Protein Alignment Myo28B1 and Mhcl

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Alignment Length: 1910
• Identity: 409/1910 - (21%)
• Similarity: 693/1910 - (36%)
• Gaps: 561/1910 - (29%)

  Fly    11 EYVW-VKPQNTTSEFAVP-----------FGARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHI 63
            |.|| |.....|:...:|           ...|::...:..|:..||..||. .||.|:
  Fly   505 ERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQN-SPALDL------ 562

  Fly    64 TSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKS 128
                 |||:..|..|.|.::|..|:.|||..||:|..|..|:.:||...|.:|:.:.:.::|...
  Fly   563 -----VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCK 622

  Fly   129 LAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKH-SWIEQQII 192
            ..::|||:::::..|::.|...:.:|.::..|.||:||:.|.|..|.|||..:|.: ::|..:.:
  Fly   623 TEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKV 687

  Fly   193 EA-NPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHI 256
            .| ..|:|||||.||..|.|::|..:.:.:.|...|.|..|.:|..|.|:.|...:...|.::||
  Fly   688 NALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHI 752

  Fly   257 FYCMLAGLSTAERERLKLQEQSPSQYH---YLAQGGCFTLPGR-GDAKDFADIRAAMKVLSFKPE 317
            ...:|||.:...::.|.|:..:....|   .|:|    .|..| ..|.||.....|.:.|:...:
  Fly   753 MTRLLAGAAGLLQKELHLENITSEDSHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAK 813

  Fly   318 EVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAA---LTQRTI 379
            .|..|.|:||||.|||....|.....:.|..:..:....::.:.|||:.:..|::|   |||...
  Fly   814 AVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNA 878

  Fly   380 FVHG----EHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFG 440
            ...|    :..|:....|.|.|..:|.|..||......:|..||..|... ...:.||.::|..|
  Fly   879 PNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTS-SHTIASIMLIDTPG 942

  Fly   441 FENFDN------NSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQ----- 494
            |:|..:      .:...|..||..|.||..|........:|.|..|.:   .||.....:
  Fly   943 FQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELV---EIEMDLASECHPGP 1004

  Fly   495 ILDLIGMKPMN-----------------LMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIY-VKG 541
            ::.||...|.|                 ::.|:|||:.:|...|.|.||:|...:|:|..: :..
  Fly  1005 LISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLR 1069

  Fly   542 KTTQTSLFGIRHYAGV--VMYNPLGFLEKNRD--------------------------------- 571
            |......|.:.|..|.  |:|...|::..:|:
  Fly  1070 KCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGA 1134

  Fly   572 -----SFSG-----DLRTL--VQRSTNKYLVDIFPHEMPMDTA-KKQPTLCVKFRNSLDMLMRTL 623
                 ||:|     .||.:  ::||              ..|| .|:.::.::.:.::|.::.||
  Fly  1135 MVFCGSFAGLEGTQSLRRVSSIRRS--------------FTTAGVKRNSIMLQVKFTVDGIIDTL 1185

  Fly   624 SQAHPYFIRCI-------KPNEY--------------KEPKNFDKELCVRQLRYSGMMETARIRR 667
            .:...:|:.|.       |..:|              .|.:..:..|...|||.|.::|.||:.|
  Fly  1186 RRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHR 1250

  Fly   668 AGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLARQICEVALPADSDRQYGKTKLFLRDEDDAS 732
            .|:|.......||.|:.||...:...:.....::                     |.:.:.|.||
  Fly  1251 LGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQI---------------------LAVNELDVAS 1294

  Fly   733 LELQRSQLMLKSIVTIQRGIRR-VLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGA 796
            ..:..||::.:|.|..:...:| ||.       .:.||.:|.:.||.|.|:|....|
  Fly  1295 YRIGPSQILFRSGVLSELEAKRDVLL-------SDRIIQLQAFCRGYLARKKMSQRR-------- 1344

  Fly   797 CIAAQQLTTKFTMVRCRTIKLQALSRGYLVRKDFQ-KKLLERRKQ--NQLKKEELLKLAKMKEAE 858
               .|:|.     |||    :|...:.:|..:|:. .:||.|...  |..:.||.||.|.    |
  Fly  1345 ---VQELA-----VRC----IQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTAN----E 1393

  Fly   859 ELLRLQQLKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQ 923
            |||.|:...|:.|.::.|.:    .|.|:|:|:.:.    ....:.::|.|..:..|..:|.|.:
  Fly  1394 ELLMLRAKLEKIECDRSEVK----AENQKLEAKLSE----LTVDLAEERSTAHIATERLEAETAE 1450

