Protein Alignment Myo28B1 and myh9a

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: NP_001091647.3
• Gene: myh9a / 333938
• ZFINID: ZDB-GENE-030131-5870
• Length: 1961
• Species: Danio rerio
• Alignment Length: 1617
• Identity: 444/1617 - (27%)
• Similarity: 720/1617 - (44%)
• Gaps: 329/1617 - (20%)

  Fly     3 AGYSPRKGEYVWVKPQNTTSEFAVPFGARIVRTEKTQTLVCD--DRNKQFWVPAGDVLKAMHITS 65
            |.::.:|  .|||..:.      :.|.|..::.|.....:.:  |..|:..|...|:.| |:...
Zfish    22 ADWATKK--LVWVPSEK------LGFEAGSIKEETGDECLVELADSGKKIKVNKDDIQK-MNPPK 77

  Fly    66 QEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQILPIYTNREIQLYRNKSLA 130
            ...||||..|..|.|.::|.||:.||...|||||:|...|.||||:.|||||...:::|:.|...
Zfish    78 FSKVEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKYLPIYTEEIVEMYKGKKRH 142

  Fly   131 ELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLA-------------AISG 182
            |:||||:||:|.|::.:.:.:|:|.::.:|||||||||:||.::||||             :|:.
Zfish   143 EMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSFKTKKDQSSIAL 207

  Fly   183 KHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQ 247
            .|..:|:|:::||||:|||||||||:|||||||||:|.|.|...|.|.||.|:.|||||||.:.|
Zfish   208 SHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQ 272

  Fly   248 SRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFADIRAAMKVL 312
            ::|||.:||||.:|.|.....|..|.|::.  ::|.:|:.|. .|:||:.|.:.||:...|.:::
Zfish   273 AKDERAFHIFYYLLTGAGDKLRSELCLEDY--NKYRFLSNGN-VTIPGQQDRELFAETIDAFRIM 334

  Fly   313 SFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQR 377
            ....:|...:|.:::|:|.|||:.|  .:..|...|.:.|....|:|:.|||:.::....|:...
Zfish   335 GIPEDEQTGLLKVVSAVLQLGNMSF--KKERNSDQASMPDDTAAQKVSHLLGMNVTDFTRAILSP 397

  Fly   378 TIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSIGVLDIFGFE 442
            .|.|..:.|..:.::|.|....:|..|:.|:.:|..:|.|||:.::|...|..:.||:|||.|||
Zfish   398 RIKVGRDFVQKAQTQEQAEFAVEALAKATYERLFRWLVMRINKALDKTKRQGASFIGILDIAGFE 462

  Fly   443 NFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEF-QDNQQILDLIGMK--PM 504
            .|:.||||||||||.||.|||.|...:|.:||:|||.|.|.|..|:| .|.|..::||...  |.
Zfish   463 IFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCIELIEKPNGPP 527

  Fly   505 NLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSL-FGIRHYAGVVMYNPLGFLEK 568
            .:::|:|||..|||.||::.:||:..:.||...:.|.|..:... |.|.||||.|.|....:|.|
Zfish   528 GILALLDEECWFPKATDKSFVEKVVQELGNNPKFQKPKKLKDDADFCIIHYAGKVDYKANEWLMK 592

  Fly   569 NRDSFSGDLRTLVQRSTNKYLVDIFPH--------------EMPMDTAKKQP----TLCVKFRNS 615
            |.|..:.::.||:.:|.:|::.:::..              |......|.:.    |:...::..
Zfish   593 NMDPLNDNVATLLNQSVDKFVSELWKDVDRIVGLDKVAGMGESLHGAVKTRKGMFRTVGQLYKEQ 657

  Fly   616 LDMLMRTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFV 680
            |..||.||...:|.|:|||.||..|:.......|.:.|||.:|::|..||.|.|:|.|..::.|.
Zfish   658 LMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFR 722

  Fly   681 ERYRLLVPPVGPLEQCDCRKLARQICEV---ALPADSD-RQYGKTKLFLRDEDDASLELQRSQLM 741
            :||.:|.|...|....|    .:|.|.:   ||..||: .:.|::|:|.|....|.||.:|...:
Zfish   723 QRYEILTPNAIPKGFMD----GKQACVLMVKALELDSNLYRIGQSKVFFRAGVLAHLEEERDMKI 783

  Fly   742 LKSIVTIQRGIRRVLFRR-YMKRYRE--AIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQL 803
            ...|::.|...|..:.|| :.||.::  |:..:||.....|:.|.:|..|. |.::...:...:.
Zfish   784 TDVIISFQAWCRGYVARRAFAKRQQQLTAMRVIQRNCAAYLKLRNWQWWRL-FTKVKPLLQVTRQ 847

