DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo28B1 and Myo10

DIOPT Version :9

Sequence 1:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster
Sequence 2:XP_008758990.2 Gene:Myo10 / 310178 RGDID:1307193 Length:2060 Species:Rattus norvegicus


Alignment Length:2373 Identity:630/2373 - (26%)
Similarity:978/2373 - (41%) Gaps:592/2373 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDAGYSPRKGEYVWVKPQ--------NTTSE----FAVPFGARIVRTEKTQTLVCDDRNKQFWVP 53
            ||:.:.  :|..||::..        |:.:|    |...:|.  |.|.|..|:.    |::    
  Rat     1 MDSFFP--EGARVWLRENGQHFPSTVNSCAEGVVVFQTDYGQ--VFTYKQSTIT----NQK---- 53

  Fly    54 AGDVLKAMHITSQEDVEDMITLGDLQEYTILRNLQNRYAKQLIYTYTGSMLVAINPYQ-ILPIYT 117
                :.|||...:|.|:||.:|.:|...:|:.||..||.:..||||.||::.::|||| |..:|.
  Rat    54 ----VTAMHPLHEEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSIIASVNPYQPIAGLYE 114

  Fly   118 NREIQLYRNKSLAELPPHIFAISDNAFQRLQRLKENQCVVISGESGAGKTESTKLILQYLAAIS- 181
            ...::.|....|.|||||||||::..::.|.:..:||||:|||||||||||||||||::|:.|| 
  Rat   115 RATMEQYSRCHLGELPPHIFAIANECYRCLWKRHDNQCVLISGESGAGKTESTKLILKFLSVISQ 179

  Fly   182 --------GKHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRFGKYIEIRFTPQGAIQGARIQQYL 238
                    .|.|.:||.|::::||||||||||||.|:|||||||::::....:|.|||.||..||
  Rat   180 HSLDLCLQEKSSSVEQAILQSSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYL 244

  Fly   239 LEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPSQYHYLAQGGCFTLPGRGDAKDFA 303
            |||:|:|.|:..||||||||.:||||...|||...|  ..|..||||.|.||.......|.:.|.
  Rat   245 LEKNRVVRQNPGERNYHIFYALLAGLDQGEREEFYL--SLPENYHYLNQSGCTEDKTISDQESFR 307

  Fly   304 DIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVANLATAEIDDTPNLQRVAQLLGIPIS 368
            .:..||:|:.|..|||..:|.|||.||||||:.|...     ..|:|.....|.|.|:|||:..:
  Rat   308 QVIEAMEVMQFSKEEVREVLRLLAGILHLGNIEFITA-----GGAQISFKTALGRSAELLGLDPT 367

  Fly   369 ALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDGIFVRIVRRINETINKQVDQPMNSI 433
            .|..|||||::|:.||.:.|.||.:.|::.||:...:||...|..::::||..|..:.|  ..||
  Rat   368 QLTDALTQRSMFLRGEEILTPLSVQQAVDSRDSLAMALYARCFEWVIKKINSRIKGKDD--FKSI 430

  Fly   434 GVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQDEYQNEHINWQHIEFQDNQQILDL 498
            |:|||||||||:.|.|||..||||||.||::|..|||.:||.||..|.:.|:.|::.||.:.|||
  Rat   431 GILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDL 495

  Fly   499 IGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYVKGKTTQTSLFGIRHYAGVVMYNPL 563
            | .|.:.|::||:|||.||:.||.|||||||.||.|...|||.:....: ||::||||.|.|:..
  Rat   496 I-EKKLGLLALINEESHFPQATDSTLLEKLHNQHANNHFYVKPRVAVNN-FGVKHYAGEVQYDVR 558

  Fly   564 GFLEKNRDSFSGDLRTLVQRSTNKYLVDIFPH---EMPMDTAK-----KQPTLCVKFRNSLDMLM 620
            |.||||||:|..||..|::.|...::.|:|.|   ....||.|     ::||:..:|::||..||
  Rat   559 GILEKNRDTFRDDLLNLLRESRFDFIYDLFEHISSRNNQDTLKCGSKHRRPTVSSQFKDSLHSLM 623

