DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo28B1 and Mhc

DIOPT Version :9

Sequence 1:	NP_723294.1	Gene:	Myo28B1 / 53515	FlyBaseID:	FBgn0040299	Length:	2122	Species:	Drosophila melanogaster
Sequence 2:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster

Alignment Length:	2105	Identity:	527/2105 - (25%)
Similarity:	848/2105 - (40%)	Gaps:	518/2105 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DRNKQFWVP--------------AGDVL-------KAMHITSQ----------EDVEDMITLGDL 78
            |..|..|:|              .||::       :...|.|:          |.:|||..:..|
  Fly    33 DSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVL 97

  Fly    79 QEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLAELPPHIFAISDNA 143
            ....:|.||:.||..:|||||:|...||||||:..|:||||..::||.|...|:|||||||||.|
  Fly    98 NTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGA 162

  Fly   144 FQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAISGKHSW---------IEQQIIEANPIME 199
            :..:.....||.::|:|||||||||:||.::.|.|.:......         :|.|:::.||::|
  Fly   163 YVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLE 227

  Fly   200 AFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGL 264
            ||||||||||||||||||:|.|.|.|.|.:.||.|:.|||||:|::.|...||:|||||.:::|
  Fly   228 AFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSG- 291

  Fly   265 STAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAI 329
            |....:.:.|...:...||.::||. .|:....||::|:....|..:|.|..:|...:..:.||:
  Fly   292 SVPGVKDICLLTDNIYDYHIVSQGK-VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAV 355

  Fly   330 LHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEA 394
            :|:|.::|  .:......||.|......||::|.|...:.|...|.:..|.|..|.||...:.:.
  Fly   356 MHMGGMKF--KQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQ 418

  Fly   395 AIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANE 459
            ......|..|.::|.:|..:|::.|||::.| .:..:.||||||.|||.|:.|.|||||||:.||
  Fly   419 VTNSIGALCKGVFDRLFKWLVKKCNETLDTQ-QKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNE 482

  Fly   460 NLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQT 523
            .|||||..|:|.:||:||:.|.|:|..|:| .|....:||| .|||.::|:::|||.|||.||||
  Fly   483 KLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLI-EKPMGILSILEEESMFPKATDQT 546

  Fly   524 LLEKLHVQH-GNRSIYVKGKT----TQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQR 583
            ..|||...| |..:.:.|.|.    .|.:.|.|.||||.|.||..|:||||:|..:..:....::
  Fly   547 FSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKK 611

  Fly   584 STNKYLVDIFPHEMPMDTAKKQ------------PTLCVKFRNSLDMLMRTLSQAHPYFIRCIKP 636
            |.||.|::||..........:|            .|:...::..|:.||.||....|:|:|||.|
  Fly   612 SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIP 676

  Fly   637 NEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKL 701
            ||.|:|...|..|.:.||..:|::|..||.|.|:|.|..|..|..||:::.|.:  |:..:..|.
  Fly   677 NEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL--LQGVEKDKK 739

  Fly   702 ARQIC--EVALPADSDRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYMKRY 764
            |.:|.  .:.||.|..| .|.||:|.|......:|..|.:.:.|.:..:|...|..|.|:..|:.
  Fly   740 ATEIIIKFIDLPEDQYR-LGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKL 803

  Fly   765 RE---AIITVQRYWRGRLQRRK---YQVMRQ-----GFHRLGACIA--------AQQLTTKFTMV 810
            :|   |:..|||..|..||.|.   |::.::     ...|:...||        |::|......|
  Fly   804 QEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKV 868

  Fly   811 RCRTIKLQALSRGYLVRK------------------------------------DFQKKLL-ERR 838
            |   .:|:||:...|..|                                    |.|::|. |..
  Fly   869 R---KELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEED 930

  Fly   839 KQNQL---KKEELLKLAKMKEAEELLRLQQLKEQKEREQREQQEK--------------RLQEEQ 886
            .:|||   ||:...:::.:|:..|.|.|...|.::::..::.|.:              :|.:|:
  Fly   931 ARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKEK 995

  Fly   887 RLKAEAAARNALAMAAVQQK----------------------RRTKPVKQEAPKAP--------- 920
            :::.|...:....:.|.:.|                      .|.|.|:.:..|:.
  Fly   996 KMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLKL 1060

  Fly   921 TLQARNSLPPPPTTLIVAAPLPTRPASAVT----------------------RINTIPESPGTID 963
            |.:|...|......|........:..|::|                      ||..:.|     :
  Fly  1061 TQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEE-----E 1120

  Fly   964 VESSKQMVDDVFRFLNDEPDAAL-RKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGA 1027
            ||:.:|.     |...::..|.| |:|..:..    ||.::                    ||..
  Fly  1121 VEAERQA-----RAKAEKQRADLARELEELGE----RLEEA--------------------GGAT 1156

  Fly  1028 TAQHE------------RKPLKKSLLKHE-----------HPIDEMASKAIWLTILR-------- 1061
            :||.|            |:.|:::.::||           ..:.|||.:...|..|:
  Fly  1157 SAQIELNKKREAELSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKN 1221

  Fly  1062 -FMGDLPDV----------------VSSPTLHVFDN-ENLMSDLASLLNTSDSYKPRLFVRQSQ- 1107
             :.|.|.|:                ::....|..:. ::.:.:....||..|:.|.:|.:..|.
  Fly  1222 EYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDL 1286