  Fly   804 TTKFTMVRCRTIKL---QALSRGYLVRKDFQKKLLERRK---QNQLKKE-ELLK---------LA 852
            ..:........:|:   |..:...|...:.::|.|...|   |.||:.| ||.:         .|
Zfish   848 EEEMVAKEEELVKMKERQQQAEDQLKESEAKQKQLNAEKLALQEQLQAETELCQEAEEMRSRLTA 912

  Fly   853 KMKEAEELLR--LQQLKEQKER-EQREQQEKRLQE-----EQRLKAEAAARNALAMAAVQQKRRT 909
            :|:|.||:|.  ..:|:|::|| .|.:.::|::|:     ||:|..|.|||..|.:..|....:.
Zfish   913 RMQEMEEVLHELESRLEEEEERVAQFQSEKKKMQQNIGDLEQQLDEEEAARQKLQLEKVTMDAKL 977

  Fly   910 KPVKQEAPKAPTLQARNSLPPPPTTLIVAAPLPTRPASAVTRINTIPESPGTIDVESSKQMVDDV 974
            |.::::........|:.|                                     :..|||.:.:
Zfish   978 KKIEEDLMVIEDQNAKLS-------------------------------------KEKKQMEERI 1005

  Fly   975 FRFLNDEPDAALRKLNNISSGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQHERKPLKKS 1039
            ..|                   |..|                          |..:.:.|.|:|.
Zfish  1006 SEF-------------------TTNL--------------------------AEEEEKSKSLQKL 1025

  Fly  1040 LLKHEHPI---------DEMASKAIWLTILRFMGDLPDVVSSPTLHVFDN-ENLMSDLASLLNTS 1094
            ..|||..|         :|...:.:.....:..||      |..||  |. ..|.:.:|.|
Zfish  1026 KTKHETMITDLEDRLRKEEKMRQELEKNRRKLEGD------STELH--DQIAELQAQIAEL---- 1078

  Fly  1095 DSYKPRLFVRQSQRRIPKPLASGEKEAQEFYQHWLNVPTSHLEKIHFIIGHGIIKNSLRDEI--- 1156
                 |..:.:.:..:...||..|:||                         .:||:.:..|
Zfish  1079 -----RAQLAKKEEELQAALARIEEEA-------------------------ALKNAAQKSIREM 1113

  Fly  1157 ---LAQICKQLYLNPSRSSYSR------GWLLLSLCLSCFPPSKEFEPHLRSFMKQGTAQLQATP 1212
               ::::.:.|.|..:..:.:.      |..|.:|       ..|.|..|.|...|...:.:...
Zfish  1114 EAQISELQEDLELEKAARNKAEKQRRDLGEELEAL-------KTELEDTLDSTAAQQELRAKRET 1171

  Fly  1213 SLQRLERTLVNGPRCQPPSLFELHAIRGRHPL---RLDIHLMDGQQRRLQVDAASTAREAV-NQL 1273
            .:.:|::||.:..|.....|.|   :|.:|..   .|:..|...::.:..||.|..|.|:. |:|
Zfish  1172 EVTQLKKTLEDEARAHEQMLSE---VRQKHNQAFEELNEQLEQSKRSKASVDKAKQALESERNEL 1233

  Fly  1274 ---CQGMGLTDTFGFGLVMSLNGKLMPL------GAGQEH-VLDAISECEQRQLDAPWKLYIRKE 1328
               .:.:..:.............:|..|      ...|:| :||.:|:. |.:|:
Zfish  1234 QIELKSLSQSKNDSENRRKKAESQLQELQVKHTESERQKHELLDKVSKM-QAELE---------- 1287

  Fly  1329 MFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEIT 1393
                    |:....|::..|.|           ::.||.:.|
Zfish  1288 --------SLQGTVTKVESKSI-----------KAAKDCSAV----------------------- 1310

  Fly  1394 AFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDL--LLEAQKRAKEDICLFAHLSWPMRH 1456
                ...|...:..:|..:|...|...:...:::|||:|  :||.::.:|:::....|.:    .
Zfish  1311 ----ESQLKDAQALLEEETRQKLAISTRLRQLEDEQNNLKEMLEEEEESKKNVEKQLHTA----Q 1367

  Fly  1457 SRLFEVVRKEGPKLQSDELMLGINSAGLFLIDETEQVLASCCFSEVLKVHVESDDKL 1513
            ::|.|:.:|...:.||.|.|   ......|..|.|.||      :.|:....|.|||
Zfish  1368 AQLAEMKKKIEQEAQSLESM---EDGKKKLQREVESVL------QQLEERNASYDKL 1415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	261/683 (38%)
		IQ	765..785	CDD:197470	5/21 (24%)
		Atrophin-1	<820..>946	CDD:460830	35/146 (24%)
		MyTH4	1031..1239	CDD:470587	42/229 (18%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	18/104 (17%)
		B41	1248..1429	CDD:214604	28/191 (15%)
		PH-like	1454..1547	CDD:473070	17/60 (28%)
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
myh9a	NP_001091647.3	None