  Fly   621 RTLSQAHPYFIRCIKPNEYKEPKNFDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRL 685
            .|||.::|:|:||||||..|.|..||:.:.:.|||||||:||.|||:|||.:|..::.|.:||::
  Rat   624 ATLSSSNPFFVRCIKPNTQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKV 688

  Fly   686 LVPPVGPLEQCDCRKLA-----RQICEVAL----PADSDRQYGKTKLFLRDEDDASLELQRSQLM 741
            |:           |.||     |..|.|.|    .::|:.|.||||:|||:..:..||.:|.:.:
  Rat   689 LM-----------RDLALPEDIRGKCTVLLQFYDASNSEWQLGKTKVFLRESLEQKLEKRREEEI 742

  Fly   742 LKSIVTIQRGIRRVLFRRYMKRYREAIITVQRYWRGRLQRRKYQVMRQGFHRLGACIAAQQLTTK 806
            .::.:.|:..|...|.|:..::....::|:|:.:|..|.|:::..:::     .|.:..:||   
  Rat   743 DRAAMVIRAHILGYLARKQYRKVLCGVVTIQKNYRAFLARKRFLHLKK-----AAIVFQKQL--- 799

  Fly   807 FTMVRCRTIKLQALSRGYLVRKDFQKKLLERRKQNQLKKEELLKLAKMKEAEELLRLQQLKEQKE 871
                           ||.|.||.:::.|.|:|                 |.||..||:   |:|:
  Rat   800 ---------------RGRLARKVYRQLLAEKR-----------------ELEERKRLE---EEKK 829

  Fly   872 REQREQQEKRLQEEQ---RLKAEAAARNALAMAAVQQKRRTKPVKQEAPKAPTLQARNSLPPPPT 933
            ||:.|::.||.|.|.   |.:.||..|....:.|:|:.:|...:.:|..|    |..|       
  Rat   830 REEEERERKRAQREADLLRAQQEAETRKQQELEALQKNQREADLTRELEK----QREN------- 883

  Fly   934 TLIVAAPLPTRPASAVTRINTIPE-----------SPGTIDVESSKQMVDDVFRFLNDEPDAA-- 985
                      :....:.|:....|           |.....::..:|:.|:..|.|.||...|  
  Rat   884 ----------KQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKLQQLRDEELRRLEDEACRAAQ 938

  Fly   986 --LRKLN---------NIS---------SGDTIRLPKSVPNNIDTSDFSYLKYAATYFGGGATAQ 1030
              |..||         ||.         ||:...|.::........:||. .|.......|..|.
  Rat   939 EFLESLNFDEIDECVRNIERSLSVGSEISGELSELAENASGEKPNFNFSQ-PYPEEEVDEGFEAD 1002

  Fly  1031 HERKPLKKSLLKHEHPIDEMASKAIWLTILRFMGDLPD---------VVSSPTLHVFDNENLMS- 1085
            .:  ..|.|....||...:..:..|     |...|..:         |.:||:.   |:..|:: 
  Rat  1003 DD--AFKDSPNPSEHGHSDQRTSGI-----RTSDDSSEEDPYMNYTVVPTSPSA---DSTVLLAA 1057

  Fly  1086 ---DLASLLNTSDSYKPRLFVRQSQRRIPKP---------------LASGEKE--AQEFYQHW-- 1128
               |.|||.|:| |.:....:.|:...:|.|               :.||...  :..:...|  
  Rat  1058 SVQDSASLHNSS-SGESTYCMPQNNGDLPSPDGDYDYDQDDYEDGAITSGSSVTFSNSYGSQWSP 1121

  Fly  1129 ---LNVPTSHLEKIHFIIGHGIIKNSLRDEILAQICKQLYLNPSRSSYSRGWLLLSLCLSCFPPS 1190
               .:|.|.:....:.....| .::|..|.  .:.....:......||.|..:...:.|      
  Rat  1122 DYRYSVGTYNSSGAYRFSSEG-AQSSFEDS--EEDFDSRFDTDDELSYRRDSVYSCVTL------ 1177

  Fly  1191 KEFEPHLRSF--MKQGTAQLQATPSLQRLERTLVNGPRCQPPSLFELHAIRGRHPLRLDIHLMDG 1253
                |:..||  ||.|                                             ||:.
  Rat  1178 ----PYFHSFLYMKGG---------------------------------------------LMNS 1193