  Fly   924 ARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDVFRFLNDEPDAALRK 988
                          ...|.........::..:.|:...:::|..                .|...
  Fly  1451 --------------RLKLEKELGDQTNKVKNLQETTEKLEMELI----------------CAKSD 1485

  Fly   989 LNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGA-TAQHERKPLKKSLLK------HEHP 1046
            ||.||..:.......|                   |||. ..::||...:....|      |||.
  Fly  1486 LNGISEDEDAENEDGV-------------------GGGVYKLKYERVARELEFTKRRLHTQHEHD 1531

  Fly  1047 IDEMASKAIWLTILRFMGDLPDVVSSPTL--------HVFDNENLMSDLASLLNTSDSYKPRLFV 1103
            ::::.:....|. ::......:||....:        ....||  |:||..||...::....|
  Fly  1532 LEQLVALKKHLE-MKLSDAYEEVVEQRQVVGQWKRKAQKMTNE--MNDLRMLLEEQNARNNLL-- 1591

  Fly  1104 RQSQRRIPKPLAS------GEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSL----RDEILA 1158
            .:.||:......|      .|::|:|.|....:|    |:...|.:...:....|    ::|.||
  Fly  1592 EKKQRKFDAECQSLQDAVRQERQAKERYGREKDV----LQAEKFTLEQTLADTRLDLEFKEEKLA 1652

  Fly  1159 QICKQL--------------YLNPSRSSYSRGWLLLSLCLSCFPPSKEFEPHLR------SFMKQ 1203
            .:.::|              .|..|::...|             .:||.|..|.      ..::|
  Fly  1653 SLQRELEEMTFGGGTEEEFAQLRRSKNETER-------------RAKEQEEELDEMAGQIQLLEQ 1704

  Fly  1204 GTAQLQAT----------PSLQR---LERTLVNGPR------CQPPSLFELHA--IRGRHPLRLD 1247
            ...:|:.|          .|.||   ||....||.:      ||..:..|...  :|.:|.|...
  Fly  1705 AKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERR 1769

  Fly  1248 IHLMDGQQRRLQVDAASTAREAVNQLCQGMGLTDTFGFGLVMSLNGKL-MPLGAGQEHVLDAISE 1311
            :..|:.:.|   ||  ..|.||:||                     || ..|...:..:.||.::
  Fly  1770 LSSMEDRDR---VD--RDAEEALNQ---------------------KLRRDLRKYKALLKDAQTQ 1808

  Fly  1312 CEQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACF 1376
            .|:.:.|.|.|..||                      |:.|.|:..|    |.:.:||
  Fly  1809 LERLKADTPGKTLIR----------------------QLRNQLEDAE----SARSLAM------- 1840

  Fly  1377 VEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAK 1441
                  :..:...:|:|.                    :.|.:::|   ...:||    |::||.
  Fly  1841 ------KARQTAEAELTE--------------------VQAMFDES---HRARND----AEERAN 1872

  Fly  1442 EDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLASCC--FSEVLK 1504
            .     ||               ::..:||:.             |:|.|:.|....  :|..:|
  Fly  1873 A-----AH---------------RDRAELQAQ-------------IEENEEELGELMKKYSATVK 1904

  Fly  1505 ------VHV-ESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGVA--------- 1553
                  ::| |::.||:.|..:..|...|.:..|       :.|||:.......:|
  Fly  1905 QLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQ-------HRLDNVENLGDPSMAMMSKRLELR 1962

  Fly  1554 ---------LDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGN 1609
                     |:......||..:..:...|.:.:..||.:::....|||
  Fly  1963 TKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQD----------------- 2010

  Fly  1610 VRVLATLTKPSEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFR-EPLDSDKAPLSK 1673
                 .:.|..:.|:|:..|  |..         .|.|.|.::::..:...: |.::|:.|
  Fly  2011 -----VIKKSQKSLRDMREE--FHA---------VSSREQESLTRRKDLEKKVEQMESEGA---- 2055

  Fly  1674 FSPEPLKAPLLKAVVKVPPLFQQAL 1698
                .||..|..|:.::..| |||:
  Fly  2056 ----ALKNDLRLALQRIADL-QQAM 2075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	182/755 (24%)
		IQ	765..785	CDD:197470	8/19 (42%)
		Atrophin-1	<820..>946	CDD:460830	29/128 (23%)
		MyTH4	1031..1239	CDD:470587	52/272 (19%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	21/91 (23%)
		B41	1248..1429	CDD:214604	31/181 (17%)
		PH-like	1454..1547	CDD:473070	19/101 (19%)
		MyTH4	1674..1819	CDD:214535	8/25 (32%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	384/1796 (21%)
		MYSc_Myo18	575..1305	CDD:276837	187/772 (24%)