DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo28B1 and MYH2

DIOPT Version :10

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:NP_060004.3 Gene:MYH2 / 4620 HGNCID:7572 Length:1941 Species:Homo sapiens


Alignment Length:2112 Identity:557/2112 - (26%)
Similarity:849/2112 - (40%) Gaps:507/2112 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 RKGEYVWVKPQNTTSEFAVPFGAR-------------------------IVRTEKTQTLVCDDRN 47
            ||.|...::.||.      ||.|:                         .|:||...||...|  
Human    18 RKSERERIEAQNR------PFDAKTSVFVAEPKESFVKGTIQSREGGKVTVKTEGGATLTVKD-- 74

  Fly    48 KQFWVPAGDVLKAMHITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQI 112
                    |.:..|:....:.:|||..:..|.|..:|.||:.|||..:||||:|...|.:|||:.
Human    75 --------DQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKW 131

  Fly   113 LPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYL 177
            ||:|....:..||.|...|.|||||:|||||:|.:...:|||.::|:||||||||.:||.::||.
Human   132 LPVYKPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYF 196

  Fly   178 AAI------------SGK-HSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAI 229
            |.|            ||| ...:|.|||.|||::|||||||||||||||||||:|.|.|...|.:
Human   197 ATIAVTGEKKKEEITSGKIQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 261

  Fly   230 QGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLP 294
            ..|.|:.|||||||:|||.:.||:||||| .:......|...:.|...:|..|.:::||. .::.
Human   262 ASADIETYLLEKSRVVFQLKAERSYHIFY-QITSNKKPELIEMLLITTNPYDYPFVSQGE-ISVA 324

  Fly   295 GRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRV 359
            ...|.::.....:|:.:|.|..||..||..|..|::|.|||:|...:  ....||.|.|....:.
Human   325 SIDDQEELMATDSAIDILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQ--REEQAEPDGTEVADKA 387

  Fly   360 AQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINK 424
            |.|..:..:.|..||....:.|..|:||...:.|.......|..|::|:.:|:.:|.|||:.::.
Human   388 AYLQSLNSADLLKALCYPRVKVGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARINQQLDT 452

  Fly   425 QVDQPMN-SIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIE 488
            :  ||.. .||||||.|||.||.||.||||||:.||.|||||..|:|.:||:||:.|.|.|..|:
Human   453 K--QPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFID 515

  Fly   489 F-QDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSI------YVKGKTTQT 546
            | .|....::|| .|||.:.|:::||..|||.||.:...||:.||..:|.      .||||.  .
Human   516 FGMDLAACIELI-EKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKA--E 577

  Fly   547 SLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEMPMD------TAKKQ 605
            :.|.:.||||||.||..|:||||:|..:..:..|.|:|..|.|..:|......:      .|||.
Human   578 AHFALIHYAGVVDYNITGWLEKNKDPLNETVVGLYQKSAMKTLAQLFSGAQTAEGEGAGGGAKKG 642

  Fly   606 --------PTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMET 662
                    .|:...||.:|:.||..|...||:|:|||.|||.|.|...:.||.:.|||.:|::|.
Human   643 GKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEG 707

  Fly   663 ARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQ-CDCRKLARQICEVALPAD-SDRQYGKTKLFL 725
            .||.|.|:|.|..|..|.:||::|.....|..| .|.:|.:.::. .::..| :..::|.||:|.
Human   708 IRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLL-ASIDIDHTQYKFGHTKVFF 771

  Fly   726 RDEDDASLELQRSQLMLKSIVTIQ---RG-IRRVLFRRYMKRYREAIITVQ---------RYW-- 775
            :......||..|...:.:.|...|   || :.||.::|.::| ||||..:|         ::|  
Human   772 KAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQRMVER-REAIFCIQYNIRSFMNVKHWPW 835

  Fly   776 -----------RGRLQRRKYQVMRQGFHRLGACIAAQQLTTK------FTMVRCRT---IKLQAL 820
                       :.....::...|::.|.::...:|..:...|      .|:::.:.   :::||.
Human   836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAE 900

  Fly   821 SRG---------YLVRKDFQ-----KKLLERRK-QNQLKKEELLKLAKMK-EAEEL------LRL 863
            :.|         .|::...|     |::.||.: :.::..|...|..|:: |..||      |.|
Human   901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965

  Fly   864 QQLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQ--KRRTKPVKQEAPKAPTL-QAR 925
            ...|.:||:...|.:.|.|.||.....|..|:......|:|:  ::....::.|..|..|| :|:
Human   966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1030

  Fly   926 NSLPPPPTTLIVAAPLPTRPASAVTR--------INTIPESPGTIDVESSKQMVDD-----VFRF 977
            ..|......|..:.....:....:.|        :....||  .:|:|:.||.:|:     .|..
Human  1031 IKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES--IMDIENEKQQLDEKLKKKEFEI 1093

  Fly   978 LN-------------------DEPDAALRKLNNISSGDTIRLPKSVPNNIDTS-DFSYLKYAATY 1022
            .|                   .|..|.:.:|......:.....|:.....|.| :...:......
Human  1094 SNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158

  Fly  1023 FGGGATAQHE------------RKPLKKSLLKHE---------H--------------------- 1045
            .||..:||.|            |:.|:::.|:||         |                     
Human  1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1223

