Protein Alignment Myo28B1 and Myo6

DIOPT Version :10

• Sequence 1: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Sequence 2: XP_008764645.1
• Gene: Myo6 / 315840
• RGDID: 1560646
• Length: 1294
• Species: Rattus norvegicus
• Alignment Length: 1347
• Identity: 401/1347 - (29%)
• Similarity: 612/1347 - (45%)
• Gaps: 262/1347 - (19%)

  Fly    44 DDRNKQFWVPAGDVLKAMHITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAIN 108
            :.:.|.|......|..|.. .|::||||..:|..|.|.|:|.|::.||:|..||||..::|:|:|
  Rat    35 NQKGKTFLALINQVFPAEE-DSKKDVEDNCSLMYLNEATLLHNVKVRYSKDRIYTYVANILIAVN 98

  Fly   109 PYQILP-IYTNREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKL 172
            ||..:| ||::..|:.|:.|||..:|||:|||:|.||:.::.||.:|.:::||||||||||:||.
  Rat    99 PYFDIPKIYSSDTIKSYQGKSLGTMPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKF 163

  Fly   173 ILQYLAAISGKHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQY 237
            :|:||....|....|:.:|:||||::|||||||||||:|||||||::||.|..:.::.|..:..|
  Rat   164 VLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHY 228

  Fly   238 LLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQG-------------- 288
            |||||||..|.::||||||||.:.||.|...||:|.|  .||..:.||.:|
  Rat   229 LLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHL--SSPDNFRYLNRGCTRYFANKETDKQI 291

  Fly   289 ------------GCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRF-TAT 340
                        |....|...|..||..:..|||.:....||...:..::|.:|||||:.| .|.
  Rat   292 LQNRKSPEYVKAGSLKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAG 356

  Fly   341 EVANLATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIF-----VHGEHVTTSLSKEAAIEGRD 400
            ..:.....:....|:|:..|:|||:....|..:||.|.:.     ..|..:...|..|.|...||
  Rat   357 STSGGCNLKNKSAPSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANSARD 421

  Fly   401 AFVKSLYDGIFVRIVRRINETINKQVDQPMNS----IGVLDIFGFENFDNNSFEQLCINYANENL 461
            |..|::|..:|..:|.|:|:..      |..:    ||||||.|||.|::|||||.||||.||.|
  Rat   422 ALAKTVYSHLFDHVVDRVNQCF------PFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL 480

  Fly   462 QQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQ---T 523
            ||||...|.|.||:.||.|.:....:.:.|||..:|||.:|.:.::.::|||::.|:.:||   :
  Rat   481 QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEVKLVGILDILDEENRLPQPSDQHFTS 545

  Fly   524 LLEKLHVQHGNRSIYVKGK-TTQTSL-----FGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLVQ 582
            ::.:.|..|...:|..|.| ....:|     |.|||:||.|.|....|:|||.|:....|.:|:.
  Rat   546 VVHQKHKDHFRLTIPRKSKLAVHRNLRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLIC 610

  Fly   583 RSTNKYLVDIFPHEM--PMDTAKKQPTLCV-----KFRNSLDMLMRTLSQAHPYFIRCIKPNEYK 640
            .|.:|::..:|....  ..||.:|...|..     ||:..|::|:..|......||||||||...
  Rat   611 ESRDKFIRALFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKM 675

  Fly   641 EPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQCDCRKLA--- 702
            ...:|:....:.||:.|||:....:.:.|:|.|.::......|:..:|          .|||
  Rat   676 TSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRASFHELYNMYKKYMP----------EKLARLD 730

  Fly   703 -RQICEVALPA----DSDRQYGKTKLFLR-------------DEDDASLELQRSQLML------- 742
             |..|:....|    :.|.::|.||:|.|             |.|..:..::|..|.|
  Rat   731 PRLFCKALFKALGLNEVDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNLWLVCSRWKK 795

  Fly   743 -----KSIVTIQRGIRRVLFRRYMKRYR-EAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQ 801
                 .|::.::..|          :|| ||.|.:|:..|..|.:|:::....|..::|   ..:
  Rat   796 VQWCSLSVIKLKNKI----------KYRAEACIKMQKTIRMWLCKRRHKPRIDGLVKVG---TLK 847