  Fly  1108 -RRIPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRS 1171
             |::.      |.|:|          .|.|.|         ||.||..::  :..|:|....||
  Fly  1287 LRQLE------EAESQ----------VSQLSK---------IKISLTTQL--EDTKRLADEESR- 1323

  Fly  1172 SYSRGWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELH 1236
              .|..||...        :..|..|.:..:|...:.:....||| :.:..|.......|.:|..
  Fly  1324 --ERATLLGKF--------RNLEHDLDNLREQVEEEAEGKADLQR-QLSKANAEAQVWRSKYESD 1377

  Fly  1237 AIRGRHPLRLDIHLMDGQQRRLQVDAASTAR--EAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLG 1299
            .:.....|       :..:|:||...|....  |::||.|.|:..|..     .:|...:.:.|.
  Fly  1378 GVARSEEL-------EEAKRKLQARLAEAEETIESLNQKCIGLEKTKQ-----RLSTEVEDLQLE 1430

  Fly  1300 AGQEHVLDAISECEQRQLD---APWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRC 1361
            ..:.:.:...:|.:|:..|   ..|||             .:|..|.:         |...:..|
  Fly  1431 VDRANAIANAAEKKQKAFDKIIGEWKL-------------KVDDLAAE---------LDASQKEC 1473

  Fly  1362 RSEKDIAMVCALACFVEYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVK 1426
            |:...                |:.|||                            ..||:.
  Fly  1474 RNYST----------------ELFRLK----------------------------GAYEEG---- 1490

  Fly  1427 EEQNDLLLEAQKRAKEDIC-----LFAHLSWPMRHSRLFEVVRKEGPKLQSDELMLGINSAGLFL 1486
            :||    |||.:|..:::.     |...:....|:....|..||. .:.:.|||...:..|...|
  Fly  1491 QEQ----LEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKR-LEAEKDELQAALEEAEAAL 1550

  Fly  1487 IDETEQVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYG 1551
            ..|..:||.:..  |:.:|..|.|.::.                :...|..|...::.|...|..
  Fly  1551 EQEENKVLRAQL--ELSQVRQEIDRRIQ----------------EKEEEFENTRKNHQRALDSMQ 1597

  Fly  1552 VALDPVVEGDLEDCLVLN--PGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLA 1614
            .:|:...:|..|...:..  ..|:.|.|..:..|......||...:     ::.|    .::.:.
  Fly  1598 ASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIK-----RYQQ----QLKDIQ 1653

  Fly  1615 TLTKPSEKLQDILRE-------------GRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDS 1666
            |..:..::.:|..||             ...:|......:|:..||:..  .:||::|  |.|:.
  Fly  1654 TALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAE--QELADAH--EQLNE 1714

  Fly  1667 DKAPLSKFS--PEPLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLPVNTDLIFQPALQ 1729
            ..|..:..|  ...|::.|......:..|..:|........|.|.|.||
  Fly  1715 VSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAAR---------------- 1763

  Fly  1730 HPLLCDELYCQLMKQLSDNPSSESEKRGWDLLYLATGLVAPSVLVMRELIILLRMRADALADACL 1794
               |.|||..:     .|:..::.:.|                ..:.:.|..|::|.|......|
  Fly  1764 ---LADELRAE-----QDHAQTQEKLR----------------KALEQQIKELQVRLDEAEANAL 1804

  Fly  1795 KRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKIYFPDDTVE--AFEIESHTRGAELIADIAQR 1857
            |..|:::.:.:::......|::|.|:|.......:...:..|:  :|:.|...:..|.:.|:..:
  Fly  1805 KGGKKAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDK 1869

  Fly  1858 LELKSPVGYSIFLKTGDRVYAMPEE 1882
            |:.|        :||..|.....||
  Fly  1870 LQQK--------IKTYKRQIEEAEE 1886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc	62..737	CDD:214580	278/713 (39%)
		MYSc_Myo7	81..726	CDD:276832	269/673 (40%)
		IQ	765..785	CDD:197470	9/25 (36%)
		DUF4355	827..>887	CDD:290964	18/113 (16%)
		MyTH4	1031..1239	CDD:295320	47/258 (18%)
		B41	1248..1429	CDD:214604	29/185 (16%)
		FERM_N	1248..>1288	CDD:286467	10/41 (24%)
		FERM_B-lobe	1342..1429	CDD:271216	10/86 (12%)
		PH-like	1454..1547	CDD:302622	19/92 (21%)
		MyTH4	1674..1819	CDD:214535	25/146 (17%)
		B41	1827..2032	CDD:214604	12/58 (21%)
		FERM_N	1829..>1877	CDD:286467	10/49 (20%)
		FERM_M	1936..2032	CDD:278785
		FERM_C2_MyoVII	2028..2121	CDD:270020
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832	5/36 (14%)
		MYSc	81..777	CDD:214580	276/704 (39%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	269/673 (40%)
		Myosin_tail_1	842..1897	CDD:279860	226/1287 (18%)
		V_Alix_like	1557..1877	CDD:187408	69/398 (17%)
		ATP-synt_B	<1671..1771	CDD:304375	24/122 (20%)
		TMPIT	1739..>1825	CDD:285135	20/125 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840