  Fly  1254 QQRRLQVDAAST------AREAVNQLCQGMGLTDTFGFGLVMSLNGKLMPLGAGQEHVLDAISEC 1312
            .:||..|....|      .:||:.|                    |.|...|.|.       |..
  Rat  1194 WKRRWCVLKDETFLWFRSKQEALKQ--------------------GWLHKKGGGS-------STL 1231

  Fly  1313 EQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGEYRCRSEKDIAMVCALACFV 1377
            .:|.....|  ::.::....:::...:.|            || |....||.|:|         :
  Rat  1232 SRRNWKKRW--FVLRQSKLMYFENDSEEK------------LK-GTVEVRSAKEI---------I 1272

  Fly  1378 -----EYGPGEILRLKPSEITAFVPSDLLAPGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQ 1437
                 |.|...|:..:...:.|..|.|        ...|..:::..:..:.....|.:|.....|
  Rat  1273 DNTNKENGIDIIMADRTFHLIAESPED--------ASQWFSVLSQVHSSTDQEIREMHDEQANPQ 1329

  Fly  1438 KRAK-------EDICLFAHLSWPMRHSRLFEVV--------RKEGPKLQSDELMLGINSAGLFLI 1487
            ....       :.:|.......|    ..|.::        ..:.|:.....:.|...|.|...:
  Rat  1330 NAVGTLDVGLIDSVCASDSPDRP----NSFVIITANRVLHCNADTPEEMHHWITLLQRSKGDTRV 1390

  Fly  1488 DETEQVLASCCFSEVLKVHVESDDKLHVMTFQHVNFVLQCSSAQDANEVINYMLDNLRQRSSYGV 1552
            :..|.::......|     |::..|:..:..:...|||..:|           ||..:......:
  Rat  1391 EGQEFIVRGWLHKE-----VKNSPKMSSLKLKKRWFVLTHNS-----------LDYYKSSEKNAL 1439

  Fly  1553 ALDPVVEGDLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVNGQWGQFLAGNVRVLATLT 1617
            .|..:|...|  |.|:.|.:.|..|.|.....:.  ..:.|||            ...::|...|
  Rat  1440 KLGTLVLNSL--CSVVPPDEKIFKETGYWNVTVY--GRKHCYR------------LYTKLLNEAT 1488

  Fly  1618 KPSEKLQDILREGRFQEPPKPTPRANYSRRRQHNISQLAESHFREPLDSD-------KAPLSKFS 1675
            :.|..:|::..    .:.|..||           ..||.:......|:||       :.|:.:::
  Rat  1489 RWSSAIQNVTD----TKAPIDTP-----------TQQLIQDIKENCLNSDVVEQIYKRNPILRYT 1538

  Fly  1676 PEPLKAPLL---------------------KAVVKVPPLFQQALVMHHHILKYMGDIARSNLPVN 1719
            ..||.:|||                     ...:|:....||        |:.|.|      |:.
  Rat  1539 HHPLHSPLLPLPYGDINLNLLKDKGYTTLQDEAIKIFNSLQQ--------LESMSD------PIP 1589

  Fly  1720 TDLIFQPALQ--HPL--LCDELYCQLMKQLS--DNPSSESEKRGWDLLYLATGLVAPSVLVMREL 1778
               |.|..||  |.|  |.|||||||:||.:  .:|.|......|.:|...:....||    |.:
  Rat  1590 ---IIQGILQTGHDLRPLRDELYCQLIKQTNKVPHPGSVGNLYSWQILTCLSCTFLPS----RGI 1647

  Fly  1779 IILLRMRADALADACLKRLKRSLAQGQRKKAPHLIEVEGIQQRCLHIYHKI-------YFPD-DT 1835
            :..|:..        |||::......:.:|            ..|.||..:       :.|. |.
  Rat  1648 LKYLKFH--------LKRIREQFPGTEMEK------------YALFIYESLKKTKCREFVPSRDE 1692