  Fly  1046 ---------PIDEMASKAIWLTILRFMGDLPDVVSSPTLHVFDNENLMSDLAS-------LLNTS 1094
                     .||::||..  .|:.:..|:|..:..  ||     |:.:|:|.|       |:|..
Human  1224 EKEKSEMKMEIDDLASNV--ETVSKAKGNLEKMCR--TL-----EDQLSELKSKEEEQQRLINDL 1279

  Fly  1095 DSYKPRL------FVRQSQRRIPKPLASGEKEA---------QEFYQHWLNVPTSHLEKIHFIIG 1144
            .:.:.||      |.||..          ||||         |.|        |..:|:      
Human  1280 TAQRGRLQTESGEFSRQLD----------EKEALVSQLSRGKQAF--------TQQIEE------ 1320

  Fly  1145 HGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHL-RSFMKQGTAQL 1208
               :|..|.:||.|:......|..||..       ..|....:...:|.:..| |:..|..|...
Human  1321 ---LKRQLEEEIKAKNALAHALQSSRHD-------CDLLREQYEEEQESKAELQRALSKANTEVA 1375

  Fly  1209 Q-----ATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDGQQRRLQVDAASTARE 1268
            |     .|.::||.|               ||...:.:...||              .||....|
Human  1376 QWRTKYETDAIQRTE---------------ELEEAKKKLAQRL--------------QAAEEHVE 1411

  Fly  1269 AVNQLCQGMGLTDTFGFGLVMSLNGKL--MPLGAGQEHVLDAISECEQRQLDAPWKLYIRKEMFA 1331
            |||..|..:..|.       ..|..::  :.|...:.:...|..:.:||..|         ::.|
Human  1412 AVNAKCASLEKTK-------QRLQNEVEDLMLDVERTNAACAALDKKQRNFD---------KILA 1460

  Fly  1332 TWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAFV 1396
            .|              ||     ||.|.....|.......:|..       |:.::|    .|:.
Human  1461 EW--------------KQ-----KCEETHAELEASQKEARSLGT-------ELFKIK----NAYE 1495

  Fly  1397 PS-DLLAPGERAIENWSRLIAATYEKSSYVKEEQNDL---LLEAQKRAKEDICLFAHLSWPMRHS 1457
            .| |.|...:|..:|              :::|.:||   :.|..||..|               
Human  1496 ESLDQLETLKRENKN--------------LQQEISDLTEQIAEGGKRIHE--------------- 1531

  Fly  1458 RLFEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVL-----ASCCFSEVLKVHVESDDKLHVMT 1517
              .|.::|: .:.:..||...:..|...|..|..::|     .:...|||.:...|.|:::..:.
Human  1532 --LEKIKKQ-VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1593

  Fly  1518 FQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVALDPVVEGDLEDCLVLNPGDLIEFEAGVTG 1582
            ..|:..|....|..||         .:|.|:. .:.|...:||||.           |.|..:..
Human  1594 RNHIRIVESMQSTLDA---------EIRSRND-AIRLKKKMEGDLN-----------EMEIQLNH 1637

  Fly  1583 AQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLATLTKPSEKLQDILREGRFQEPPKPTPRANYSRR 1647
            |..||..|...||   |.|            ..|......|.|.||.   ||..| ...|...||
Human  1638 ANRMAAEALRNYR---NTQ------------GILKDTQIHLDDALRS---QEDLK-EQLAMVERR 1683

  Fly  1648 RQHNISQLAESHFREPLDSDKAPLSKFSPEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDIA 1712
            .  |:.|......|..|:.     ::.|.:..:..||.|..:|..|..|...:.:...|...|| 
Human  1684 A--NLLQAEIEELRATLEQ-----TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI- 1740

  Fly  1713 RSNLPVNTDLIFQPA-----------LQHPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATG 1766
             |.:....:.|.|.|           ....::.:|    |.|:...:...|..|:.         
Human  1741 -SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE----LKKEQDTSAHLERMKKN--------- 1791

  Fly  1767 LVAPSVLVMRELIILLRMRADALADACLKRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYF 1831
                    |.:.:..|::|.|......||..|:.:.:.:.:......|||..|:|.......:..
Human  1792 --------MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848

  Fly  1832 PDDTVE--AFEIESHTRGAELIADIAQRLELK 1861
            .:..|:  .::.|...:....:.|:..:|:.|
Human  1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAK 1880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc_Myo7 81..726 CDD:276832 277/681 (41%)
IQ 765..785 CDD:197470 6/41 (15%)
Atrophin-1 <820..>946 CDD:460830 33/150 (22%)
MyTH4 1031..1239 CDD:470587 56/286 (20%)
FERM1_F1_Myosin-VII 1243..1334 CDD:340612 17/92 (18%)
B41 1248..1429 CDD:214604 31/183 (17%)
PH-like 1454..1547 CDD:473070 19/97 (20%)
MyTH4 1674..1819 CDD:214535 29/155 (19%)
FERM2_F1_Myosin-VII 1825..1919 CDD:340613 5/39 (13%)
B41 1827..2032 CDD:214604 5/37 (14%)
FERM_C2_MyoVII 2028..2121 CDD:270020
MYH2NP_060004.3 Myosin_N 33..77 CDD:460670 8/53 (15%)
MYSc_Myh2_mammals 100..772 CDD:276877 277/681 (41%)
Actin-binding. /evidence=ECO:0000250 661..683 11/21 (52%)
Actin-binding. /evidence=ECO:0000250 763..777 4/13 (31%)
Myosin_tail_1 852..1929 CDD:460256 242/1251 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1149 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1155..1174 5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

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