DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo28B1 and MYH9

DIOPT Version :10

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:NP_002464.1 Gene:MYH9 / 4627 HGNCID:7579 Length:1960 Species:Homo sapiens


Alignment Length:2118 Identity:545/2118 - (25%)
Similarity:899/2118 - (42%) Gaps:450/2118 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 AGYSPRKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCD--DRNKQFWVPAGDVLKAMHITS 65
            |.::.:|  .||| |.:.:.     |....::.|..:..:.:  :..|:..|...|:.| |:...
Human    24 ADWAAKK--LVWV-PSDKSG-----FEPASLKEEVGEEAIVELVENGKKVKVNKDDIQK-MNPPK 79

  Fly    66 QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLA 130
            ...||||..|..|.|.::|.||:.||...|||||:|...|.||||:.||||:...:::|:.|...
Human    80 FSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRH 144

  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKH------SWIEQ 189
            |:||||:||:|.|::.:.:.:|:|.::.:|||||||||:||.::||||.::..|      ..:|:
Human   145 EMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELER 209

  Fly   190 QIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNY 254
            |:::||||:|||||||||:|||||||||:|.|.|...|.|.||.|:.|||||||.:.|:::||.:
Human   210 QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTF 274

  Fly   255 HIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEV 319
            ||||.:|:|  ..|..:..|..:..::|.:|:.|. .|:||:.|...|.:...||:::....||.
Human   275 HIFYYLLSG--AGEHLKTDLLLEPYNKYRFLSNGH-VTIPGQQDKDMFQETMEAMRIMGIPEEEQ 336

  Fly   320 WSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGE 384
            ..:|.:::.:|.|||:.|  .:..|...|.:.|....|:|:.||||.::.....:....|.|..:
Human   337 MGLLRVISGVLQLGNIVF--KKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRD 399

  Fly   385 HVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSF 449
            :|..:.:||.|....:|..|:.|:.:|..:|.|||:.::|...|..:.||:|||.|||.||.|||
Human   400 YVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSF 464

  Fly   450 EQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDLIGMK--PMNLMSLID 511
            |||||||.||.|||.|...:|.:||:|||.|.|.|..|:| .|.|..:|||...  |..:::|:|
Human   465 EQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLD 529

  Fly   512 EESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSL-FGIRHYAGVVMYNPLGFLEKNRDSFSG 575
            ||..|||.||::.:||:..:.|....:.|.|..:... |.|.||||.|.|....:|.||.|..:.
Human   530 EECWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLND 594

  Fly   576 DLRTLVQRSTNKYLVDIFP--------------HEMPMDTAKKQ-----PTLCVKFRNSLDMLMR 621
            ::.||:.:|::|::.:::.              .|..:..|.|.     .|:...::..|..||.
Human   595 NIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMA 659

  Fly   622 TLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLL 686
            ||...:|.|:|||.||..|:....|..|.:.|||.:|::|..||.|.|:|.|..::.|.:||.:|
Human   660 TLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEIL 724

  Fly   687 VP---PVGPLEQCDCRKLARQICEV---ALPADSD-RQYGKTKLFLRDEDDASLELQRSQLMLKS 744
            .|   |.|.::       .:|.|.:   ||..||: .:.|::|:|.|....|.||.:|...:...
Human   725 TPNSIPKGFMD-------GKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDV 782

  Fly   745 IVTIQRGIRRVLFRR-YMKRYRE--AIITVQRYWRGRLQRRKY-------------QVMRQGFHR 793
            |:..|...|..|.|: :.||.::  |:..:||.....|:.|.:             ||.||....
Human   783 IIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEM 847

  Fly   794 LG-----ACIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQ------KKLLERRKQNQLKKEE 847
            :.     ..:..:||..:..:....|::.|.::....:::..|      .:..|.|.:...||:|
Human   848 MAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQE 912

  Fly   848 LLKL-----AKMKEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKR 907
            |.::     |:::|.||  |.|.|:.:|::.|:..||.    |::|:.|.:||..|.:..|..:.
Human   913 LEEICHDLEARVEEEEE--RCQHLQAEKKKMQQNIQEL----EEQLEEEESARQKLQLEKVTTEA 971

  Fly   908 RTKPVKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQ--M 970
            :.|.:::|   ...|:.:|........|     |..|.|...|.:....|...::....:|.  |
Human   972 KLKKLEEE---QIILEDQNCKLAKEKKL-----LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028

  Fly   971 VDDVFRFLNDEPD--AALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHER 1033
            :.|:...|..|..  ..|.|......||:..|...:                      |..|.:.
Human  1029 ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQI----------------------AELQAQI 1071

  Fly  1034 KPLKKSLLKHEHPI--------DEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLAS- 1089
            ..||..|.|.|..:        :|.|.|.:.|..:|   :|...:|..      .|:|.|:.|| 
Human  1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIR---ELESQISEL------QEDLESERASR 1127

  Fly  1090 --------------------LLNTSDSYKPRLFVRQSQRR----IPKPLASGEKEAQEFYQHWLN 1130
                                |.:|.||...:..:|..:.:    :.|.|   |:||:........
Human  1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL---EEEAKTHEAQIQE 1189

