Protein Alignment Myo28B1 and MYO1B

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_047300366.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 1152
• Identity: 369/1152 - (32%)
• Similarity: 572/1152 - (49%)
• Gaps: 203/1152 - (17%)

  Fly    51 WVPAGDVLKAMH--------ITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAI 107
            |...|..|:.|.        :.:...|.||:.|..|.|.|.:.||:.|:....||||.||:::::
Human    11 WGRRGSELETMAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISV 75

  Fly   108 NPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKL 172
            |||:.||||:..:::.|||::..||.|||||:||.|::.|:...::||::|:|||||||||::||
Human    76 NPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKL 140

  Fly   173 ILQYLAAISGKHSWIEQ---QIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARI 234
            ::.|:||:.||.:.:.|   |::::||::||||||||||||||||||||::|.|..:|...|..|
Human   141 VMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVI 205

  Fly   235 QQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDA 299
            ..|||||||:|.|.|.|||:|:||.:|:|.|.....:||| |:..|:|:||:.... .:.|..||
Human   206 SNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKL-ERDFSRYNYLSLDSA-KVNGVDDA 268

  Fly   300 KDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRF-TATEVANLATAEIDDTPNLQRVAQLL 363
            .:|..:|.||:::.|...|..|:|:::||:|.|||:.| ..:.|..|..::|.|...|:.:.:|.
Human   269 ANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELT 333

  Fly   364 GIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQ 428
            ||..|.|..|.:.||:....|.|:|:|:...|...|||..|:||..:|..:|.||||:|..|...
Human   334 GIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKV 398

  Fly   429 PMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQ 493
            ....:|||||:|||.|::|||||..|||.||.|||.|:....|.||:||..|.|.|.||::.:|.
Human   399 RKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNA 463

  Fly   494 QILDLIGMKPMNLMSLIDEESKFP-KGTDQTLLEKLHV-----QH-----GNRSIYVKGKTTQTS 547
            .|.|||......:::::|||...| ..||:|.||||:.     ||     ...|.::...:...|
Human   464 IICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHS 528

  Fly   548 LFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPHEMPMD-TAKKQPTLCVK 611
            .|.|:||||.|:|...||::||.|....||...:.::::..:..:||...|.. ..|:.||...:
Human   529 CFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQ 593

  Fly   612 FRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAY 676
            |:.|:..||:.|...:|.:|||||||:.|....|::.|...|:||.|::|..|:|||||..|.||
Human   594 FKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAY 658

  Fly   677 RAFVERYRLLVPPVGPLEQCDCRKLARQIC-EVALPADSDRQYGKTKLFLRD------------- 727
            ...:|||::|.....|..:...|.....:. |:.:|.: :..:|::|:|:|:
Human   659 EPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVE-EYSFGRSKIFIRNPRTLFKLEDLRKQ 722

  Fly   728 --EDDAS---------------LELQRSQLML-----------------KSIVTIQRGIR----R 754
              ||.|:               |.:::||:::                 .|.:.||..||    |
Human   723 RLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKAR 787

  Fly   755 VLFR--RYMKRYREAIITVQRYWRGRLQRRKYQVMRQ---GFHRLGACIAAQQLTTKFTMVRCRT 814
            .:.|  ::.||.:||:.|:..||.|...||:.:.:::   ..|.: |.|.|..|.:| .....:.
Human   788 KILRELKHQKRCKEAVTTIAAYWHGTQARRELRRLKEEARNKHAI-AVIWAYWLGSK-ARRELKR 850

  Fly   815 IKLQALSR-----------GYLVRKDFQ--------KKLLERRKQNQLKKEELLKLAKM------ 854
            :|.:|..:           |..||::::        ||:.|...|..::|..|....||
Human   851 LKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPI 915

  Fly   855 ----------------KEAEELLRLQQLKEQKEREQREQQEKRLQEEQRLKAEAAA----RNALA 899
                            ||.:.:..|.:.|  |.|:|...|:|.:.||   |.||:.    :.||.
Human   916 DKNWPSRPYLFLDSTHKELKRIFHLWRCK--KYRDQFTDQQKLIYEE---KLEASELFKDKKALY 975

  Fly   900 MAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDV 964
            .::|.|     |.:                                 .|...||..|:.....|.
Human   976 PSSVGQ-----PFQ---------------------------------GAYLEINKNPKYKKLKDA 1002

  Fly   965 ESSKQMVDDVFRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSD------------FSYLK 1017
            ...|.::.:|           :.|:|..:...|.|:.....||:..:|            ....|
Human  1003 IEEKIIIAEV-----------VNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTK 1056

  Fly  1018 YAATYFGGGATAQHERKPLKKS-----LLKHEHPIDEMASKAIWLTI 1059
            .:.:....|..|.|.::..:.:     |...:|.| |||:|....|:
Human  1057 VSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLI-EMATKLYRTTL 1102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	271/661 (41%)
		IQ	765..785	CDD:197470	8/19 (42%)
		Atrophin-1	<820..>946	CDD:460830	30/170 (18%)
		MyTH4	1031..1239	CDD:470587	9/34 (26%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
MYO1B	XP_047300366.1	MYSc_Myo1	49..708	CDD:276829	271/661 (41%)
		IQ	769..791	CDD:197470	6/21 (29%)
		Myosin_TH1	961..1138	CDD:461801	34/192 (18%)