Protein Alignment Myo28B1 and Myo3b

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001380706.1
• Gene: Myo3b / 366069
• RGDID: 1560313
• Length: 1333
• Species: Rattus norvegicus
• Alignment Length: 1102
• Identity: 351/1102 - (31%)
• Similarity: 536/1102 - (48%)
• Gaps: 223/1102 - (20%)

  Fly    30 ARIVRTEKTQTLVCDDRNKQFWVPAGDVLKAMHITSQEDVE---------DMITLGDLQEYTILR 85
            |:::..:|.|..|...|:::           ||......||         |::.|..|.|.||:.
  Rat   324 AKVLWDQKHQNPVAKTRHER-----------MHTGRPHHVEDAGKCCLEDDLVNLEVLDEDTIIY 377

  Fly    86 NLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRL 150
            .||.|||..|||||.|.:|:|:||:|.|.||:.:..:||.....:..||||||.:|||:|.|...
  Rat   378 WLQKRYADALIYTYVGDILIALNPFQNLSIYSPQFSRLYHGVKRSSNPPHIFASADNAYQCLVTF 442

  Fly   151 KENQCVVISGESGAGKTESTKLILQYLAAISGK--HSWIEQQIIEANPIMEAFGNAKTVRNDNSS 213
            .::||:|||||||:||||:..||:|:|..: ||  :..:.|:|::.|.::||||||:|..|||||
  Rat   443 SKDQCIVISGESGSGKTENAHLIVQHLTFL-GKANNQTLRQKILQVNSLVEAFGNARTAINDNSS 506

  Fly   214 RFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAER-ERLKLQEQ 277
            |||||:|:.|||.||:.||||.:|||||||::.|:..|:|:||||.:.|||...:: ...:|.|:
  Rat   507 RFGKYLEMMFTPTGAVMGARISEYLLEKSRVIQQAAGEKNFHIFYYIYAGLYHQKKLAEFRLPEE 571

  Fly   278 SPSQYHYLAQGGCFT---LPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTA 339
            .|.:| ..|:....|   .......:.|..|:...:::.|..:||.|:..:||.||::||:.|.|
  Rat   572 KPPRY-IAAETERVTQDITSKESYRRQFDVIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAA 635

  Fly   340 TEVANLATAEIDDTPN---LQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDA 401
              :::....:..:.||   |:..|.:|.|....|..|||...:...||.:..:.:.:.|.:.|||
  Rat   636 --ISSQHQTDKSEVPNPEALENAASVLCINSEELQEALTSHCVVTRGETIVRANTVDRAEDVRDA 698

  Fly   402 FVKSLYDGIFVRIVRRINETI--NKQV---DQPMNSIGVLDIFGFENFDNNSFEQLCINYANENL 461
            ..|:||..:|..||.|||..:  :|.:   :..|| :|:|||||||:|..|||||||||.|||.:
  Rat   699 MSKALYGRLFSWIVNRINTLLQPDKNICSAEDRMN-VGILDIFGFEDFQRNSFEQLCINIANEQV 762

  Fly   462 QQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLE 526
            |.:|..|:|.:||.||:.|.::...::::||:.:||:...||:.|::|:||||:||:||||||::
  Rat   763 QFYFNQHVFALEQMEYKKEGVDAVLVQYEDNRPLLDMFLQKPLGLLALLDEESRFPQGTDQTLVD 827

  Fly   527 KLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQRSTNKYLVD 591
            |.. .:.....:.:.|..:.| |||:||||.|:|:..|.||||||:...|:..:::.|.||.|..
  Rat   828 KFE-DNLRCKFFWRPKGVELS-FGIQHYAGPVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQ 890

  Fly   592 IF-------------------------PH--------------EMPMDTAK-KQPTLCVKFRNSL 616
            :|                         ||              ..|.:|.. |:.|:...||.||
  Rat   891 LFSIPLTKTGNLAQTRARITASSRSLPPHFSAGRAKVDTLEVIRHPEETTNMKRQTMASYFRYSL 955

  Fly   617 DMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVE 681
            ..|:..:....|:|:||||||:.::...|.::..:.|||.:|::||..|||.||..|..:..||.
  Rat   956 MDLLSKMVVGQPHFVRCIKPNDDRKALQFSQDRVLAQLRSTGILETVSIRRQGYSHRILFEEFVR 1020

  Fly   682 RYRLL------VPPVGPLEQCDCRKLARQICEVALPADSDRQY---GKTKLFLRDEDDASLELQR 737
            ||..|      .||... |.|           ||:...|...:   ||||:||:     ...:::
  Rat  1021 RYYYLAFRAHQTPPANK-ESC-----------VAILEKSRLDHWVLGKTKVFLK-----YYHIEQ 1068

  Fly   738 SQLMLKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQ 802
            ..|:|:.::.     |.|:.:.|.|.:    :..:||.|.:.:|.|
  Rat  1069 LNLLLREVMG-----RVVMLQAYTKGW----LGARRYKRAKEKREK------------------- 1105

  Fly   803 LTTKFTMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLRLQQLK 867
                      ..|.:|:..|||..|:.| |:...||.::....:.:|
  Rat  1106 ----------SAITIQSAWRGYDTRRKF-KQTRHRRNESAAHTQAVL------------------ 1141

  Fly   868 EQKEREQREQQEKRLQE---EQRLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTL------- 922
                  |....|||..:   |...:.|..:||..|.|...    ..|..|.:|.:..:
  Rat  1142 ------QTTPDEKRFPDSGVESNSRHEETSRNCPAEADTD----WHPQTQSSPASSDVTSGHADK 1196

  Fly   923 QARNSLPPPPTTLIVAAP--LPTR---PASAVTRINTIPES--PGTIDVESSKQMVDDVFRFLND 980
            :|.|::    ..|.||..  .|:|   .|:|..|::....|  ||:.:..|.||.
  Rat  1197 EAGNAV----AELSVAGTDGSPSRVCHTATAHHRLSPCEVSLKPGSEEGLSQKQR---------- 1247

  Fly   981 EPDAALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKSLLK 1042
               |..|:...         ||.:.:..||..::.|.....|.|.      :|||.|...:|
  Rat  1248 ---APRRRCQQ---------PKMLSSPEDTMYYNQLNGTLEYQGS------QRKPRKLGQIK 1291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	272/707 (38%)
		IQ	765..785	CDD:197470	5/19 (26%)
		Atrophin-1	<820..>946	CDD:460830	29/140 (21%)
		MyTH4	1031..1239	CDD:470587	5/12 (42%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
Myo3b	NP_001380706.1	Protein Kinases, catalytic domain	20..310	CDD:473864
		MYSc_Myo3	373..1062	CDD:276830	272/707 (38%)
		IQ	1102..1124	CDD:197470	9/51 (18%)