  Fly  1836 VEA--------------------FEIESHTRGAELIADIAQRLELK-SPVGYSIFLKTGDRVYAM 1879
            :||                    ..|.|||...|::..:.:.|.:: |...:::|...|....|:
  Rat  1693 IEALIHRQEMTSTVYCHGGGSCKITINSHTTAGEVVEKLIRGLAMEDSRNMFALFEYNGQVDKAI 1757

  Fly  1880 PEEEFVFDFITQLIYWLRQQRTIRSISDGQYQLHFMRKLWLNNHPGEDLNGDMIFSYPQELHKYL 1944
            .....|.|.:.:    ..:........|..::.:|....:|:.......:.:..|.:.|.....:
  Rat  1758 ESRTIVADVLAK----FEKLAATSEAGDAPWKFYFKLYCFLDTDSMPKDSVEFAFMFEQAHEAVI 1818

  Fly  1945 KGYYPIDCEQASRLAIL--------------VYSADHDVSLQRLPE------------------- 1976
            .|::|...|....||.|              |...:...|||||..                   
  Rat  1819 HGHHPAPEESLQVLAALRLQYLQGDYTLHTSVPPLEEVYSLQRLKARISQSTKTFTPYERLEKRR 1883

  Fly  1977 ------VLTRLIPEDLIPLQTVAE------W--------RQQILPKVHR-DHLTEDHAKILFLQE 2020
                  .|.|......:..|.|.|      |        |..|:.|..: ..::::.|...::..
  Rat  1884 TSFLEGTLRRSFRTGTVARQKVEEEQMLDMWIKEEICSARASIIDKWKKLQGVSQEQAMAKYMAL 1948

  Fly  2021 LSHFACFGSTFFVVKQQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQLGIWSSG---KN 2082
            :..:..:|||.|.| :..:...|:.|.:.:::....:......:.|..::|..  |.|.|   .|
  Rat  1949 IKEWPGYGSTLFDV-ECKEGGFPQELWLGVSADAVSVYKRGEGKPLEVFQYEH--ILSFGAPLAN 2010

  Fly  2083 HFHIRFGNMIGASKLLCSTTQGYKMDDLLASYV 2115
            .:.|    ::...:||..|::...:..|:.:|:
  Rat  2011 TYKI----VVDERELLFETSEVVDVAKLMKAYI 2039

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 324/701 (46%)
MYSc_Myo7 81..726 CDD:276832 313/671 (47%)
IQ 765..785 CDD:197470 5/19 (26%)
DUF4355 827..>887 CDD:290964 19/62 (31%)
MyTH4 1031..1239 CDD:295320 40/244 (16%)
B41 1248..1429 CDD:214604 31/191 (16%)
FERM_N 1248..>1288 CDD:286467 9/45 (20%)
FERM_B-lobe 1342..1429 CDD:271216 14/91 (15%)
PH-like 1454..1547 CDD:302622 15/100 (15%)
MyTH4 1674..1819 CDD:214535 40/171 (23%)
B41 1827..2032 CDD:214604 46/287 (16%)
FERM_N 1829..>1877 CDD:286467 13/76 (17%)
FERM_M 1936..2032 CDD:278785 26/149 (17%)
FERM_C2_MyoVII 2028..2121 CDD:270020 19/91 (21%)
Myo10XP_008758990.2 MYSc 58..739 CDD:214580 324/702 (46%)
MYSc_Myo10 77..727 CDD:276840 313/671 (47%)
IQ 741..763 CDD:197470 4/21 (19%)
SPEC <843..957 CDD:295325 26/134 (19%)
MYO10_CC 882..932 CDD:293340 8/66 (12%)
PH-like 1183..>1225 CDD:302622 15/106 (14%)
PH2_MyoX 1217..1318 CDD:270108 23/159 (14%)
PH 1217..1312 CDD:278594 23/153 (15%)
PH3_MyoX-like 1383..1508 CDD:270109 31/171 (18%)
PH 1398..1497 CDD:278594 25/130 (19%)
MyTH4 1551..1697 CDD:214535 42/186 (23%)
UBQ 1703..>1748 CDD:294102 7/44 (16%)
B41 1706..1960 CDD:214604 42/257 (16%)
FERM_M 1801..1960 CDD:278785 27/158 (17%)
FERM_C_MyoX 1956..2044 CDD:270023 19/91 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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