  Fly  1131 VPTSHLEKIHFIIGHGIIKNSLRDEILAQI--CKQLYLNPSRSSYS----RGWLL--LSLCLSCF 1187
            :...|.:.:              :|:..|:  .|::..|..::..:    ||.|.  :.:.|.  
Human  1190 MRQKHSQAV--------------EELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ-- 1238

  Fly  1188 PPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRLD----- 1247
              .|....|.|   |:..||      ||.|:.....|.|.:.    ||.....:..:.||     
Human  1239 --GKGDSEHKR---KKVEAQ------LQELQVKFNEGERVRT----ELADKVTKLQVELDNVTGL 1288

  Fly  1248 IHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISEC 1312
            :...|.:..:|..|.::...:          |.||  ..|:...|.:.:.|....:.|.|..:..
Human  1289 LSQSDSKSSKLTKDFSALESQ----------LQDT--QELLQEENRQKLSLSTKLKQVEDEKNSF 1341

  Fly  1313 -EQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKC----GEYRCRSEKDIAMVCA 1372
             ||.:.:...|..:.|:: ||.:....|.|      |::.:.:.|    .|.:.:.:||:     
Human  1342 REQLEEEEEAKHNLEKQI-ATLHAQVADMK------KKMEDSVGCLETAEEVKRKLQKDL----- 1394

  Fly  1373 LACFVEYGPGEILRLKPSEITAFVP-------------SDLLAP----------GERAIENWSRL 1414
                      |.|..:..|..|...             .|||..          .|:..:.:.:|
Human  1395 ----------EGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449

  Fly  1415 IAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGI 1479
            :|.....|:...||::....||:::..:.:.|...|...|......|.:.|:. :.:.::||...
Human  1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQF-RTEMEDLMSSK 1513

  Fly  1480 NSAG--LFLIDETEQVLASCCFSEVLKVHVE---------SDDKLHVMTFQHVNFVLQCSSAQDA 1533
            :..|  :..::::::.|....  |.:|..:|         .|.||.:    .||  ||...||..
Human  1514 DDVGKSVHELEKSKRALEQQV--EEMKTQLEELEDELQATEDAKLRL----EVN--LQAMKAQFE 1570

  Fly  1534 NEV--------------------INYMLDNLRQRSSYGVALDPVVEGDLEDCLVLNPGDLIEFEA 1578
            .::                    :...|::.|::.|..||....:|.||:|           .||
Human  1571 RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD-----------LEA 1624

  Fly  1579 GVTGA---------QLMAGNAQ--DCYRGCVNGQWGQFLAGNVRVLATLTKPSEKLQDILREG-R 1631
            .:..|         ||....||  ||.|     :.....|....:||...:..:||:.:..|. :
Human  1625 HIDSANKNRDEAIKQLRKLQAQMKDCMR-----ELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684

  Fly  1632 FQEPPKPTPRANYSRRRQHNISQLAE-----------------------SHFREPLDSDKAPLSK 1673
            .||......||  .|:.|....:||:                       :...|.|:.::.    
Human  1685 LQEELAAAERA--KRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG---- 1743

  Fly  1674 FSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLP-VNTDLIFQ------------ 1725
             :.|.:...|.||.:::..:.....:...|..|  .:.||..|. .|.:|..:            
Human  1744 -NTELINDRLKKANLQIDQINTDLNLERSHAQK--NENARQQLERQNKELKVKLQEMEGTVKSKY 1805

  Fly  1726 ----PALQHPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILL---R 1783
                .||:..:      .||.:|| ||.:.|.:        .|...|..:...::::::.:   |
Human  1806 KASITALEAKI------AQLEEQL-DNETKERQ--------AACKQVRRTEKKLKDVLLQVDDER 1855

  Fly  1784 MRADALADAC------LKRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVEAFEIE 1842
            ..|:...|..      ||:|||.|.           |.|...||......|:        ..|:|
Human  1856 RNAEQYKDQADKASTRLKQLKRQLE-----------EAEEEAQRANASRRKL--------QRELE 1901

  Fly  1843 SHTRGAELIADIAQRLELKSPVGYSIFLKTGDRVYAMP 1880
            ..|..|:.:......|:.|        |:.||..:.:|
Human  1902 DATETADAMNREVSSLKNK--------LRRGDLPFVVP 1931

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc_Myo7 81..726 CDD:276832 261/680 (38%)
IQ 765..785 CDD:197470 5/34 (15%)
Atrophin-1 <820..>946 CDD:460830 32/136 (24%)
MyTH4 1031..1239 CDD:470587 49/248 (20%)
FERM1_F1_Myosin-VII 1243..1334 CDD:340612 19/96 (20%)
B41 1248..1429 CDD:214604 36/208 (17%)
PH-like 1454..1547 CDD:473070 21/123 (17%)
MyTH4 1674..1819 CDD:214535 33/170 (19%)
FERM2_F1_Myosin-VII 1825..1919 CDD:340613 11/56 (20%)
B41 1827..2032 CDD:214604 11/54 (20%)
FERM_C2_MyoVII 2028..2121 CDD:270020
MYH9NP_002464.1 Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547 2..838 298/834 (36%)
Myosin_N 27..72 CDD:460670 9/52 (17%)
Motor_domain 95..764 CDD:473979 261/680 (38%)
Actin-binding 654..676 11/21 (52%)
Myosin_tail_1 841..1921 CDD:460256 241/1268 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1137 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1960 17/82 (21%)
Blue background indicates that the domain is not in the aligned region.

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