  Fly   802 QLTTKFTMVRC----------RTIKLQALSRGYLVRKDFQKKLLERRKQNQLKKEELLK------ 850
            :...||..|..          |.||...:|...|:.|  .|..:..|:|.|.:.:.|:|
  Rat   848 KRLDKFNEVVSALKDGKPEVNRQIKDLEISIDALMAK--IKSTMMTREQIQKEYDALVKSSEDLL 910

  Fly   851 --LAKMK----EAEELLRLQQ--LKEQKEREQREQQEKRLQEEQRLKAEAAARNALAMAAVQQKR 907
              |.|.|    |||.|.|:|:  .||:|.||:.||:.::.:||:|:|.|...:.  .....::|:
  Rat   911 SALQKKKQQEEEAERLRRIQEEMEKERKRREEDEQRRRKEEEERRMKLEMEVKR--KQEEEERKK 973

  Fly   908 RTKPVKQEAPKAPTLQARNSLPPPPTTLIVA----------------APLPTRPASAVTRINTIP 956
            |....|:...:.....||..........::|                :.|.:..|...|.:.:..
  Rat   974 REDDEKRIQAEVEAQLARQREEESQQQAVLAQECRDRELALRIAQNESELISDEAQGDTALRSSS 1038

  Fly   957 ESP------GTIDVESSKQMVDDVFRFLNDEP------DAALRKLNNISSGDTIRLPKSVPNNID 1009
            ..|      ||....:.:||..::...|:..|      .||..|.:::|......|    .:.|:
  Rat  1039 SCPASSKTNGTRPQMTPEQMAKEMSDILSRGPAVQATKAAAGTKKHDLSKWKYAEL----RDTIN 1099

  Fly  1010 TS-DFSYLKYAATYFGGGATAQHERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPDVVSSP 1073
            || |...|......|.......|..|...|   |.....::.|.|::           .|.
  Rat  1100 TSCDIELLAACREEFHRRLKVYHAWKSKNK---KRNTETEQRAPKSV-----------TDY---- 1146

  Fly  1074 TLHVFDNENLMSDLASLLNTSDSYKP--RLFVRQ-------SQR--RIP--KPLASGEKEAQE-- 1123
                        |.|..||.|....|  :|..||       .||  |||  :| |...|:.|.
  Rat  1147 ------------DFAPFLNNSPQQNPAAQLPARQQEIEMNRQQRFFRIPFIRP-ADQYKDPQNKK 1198

  Fly  1124 ---FYQH----WL-NVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLL 1180
               :|.|    |: .....|.:|...::..|      :|::  ::| :|.|..:..:..||..:|
  Rat  1199 KGWWYAHFDGPWIARQMELHPDKPPILLVAG------KDDM--EMC-ELNLEETGLTRKRGAEIL 1254

  Fly  1181 SLCLSCFPPSKEFE---------PHLRSFMKQGTAQ-LQATPSLQRL 1217
                     .::||         .:|:|.::...|: ..||..||.|
  Rat  1255 ---------PRQFEEIWERCGGIQYLQSAIESRQARPTYATAMLQNL 1292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	259/705 (37%)
		IQ	765..785	CDD:197470	8/20 (40%)
		Atrophin-1	<820..>946	CDD:460830	37/155 (24%)
		MyTH4	1031..1239	CDD:470587	48/220 (22%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612
		B41	1248..1429	CDD:214604
		PH-like	1454..1547	CDD:473070
		MyTH4	1674..1819	CDD:214535
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613
		B41	1827..2032	CDD:214604
		FERM_C2_MyoVII	2028..2121	CDD:270020
Myo6	XP_008764645.1	MYSc_Myo6	71..759	CDD:276833	259/705 (37%)
		CBD_MYO6-like	770..917	CDD:409646	35/161 (22%)
		MYO6_MIU_linker	999..1068	CDD:412090	10/68 (15%)
		MyUb_Myo6	1082..1122	CDD:439319	9/43 (21%)
		Myosin-VI_CBD	1177..1267	CDD:465157	24/108 (22%)