSYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGN-AQDCYRGCV 1598
             .:...|::.|::.:..||....:|.||:|         :|       ||:.|.| |:|
Human  1630 RELEAELEDERKQRALAVASKKKMEIDLKD---------LE-------AQIEAANKARD------ 1672

  Fly  1599 NGQWGQFLAGNVRVLATLTKPSEKLQDILRE------------GRFQEPPKPTPR---------- 1641
                        .|:..|.|...:::|..||            .:.:|..|....
Human  1673 ------------EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1725

  Fly  1642 --ANYSRRRQHNISQLAESHFREPLDSDKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHI 1704
              |:..|.|:|     ||.. |:.| :|:...|......|.....:...::..|.::.
Human  1726 ELASSERARRH-----AEQE-RDEL-ADEITNSASGKSALLDEKRRLEARIAQLEEEL------- 1776

  Fly  1705 LKYMGDIARSNLPVNTDLIFQPALQHPLLCDELYCQ-LMKQLSDNPSSESEKRGWDL---LYLAT 1765
                 :..:||:.:..|...:..||...|..||..: ...|.|||...:.|::..:|   |....
Human  1777 -----EEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELE 1836

  Fly  1766 GLV------------------------------APSVLV------MRELIILL---RMRADAL-- 1789
            |.|                              |.:.||      ::|:.:.:   |..||..
Human  1837 GAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKE 1901

  Fly  1790 ----ADACLKRLKRSL---------AQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVEAFEI 1841
                |:|.:|:|||.|         |...|:|.          ||.|         ||..||.|.
Human  1902 QMEKANARMKQLKRQLEEAEEEATRANASRRKL----------QREL---------DDATEANEG 1947

  Fly  1842 ESHTRGAELIADIAQRLELKSPVGYS 1867
            .|..     ::.:..||....|:.:|
Human  1948 LSRE-----VSTLKNRLRRGGPISFS 1968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	267/713 (37%)
		IQ	765..785	CDD:197470	5/21 (24%)
		Atrophin-1	<820..>946	CDD:460830	36/159 (23%)
		MyTH4	1031..1239	CDD:470587	35/230 (15%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	19/109 (17%)
		B41	1248..1429	CDD:214604	36/229 (16%)
		PH-like	1454..1547	CDD:473070	19/119 (16%)
		MyTH4	1674..1819	CDD:214535	36/202 (18%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	10/43 (23%)
		B41	1827..2032	CDD:214604	10/41 (24%)
		FERM_C2_MyoVII	2028..2121	CDD:270020
MYH10	NP_001242941.1	Myosin_N	31..76	CDD:460670	8/52 (15%)
		MYSc_Myh10	99..802	CDD:276952	267/713 (37%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	692..714		11/21 (52%)
		Myosin_tail_1	879..1959	CDD:460256	229/1275 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1158..1178		4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1728..1759		10/37 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1903..2007		23/90 (26%)